《具有重要生物活性的寡糖及其綴合物的合成研究》是葉新山為項目負責人,北京大學為依託單位的重點項目。
基本介紹
- 中文名:具有重要生物活性的寡糖及其綴合物的合成研究
- 項目類別 :重點項目
- 項目負責人:葉新山
- 依託單位 :北京大學
科研成果
序號 | 標題 | 類型 | 作者 |
---|---|---|---|
1 | Nitro-polyols via Pyridine Promoted C=C Cleavage of 2-Nitroglycals. Application to the Synthesis of (-)-Hyacinthacine A1 | 期刊論文 | Tang, Shengbiao(#),Xiong, De-Cai,Jiang, Shende(*),Ye, Xin-Shan(*) |
2 | Convergent synthesis of oligosaccharides on the gram-scale using cetyl thioglycoside based on a hydrophobically assisted switching phase method | 期刊論文 | Meng, Shuai,Tian, Tian,Wang, Yun-He,Meng, Xiang-Bao,Li, Zhong-Jun(*) |
3 | 簡捷合成高光學純度噻唑胺基酸的新方法 | 專利 | 劉義,杜宇國 |
4 | Amild and efficient method for the selective cleavage of primary p-methoxybenzylprotecting group of saccharides by Co2(CO)8-Me2PhSiH-COsystem | 期刊論文 | Pengzhan Qian(#),Wang Yao,Lubai Huang,Xiangbao Meng,Zhongjun Li(*) |
5 | Ligand-Controlled Monoselective C-Aryl Glycoside Synthesis via Palladium-Catalyzed C-H Functionalization of N-Quinolyl Benzamides with 1-lodoglycals | 期刊論文 | Liu, Minglong(#),Niu, Youhong,Wu, Yan-Fen(*),Ye, Xin-Shan(*) |
6 | 具有抗腫瘤活性的KRN7000類似物及合成方法 | 專利 | 杜宇國,畢晶晶,王元成 |
7 | Co-2(CO)(6)-propargyl cation mediates glycosylation reaction by using thioglycoside | 期刊論文 | Xia, Meng-jie,Yao, Wang,Meng, Xiang-bao,Louh, Qing-hua,Li, Zhong-jun(*) |
8 | Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units | 期刊論文 | Wu, Yong(#),Xiong, De-Cai,Chen, Si-Cong,Wang, Yong-Shi,Ye, Xin-Shan(*) |
9 | Synthesis and structural reconfirmation of bacillamideB | 期刊論文 | Xue Sun(#),Yi Liu,Jun Liu,Guofeng Gu,Yuguo Du(*) |
10 | Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide | 期刊論文 | Guo, Jian(#),Li, Wenming,Xue, Weiwei,Ye, Xin-Shan(*) |
11 | Stereoselective Koenigs-Knorr Glycosylation Catalyzed by Urea | 期刊論文 | Sun, Lifeng(#),Wu, Xiaowei,Xiong, De-Cai,Ye, Xin-Shan(*) |
12 | 3-Butenyloxycarbonyl as a new hydroxyl protecting group in carbohydrate synthesis | 期刊論文 | Zeng, Nana,Niu, Youhong,Ye, Xin-Shan(*) |
13 | Semi-synthesis of Neomangiferin from Mangiferin | 期刊論文 | Xiong Wei,Danlin Liang,Maoheng Ning,Qing Wang,Xiangbao Meng,Zhongjun Li(*) |
14 | 一種芒果苷單位點衍生物及其製備方法和用途 | 專利 | 李中軍,魏雄,孟祥豹,梁丹琳,王青,李樹春 |
15 | Total synthesis of mangiferin, homomangiferin, and neomangiferin | 期刊論文 | Wei, Xiong(#),Liang, Danlin,Wang, Qing,Meng, Xiangbao(*),Li, Zhongjun(*) |
16 | 2-Pyridyl Glycoside: An Alternative Glycosyl Donor inPreactivation Protocol | 期刊論文 | De-Cai Xiong; An-Qi Yang; Yang Yu; *Xin-Shan Ye |
17 | 新芒果苷的化學合成方法及中間體化合物 | 專利 | 李中軍,梁丹琳,,魏雄,王青,孟祥豹,李樹春,陳世忠 |
18 | Design and synthesis of new KRN7000 analogues | 期刊論文 | Sun, Man; Wang, Yuhang; *Ye, Xin-Shan |
