基本介紹
人物經歷,學術兼職,研究方向,獲獎,學術成果,發表文章,
人物經歷
1994年獲西北農業大學（現西北農林科技大學）農學系遺傳育種專業學士學位，
1997年獲西北農業大學基礎科學系生物化學專業碩士學位，
2005年在中科院微生物所獲微生物學博士學位，
2005-2008年為美國普度大學生物科學系博士後，
2008-2010年任中科院武漢病毒所病毒學國家重點實驗室副研究員，
2010年作為引進人才擔任西北農林科技大學生命科學學院教授、博導，
學術兼職
中國微生物學會普通微生物專業委員會委員，國際期刊Frontiers in Microbiology特刊聯合編輯及十多個微生物國際期刊審稿人，
研究方向
主要從事農業與環境微生物學研究。
獲獎
學術成果
近5年以通訊作者在Nature Communications、PNAS、PLoS Pathogens、mBio、Envrionmental Microbiology等國際著名期刊發表SCI論文40餘篇，其中兩篇入選Faculty of 1000，並被NewsRx, Advances in Yersinia Research and Treatment, Front. Cell. Infect. Microbiol., Curr Opin Microbiol.等多次推薦點評。獲授權專利3件。曾作為主要研究人員參加國家重大專項，973，863, 國家自然科學基金等項目的研究。多次應邀在國際、國內學術會議做大會報告及分會場主旨報告。
沈錫輝教授在細菌六型分泌系統的功能研究及效應蛋白鑑定、細菌生物膜形成及運動性調控、植物內共生微生物組及其對農作物的促生抗旱功能研究、芳香化合物降解機制等方面取得了比較突出的成績， 包括 1、首次發現細菌六型分泌系統的離子轉運功能，率先報導了一類離子結合型T6SS效應蛋白在離子轉運和細菌抗環境脅迫及宿主營養免疫中發揮重要作用；2、以谷氨酸棒桿菌為模型系統揭示了分枝硫醇在細菌抗多重環境脅迫中的多樣化作用機制；3、發現細菌鞭毛三型分泌系統伴侶蛋白FliS通過與FlgM相互作用而抑制其分泌，進而影響細菌鞭毛系統基因表達調控，從而揭示了鞭毛系統基因表達的關閉機制。
發表文章
(*為通訊作者)：
Jinshui Lin, Weipeng Zhang, Juanli Cheng, Xu Yang, Kaixiang Zhu, Yao Wang, Gehong Wei, Pei-Yuan Qian, Zhao-Qing Luo and Xihui Shen*. A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition. Nat. Commun., 2017, 8:14888
Meiru Si, Chao Zhao, Brianne Burkinshaw, Bing Zhang, Dawei Wei, Yao Wang, Tao G. Dong* and Xihui Shen*. Manganese scavenging and oxidative stress response mediated by the type VI secretion system in Burkholderia thailandensis. PNAS, 2017, 114(11):E2233-E2242. (cited by Faculty of 1000 Prime)
Si M, Wang T, Pan J, Lin J, Chen C, Wei Y, Lu Z, Wei G, Shen X*. Graded response of the multifunctional 2-Cys peroxiredoxin CgPrx to increasing levels of hydrogen peroxide in Corynebacterium glutamicum. Antioxid Redox Signal. 2017, 26(1):1-14.
Chen C, Xin K, Liu H, Cheng J, Shen X, Wang Y, Zhang L. Pantoea alhagi, a novel endophytic bacterium with ability to improve growth and drought tolerance in wheat. Sci Rep. 2017, 7:41564.
Chen C, Pan J, Yang X, Xiao H, Zhang Y, Si M, Shen X*, Wang Y*. Global transcriptomic analysis of the response of Corynebacterium glutamicum to ferulic acid. Arch. Microbiol. 2017, 199:325-334.
