賈洪林，男，博士，中國農業科學院哈爾濱獸醫研究所研究員，研究生導師，寵物疫病創新團隊首席科學家，延邊大學客座教授，第九屆中國動物學會寄生蟲專業委員會委員，第七屆、八屆中國畜牧獸醫學會獸醫寄生蟲學分會理事。
主要研究方向為貓寵物疫病以及弓形蟲等寵物源人獸共患病的病原生物學研究以及防控制劑研發。在PLoS Pathogens、Autophagy、Nature Structural & Molecular Biology和mBio等國際著名期刊發表SCI文章50多篇，被引用700多次，擔任多個國際期刊審稿人。
基本介紹
人物經歷,教育經歷,工作經歷,主要成就,科研項目,期刊論文,
人物經歷
教育經歷
1997.09-2001.06 延邊大學 獸醫專業 學士
2001.09-2004.06 延邊大學 預防獸醫專業 碩士
2006.04-2009.03 日本帶廣畜產大學 畜產衛生專業 博士
工作經歷
2004.07-2005.01 延邊大學 助教
2005.02-2006.03 日本帶廣畜產大學國立原蟲病研究中心 研究職員
2009.04-2011.09 日本北海道大學人獸共患病研究中心 博士後
2011.10-2020.12 中國農業科學院哈爾濱獸醫研究所 副研究員
2021.01-至今 中國農業科學院哈爾濱獸醫研究所 研究員
主要成就
科研項目
(1) 黑龍江省傑出青年基金：弓形蟲頂質體跨膜轉運分子機制，2022-2025
(2) 黑龍江省重點研發專項：伴侶動物疫病防控制劑創製，2022-2025
(3) “十四五” 國家重點研發計畫項目：動物重要寄生蟲的生長發育與寄生機制，2022-2025
(4) 國家自然科學基金面上項目：弓形蟲SNARE蛋白在分泌性細胞器生物發生過程中的作用機制研究，2018-2022
(5) “十三五” 國家重點研發計畫項目：畜禽重要胞內寄生原蟲的寄生與免疫機制研究，2017-2022
(6) “十三五” 國家重點研發計畫項目：畜禽重要人獸共患寄生蟲病源頭防控與阻斷技術研究，2017-2022
(7) 國家自然科學基金青年基金項目：弓形蟲氨基肽酶的功能解析及其作為藥物靶點的可行性研究，2012-2015
(8) 黑龍江省自然科學基金面上項目：弓形蟲甲硫氨酸氨基肽酶藥物靶點的鑑定，2015-2017
期刊論文
Fu J, Zhao L, Chen H, Cao S, Jia H*. An unconventional SNARE complex mediates exocytosis at the plasma membrane and vesicular fusion at the apical annuli in Toxoplasma gondii. PLoS Pathogens. 2023, 19(3):e1011288
Cao H, Gu H, Kang H* and Jia H*. Development of a rapid reverse genetics system for feline coronavirus based on TAR cloning in yeast. Front. Microbiol. 2023, 14:1141101.
Fu J, Zhao L, Pang Y, Chen H, Yamamoto H, Chen Y, Li Z, Mizushima N,Jia H*. Apicoplast biogenesis mediated by ATG8 requires the ATG12-ATG5-ATG16L and SNAP29 complexes in Toxoplasma gondii. Autophagy. 2023, 19(4):1258-1276.
