蔡潭溪

蔡潭溪

蔡潭溪,男,中國科學院生物物理研究所副研究員。

基本介紹

人物經歷,研究方向,科研成果,研究論文,科研活動,

人物經歷

2015-01~現在, 中國科學院生物物理研究所, 副研究員
2011-09~2015-01,中國科學院大學, 博士學位
2006-07~2014-12,中國科學生物物理研究所, 助理研究員
1999-09~2006-06,南京農業大學, 學士,碩士學位

研究方向

分析生物化學及樣品製備
生命科學研究中的色譜、質譜和組學技術
生物技術藥物
ABSP lab exercise
生物樣品分離與質譜鑑定技術

科研成果

研究論文

(1) Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs., Mol Cell Proteomics ., 2021, 第 1 作者
(2) LncRNA-encoded microproteins: A new form of cargo in cell culture-derived and circulating extracellular vesicles, Journal of Extracellular Vecicles, 2021, 第 1 作者
(3) Proteomics reveals the function reverse of MPSSS‐treated prostate cancer‐associated fibroblasts to suppress PC‐3 cell viability via the FoxO pathway, Cancer medicine, 2021, 第 5 作者
(4) Sequential Precipitation and Delipidation Enables Efficient Enrichment of Low-Molecular Weight Proteins and Peptides from Human Plasma, J. Proteome Res., 2020, 通訊作者
(5) Separation and characterization of extracellular vesicles from human plasma by asymmetrical flow field-flow fractionation, Anal Chim Acta ., 2020, 第 8 作者
(6) Phospholipid and Phospholipidomics in Health and Diseases, Phospholipid and Phospholipidomics in Health and Diseases, 2018, 第 1 作者
(7) MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins., Nucleic Acids Res., 2017, 第 1 作者
(8) Strategies for Characterization of Low-Abundant Intact or Truncated Low-Molecular-Weight Proteins From Human Plasma., Enzymes, 2017, 第 1 作者
(9) CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development., Proc Natl Acad Sci U S A, 2017, 第 4 作者
(10) SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci., Brief Bioinform., 2017, 第 4 作者
(11) Pore architecture of TRIC channels and insights into their gating mechanism., Nature, 2016, 第 5 作者
(12) Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling, Journal of Lipid Research, 2016, 第 1 作者
(13) Profiling and relative quantitation of phosphoinositides by multiple precursor ion scanning based on phosphate methylation and isotopic labeling., Analytical Chemistry, 2015, 第 1 作者
(14) Proteomic Comparison and MRM-Based Comparative Analysis of Metabolites Reveal Metabolic Shift in Human Prostate Cancer Cell Lines, Jouranl of Proteome Research, 2015, 第 1 作者
(15) Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins, Mol Cell Proteomics, 2015, 第 1 作者
(16) Integrative proteomic and transcriptomic analyses reveal multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis, Mol Cell Proteomics, 2013, 第 1 作者

科研活動

科研項目
( 1 ) 高密度脂蛋白主要組成成分及其修飾的動態變化與糖尿病和冠心病之間的關聯性研究, 主持, 國家級, 2017-01--2020-12
( 2 ) 基於中藥複方抗糖尿病新靶標的發現, 參與, 部委級, 2016-01--2018-12
( 3 ) Study on the pathogenesis of obesity and type 2 diabetes mellitus (T2DM) using comparative lipoproteomics approach, 參與, 部委級, 2016-01--2016-12
參與會議
(1)Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling 2016-06-05
(2)Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins. 2015-07-06
(3)Comparative proteomics-based in silico analyzes further our understanding of mouse spermatogenesis and fertility 2014-06-04
專利成果
( 1 ) 一種用於富集內源性低分子量蛋白和多肽的試劑盒及方法, 2020, 第 3 作者, 專利號: 202010519120.8
( 2 ) 一種基於穩定同位素標記的磷脂分類檢測和定量方法, 2019, 第 1 作者, 專利號: 201510446558.7
( 3 ) 一種基於化學衍生的磷脂分類檢測和定量方法, 2017, 第 1 作者, 專利號: 201510446589.2
( 4 ) 一種逆流色譜儀及其專用逆流色譜柱, 2012, 第 2 作者, 專利號: 201120031345.5

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