19 | Synthesis of Iminosugar-Containing KRN7000 Analogues | 期刊論文 | Zhang, Lei(#),Ye, Xin-Shan(*) |
20 | RapidProbing of Sialylated Glycoproteins in vitro and in vivo via Metabolic Oligosaccharide Engineering of Minimal Cyclopropene Reporter | 期刊論文 | De-Cai Xiong; Jingjing Zhu; Ming-Jie Han; Hui-Xin Luo; Cong Wang; Yang Yu; Yuqian Ye; Guihua Tai; *Xin-Shan Ye |
21 | Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3 | 期刊論文 | Wang Yao,Meng-jie Xia,Xiang-bao Meng,Qing Li(*),Zhong-jun Li(*) |
22 | Synthesisof N-Dialkylphosphoryl Iminosugar Derivatives and TheirImmunosuppressive Activities | 期刊論文 | Xuemei Yang; De-Cai Xiong; Chengcheng Song; Guihua Tai; *Xin-Shan Ye |
23 | “Ring Opening-Ring Closure” Strategy for the Synthesis of Aryl-C-glycosides | 期刊論文 | Chen-Fu Liu; De-Cai Xiong; *Xin-Shan Ye |
24 | Synthesis of trisaccharide-coated magnetic nanoparticles for antibody removal | 期刊論文 | Yan, Shuaihu(#),Zhao, Cuixia,Ren, Qidong,Xie, Xinni,Yang, Feng,Du, Yuguo(*) |
25 | EfficientAssembly of oligomannosides using the hydrophobically assisted switching phasemethod | 期刊論文 | Shuai Meng(#),Tian Tian,Dong Han,Lin-Na Wang,Shao-Geng Tang,Xiang-Bao Meng,Zhong-Jun Li(*) |
26 | Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen from Salmonella typhi | 期刊論文 | Zhang, Gao-Lan(#),Yang, Lin,Zhu, Jingjing,Wei, Mengman,Yan, Wanjun,Xiong, De-Cai,Ye, Xin-Shan(*) |
27 | 具有血凝活性的硫代甘露三糖及其簇合物的合成 | 專利 | 杜宇國,畢晶晶 |
28 | A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model | 期刊論文 | Song, Chengcheng(#),Zheng, Xiu-Jing,Liu, Chang-Cheng,Zhou, Yifa(*),Ye, Xin-Shan(*) |
29 | Altering the Specificity of the Antibody Response to HIV gp120 with a Glycoconjugate Antigen | 期刊論文 | Liu, Chang-Cheng,Zhai, Canjia,Zheng, Xiu-Jing,Ye, Xin-Shan(*) |
30 | Cell cycle arrest, apoptosis and autophagy induced by iminosugars on K562 cells | 期刊論文 | Jingjing Zhu; Yifa Zhou; Guan-Nan Wang; *Guihua Tai; *Xin-Shan Ye |
31 | Synthesis of triazolyl-linked polysialic acids | 期刊論文 | De-Cai Xiong; Yichuan Zhou; Yuxin Cui; *Xin-Shan Ye |
32 | Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates | 期刊論文 | Song, Chengcheng(#),Sun, Shuang,Huo, Chang-Xin,Li, Qin,Zheng, Xiu-Jing,Tai, Guihua,Zhou, Yifa(*),Ye, Xin-Shan(*) |
33 | 寡糖的合成及某些基於糖類的藥物發現 | 科研獎勵 | 葉新山(#) |
34 | Synthesis of 2-Deoxy-C-glycosides via Lewis Acid-Mediated Rearrangement of 2,3-Anhydro-1-thiopyranosides | 期刊論文 | De-Cai Xiong; Chao Gao; Wenming Li; Yuan Wang; Qin Li; *Xin-Shan Ye |
35 | A unified synthesis of cyclic ethers or lactones via Pd-catalyzed intramolecular O-functionalization of sp(3) C-H bonds | 期刊論文 | Wang, Haifeng,Niu, Youhong,Zhang, Guoying,Ye, Xin-Shan(*) |
