董傳甫，男，博士，中山大學生命科學學院副教授、博士生導師。
基本介紹
- 中文名：董傳甫
- 學位/學歷：博士
- 專業方向：病毒性病害
- 任職院校：中山大學
研究方向,學術成就,承擔課題,論文專著,發明專利,
研究方向
病毒性病害——病原生物學、疫苗與免疫生物學
學術成就
1.在國內率先建立了對淡、海水魚類ISKNV型和RSIV型腫大細胞病毒長期持續高敏感MFF-1細胞系(Donget al.,Virus Res, 2008; 2010)，系統解決了ISKNV型和RSIV型腫大細胞虹彩病毒的規模化細胞培養、結構蛋白解析、細胞疫苗研製及免疫學診斷（單抗）等學科領域內關鍵科學問題(Donget al,J Virol, 2011;Vet Microbiol, 2013; Donget al,FSIM, 2013; Shuanget al.,Virology, 2013)；作為主要研發人參與研製的《鱖傳染性脾腎壞死病滅活疫苗（NH0618株）》獲農業部臨床試驗批准（批件號：2015043），目前已經完成臨床試驗工作，正進行新獸藥註冊。
2.建立一株新型錦鯉鰭條細胞系KCF-1 (Donget al., Virus Res, 2011)，在國內率先分離、培養並純化到錦鯉皰疹病毒（CyHV3/KHV）本土分離株（含一株在國際上十分罕見的歐--亞過渡性歐洲基因型毒株CyHV-3/KHV-GZ11），建立了研究平台(Donget al,Virus Res, 2011;Vet Microbiol, 2013; Liet al,Vet Microbiol, 2015; Yiet al,Virus Res, 2014;FSIM, 2015)；
3.建立自主智慧財產權魚類傳代細胞系6個；收集、分離並保存有多個經濟魚類的新生脊椎動物虹彩病毒、彈狀病毒及皰疹病毒，並建立了比較完備的細胞感染模型和動物模型。
承擔課題
主持博士後基金面上（一等）和博士後特別基金、國家自然科學基金青年和面上、973子課題、教育部中央高校基金、中山大學套用性科技成果轉化基金、廣東漁業科技專項等多個項目；
參與國家級、省級重點項目多項。
論文專著
Selected Peer-reviewed Published Articles(*or**, corresponding author)：
23.Gao Y, Suárez Nicolás M., Wilkie Gavin S.,Dong C, Bergmann Sven, Lee Pei Yu Alison, Davison Andrew J., Vanderplasschen Alain F. C.* and Boutier Maxime.2018. Genomic and biologic comparisons of cyprinid herpesvirus 3 strains.Vet Res(2018) 49:40.
22. Zhu Z,Dong C*, Weng S and He J*.2018. The high prevalence of pathogenicVibrio harveyiwith multiple antibiotic resistance in scale drop and muscle necrosis disease of the hybrid grouper,Epinephelus fuscoguttatus(♀) ×E. lanceolatus(♂), in China.J Fish Dis. 41(4):589-601.
21.Dong C*, Wang Z, Weng S and He J.2017. Occurrence of a lethal ranavirus in hybrid mandarin (Siniperca scherzeri×Siniperca chuatsi) in Guangdong, South China.Vet microbiol,203,28-33.
20. Lee X, Weng S, Zhang H, Zeng J, He J* andDong C*.2016. Identification and expression analysis of cellular and viral microRNAs in CyHV3-infected KCF-1 cells.Gene, 592(1):154-63.
19. Qi H, Yi Y, Weng S, Zou W, He J* andDong C*.2016. Differential autophagic effects triggered by five different vertebrate iridoviruses in a common, highly permissive mandarinfish fry (MFF-1) cell model.Fish Shellfish Immunol.49, 407-419.
18. Lee X, Yi Y, Weng S, Zeng J, Zhang H, He J* andDong C*.2016. Transcriptomic analysis of koi (Cyprinus carpio) spleen tissue upon cyprinid herpesvirus 3 (CyHV3) infection using next generation sequencing.Fish Shellfish Immunol. 49, 213-224.