Meiru Si, Yanyan Feng, Keqi Chen, Yiwen Kang, Can Chen, Yao Wang* and Xihui Shen*. Functional Comparison of Methionine Sulphoxide Reductase A and B in Corynebacterium glutamicum. J. Gen. Appl. Microbiol. 2017. (Accepted)
Lei Zhang, Jun Zhong, Hao Liu, Kaiyun Xin, Chaoqiong Chen, Qiqi Li, Yahong Wei, Yao Wang, Fei Chen*, Xihui Shen*. Complete genome sequence of the drought resistance-promoting endophyte Klebsiella sp. LTGPAF-6F. J. Biotechnol. 2017, 246:36-39
Tietao Wang, Keqi Chen, Fen Gao, Yiwen Kang, Muhammad Tausif Chaudhry, Zhuo Wang, Yao Wang*, Xihui Shen*. ZntR positively regulates T6SS4 expression in Yersinia pseudotuberculosis. J. Microbiol. 2017 [Epub ahead of print]
Ruoxi Zhao, Yunhong Song, Qingyun Dai, Yiwen Kang, Junfeng Pan, Lingfang Zhu, Lei Zhang, Yao Wang*, XihuiShen*. A starvation-induced regulator, RovM, acts as a switch for planktonic/biofilm state transition in Yersinia pseudotuberculosis. Sci Rep. 2017. (Accepted)
Sihuai Sun, Xiaobing Yang, Yao Wang and Xihui Shen*. In Vivo Analysis of Protein–Protein Interactions with Bioluminescence Resonance Energy Transfer (BRET): Progress and Prospects. Int. J. Mol. Sci. 2016, 17(10). pii: E1704
Chen C, Pan J, Yang X, Guo C, Ding W, Si M, Zhang Y, Shen X*, Wang Y*. Global Transcriptomic Analysis of the Response of Corynebacterium glutamicum to Vanillin. PLoS One. 2016, 11(10):e0164955.
Xin K, Li M, Chen C, Yang X, Li Q, Cheng J, Zhang L*, Shen X*. Paenibacillus qinlingensis sp. nov., an indole-3-acetic acid-producing bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying. Int J Syst Evol Microbiol. 2016 Nov 16. doi: 10.1099/ijsem.0.001666. [Epub ahead of print]
Chen C, Xin K, Li M, Li X, Cheng J, Zhang L*, Shen X*. Paenibacillus sinopodophylli sp. nov., a siderophore-producing endophytic bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying. Int J Syst Evol Microbiol. 2016, 66(12):4993-4999
Tietao Wang, Xiaobing Yang, Fen Gao, Chao Zhao, Yiwen Kang, Yao Wang and Xihui Shen*. Zinc acquisition via ZnuABC in Yersina pseudotuberculosis facilitates resistance to oxidative stress. Ann. Microbiol. 2016, 66:1689-1197
Yingbao Liu, Xiaobing Yang, Yajie Yin, Jinshui Lin, Can Chen, Junfeng Pan, Meiru Si* and Xihui Shen*. Mycothiol protects Corynebacterium glutamicum against acid stress via maintaining intracellular pH homeostasis, scavenging ROS, and S-mycothiolating MetE. J. Gen. Appl. Microbiol. 2016, 62(3):144-53
Wang T, Gao F, Kang Y, Zhao C, Su T, Li M, Si M, Xihui Shen*. Mycothiol peroxidase MPx protects Corynebacterium glutamicum against acid stress by scavenging ROS. Biotechnol. Lett. 2016, 38(7):1221-8.
Si M, Zhao C, Zhang B, Wei D, Chen K, Yang X, Xiao H, Shen X*. Overexpression of Mycothiol Disulfide Reductase Enhances Corynebacterium glutamicum Robustness by Modulating Cellular Redox Homeostasis and Antioxidant Proteins under Oxidative Stress. Sci Rep. 2016, 6:29491.
Wei YQ, Long RJ, Yang H, Yang HJ, Shen XH, Shi RF, Wang ZY, Du JG, Qi XJ, Ye QH. Fiber degradation potential of natural co-cultures of Neocallimastix frontalis and Methanobrevibacter ruminantium isolated from yaks (Bos grunniens) grazing on the Qinghai Tibetan Plateau. Anaerobe. 2016, 39:158-64.
Shi X, Li C, Zhao L, Si M, Zhu L, Xin K, Chen C, Wang Y, Shen X, Zhang L. Rhizobium gei sp. nov., a bacterial endophyte of Geum aleppicum. Int J Syst Evol Microbiol. 2016, 66(10):4282-4288.
Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R, Zhang X*. Ficolin-2 binds to HIV-1 gp120 and blocks viral infection. Virol Sin. 2016, 31(5):406-414
Liang J, Zhang M, Lu M, Li Z, Shen X, Chou M*, Wei G*. Functional characterization of a csoR-cueA divergon in Bradyrhizobium liaoningense CCNWSX0360, involved in copper, zinc and cadmium cotolerance. Sci Rep. 2016, 6:35155.
Tietao Wang, Meiru Si, Yunhong Song, Yao Wang, Fen Gao, Weipeng Zhang, Lei Zhang, Gehong Wei, Zhao-Qing Luo, Xihui Shen*. Type VI secretion system transports Znto combat multiple stresses and host immunity. PLoS Pathog. 2015, 11(7):e1005020.
Yunhong Song, Xiao Xiao, Changfu Li, Tietao Wang, Ruoxi Zhao, Weipeng Zhang, Lei Zhang, Yao Wang and Xihui Shen*. The dual transcriptional regulator RovM regulates the expression of AR3- and T6SS4-dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis. Environ. Microbiol. 2015, 17(11):4631-45.
Jinshui Lin, Juanli Cheng, Keqi Chen, Chenghao Guo, Weipeng Zhang, Xu Yang, Wei Ding, Li Ma, Yao Wang and Xihui Shen*. The icmF3 locus is involved in multiple adaptation- and virulence-related characteristics in Pseudomonas aeruginosa PAO1. Front Cell Infect Microbiol. 2015, 5:70.
Commentary: The icmF3 locus is involved in multiple adaptation- and virulence-related characteristics in Pseudomonas aeruginosa PAO1.Tang L,Liang X,Moore R, Dong TG. Front Cell Infect Microbiol. 2015, 5:83.
Meiru Si, Yixiang Xu, Tietao Wang, Mingxiu Long, Wei Ding, Can Chen, Xinmeng Guan, Yingbao Liu, Yao Wang, Xihui Shen* and Shuang-Jiang Liu. Functional characterization of a mycothiol peroxidase in Corynebacterium glutamicum that uses both mycoredoxin and thioredoxin reducing systems as proton donor for oxidative stress response. Biochem. J. 2015, 469(1):45-57.
Wei Ding, Meiru Si, Weipeng Zhang, Yaoling Zhang, Can Chen, Lei Zhang, Zhiqiang Lu, Shaolin Chen, Xihui Shen*. Functional and biochemical characterization of a vanillin dehydrogenase in Corynebacterium glutamicum. Sci Rep. 2015, 5:8044
Meiru Si, Lei Zhang, Muhammad Tausif Chaudhry, Yixiang Xu, Can Chen, Wei Ding, Ali Akbar, Xihui Shen* and Shuang-Jiang Liu. Corynebacterium glutamicum methionine sulfoxide reductase (MsrA) uses both mycoredoxin and thioredoxin for regeneration and oxidative stress resistance. Appl. Environ. Microbiol. 2015, 81(8):2781-2796.
Jingyuan Guan, Xiao Xiao, Shengjuan Xu, Fen Gao, Jianbo Wang, Tietao Wang, Yunhong Song, Junfeng Pan, Xihui Shen* and Yao Wang*. Roles of RpoS in Yersinia pseudotuberculosis stress survival, motility, biofilm formation and type VI secretion system expression. J. Microbiol. 2015, 53(9):633-42.
Xiao Xiao, Mei-Ru Si, Zhi-Fang Yang, Yao-Ling Zhang, Jing-Yuan Guan, Muhammad Tausif Chaudhry, Yao Wang and Xi-Hui Shen*. Molecular characterization of a eukaryotic-like phenol hydroxylase from Corynebacterium glutamicum. J Gen Appl Microbiol. 2015, 61(4):99-107.
Meiru Si, Jianbo Wang, Xiao Xiao, Jingyuan Guan, Yaoling Zhang, Wei Ding, Muhammad Tausif Chaudhry, Yao Wang*, Xihui Shen*. Ohr protects Corynebacterium glutamicum against organic hydroperoxide induced oxidative stress. PLoS One 2015, 10(6):e0131634.
