吳鈺周，女，1985年生，華中科技大學化學與化工學院教授。研究方向為生物納米技術與生物材料。
基本介紹
- 中文名：吳鈺周
- 出生日期：1985年5月
- 學位/學歷：博士
- 專業方向：生物納米技術與生物材料
- 職稱：教授
個人簡介,個人經歷,研究方向,獲得榮譽,承擔課題,發表論文,
個人簡介
個人經歷
教育經歷：
2010-2013 德國烏爾姆大學化學系，博士 (summa cum laude)
2008-2010 新加坡國立大學化學系，碩士
2004-2008 浙江大學化學系，學士
工作經歷：
2016年9月 至今華中科技大學化學與化工學院，教授，博士生導師，
2016年9月 至今 德國馬克思普朗克高分子研究所，課題組長（兼職）
2016年5月-2016年9月 德國馬克思普朗克高分子研究所，課題組長，
2013-2016德國烏爾姆大學，課題組長 (Habilitation)
研究方向
研究領域：
智慧型生物納米材料，納米醫藥及靶向藥物載體，複合高分子材料，DNA 摺紙術
研究方向：
本課題組主要致力於以蛋白質及核酸等生物大分子為原料設計和製備智慧型生物納米材料的研究。結合生物工程技術和化學合成技術的手段對天然蛋白質及核酸進行改造，設計和誘導其有序的自組裝過程，同時研究生物大分子與合成高分子的複合材料，設計和製備能夠用於納米醫藥，靶向藥物傳遞，生物成像，癌症診療等領域的新型智慧型納米材料。
獲得榮譽
2015 Forschungsboni der Ulmer Universitätsgesellschaft (Ulm University)
2014 Promotionspreis der Ulmer Universitätsgesellschaft (Ulm University)
2013 Finalist of 2013 Reaxys PhD Prize
2013 Finalist of the Lanxess Talent award
2012 國家自費留學生獎學金
2008-2010 Research Scholarship (National University of Singapore, Singapore).
2008 浙江省優秀畢業生
承擔課題
2016-2019，歐盟Horizon 2020 – Hyperdiamond: The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe. 子課題主持，項目經費€ 400,000，
2014-2017，德國Baden-Württemberg Stiftung BioMatS-15: Protein-DNA Hybrid Hydrogels as Sustainable Materials for Tissue Engineering. 主持，項目經費€ 340,000，
2014-2016，德國Volkswagen Stiftung: Engineering binding cavities and surface amphiphilicity at the molecular scale for efficient in vivo drug delivery. 參與，項目經費€194,400
2013-2019，歐盟ERC Synergy grant: Diamond quantum devices and biology. 參與，項目經費€ 357,6960
發表論文
1. Yu Tokura, Yanyan Jiang, Alexander Welle,Martina H Stenzel, Katarzyna Krzemien, Jens Michaelis, Christopher Barner-Kowollik,Yuzhou Wu*,Tanja Weil*,Bottom-up Fabrication of Nanopatterned Polymers on DNA Origami Nanotile by In-situ Atom Transfer Radical Polymerization, Angew. Chem. Int. Ed.,2016,55, 5692-5697. (Frontispiece)
2.Yuzhou Wu*, Fedor Jelezko, Martin Plenio, Tanja Weil*, Diamond Quantum Sensing in Biology,Angew. Chem. Int. Ed.,2016,55, 6586-6598.
3. David Palesch, Felix Boldt, Janis A. Müller, Klaus Eisele, Christina M. Stürzel,Yuzhou Wu*, Jan Münch*, Tanja Weil*. PEGylated cationic serum albumin to boost retroviral gene transfer. ChemBioChem,2016, DOI: 10.1002/cbic.201600193. 2.85
4. Felix Boldt, Weina Liu,YuzhouWu*, Tanja Weil*. Converting Human Proteins into Precision Polymer Therapeutics. Curr Pharm Des.,2016, 22, 2866-2872. 3.052
5. Tao Wang, Andreas Riegger, Markus Lamla, Sebastian Wiese, Patrick Oeckl, Markus Otto,Yuzhou Wu, Stephan Fischer, Holger Barth, Seah Ling Kuan and Tanja Weil*, Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides, Chem. Sci.,2016, 7, 3234-3239
6. Seah Ling Kuan, Christina Förtsch, David Y. W. Ng, Stephan Fischer, Yu Tokura, Weina Liu,Yuzhou Wu, Kaloian Koynov, Holger Barth and Tanja Weil1*, A supramolecular approach toward bioinspired PAMAM-dendronized fusion toxins,2016, Macromol. Biosci. DOI: 10.1002/mabi.201500417
7. Christiane Seidler, David. Y. W. Ng,Yuzhou Wuand Tanja Weil*, pH responsive supramolecular core-shell protein hybrids, Supramolecular Chemistry,2016, DOI:10.1080/10610278.2016.1140764
8. Sylvia Schmid,* David. Y. W. Ng, Elena. Mena-Osteritz,Yuzhou Wu, Tanja Weiland Peter Bäuerle, Self-assembling oligothiophene–bolaamphiphiles for loading and controlled release of doxorubicin into living cells. Chem. Commun.,2016, 52, 3235-3238.
