具有重要生物活性的寡糖及其綴合物的合成研究

《具有重要生物活性的寡糖及其綴合物的合成研究》是葉新山為項目負責人,北京大學為依託單位的重點項目。

基本介紹

  • 中文名:具有重要生物活性的寡糖及其綴合物的合成研究
  • 項目類別 :重點項目
  • 項目負責人:葉新山
  • 依託單位 :北京大學
科研成果,項目摘要,

科研成果

序號
標題
類型
作者
1
Nitro-polyols via Pyridine Promoted C=C Cleavage of 2-Nitroglycals. Application to the Synthesis of (-)-Hyacinthacine A1
期刊論文
Tang, Shengbiao(#),Xiong, De-Cai,Jiang, Shende(*),Ye, Xin-Shan(*)
2
Convergent synthesis of oligosaccharides on the gram-scale using cetyl thioglycoside based on a hydrophobically assisted switching phase method
期刊論文
Meng, Shuai,Tian, Tian,Wang, Yun-He,Meng, Xiang-Bao,Li, Zhong-Jun(*)
3
簡捷合成高光學純度噻唑胺基酸的新方法
專利
劉義,杜宇國
4
Amild and efficient method for the selective cleavage of primary p-methoxybenzylprotecting group of saccharides by Co2(CO)8-Me2PhSiH-COsystem
期刊論文
Pengzhan Qian(#),Wang Yao,Lubai Huang,Xiangbao Meng,Zhongjun Li(*)
5
Ligand-Controlled Monoselective C-Aryl Glycoside Synthesis via Palladium-Catalyzed C-H Functionalization of N-Quinolyl Benzamides with 1-lodoglycals
期刊論文
Liu, Minglong(#),Niu, Youhong,Wu, Yan-Fen(*),Ye, Xin-Shan(*)
6
具有抗腫瘤活性的KRN7000類似物及合成方法
專利
杜宇國,畢晶晶,王元成
7
Co-2(CO)(6)-propargyl cation mediates glycosylation reaction by using thioglycoside
期刊論文
Xia, Meng-jie,Yao, Wang,Meng, Xiang-bao,Louh, Qing-hua,Li, Zhong-jun(*)
8
Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units
期刊論文
Wu, Yong(#),Xiong, De-Cai,Chen, Si-Cong,Wang, Yong-Shi,Ye, Xin-Shan(*)
9
Synthesis and structural reconfirmation of bacillamideB
期刊論文
Xue Sun(#),Yi Liu,Jun Liu,Guofeng Gu,Yuguo Du(*)
10
Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide
期刊論文
Guo, Jian(#),Li, Wenming,Xue, Weiwei,Ye, Xin-Shan(*)
11
Stereoselective Koenigs-Knorr Glycosylation Catalyzed by Urea
期刊論文
Sun, Lifeng(#),Wu, Xiaowei,Xiong, De-Cai,Ye, Xin-Shan(*)
12
3-Butenyloxycarbonyl as a new hydroxyl protecting group in carbohydrate synthesis
期刊論文
Zeng, Nana,Niu, Youhong,Ye, Xin-Shan(*)
13
Semi-synthesis of Neomangiferin from Mangiferin
期刊論文
Xiong Wei,Danlin Liang,Maoheng Ning,Qing Wang,Xiangbao Meng,Zhongjun Li(*)
14
一種芒果苷單位點衍生物及其製備方法和用途
專利
李中軍,魏雄,孟祥豹,梁丹琳,王青,李樹春
15
Total synthesis of mangiferin, homomangiferin, and neomangiferin
期刊論文
Wei, Xiong(#),Liang, Danlin,Wang, Qing,Meng, Xiangbao(*),Li, Zhongjun(*)
16
2-Pyridyl Glycoside: An Alternative Glycosyl Donor inPreactivation Protocol
期刊論文
De-Cai Xiong; An-Qi Yang; Yang Yu; *Xin-Shan Ye
17
新芒果苷的化學合成方法及中間體化合物
專利
李中軍,梁丹琳,,魏雄,王青,孟祥豹,李樹春,陳世忠
18
Design and synthesis of new KRN7000 analogues
期刊論文
Sun, Man; Wang, Yuhang; *Ye, Xin-Shan
19
Synthesis of Iminosugar-Containing KRN7000 Analogues
期刊論文