36 | Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines | 期刊論文 | Xiao, An,Zheng, Xiu-Jing,Song, Chengcheng,Gui, Yue,Huo, Chang-Xin,Ye, Xin-Shan(*) |
37 | Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP) | 期刊論文 | Yang, An-Qi(#),Li, Daoyuan,Chi, Lianli,Ye, Xin-Shan(*) |
38 | (KOBu)-Bu-t-mediated aromatic O-glycosylation of 1,2-anhydrosugar and aryl boronic acid | 期刊論文 | Liu, Chen-Fu(#),Xiong, De-Cai,Ye, Xin-Shan(*) |
39 | Direct C-H Trifluoromethylation of Glycals by PhotoredoxCatalysis | 期刊論文 | Bang Wang; *De-Cai Xiong; *Xin-Shan Ye |
40 | HighlySubstituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors | 期刊論文 | Wenming Li; Youhong Niu; De-Cai Xiong; Xiaoping Cao; *Xin-Shan Ye |
41 | Synthesis and Evaluation of Glycoconjugates Comprising N-Acyl-Modified Thomsen-Friedenreich Antigens as Anticancer Vaccines | 期刊論文 | Sun, Shuang,Zheng, Xiu-Jing,Huo, Chang-Xin,Song, Chengcheng,Li, Qin(*),Ye, Xin-Shan(*) |
42 | A mild method for regioselective de-O-methylation of saccharides by Co-2(CO)(8)/Et3SiH/CO system | 期刊論文 | Zhao, Yue-tao(#),Huang, Lu-bai,Li, Qing,Li, Zhong-jun(*) |
43 | Indolo-quinoline boron difluoride dyes: synthesis and spectroscopic properties | 期刊論文 | Luo, Hui-Xin,Niu, Youhong,Jin, Xiaojie,Cao, Xiao-Ping,Yao, Xiaojun,Ye, Xin-Shan(*) |
44 | Assembly of a beta-(1 -> 3)-glucan laminarihexaose on ionic liquid support | 期刊論文 | Wang, Yanhui,Zhao, Xiaoke,Kong, Qiuyun,Yao, Jiajian,Meng, Xiangbao,Li, Zhongjun(*) |
45 | Additive-controlledStereoselective Glycosylations of 2,3-Oxazolidinone Protected Glucosamine orGalactosamine Thioglycoside Donors with Phenols Based on Preactivation Protocol | 期刊論文 | Qi Qin; De-Cai Xiong; *Xin-Shan Ye |
46 | A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus | 期刊論文 | Bai, Xiaohui(#),Niu, Youhong,Zhu, Jingjing,Yang, An-Qi,Wu, Yan-Fen(*),Ye, Xin-Shan(*) |
47 | Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2 | 期刊論文 | Fei-Fei Xu; Yue Wang; De-Cai Xiong; *Xin-Shan Ye |
48 | 岩藻糖基化硫酸軟骨素寡糖糖簇及其製備方法 | 專利 | 李中軍 |
49 | Photoinduced C-S Bond Cleavage of Thioglycosides andGlycosylation | 期刊論文 | Run-Ze Mao; Fan Guo; *De-Cai Xiong; Qin Li; Jinyou Duan; *Xin-Shan Ye |
50 | Conciseand direct construction of cis-pyrano[4,3-b]pyran-5-one skeleton from glucalderivatives: synthesis of ent-4-deoxy-2,3-di-epi- dinemasone BC | 期刊論文 | Xiaochao Xue(#),Wei Li,Zhaojun Yin,Xiangbao Meng,Zhongjun Li(*) |
51 | 透明質酸寡糖糖簇及其製備方法和用途 | 專利 | 李中軍,沙勐,姚望,張肖,孟祥豹,李慶,李樹春 |
52 | Synthesis of novel N-glycoside derivatives via CuSCN-catalyzed reactions and their SGLT2inhibition activities | 期刊論文 | Shao-Tao Bai; De-Cai Xiong; Youhong Niu; *Yan-Fen Wu; *Xin-Shan Ye |