9.Yuzhou Wu*, Anna Ermakova, Weina Liu, Goutam Pramanik, Minh Vu, Andrea Kurz, Liam McGuinness, Boris Naydenov, Susanne Hafner, Rolf Reuter, Joerg Wrachtrup, Dominique Böcking, Junichi Isoya, Thomas Simmet, Fedor Jelezko*, Tanja Weil*, Programmable Biopolymers for Advancing Biomedical Applications of Fluorescent Nanodiamonds, Adv. Funct. Mater.,2015, 25, 6576–6585.
10.Yuzhou Wu, David Yuen Wah Ng, Seah Ling Kuan, Tanja Weil*, “Protein-Polymer Therapeutics – A Macromolecular Perspective”, Biomaterials Science,2015, 3, 214-230. 3.614
11. René Stangenberg,Yuzhou Wu, Seah Ling Kuan, Dennis Kurzbach, Dariush Hinderberger, Jana Hedrich, Malin Insa Preiß, Heiko J. Luhmann, Tanja Weil* and Klaus Müllen*, “A Polyphenylene Dendrimer Drug Transporter with Precisely Positioned Amphiphilic Surface Patches”,Adv. Healthcare Mater.,2015, 4, 377-384.(Shared first authorship).
12. Tao Zhang, Andre Neumann, Jessica Lindlau,Yuzhou Wu, Goutam Pramanik, Boris Naydenov, Fedor Jelezko, Florian Schüder, Sebastian Huber, Marinus Huber, Florian Stehr, Alexander Högele*, Tanja Weil* and Tim Liedl*, DNA-based self-assembly of fluorescent nanodiamonds, J. Am. Chem. Soc.,2015, 31, 9776–9779.
13. Tao Wang,Yuzhou Wu, Seah Ling Kuan, Oliver Dumele, Markus Lamla, David Y. W. Ng, Matthias Arzt, Jessica Thomas, Jan. O. Mueller, Christopher Barner-Kowollik*, Tanja Weil*, A Disulfide Intercalator Toolbox for Site-Directed Polypeptide Modification, Chemistry – a European Journal,2015, 21, 228-238.
14. Tao Wang, Natalia Zabarska,Yuzhou Wu, MarkusLamla, Stephan Fischer, Katharina Monczak, David Y. W.Ng,* SvenRau* and TanjaWeil*, Receptor Selective Ruthenium-Somatostatin Photosensitizer for Cancer Targeted Photodynamic Applications, Chem. Commun.2015, 51, 12552-12555.
15.Yuzhou Wu*,Chuang Li, Felix Boldt, Christina Förtsch, Holger Barth, Yanran Wang, Seah Ling Kuan, Thuy Tam Tran, Viktoria Mikhalevich, Zhongqiang Yang, Dongsheng Liu*, Tanja Weil*, “Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins”, Chem. Comm.,2014, 50, 14620-14622.
16. David Yuen Wah Ng,Yuzhou Wu, Seah Ling Kuan and Tanja Weil*, “Programming Supramolecular Biohybrids as Precision Therapeutics”, Acc. Chem. Res.,2014, 47, 3471-3480.(Shared first authorship).
17. Chuang Li, Ping Chen, Yu Shao, Xu Zhou,Yuzhou Wu, Zhongqiang Yang, Zhibo Li, Tanja Weil, Dongsheng Liu*, “A writable polypeptide-DNA hydrogel with rationally designed multi-modification sites”, Small,2014,11, 1138-1143.
18. Tao Wang, David Y. W. Ng,Yuzhou Wu, Jessica Thomas, Thuy TamTran and Tanja Weil*. “Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release”Chem. Commun.,2014,50, 1116-1118.
19. David Y. W. Ng, Matthias Arzt,Yuzhou Wu, Seah Ling Kuan, Markus Lamla, Tanja Weil*. “Constructing Hybrid Protein Zymogens through Protective Dendritic Assembly”Angew.Chem. Int. Ed.2014,53, 324-328.
20. Christoph Meier,Yuzhou Wu, Goutam Pramanik, Tanja Weil*. “Self-?Assembly of High Molecular Weight Polypeptide Copolymers Studied via Diffusion Limited Aggregation”Biomacromolecules,2014,15, 219-227.