Zhang, Lei(#),Ye, Xin-Shan(*)
20
RapidProbing of Sialylated Glycoproteins in vitro and in vivo via Metabolic Oligosaccharide Engineering of Minimal Cyclopropene Reporter
期刊論文
De-Cai Xiong; Jingjing Zhu; Ming-Jie Han; Hui-Xin Luo; Cong Wang; Yang Yu; Yuqian Ye; Guihua Tai; *Xin-Shan Ye
21
Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3
期刊論文
Wang Yao,Meng-jie Xia,Xiang-bao Meng,Qing Li(*),Zhong-jun Li(*)
22
Synthesisof N-Dialkylphosphoryl Iminosugar Derivatives and TheirImmunosuppressive Activities
期刊論文
Xuemei Yang; De-Cai Xiong; Chengcheng Song; Guihua Tai; *Xin-Shan Ye
23
“Ring Opening-Ring Closure” Strategy for the Synthesis of Aryl-C-glycosides
期刊論文
Chen-Fu Liu; De-Cai Xiong; *Xin-Shan Ye
24
Synthesis of trisaccharide-coated magnetic nanoparticles for antibody removal
期刊論文
Yan, Shuaihu(#),Zhao, Cuixia,Ren, Qidong,Xie, Xinni,Yang, Feng,Du, Yuguo(*)
25
EfficientAssembly of oligomannosides using the hydrophobically assisted switching phasemethod
期刊論文
Shuai Meng(#),Tian Tian,Dong Han,Lin-Na Wang,Shao-Geng Tang,Xiang-Bao Meng,Zhong-Jun Li(*)
26
Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen from Salmonella typhi
期刊論文
Zhang, Gao-Lan(#),Yang, Lin,Zhu, Jingjing,Wei, Mengman,Yan, Wanjun,Xiong, De-Cai,Ye, Xin-Shan(*)
27
具有血凝活性的硫代甘露三糖及其簇合物的合成
專利
杜宇國,畢晶晶
28
A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model
期刊論文
Song, Chengcheng(#),Zheng, Xiu-Jing,Liu, Chang-Cheng,Zhou, Yifa(*),Ye, Xin-Shan(*)
29
Altering the Specificity of the Antibody Response to HIV gp120 with a Glycoconjugate Antigen
期刊論文
Liu, Chang-Cheng,Zhai, Canjia,Zheng, Xiu-Jing,Ye, Xin-Shan(*)
30
Cell cycle arrest, apoptosis and autophagy induced by iminosugars on K562 cells
期刊論文
Jingjing Zhu; Yifa Zhou; Guan-Nan Wang; *Guihua Tai; *Xin-Shan Ye
31
Synthesis of triazolyl-linked polysialic acids
期刊論文
De-Cai Xiong; Yichuan Zhou; Yuxin Cui; *Xin-Shan Ye
32
Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates
期刊論文
Song, Chengcheng(#),Sun, Shuang,Huo, Chang-Xin,Li, Qin,Zheng, Xiu-Jing,Tai, Guihua,Zhou, Yifa(*),Ye, Xin-Shan(*)
33
寡糖的合成及某些基於糖類的藥物發現
科研獎勵
葉新山(#)
34
Synthesis of 2-Deoxy-C-glycosides via Lewis Acid-Mediated Rearrangement of 2,3-Anhydro-1-thiopyranosides
期刊論文
De-Cai Xiong; Chao Gao; Wenming Li; Yuan Wang; Qin Li; *Xin-Shan Ye
35
A unified synthesis of cyclic ethers or lactones via Pd-catalyzed intramolecular O-functionalization of sp(3) C-H bonds
期刊論文
Wang, Haifeng,Niu, Youhong,Zhang, Guoying,Ye, Xin-Shan(*)
36
Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines
期刊論文
Xiao, An,Zheng, Xiu-Jing,Song, Chengcheng,Gui, Yue,Huo, Chang-Xin,Ye, Xin-Shan(*)
