基本介紹
科研簡歷,研究方向,科研項目,代表論文,
科研簡歷
1993年畢業於安徽大學生物化學專業，獲理學學士。
2002年和2006年，分別獲得中國科學技術大學生化與分子生物學專業的碩士和博士學位。
2006年在美國喬治亞大學生化與分子生物學系作為訪問學者工作和學習。
2009年獲得安徽省第五批優秀青年基金資助。
2010年入選安徽省第七批學術與技術帶頭人後備人選。
研究方向
圍繞生物大分子結構與功能的關係，開展重要蛋白質的克隆表達純化、生化和酶學分析以及蛋白質晶體學等方面的研究工作，主持和參與了多個國家自然科學基金項目和科技部973子課題。
科研項目
國家自然科學基金主任基金（31340044）集胞藻鎂原卟啉IX甲基轉移酶的分子機理研究
國家自然科學基金面上項目（30970565）擬南芥VSP蛋白的晶體結構和催化特性研究
973項目子課題（2009CB825502）：組蛋白泛素化的結構基礎
代表論文
[1]Zhang M#, Zhang F#, Fang Y, Chen X, Chen Y, Zhang W, Dai H.E, Lin R, Liu L*, The non-canonical tetratricopeptide repeat (TPR) domain of fluorescent (FLU) mediates complex formation with glutamyl-tRNA reductase, The Journal of Biological Chemistry, 2015, 290(28): 17559-17565
[2] Li J#, Wang X#, Gong W, Niu C*,Zhang M*, Crystallization and preliminary X-ray analysis of Rv1674c from Mycobacterium tuberculosis, Structural Biology and Crystallization Communications, 2015, 71(3): 354-357
[3] Ma C, Song M, Zhang Y, Yan M,Zhang M*, Bi H*, Nickle nanowires induce cell cycle arrest and apoptosis by generation of reactive oxygen species in Hela cells, Toxicology Reports, 2014, 1: 114�121
[4] Chen Y.Q, Chen C.C, He Y, Yu M, Xu L, Tian C.L, Guo Q.X, Shi J,Zhang M*, Li Y.M*, Efficient synthesis of trypsin inhibitor SFTI-1 via intramolecular ligation of peptide hydrazide, Tetrahedron Letters, 2014, 55(17): 2883-2886
[5] Liu G#, Shi Z #, Jiao S#, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L, Zhang Z, Zhou Z*,Zhang M*, Structure of MST2 SARAH domain provides insights into its interaction with RAPL, Journal of Structural Biology, 2014, 185(3): 366-374
[6]Zhang M, Xu H, Wang Y, Shi Z, Zhang N. Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. Acta Crystallographica Section F. 2013, 69(10), 1089-1093.
[7] Zhang Z, Wang Y, Shi Z*,Zhang M*. Structure of zebrafish MO25. Acta Crystallographica Section F. 2013, 69(9), 989-993
[8] Chen Y, Wei J, Wang M, Shi Z, Gong W*,Zhang M*. The crystal structure of Arabidopsis VSP1 reveals the plant class C-like phosphatase structure of the DDDD superfamily of phosphohydrolases. PLoS One. 2012, 7(11):e49421
[9] Shi Z, Ge H, Zhao P,Zhang M*. Crystallization and preliminary crystallographic analysis of recombinant VSP1 from Arabidopsis thaliana. Acta Crystallographica Section F. 2010, 66(2), 201-203
[10]Zhang M, Wei Z, Chang S, Teng M, Gong W*. Crystal structure of a papainfold protein without the catalytic residue: a novel member in cysteine proteinase family. Journal of Molecular Biology. 2006, 358(1): 97-105
[11]Zhang M, Wu F, Wei Z, Xiao Y, Gong W*. Characterization and decolorization ability of a laccase from Panus rudis. Enzyme and Microbial Technology. 2006, 39(1): 92-97