21. David Yuen Wah Ng, Jörg Fahrer,Yuzhou Wu, Klaus Eisele, Seah Ling Kuan, Holger Barth*, Tanja Weil*. “Efficient Delivery of p53 and Cytochrome C by Supramolecular Assembly of a Dendritic Multi-Domain Delivery System”Adv. Healthcare Mater.2014,2, 1620-1629.
22.Yuzhou Wu, Susann Ihme, Michaela Feuring-Buske, Seah Ling Kuan, Klaus Eisele, Markus Lamla, Yanran Wang, Christian Buske, and Tanja Weil*. “A Core-shell Albumin Copolymer Nanotransporter for High Capacity Loading and Two-step Release of Doxorubicin with Enhanced Anti-leukemia Activity”Adv. Healthcare Mater.,2013, 2, 884-894.
23. Diego Pesce,Yuzhou Wu, Anke Kolbe, Tanja Weil* and Andreas Herrmann*. “Enhancing Cellular Uptake of GFP via Unfolded Supercharged Protein Tags” Biomaterials,2013, 34, 4360.(Shared first authorship).
24. Seah Ling Kuan, David Y. W. Ng,Yuzhou Wu, Christina Förtsch, Holger Barth, Mikheil Doroshenko, Kaloian Koynov, Christoph Meier, Tanja Weil*.J. Am. Chem. Soc.2013, 135, 17254.
25. Jana Hedrich,Yuzhou Wu, Seah Ling Kuan, Frauke Kuehn, Eweline Pietrowski, Mike Sahl, Sandra Muth, Klaus Müllen, Heiko J. Luhmann, Tanja Weil, Manfred Schmidt. “Polymer Complexes in Biological Applications”Adv. Polym. Sci.2013, doi: 10.1007/12_2013_229.(Book Chapter).
26. Tao Wang, Anne Pfisterer, Seah Ling Kuan,Yuzhou Wu, Oliver Dumele, Markus Lamla, Klaus Müllen and Tanja Weil*.“A Versatile and Orthogonal Approach for the Cross-Conjugation of DNA, Proteins and Peptidesviathe pH Switch”Chem. Sci.,2013, 4, 1889-1894.
27. Seah Ling Kuan,Yuzhou Wu, Tanja Weil*. “Precision Biopolymers from Protein Precursors for Biomedical Applications”MacromolRapid Commun.,2013,34, 380.
28. Seah Ling Kuan, Bettina Stöckle, David Y.W. Ng,Yuzhou Wu, Mikheil Doroshenko, Jörg Reichenwallner, Kaloian Koynov, Dariush Hinderberger, Klaus Müllen and Tanja Weil*. “Dendronized Albumin Biohybrids as Efficient Core-Shell Doxorubicin Delivery Systems”Biomacromolecules,2013, 14 (2): 367–376.
29.Yuzhou Wu, Klaus Eisele, Mikheil Doroshenko, Gerardo Algara-Siller, Ute Kaiser, Kaloian Koynov, Tanja Weil*. “A Quantum Dot Photoswitch for DNA Detection, Gene Transfection, and Live-Cell Imaging”Small,2012, 8(22): 3465–3475.(Cover article)
30.Yuzhou Wu, Goutam Pramanik, Klaus Eisele, Tanja Weil*.“Convenient Approach to Polypeptide Copolymers Derived from Native Proteins”Biomacromolecules,2012, 13(6):1890-1898.
31.Yuzhou Wu, Tao Wang, David Y.W. Ng, Tanja Weil*. “Multifunctional Polypeptide-PEO Nanoreactors via the Hydrophobic Switch”Macromol. Rapid Commun.,2012, 33(17):1474-1481.
32.Yuzhou Wu,Tanja Weil*. “An Efficient Approach for Preparing Giant Polypeptide Triblock Copolymers by Protein Dimerization”Macromol. Rapid Commun.,2012, 33(15):1304-1309.
33.Yuzhou Wu, Kai Shih Er, Arvind Ramanathan, Subhash Vasudevan, Tanja Weil*. “Nano-sized Albumin-copolymer Micelles for Efficient Doxorubicin Delivery”Biointerphases.2012, 7(1-4):5.
34. Yasar Akdogan,Yuzhou Wu, Klaus Eisele, Manuela Schaz, Tanja Weil* and Dariush Hinderberger*.“Host-Guest Interactions in Polycationic Human Serum Albumin Bioconjugates”Soft Matter,2012, 8(43): 11106-11114.
35.Yuzhou Wu, Sabyasachi Chakrabortty, Radu A. Gropeanu,Joerg Wilhelmi,Yang Xu, Kai Shih Er, Seah Ling Kuan, Kaloian Koynov, Yinthai Chan* and Tanja Weil*. “pH-Responsive Quantum Dotsviaan Albumin Polymer Surface Coating”J. Am. Chem. Soc.,2010, 132(14):5012-5014.