37
Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP)
期刊論文
Yang, An-Qi(#),Li, Daoyuan,Chi, Lianli,Ye, Xin-Shan(*)
38
(KOBu)-Bu-t-mediated aromatic O-glycosylation of 1,2-anhydrosugar and aryl boronic acid
期刊論文
Liu, Chen-Fu(#),Xiong, De-Cai,Ye, Xin-Shan(*)
39
Direct C-H Trifluoromethylation of Glycals by PhotoredoxCatalysis
期刊論文
Bang Wang; *De-Cai Xiong; *Xin-Shan Ye
40
HighlySubstituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors
期刊論文
Wenming Li; Youhong Niu; De-Cai Xiong; Xiaoping Cao; *Xin-Shan Ye
41
Synthesis and Evaluation of Glycoconjugates Comprising N-Acyl-Modified Thomsen-Friedenreich Antigens as Anticancer Vaccines
期刊論文
Sun, Shuang,Zheng, Xiu-Jing,Huo, Chang-Xin,Song, Chengcheng,Li, Qin(*),Ye, Xin-Shan(*)
42
A mild method for regioselective de-O-methylation of saccharides by Co-2(CO)(8)/Et3SiH/CO system
期刊論文
Zhao, Yue-tao(#),Huang, Lu-bai,Li, Qing,Li, Zhong-jun(*)
43
Indolo-quinoline boron difluoride dyes: synthesis and spectroscopic properties
期刊論文
Luo, Hui-Xin,Niu, Youhong,Jin, Xiaojie,Cao, Xiao-Ping,Yao, Xiaojun,Ye, Xin-Shan(*)
44
Assembly of a beta-(1 -> 3)-glucan laminarihexaose on ionic liquid support
期刊論文
Wang, Yanhui,Zhao, Xiaoke,Kong, Qiuyun,Yao, Jiajian,Meng, Xiangbao,Li, Zhongjun(*)
45
Additive-controlledStereoselective Glycosylations of 2,3-Oxazolidinone Protected Glucosamine orGalactosamine Thioglycoside Donors with Phenols Based on Preactivation Protocol
期刊論文
Qi Qin; De-Cai Xiong; *Xin-Shan Ye
46
A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus
期刊論文
Bai, Xiaohui(#),Niu, Youhong,Zhu, Jingjing,Yang, An-Qi,Wu, Yan-Fen(*),Ye, Xin-Shan(*)
47
Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2
期刊論文
Fei-Fei Xu; Yue Wang; De-Cai Xiong; *Xin-Shan Ye
48
岩藻糖基化硫酸軟骨素寡糖糖簇及其製備方法
專利
李中軍
49
Photoinduced C-S Bond Cleavage of Thioglycosides andGlycosylation
期刊論文
Run-Ze Mao; Fan Guo; *De-Cai Xiong; Qin Li; Jinyou Duan; *Xin-Shan Ye
50
Conciseand direct construction of cis-pyrano[4,3-b]pyran-5-one skeleton from glucalderivatives: synthesis of ent-4-deoxy-2,3-di-epi- dinemasone BC
期刊論文
Xiaochao Xue(#),Wei Li,Zhaojun Yin,Xiangbao Meng,Zhongjun Li(*)
51
透明質酸寡糖糖簇及其製備方法和用途
專利
李中軍,沙勐,姚望,張肖,孟祥豹,李慶,李樹春
52
Synthesis of novel N-glycoside derivatives via CuSCN-catalyzed reactions and their SGLT2inhibition activities
期刊論文
Shao-Tao Bai; De-Cai Xiong; Youhong Niu; *Yan-Fen Wu; *Xin-Shan Ye
53
Synthesis of L-glucose andl-galactose derivatives fromd-sugars
期刊論文
Tian-Yu Xia,Yang-Bing Li,Zhao-Jun Yin,Xiang-Bao Meng,Shu-Chun Li,Zhong-Jun Li(*)
54
Visible Light Photoredox-Catalyzed O-Sialylation Using Thiosialoside Donors
