《生物化學（留學生與雙語教學用）（英文原版改編版）》是2021年清華大學出版社出版的圖書，作者是(美)克里斯托弗 ? K. 馬修斯（Christopher K. Mathews） （美）K. E. 范霍爾德（K. E. Van Holde） （美）迪安 ? R.。
基本介紹
- 中文名：生物化學(留學生與雙語教學用)(英文原版改編版）
- 作者：(美)克里斯托弗 ? K. 馬修斯（Christopher K. Mathews） （美）K. E. 范霍爾德（K. E. Van Holde） （美）迪安 ? R.
- 出版時間：2021年3月1日
- 出版社：清華大學出版社
- ISBN：9787302577010
- 定價：238 元
- 印刷日期：2021年4月12日
- 印次：1-1
內容簡介,圖書目錄,
內容簡介
《 生物化學(留學生與雙語教學用)(英文原版改編版)》是清華大學出版社出版的一本圖書，作者：(美)克里斯托弗 ? K. 馬修斯（Christopher K. Mathews） （美）K. E. 范霍爾德（K. E. Van Holde） （美）迪安 ? R.。 The fourth edition of Biochemistry preserves the clear writing, strong physical chemistry background, and the use of the "Tools of Biochemistry" feature to underscore the experimental nature of biochemistry. This edition has been comprehensively and consistently updated to present the current developments in a rapidly evolving field.
圖書目錄
PART 1 The Realm of Biochemistry
CHAPTER 1 The Scope of Biochemistry ............................................3
Biochemistry and the Biological Revolution.......................................3
The Roots of Biochemistry................. ... ................................4
Biochemistry as a Chemical Science..............................................7
Biochemistry as a Biological Science ...........................................10
Biochemistry and the Information Explosion .....................................13
PART 2 Molecular Architecture of Living Matter
CHAPTER 2 Nucleic Acids......................................................17
The Nature of Nucleic Acids ....................................................17
Primary Structure of Nucleic Acids.............................................22
Secondary and Tertiary Structure of Nucleic Acids ...............................24
The Biological Functions of Nucleic Acids: A Preview of Molecular Biology..........35
Plasticity of Secondary and Tertiary DNA Structure .............................40
Stability of Secondary and Tertiary Structure.................................43
CHAPTER 3 Introduction to Proteins: The Primary Level of Protein Structure .......46
Amino Acids ..................................................................46
Peptides and the Peptide Bond ......... ......................................55
Proteins: Polypeptides of Defined Sequence......................................58
From Gene to Protein..........................................................60
Protein Sequence Homology ....................................................61
CHAPTER 4 The Three-Dimensional Structure of Proteins.........................64
Secondary Structure: Regular Ways to Fold the Polypeptide Chain..................64
Fibrous Proteins: Structural Materials of Cells and Tissues .....................71
Globular Proteins: Tertiary Structure and Functional Diversity...................76
Factors Determining Secondary and Tertiary Structure ............................79
Prediction of Secondary and Tertiary Protein Structure...........................88
Quaternary Structure of Proteins..............................................88
CHAPTER 5 Protein Function and Evolution......................................93
Oxygen Transport: The Roles of Hemoglobin and Myoglobin.......................94
The Mechanism of Oxygen Binding by Heme Proteins ................................95
Oxygen Transport: Hemoglobin.................................................100
Allosteric Effectors of Hemoglobin ...........................................110
Protein Evolution: Myoglobin and Hemoglobin as Examples........................114
Hemoglobin Variants: Evolution in Progress ..................................118
PART 3 Dynamics of Life: Catalysis and Metabolism
CHAPTER 6 Enzymes: Biological Catalysts .....................................127
The Role of Enzymes .........................................................127
Chemical Reaction Rates and the Effects of Catalysts: A Review ...................127
How Enzymes Act as Catalysts: Principles and Examples...........................131
Enzyme Inhibition............................................................142
Cofactors, Vitamins, and Essential Metals ....................................146
The Diversity of Enzymatic Function............................................148
Nonprotein Biocatalysts: Catalytic Nucleic Acids ............................148
The Regulation of Enzyme Activity: Allosteric Enzymes ..........................151
Covalent Modifications Used to Regulate Enzyme Activity .......................154
CHAPTER 7 Chemical Logic of Metabolism......................................159
A First Look at Metabolism ...................................................159
Freeways on the Metabolic Road Map............................................161
Biochemical Reaction Types ..................................................165
Some Bioenergetic Considerations ............................................165