Xi-Hui Shen, Tang Li, Ying Xu, Ning-Yi Zhou and Shuang-Jiang Liu. Transport, degradation and assimilation of aromatic compounds and their regulation in Corynebacterium glutamicum. In “Corynebacterium glutamicum: From systems biology to biotechnological applications”, edited by Andreas Burkovski, Caister Academic Press, 2015
Zhu L, Xin K, Chen C, Li C, Si M, Zhao L, Shi X, Zhang L*, Shen X*. Sphingobium endophyticus sp. nov., isolated from the root of Hylomecon japonica. Antonie Van Leeuwenhoek. 2015, 107(4):1001-8.
Akbar A, Chen C, Zhu L, Xin K, Cheng J, Yang Q, Zhao L, Zhang L*, Shen X*. Sphingomonas hylomeconis sp. nov., isolated from the stem of Hylomecon japonica. Int J Syst Evol Microbiol. 2015, 65(11):4025-4031
Zhang W, Sun J, Ding W, Lin J, Tian R, Lu L, Liu X, Shen X, Qian PY. Extracellular matrix-associated proteins form an integral and dynamic system during Pseudomonas aeruginosa biofilm development. Front Cell Infect Microbiol. 2015, 5:40.
Zhu L, Si M, Li C, Xin K, Chen C, Shi X, Huang R, Zhao L, Shen X, Zhang L*. Sphingomonas gei sp. nov., isolated from roots of Geum aleppicum. Int J Syst Evol Microbiol. 2015, 65(Pt 4):1160-6.
Wei L, Si M, Long M, Zhu L, Li C, Shen X, Wang Y, Zhao L, Zhang L. Rhizobacter bergeniae sp. nov., isolated from the root of Bergenia scopulosa. Int J Syst Evol Microbiol. 2015, 65(Pt 2):479-84.
Boyu Cui, Yao Wang, Yunhong Song, Tietao Wang, Changfu Li, Yahong Wei, Zhao-Qing Luo* and Xihui Shen*. A bioluminescence resonance energy transfer (BRET) system for measuring dynamic protein-protein interactions in bacteria. mBio 2014, 5(3):e01050-14
Shengjuan Xu, Zhong Peng, Boyu Cui, Tietao Wang, Yunhong Song, Lei Zhang, Gehong Wei, Yao Wang* and Xihui Shen*. FliS modulates FlgM activity by acting as a noncanonical chaperone to control late flagellar gene expression, motility and biofilm formation in Yersinia pseudotuberculosis. Environ. Microbiol. 2014, 16(4):1090-104 (cited by Faculty of 1000 Prime)
Mei-Ru Si, Lei Zhang, Zhi-Fang Yang, Yi-Xiang Xu, Ying-Bao Liu, Cheng-Ying Jiang, Yao Wang, Xi-Hui Shen*, and Shuang-Jiang Liu. NrdH-redoxin enhances resistance to multiple oxidative stresses by acting as a peroxidase cofactor in Corynebacterium glutamicum. Appl. Environ. Microbiol. 2014, 80(5):1750-62
Si M, Long M, Chaudhry MT, Xu Y, Zhang P, Zhang L, Shen X*. Functional characterization of Corynebacterium glutamicum mycothiol S-conjugate amidase. PLoS One. 2014, 9(12):e115075
Boyu Cui, Lifeng Zhang, Yunhong Song, Jinsong Wei, Changfu Li, Tietao Wang, Yao Wang, Tianyong Zhao*, and Xihui Shen*. Engineering an enhanced, thermostable, monomeric bacterial luciferase gene as a reporter in plant protoplast. PLoS One. 2014, 9(10):e107885
Zhang L, Zhu L, Si M, Li C, Zhao L, Wei Y, Shen X*. Solirubrobacter taibaiensis sp. nov., isolated from a stem of Phytolacca acinosa Roxb. Antonie Van Leeuwenhoek. 2014, 106(2):279-85.