期刊論文
Yu, Yang,Xiong, De-Cai(*),Mao, Run-Ze,Ye, Xin-Shan(*)
55
An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide
期刊論文
Gao, Ze-Shen,Sun, Sheng,Li, Wei,Ma, Qing,Li, Qing,Li, Zhong-Jun(*)
56
Broadly Neutralizing Antibody-Guided Carbohydrate-Based HIV Vaccine Design: Challenges and Opportunities
期刊論文
Liu, Chang-Cheng(#),Zheng, Xiu-Jing,Ye, Xin-Shan(*)
57
Light-driven highly efficient glycosylation reactions
期刊論文
Mao, Run-Ze,Xiong, De-Cai,Guo, Fan,Li, Qin,Duan, Jinyou,Ye, Xin-Shan(*)
58
Synthetic and Immunological Studies of N-Acyl Modified S-Linked STn Derivatives as Anticancer Vaccine Candidates
期刊論文
Chang-Xin Huo; Xiu-Jing Zheng; An Xiao; Chang-Cheng Liu; Shuang Sun; Zhuo Lv; *Xin-Shan Ye
59
N-Arylated lactam-type iminosugars as new immunosuppressive agents: discovery, optimization, and biological evaluation
期刊論文
Xiao-Wei Wu; Fu-Yu Zhang; Jingjing Zhu; Chengcheng Song; De-Cai Xiong; Yifa Zhou; Yuxin Cui; *Xin-Shan Ye
60
硫酸軟骨素四糖的合成方法及其中間體化合物
專利
李中軍(#)(*)
61
具有抗HIV-1活性的Ritonavir硒唑衍生物及其合成方法
專利
杜宇國,喬俊飛
62
General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Cocatalyzed C H Functionalization Strategy
期刊論文
Zhang, Shuo(#),Niu, You-Hong,Ye, Xin-Shan(*)
63
苯乙醇苷類似物及其合成方法和套用
專利
葉新山(#),劉穎果,熊德彩,蒲小平,李夏溪
64
ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis
期刊論文
Peng Peng; De-Cai Xiong; *Xin-Shan Ye
65
Improvementof the Immune Efficacy of Carbohydrate Vaccines by Chemical Modification on theGM3 Antigen
期刊論文
Xiu-Jing Zheng; Fan Yang; Mingwei Zheng; Chang-Xin Huo; Ye Zhang; *Xin-Shan Ye
66
Synthetic Phenylethanoid Glycoside Derivatives asPotent Neuroprotective Agents
期刊論文
Yingguo Liu; Xiaxi Li; De-Cai Xiong; Binhan Yu; *Xiaoping Pu; *Xin-Shan Ye
67
2-Trifluoromethylthiolation of glycals
期刊論文
Yu, Yang,Xiong, De-Cai,Ye, Xin-Shan(*)
68
Total Syntheses of Cochliomycin B and Zeaenol
期刊論文
Yangguang Gao,Jun Liu,Linlin Wang,Ming Xiao,Yuguo Du(*)
69
Synthesis and biological evaluation of N-arylated-lactam-type iminosugars as potential immunosuppressive agents
期刊論文
Liu, Hai-Qian(#),Song, Cheng-Cheng,Niu, You-Hong,Li, Tao,Li, Qin(*),Ye, Xin-Shan(*)
70
Cyclopropenes for the Synthesis ofCyclopropane-fused Dihydroquinolines and Benzazepines
期刊論文
Hui-Xin Luo; You-Hong Niu; *Xiao-Ping Cao; *Xin-Shan Ye

項目摘要

本項目針對寡糖及其綴合物合成中的關鍵科學問題,在項目組已取得的大量前期工作積累的基礎上,以寡糖及其綴合物的高效合成為導向,計畫開展以下內容的研究:(1)發展新的高效、高選擇性的糖基化方法,發展或完善新的寡糖高效組裝策略;(2)將發展的方法和策略套用於若干具有重要生物活性和潛在藥用價值的複雜寡糖及其衍生物的合成,並對其生物活性進行評價,發現寡糖類先導化合物;(3)發展用於蛋白質修飾的新的生物正交化學反應,用於糖蛋白的合成,為其相應的功能研究奠定基礎。本項目的實施將促進我國糖化學研究的發展,並帶動糖化學生物學和糖類藥物研究的進步。

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