《生物化學》是2021年清華大學出版社出版的圖書。
基本介紹
- 中文名：生物化學
- 作者：克里斯托弗·K
- 譯者：呂立夏 、王秀宏 、劉欣
- 出版時間：2021年
- 出版社： 清華大學出版社
- ISBN： 9787302577010
內容簡介,圖書目錄,作者簡介,
內容簡介
本教材在充分尊重原著的基礎上，保留其基本框架，參考清華大學出版社出版的《來華留學生臨床醫學專業本科（英語授課）教學大綱》和國家執業醫師資格考試大綱進行改編，內容涵蓋大分子結構與功能、物質代謝與調節，以及遺傳信息傳遞等。本書編排上力求簡明扼要，重點突出，可作為來華留學臨床醫學學士（MBBS）和我國長學制臨床醫學專業學生使用的教材，也可作為相關學科的碩士研究生、進修生和教師的參考書。
圖書目錄
PART 1 The Realm of Biochemistry
CHAPTER 1 The Scope of Biochemistry
Biochemistry and the Biological Revolution
The Roots of Biochemistry
Biochemistry as a Chemical Science
Biochemistry as a Biological Science
Biochemistry and the Information Explosion
PART 2 Molecular Architecture of Living Matter
CHAPTER 2 Nucleic Acids
The Nature of Nucleic Acids
Primary Structure of Nucleic Acids
Secondary and Tertiary Structure of Nucleic Acids
The Biological Functions of Nucleic Acids: A Preview of Molecular Biology
Plasticity of Secondary and Tertiary DNA Structure
Stability of Secondary and Tertiary Structure
CHAPTER 3 Introduction to Proteins: The Primary Level of Protein Structure
Amino Acids
Peptides and the Peptide Bond
Proteins: Polypeptides of Defined Sequence
From Gene to Protein
Protein Sequence Homology
CHAPTER 4 The Three-Dimensional Structure of Proteins
Secondary Structure: Regular Ways to Fold the Polypeptide Chain
Fibrous Proteins: Structural Materials of Cells and Tissues
Globular Proteins: Tertiary Structure and Functional Diversity
Factors Determining Secondary and Tertiary Structure
Prediction of Secondary and Tertiary Protein Structure
Quaternary Structure of Proteins
CHAPTER 5 Protein Function and Evolution
Oxygen Transport: The Roles of Hemoglobin and Myoglobin
The Mechanism of Oxygen Binding by Heme Proteins
Oxygen Transport: Hemoglobin
Allosteric Effectors of Hemoglobin
Protein Evolution: Myoglobin and Hemoglobin as Examples
Hemoglobin Variants: Evolution in Progress
PART 3 Dynamics of Life: Catalysis and Metabolism
CHAPTER 6 Enzymes: Biological Catalysts
The Role of Enzymes
Chemical Reaction Rates and the Effects of Catalysts: A Review
How Enzymes Act as Catalysts: Principles and Examples
Enzyme Inhibition
Cofactors, Vitamins, and Essential Metals
The Diversity of Enzymatic Function
Nonprotein Biocatalysts: Catalytic Nucleic Acids
The Regulation of Enzyme Activity: Allosteric Enzymes
Covalent Modifications Used to Regulate Enzyme Activity
CHAPTER 7 Chemical Logic of Metabolism
A First Look at Metabolism
Freeways on the Metabolic Road Map
Biochemical Reaction Types
Some Bioenergetic Considerations
Major Metabolic Control Mechanisms
CHAPTER 8 Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway
Glycolysis: An Overview
Reactions of Glycolysis
Metabolic Fates of Pyruvate
Energy and Electron Balance Sheets
Gluconeogenesis
Coordinated Regulation of Glycolysis and Gluconeogenesis
Entry of Other Sugars into the Glycolytic Pathway
Polysaccharide Metabolism
Glycogen Metabolism in Muscle and Liver
Coordinated Regulation of Glycogen Metabolism
Biosynthesis of Other Polysaccharides
A Biosynthetic Pathway That Oxidizes Glucose: The Pentose Phosphate Pathway
CHAPTER 9 Citric Acid Cycle
Overview of Pyruvate Oxidation and the Citric Acid Cycle
Pyruvate Oxidation: A Major Entry Route for Carbon into the Citric Acid Cycle
Coenzymes Involved in Pyruvate Oxidation and the Citric Acid Cycle
Action of the Pyruvate Dehydrogenase Complex
The Citric Acid Cycle
Stoichiometry and Energetics of the Citric Acid Cycle
Regulation of Pyruvate Dehydrogenase and the Citric Acid Cycle
CHAPTER 10 Electron Transport and Oxidative Phosphorylation
Electron Transport
Oxidative Phosphorylation
CHAPTER 11 Lipid MetabolismⅠ: Fatty Acids, Triacylglycerols, and Lipoproteins
Utilization and Transport of Fat and Cholesterol
Fatty Acid Oxidation
Fatty Acid Biosynthesis
CHAPTER 12 Interorgan and Intracellular Coordination of
Energy Metabolism in Vertebrates
Interdependence of the Major Organs in Vertebrate Fuel Metabolism
作者簡介
楊潔，教授，博導。1997年7月中山醫科大學生化博士畢業後執教醫學基礎課程-生化與分子生物學多年，承擔了五年制、七年制、留學生和研究生的《生物化學》課程以及研究生的《分子生物學進展》等課程，積累了大量教育教學經驗。2007年被評為天津市優秀教師，國家教育部新世紀人才支持計畫、天津市特聘教授。參編專著《分子遺傳學與基因工程》，人衛教材《醫學細胞生物學》、《醫學免疫學》。現今為中華醫學會醫學細胞生物學常務委員、中華微生物與免疫學會青年委員會副主委、臨床生物化學與分子生物學會理事、中國細胞生物學會醫學細胞生物學分會理事、天津市生化與分子生物學常務理事。作為基礎醫學院的院長，對基礎醫學課程體系及規範課程的改革和最佳化做出了積極的推動作用。作為211重點學科帶頭人，2006年以來獲得863、國家基金面上、重大研究計畫培育等科研項目，在Nat Struct Mol Biol.，JBC.，NAR等國際雜誌發表SCI收錄論文10餘篇，培養研究生18名。