Major Metabolic Control Mechanisms...........................................171
CHAPTER 8 Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway ...............................176
Glycolysis: An Overview .....................................................176
Reactions of Glycolysis......................................................178
Metabolic Fates of Pyruvate ...................................................185
Energy and Electron Balance Sheets............................................186
Gluconeogenesis..............................................................188
Coordinated Regulation of Glycolysis and Gluconeogenesis ......................192
Entry of Other Sugars into the Glycolytic Pathway............................197
Polysaccharide Metabolism....................................................200
Glycogen Metabolism in Muscle and Liver ......................................200
Coordinated Regulation of Glycogen Metabolism................................203
Biosynthesis of Other Polysaccharides ........................................208
A Biosynthetic Pathway That Oxidizes Glucose: The Pentose Phosphate Pathway......208
CHAPTER 9 Citric Acid Cycle.................................................216
Overview of Pyruvate Oxidation and the Citric Acid Cycle........................216
Pyruvate Oxidation: A Major Entry Route for Carbon into the Citric Acid Cycle......219
Coenzymes Involved in Pyruvate Oxidation and the Citric Acid Cycle ...............221
Action of the Pyruvate Dehydrogenase Complex..................................223
The Citric Acid Cycle........................................................225
Stoichiometry and Energetics of the Citric Acid Cycle .......................229
Regulation of Pyruvate Dehydrogenase and the Citric Acid Cycle .................230
CHAPTER 10 Electron Transport and Oxidative Phosphorylation...................234
Electron Transport ...........................................................236
Oxidative Phosphorylation....................................................247
CHAPTER 11 Lipid MetabolismⅠ: Fatty Acids, Triacylglycerols, and Lipoproteins..263
Utilization and Transport of Fat and Cholesterol ............................263
Fatty Acid Oxidation ........................................................277
Fatty Acid Biosynthesis.......................................................287
CHAPTER 12 Interorgan and Intracellular Coordination of
Energy Metabolism in Vertebrates .............................................301
Interdependence of the Major Organs in Vertebrate Fuel Metabolism ..............301
Hormonal Regulation of Fuel Metabolism.........................................305
Responses to Metabolic Stress: Starvation, Diabetes ........................310
CHAPTER 13 Lipid Metabolism Ⅱ: Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids..315
Metabolism of Glycerophospholipids...........................................315
Metabolism of Sphingolipids .................................................322
Steroid Metabolism...........................................................323
Other Isoprenoid Compounds ...................................................328
Eicosanoids: Prostaglandins, Thromboxanes, and Leukotrienes....................330
CHAPTER 14 Metabolism of Nitrogenous CompoundsⅠ: Principles of Biosynthesis, Utilization, and Turnover.....................................................336
Utilization of Ammonia: Biogenesis of Organic Nitrogen.........................336
The Nitrogen Economy: Aspects of Amino Acid Synthesis and Degradation ............338
Protein Turnover.............................................................340
Amino Acid Degradation and Metabolism of Nitrogenous End Products...............342
Coenzymes Involved in Nitrogen Metabolism.....................................347
CHAPTER 15 Metabolism of Nitrogenous Compounds Ⅱ: Amino Acids, Porphyrins, and
Neurotransmitters ...........................................................355
Pathways of Amino Acid Degradation............................................355
Amino Acids as Biosynthetic Precursors........................................359
Porphyrin and Heme Metabolism ...............................................364
Amino Acids and Their Metabolites as Neurotransmitters and Biological Regulators ....367
Amino Acid Biosynthesis......................................................369
Methionine as the Source of Cysteine Sulfur in Animals.......................370
CHAPTER 16 Nucleotide Metabolism.............................................372
Outlines of Pathways in Nucleotide Metabolism..................................372
De Novo Biosynthesis of Purine Nucleotides....................................375
Purine Degradation and Clinical Disorders of Purine Metabolism.................379