Zhang L, Wei L, Zhu L, Li C, Wang Y, Shen X*. Pseudoxanthomonas gei sp. nov., a novel endophytic bacterium isolated from the stem of Geum aleppicum. Antonie Van Leeuwenhoek. 2014,105(4):653-61.
Liu YB, Can Chen, Muhammad Tausif Chaudhry, Si MR, Zhang L, Wang Y, Shen XH*. Enhancing Corynebacterium glutamicum robustness by over-expressing a gene, mshA, for mycothiol glycosyltransferase. Biotechnol Lett. 2014, 36:1453-1459.
Zhang L, Si M, Zhu L, Li C, Wei Y, Shen X*. Draft genome sequence of Nafulsella turpanensis ZLM-10T, a novel member of the family Flammeovirgaceae. Genome Announc. 2014, 2(2).
Zhu L, Long M, Si M, Wei L, Li C, Zhao L, Shen X, Wang Y, Zhang L*. Asticcacaulis endophyticus sp. nov., a prosthecate bacterium isolated from the root of Geum aleppicum. Int J Syst Evol Microbiol. 2014, 64:3964-3969.
Zhang L, Shi X, Si M, Li C, Zhu L, Zhao L, Shen X, Wang Y*. Rhizobium smilacinae sp. nov., an endophytic bacterium isolated from the leaf of Smilacina japonica. Antonie Van Leeuwenhoek. 2014, 106(4):715-23.
Wei L, Ouyang S, Wang Y, Shen X, Zhang L*. Solirubrobacter phytolaccae sp. nov., a novel endophytic bacterium isolated from the root of Phytolacca acinosa Roxb. Int J Syst Evol Microbiol. 2014, 64(3):858-62.
Weipeng Zhang, Yao Wang, Yunhong Song, Tietao Wang, Shengjuan Xu, Zhong Peng, Xiaoli Lin, Lei Zhang, Xihui Shen*. A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ. Microbiol. 2013, 15(2):557-69.
(NewsRx報導) (Advances in Yersinia Research and Treatment 2013收錄)
Liu YB, Long MX, Yin YJ, Si MR, Zhang L, Lu ZQ, Wang Y, Shen XH*. Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum. Arch. Microbiol. 2013, 195(6):419-29.
Zhang L, Zhu L, Wei L, Li C, Wang Y, Shen X*. Pontibacter toksunensis sp. nov., isolated from soil, and emended descriptions of Pontibacter roseus and Pontibacter akesuensis. Int J Syst Evol Microbiol. 2013. 63(Pt 12):4462-4468.
Zhang L, Wang Y, Wei L, Wang Y, Shen X*, Li S. Taibaiella smilacinae gen. nov., sp. nov., a novel endophytic member of the family Chitinophagaceae isolated from the stem of Smilacina japonica and emended description of Flavihumibacter petaseus. Int J Syst Evol Microbiol. 2013, 63(Pt 10):3769-76.
Zhang L, Shen X, Liu Y, Li S*. Nafulsella turpanensis gen. nov., sp. nov., a novel member of the phylum Bacteroidetes isolated from soil of an arid area in Xinjiang, China. Int J Syst Evol Microbiol 2013, 63(Pt 5):1639-45.
Xi-Hui Shen, Ning-Yi Zhou and Shuang-Jiang Liu. Degradation and assimilation of aromatic compounds by Corynebacterium glutamicum: another potential for applications for this bacterium? Appl. Microbiol. Biot. 2012, 95(1):77-89.
Mary Fontana, Simran Banga, Kevin Barry, Xihui Shen, Yunhao Tan, Zhao-Qing Luo, Russell Vance. Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 2011, 7(2): e1001289
Li Xu, Xihui Shen, Andrew Bryan, Simran Banga, Michele S. Swanson, Zhao-Qing Luo. Inhibition of Host Vacuolar H -ATPase Activity by a Legionella pneumophila effector. PLoS Pathog. 2010, 6(3): e1000822 （共同第一作者）
Weipeng Zhang, Shengjuan Xu, Jing Li, Xihui Shen, Yao Wang and Zhiming Yuan. Modulation of a thermoregulated type VI secretion system by AHL-dependent Quorum Sensing in Yersinia pseudotuberculosis. Arch. Microbiol. 2011, 193(5):351-63
Gong J, Shen XH, Qiu H, Chen C, Yang RG. Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3- complex-mediated NF-κB activation. Arch. Virol. 2011,156(11):1997-2006.