53 | Synthesis of L-glucose andl-galactose derivatives fromd-sugars | 期刊論文 | Tian-Yu Xia,Yang-Bing Li,Zhao-Jun Yin,Xiang-Bao Meng,Shu-Chun Li,Zhong-Jun Li(*) |
54 | Visible Light Photoredox-Catalyzed O-Sialylation Using Thiosialoside Donors | 期刊論文 | Yu, Yang,Xiong, De-Cai(*),Mao, Run-Ze,Ye, Xin-Shan(*) |
55 | An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide | 期刊論文 | Gao, Ze-Shen,Sun, Sheng,Li, Wei,Ma, Qing,Li, Qing,Li, Zhong-Jun(*) |
56 | Broadly Neutralizing Antibody-Guided Carbohydrate-Based HIV Vaccine Design: Challenges and Opportunities | 期刊論文 | Liu, Chang-Cheng(#),Zheng, Xiu-Jing,Ye, Xin-Shan(*) |
57 | Light-driven highly efficient glycosylation reactions | 期刊論文 | Mao, Run-Ze,Xiong, De-Cai,Guo, Fan,Li, Qin,Duan, Jinyou,Ye, Xin-Shan(*) |
58 | Synthetic and Immunological Studies of N-Acyl Modified S-Linked STn Derivatives as Anticancer Vaccine Candidates | 期刊論文 | Chang-Xin Huo; Xiu-Jing Zheng; An Xiao; Chang-Cheng Liu; Shuang Sun; Zhuo Lv; *Xin-Shan Ye |
59 | N-Arylated lactam-type iminosugars as new immunosuppressive agents: discovery, optimization, and biological evaluation | 期刊論文 | Xiao-Wei Wu; Fu-Yu Zhang; Jingjing Zhu; Chengcheng Song; De-Cai Xiong; Yifa Zhou; Yuxin Cui; *Xin-Shan Ye |
60 | 硫酸軟骨素四糖的合成方法及其中間體化合物 | 專利 | 李中軍(#)(*) |
61 | 具有抗HIV-1活性的Ritonavir硒唑衍生物及其合成方法 | 專利 | 杜宇國,喬俊飛 |
62 | General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Cocatalyzed C H Functionalization Strategy | 期刊論文 | Zhang, Shuo(#),Niu, You-Hong,Ye, Xin-Shan(*) |
63 | 苯乙醇苷類似物及其合成方法和套用 | 專利 | 葉新山(#),劉穎果,熊德彩,蒲小平,李夏溪 |
64 | ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis | 期刊論文 | Peng Peng; De-Cai Xiong; *Xin-Shan Ye |
65 | Improvementof the Immune Efficacy of Carbohydrate Vaccines by Chemical Modification on theGM3 Antigen | 期刊論文 | Xiu-Jing Zheng; Fan Yang; Mingwei Zheng; Chang-Xin Huo; Ye Zhang; *Xin-Shan Ye |
66 | Synthetic Phenylethanoid Glycoside Derivatives asPotent Neuroprotective Agents | 期刊論文 | Yingguo Liu; Xiaxi Li; De-Cai Xiong; Binhan Yu; *Xiaoping Pu; *Xin-Shan Ye |
67 | 2-Trifluoromethylthiolation of glycals | 期刊論文 | Yu, Yang,Xiong, De-Cai,Ye, Xin-Shan(*) |
68 | Total Syntheses of Cochliomycin B and Zeaenol | 期刊論文 | Yangguang Gao,Jun Liu,Linlin Wang,Ming Xiao,Yuguo Du(*) |
69 | Synthesis and biological evaluation of N-arylated-lactam-type iminosugars as potential immunosuppressive agents | 期刊論文 | Liu, Hai-Qian(#),Song, Cheng-Cheng,Niu, You-Hong,Li, Tao,Li, Qin(*),Ye, Xin-Shan(*) |
70 | Cyclopropenes for the Synthesis ofCyclopropane-fused Dihydroquinolines and Benzazepines | 期刊論文 | Hui-Xin Luo; You-Hong Niu; *Xiao-Ping Cao; *Xin-Shan Ye |