Pyrimidine Nucleotide Metabolism ............................................383
Deoxyribonucleotide Biosynthesis and Metabolism...............................386
Thymidylate Synthase: A Target Enzyme for Chemotherapy .......................391
Biological and Medical Importance of Other Nucleotide Analogs..................394
CHAPTER 17 Mechanisms of Signal Transduction ................................398
An Overview of Hormone Action ...............................................398
Hierarchical Nature of Hormonal Control........................................400
Synthesis of Peptide Hormone Precursors........................................401
Signal Transduction: Receptors...............................................402
Transducers: G Proteins ......................................................404
Effectors: Adenylate Cyclase..................................................407
Second-Messenger Systems.....................................................408
Receptor Tyrosine Kinases.....................................................412
Steroid and Thyroid Hormones: Intracellular Receptors..........................415
Signal Transduction, Oncogenes, and Cancer ...................................418
PART 4 Information CHAPTER 18 Genes, Genomes, and Chromosomes ..................427
Prokaryotic and Eukaryotic Genomes ...........................................427
Restriction and Modification ................................................430
Determining Genome Nucleotide Sequences .....................................433
Physical Organization of Genes: The Nucleus, Chromosomes, and Chromatin.........435
CHAPTER 19 DNA Replication...................................................442
Early Insights into DNA Replication...........................................442
DNA Polymerases: Enzymes Catalyzing Polynucleotide Chain Elongation.............443
Multiple DNA Polymerases ....................................................445
Other Proteins at the Replication Fork........................................445
Proteins in Eukaryotic DNA Replication.........................................449
Replication of Chromatin.....................................................449
Initiation of DNA Replication ................................................450
Replication of Linear Genomes................................................452
Fidelity of DNA Replication..................................................453
RNA Viruses: The Replication of RNA Genomes ..................................454
CHAPTER 20 DNA Restructuring: Repair, Recombination, Rearrangement, Amplification ...457
DNA Repair ..................................................................457
Mismatch Repair .............................................................464
Recombination................................................................470
Gene Rearrangements ..........................................................475
Gene Amplification...........................................................477
CHAPTER 21 Information Readout: Transcription and Post-transcriptional Processing..479
DNA as the Template for RNA Synthesis ......................................480
Enzymology of RNA Synthesis: RNA Polymerase.................................480
Mechanism of Transcription...................................................483
Transcription and Its Control in Eukaryotic Cells ............................489
Post-transcriptional Processing..............................................498
CHAPTER 22 Information Decoding: Translation and Post-translational Protein Processing ..506
An Overview of Translation....................................................506
The Genetic Code ............................................................506
The Major Participants in Translation: mRNA, tRNA, and Ribosomes................509
Mechanism of Translation ....................................................515
Inhibition of Translation by Antibiotics......................................520
Translation in Eukaryotes....................................................522
Rates and Energetics of Translation ..........................................524
The Final Stages in Protein Synthesis: Folding and Covalent Modification .........525
Protein Targeting in Eukaryotes .............................................527
CHAPTER 23 Regulation of Gene Expression.....................................533
Regulation of Transcription in Bacteria ......................................533
Transcriptional Regulation in Eukaryotes.....................................540
DNA Methylation, Gene Silencing, and Epigenetics.............................543
Regulation of Translation....................................................546
RNA Interference .............................................................550
RNA Editing .................................................................552