Jian Gong, Xi-Hui Shen, Chao Chen, Hui Qiu and Rong-Ge Yang*. Down-regulation of HIV-1 infection by inhibition of the MAPK signaling pathway. Virol Sin. 2011, 26(2):114-122
Gong J, Shen XH, Qiu H, Chen C, Yang RG*. Rhesus monkey TRIM5α has distinct HIV-1 restriction activity among different mammalian cell lines. Curr. Microbiol. 2011, 63(6):531-7.
Gong J, Wang XQ, Tong X, Shen XH, Yang RG*. Emerging trends of drug-resistant HIV-1 among drug-treated patients in former blood donors in Hubei, China: a three-year surveillance from 2004 to 2006. Virol Sin. 2011, 6(6):386-92.
Xihui Shen, Simran Banga, Yancheng Liu, Li Xu, Ping Gao, Ilya Shamovsky, Evgeny Nudler, Zhao-Qing Luo. Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cell. Microbiol. 2009, 11(6):911-26.
Yan Huang, Kexin Zhao,Xihui Shen, Chengying Jiang, and Shuang-Jiang Liu. Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Corynebacterium glutamicum. Appl. Microbiol. Biot. 2008, 78(1):75-83.
Banga S, Gao P, Shen XH, Fiscus V, Zong WX, Chen L, Luo ZQ. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 family.PNAS2007, 104(12):5121-6.
Chaudhry MT, Huang Y, Shen XH, Poetsch A, Jiang CY, Liu SJ. Genome-wide investigation of aromatic acid transporters in Corynebacterium glutamicum. Microbiology. 2007,153(3):857-65.
Huang Y, Zhao KX, Shen XH, et al. Genetic characterization of the resorcinol catabolic pathway in Corynebacterium glutamicum. Appl. Environ. Microbiol. 2006 Nov;72(11):7238-45.
Jie Feng, Yongsheng Che, Johanna Milse, Ya-Jie Yin, Lei Liu, Christian, Rückert, Xi-Hui Shen, Su-Wei Qi, Jörn Kalinowski, and Shuang-Jiang Liu. The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum. J. Biol. Chem. 2006 281(16):10778-85.
Xihui Shen, Chengying Jiang, Yan Huang, Zhipei Liu, and Shuang-Jiang Liu. Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum. Appl. Environ. Microbiol. 2005,71(7):3442-52.
Xi-Hui Shen, Yan Huang，Shuang-Jiang Liu. Genomic analysis and identification of catabolic pathways for aromatic compounds in Corynebacterium glutamicum. Microbes Environ. 2005, 20(3):160-167.
Xihui Shen, Shuang-Jiang Liu. Molecular basis of the protocatechuate branch of the β-ketoadipate pathway for aromatic degradation in Corynebacterium glutamicum. Science in China 2005, 48: 241-249.
Xihui Shen, Zhipei Liu, and Shuang-Jiang Liu. Functional identification of the gene locus (ncg12319) and characterization of catechol 1,2-dioxygenase in Corynebacterium glutamicum. Biotechnol Lett. 2004, 26:575-580.
沈錫輝，劉雙江。谷氨酸棒桿菌代謝芳烴過程中β-酮己二酸途徑中原兒茶酸支路的分子基礎。中國科學C輯:生命科學 2004, 34(6) 547-554
沈錫輝，劉志培，王保軍，劉雙江。苯酚降解菌紅球菌PNAN5菌株(Rhodococcus sp. PNAN5)的分離鑑定、降解特性及其開環雙加氧酶性質研究。環境科學學報 2004, 24: 482-486.
沈錫輝，王開梅，張志剛，陳在佴，鎮達。用離子交換吸附法回收Bt發酵液上清中的增效物質。中國生物防治2004, 20:34-37.
吳建峰, 沈錫輝, 周宇光，劉雙江。一株降解對氯硝基苯的 Comamonas sp . CNB1的分離鑑定及其降解特性。微生物學報 2004, 44:8-12