17. Yi, Y., Qi, H., Yuan, J., Wang, R., Weng, S., He, J.,Dong, C*.2015. Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome.Fish Shellfish Immunol. 45 (2), 757-770.
16. Li, W., Lee, X., Weng, S., He, J*.,Dong, C*.2015. Whole-genome sequence of a novel Chinese cyprinid herpesvirus 3 isolate reveals the existence of a distinct European genotype in East Asia.Vet microbiol, 175, 185-194.
15.Dong C*, Shuang F, Weng S and He J.2014. Cloning of a new fibroblast cell line from an early primary culture from mandarin fish (Siniperca chuatsi) fry for efficient proliferation of megalocytiviruses.Cytotechnology, 66:883–890.
14. Yi Y, Zhang H, Lee X, Weng S, He J andDong C*.2014. Extracellular virion proteins of two Chinese CyHV-3/KHV isolates, and identification of two novel envelope proteins.Virus Res191, 108-116.
13. Xiang Z, Weng S, Qi H, He J andDong C*.2014. Identification and characterization of a novel FstK-like protein from spotted knifejaw iridovirus (genusMegalocytivirus).Gene, 545, 233-240.
12. Li, W., Zhang, X., Weng, S., Zhao, G., He, J.,Dong, C*.2014. Virion-associated viral proteins of a Chinese giant salamander (Andrias davidianus) iridovirus (genusRanavirus) and functional study of the major capsid protein (MCP).Vet Microbiol, 172, 129-139.
10. Shuang F, Luo Y, Xiong X, Weng S, Li Y, He J*, andDong C**.2013. Virion proteins of an RSIV type megalocytivirus from spotted knifejawOplegnathus punctatus(SKIV-ZJ07).Virology, 437(2): 89-99.
9.Dong C, Xiong X, Luo Y, Weng S, Wang Q and He J*.2013. Efficacy of a formalin-killed cell vaccine against infectious spleen and kidney necrosis virus (ISKNV) and immunoproteomic analysis of its major immunogenic proteins. Vet microbiol, 162(2-4): 419-428.
8. Dong, Y., Weng, S., He, J.,Dong, C*.2013. Field trial tests of FKC vaccines against RSIV genotype Megalocytivirus in cage-cultured mandarin fish (Siniperca chuatsi) in an inland reservoir.Fish Shellfish Immuno, l 35, 1598-1603.
7.Dong C, Weng S, Li W, Li X, Yi Y, Liang Q, He J*.2011. Characterization of a new cell line from caudal fin of koi,Cyprinus carpio koi, and first isolation of cyprinid herpesvirus 3 in China.Virus Res, 161(2):140-9.
6.Dong C, Xiong X, Shuang F, Weng S, Zhang J, Zhang Y, Luo Y, He J*.2011. Global landscape of structural proteins of infectious spleen and kidney necrosis virus.J Virol, 85(6):2869-77.
5.Xiong X,Dong C, Weng S, Zhang J, Zhang Y, He J*.2011. Antigenic identification of virion structural proteins from infectious spleen and kidney necrosis virus.Fish Shellfish Immunol, 31(6):919-24.
4. Xiong X,Dong C, Xu X, Weng S, Liu Z, He J*.2011. Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus.Dev Comp Immunol, 35(4):431-40.
3.Xiang Z,Dong C(Co-first authors), Qi L, Chen W, Huang L, Li Z, Xia Q, Liu D, Huang M, Weng S, He J*.2010. Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio).Dev Comp Immunol, 34(12):1263-73.
2.Dong C, Weng S, Luo Y, Huang M, Ai H, Yin Z, He J*.2010. A new marine megalocytivirus from spotted knifejaw,Oplegnathus punctatus, and its pathogenicity to freshwater mandarinfish,Siniperca chuatsi. Virus Res, 147(1):98-106.
1.Dong C, Weng S, Shi X, Xu X, Shi N, He J*.2008. Development of a mandarin fishSiniperca chuatsifry cell line suitable for the study of infectious spleen and kidney necrosis virus (ISKNV).Virus Res, 135(2):273-81.
發明專利
何建國，董傳甫，殷志新，翁少萍。傳染性脾腎壞病毒疫苗及其製備方法和套用，專利號：ZL200910038692.8。授權時間，2012.2。