The Dissection of SNAREs Reveals Key Factors for Vesicular Trafficking to the Endosome-like Compartment and Apicoplast via the Secretory System in Toxoplasma gondii. Cao S., Yang J., Fu J., Chen H., Jia H*. mBio. 2021,12(4):e0138021. 通訊作者
Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system. Pang, Y., Yamamoto, H., Sakamoto, H., Oku, M., Mutungi, J. K., Sahani, M. H., Kurikawa, Y., Kita, K., Noda, N. N. & Sakai, Y., Jia, H.*, Mizushima, N*. Nature structural & molecular biology, 2019, 26: 289-296, 共同通訊作者
TgMAP1c is involved in apicoplast biogenesis in Toxoplasma gondii. Zheng, J., Su, W., Cao, S., Zhang, Z., Du, C., Jia, H.* International Journal for Parasitology, 2020,50 :487-499, 通訊作者
Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth through an Aspartate Aminotransferase-Independent Pathway, Li, J., Guo, H., Galon, E.M., Gao, Y., Lee, S., Liu, M., Li, Y., Ji, S., Jia, H*., Xuan，X*., Antimicrob Agents Chemother, 2020, 64(3): e01889-19. 共同通訊作者
GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon. Zhang, Z., Gu, H., Li, Q., Zheng, J., Cao, S., Weng, C., Jia, H.* Infection and Immunity, 2020, 88: e00054-20, 通訊作者
The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii. Cao, S., Chen, H., Liang, X., Fu, J., Wang, S., Zheng, J., Zhang, Z., Pang, Y., Wang, J. & Shen, B., Jia, H.*. Molecular microbiology, 2019, 113: 208-221, 通訊作者
Translationally controlled tumor protein is required for the fast growth of Toxoplasma gondii and maintenance of its intracellular development. Zheng, J., Chen, Y., Li, Z., Cao, S., Zhang, Z. & Jia, H.* FASEB J, 2018, 32: 906-919, 通訊作者
Knockout of leucine aminopeptidase in Toxoplasma gondii using CRISPR/Cas9. Zheng, J., Jia, H.*, & Zheng, Y. International Journal for Parasitology, 2015, 45:141-148, 通訊作者
Characterization of aspartyl aminopeptidase from Toxoplasma gondii. Zheng, J., Cheng, Z., Jia, H.* & Zheng, Y. Sci Rep, 2016, 6: 34448, 通訊作者
Toxoplasma gondii Clp family protein: TgClpB1 plays a crucial role in thermotolerance. Cao, S., Nali Du, Chen, H., Pang, Yu., Zhang, Z., Zheng, J. Jia, H.* Oncotarget. 2017, 8:86117-86129.
Wang, M., Cao, S., Du, N., Fu, J., Li, Z., Jia, H.＊, Mingxin Song*. The moving junction protein RON4, although not critical, facilitates host cell invasion and stabilizes MJ members. Parasitology. 2017, 144(11): 1490-1497
Functional characterization of X-prolyl aminopeptidase from Toxoplasma gondii. Yang, M., Zheng, J., Jia, H.,*, Song, M.* Parasitology. 2016, 143(11):1443-9.
Meng, X., , Zheng, J., He, X., Jia, H. *, Zhang, Y.* First characterization in China of Encephalitozoon cuniculi in the blue fox (Alopex lagopus). J Eukaryot Microbiol. 2014, 61(6):580-5.
Evaluation of spore wall protein 1 as an alternative antigen for the diagnosis of Encephalitozoon cuniculi infection of farmed foxes using an enzyme-linked immunosorbent assay. Meng, X., Zheng, J., Gao, Y., Zhang, Y*. & Jia, H* . Veterinary Parasitology, 2014, 203: 331-334, 通訊作者
Jia, H., Nishikawa, Y., Luo, Y., Yamagishi, J., Sugimoto, C., Xuan, X., Characterization of a leucine aminopeptidase from Toxoplasma gondii. Mol Biochem Parasitol 170, 1-6.
Jia, H., Zhou, J., Ikadai, H., Matsuu, A., Suzuki, H., Igarashi, I., Fujisaki, K., Xuan, X., 2006. Identification of a novel gene encoding a secreted antigen 1 of Babesia gibsoni and evaluation of its use in serodiagnosis. Am J Trop Med Hyg 75, 843-850.
Jia, H., Liao, M., Lee, E., Nishikawa, Y., Inokuma, H., Ikadai, H., Matsuu, A., Igarashi, I., Xuan, X., 2007. Development of an immunochromatographic test with recombinant BgSA1 for the diagnosis of Babesia gibsoni infection in dogs. Parasitol Res 100, 1381-1384.
Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Zhou, J., Lee, E.G., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2008. Babesia gibsoni: identification of an immunodominant, interspersed repeat antigen. Exp Parasitol 118, 146-149.
Jia, H., Aboge, G.O., Terkawi, M.A., Goo, Y.K., Nishikawa, Y., Kuriki, K., Lee, K.K., Jang, H.K., Kim, S., Fujisaki, K., Xuan, X., 2009. Genetic diversity of two selected antigen loci in Babesia gibsoni Asian genotype obtained from Japan and Jeju island of South Korea. Vet Parasitol 162, 142-146.
Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Luo, Y., Li, Y., Yamagishi, J., Nishikawa, Y., Igarashi, I., Sugimoto, C., Fujisaki, K., Xuan, X., 2009. Characterization of a leucine aminopeptidase of Babesia gibsoni. Parasitology 136, 945-952.
Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Ma, L., Zhou, J., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2009. Identification of secreted antigen 3 from Babesia gibsoni. Clin Vaccine Immunol 16, 944-948.
