基本介紹
- 中文名：葛峰
- 畢業院校：新加坡國立大學
- 職務：博士生導師
人物經歷,個人成就,學術研究,研究領域,研究方向,課題研究,所獲榮譽,社會任職,代表論著,
人物經歷
1988.08-1992.07山東大學學士；
1992.07-1994.07安徽省工商局技術員；
1994.08-1997.07中科院武漢病毒所碩士；
1997.09-2000.07中國科學技術大學講師；
2000.09-2002.07 美國南加州大學訪問學者；
2002.07-2005.07新加坡國立大學博士；
2006.08-2009.07暨南大學副教授；
2009.08-2010.07日本長崎大學研究員；
2010.08-任中國科學院水生生物研究所,研究員，博導。
個人成就
學術研究
系統深入的開展了藍細菌中蛋白質的翻譯後修飾組及其功能、脅迫適應的分子機制、蛋白基因組學等方面的研究, 取得了系列重要進展,完成了模式藍細菌的蛋白基因組學研究，建立了全新的適用於原核生物的蛋白基因組注釋和翻譯後修飾規模發現和分析技術；鑑定了模式藍細菌的磷酸蛋白質組和乙醯化蛋白質組；系統揭示了磷酸化和乙醯化修飾在藍細菌光合作用中的新的調控模式；系統、全面揭示了藍細菌高光耐受的蛋白調控網路，發現了高光適應的關鍵蛋白分子。 在PNAS, Plant Cell, Molecular & Cellular Proteomics, Journal of Proteome Research等國際專業雜誌發表通訊作者論文29 篇,平均影響因子大於5.0,論文被他引345次。
研究領域
從事功能蛋白質組學領域相關的研究工作，以重要水生模式生物為研究對象；發展基於質譜的定量蛋白質組學方法和重要翻譯後修飾的鑑定技術；以水生生物的翻譯後修飾組學和蛋白基因組學為研究核心和特色；開展水生生物的功能蛋白質組學研究；推動水生生物蛋白質組學這一新的研究領域的發展並解決水生生物研究中的一些重大科學問題。
研究方向
課題研究
承擔有國家重點研發計畫項目、
國家自然科學基金面上和重大研究計畫項目、
中科院先導B等多項課題研究。
所獲榮譽
中國科學院水生生物研究所 “百人計畫”（2010年）。
社會任職
擔任湖北省生化學會常務理事、國際專業雜誌Proteomics學術編輯，受邀在國際蛋白質組學年度大會上做大會報告。作為項目負責人主持國家重點研發計畫、自然科學基金重大項目及中科院先導專項等8項課題（實到經費超過1000萬元）。
代表論著
1: Mingkun Yang, Xiaohuang Lin, Xin Liu, Jia Zhang, Feng Ge*. Genome annotation of a model diatom Phaeodactylum tricornutum using an integrated proteogenomic pipeline. Molecular Plant. In Press. DOI: 10.1016/j.molp.2018.08.005. （*通訊作者）
2: Liu X, Yang M, Wang Y, Chen Z, Zhang J, Lin X, Ge F*,Zhao J*. Effects of PSII Manganese-Stabilizing Protein Succinylation on Photosynthesis in the Model Cyanobacterium Synechococcus sp. PCC 7002. Plant and Cell Physiology. 2018 Jul 1;59(7):1466-1482. （*通訊作者）
3: Ren S, Yang M, Yue Y, Ge F, Li Y, Guo X, Zhang J, Zhang F, Nie X, Wang S. Lysine Succinylation Contributes to Aflatoxin Production and Pathogenicity in Aspergillus flavus. Molecular & Cellular Proteomics. 2018 Mar;17(3):457-471.
4: Wu Y, Xiong Q, Li S, Yang X, Ge F*. Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr). Molecular & Cellular Proteomics. 2018 Jan; 17(1): 146-159. （*通訊作者）
5: Yang X, Xiong Q, Wu Y, Li S, Ge F*. Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells. Journal of Proteome Research. 2017 Oct 6;16(10):3891-3902. （*通訊作者）
6: Chen, Zhuo; Zhang, Guiying; Yang, Mingkun; Li, Tao*; Ge, Feng*; Zhao, Jindong. Lysine Acetylome Analysis Reveals Photosystem II Manganese-stabilizing Protein Acetylation is Involved in Negative Regulation of Oxygen Evolution in Model Cyanobacterium Synechococcus sp. PCC 7002. Molecular & Cellular Proteomics. 2017;16(7):1297-1311.（*通訊作者）
7: Ma, Yanyan; Yang, Mingkun; Lin, Xiaohuang; Liu, Xin; Huang, Hui; Feng Ge*. Malonylome Analysis Reveals the Involvement of Lysine Malonylation in Metabolism and Photosynthesis in Cyanobacteria. Journal of Proteome Research. 2017;16(5):2030-2043. （*通訊作者）
8: Jia Zhang, Ming-kun Yang, Honghui Zeng, and Feng Ge*. GAPP: A Proteogenomic Software for Genome Annotation and Global Profiling of Post-translational Modifications in Prokaryotes. Molecular & Cellular Proteomics. 2016;15(11):3529-3539. （*通訊作者）
9: 吳英; 熊倩; 葛峰*. 長鏈非編碼RNA HOTAIR在細胞增殖中的作用機制. 生命科學. 2016, 28: 6; 680-685. (*通訊作者)
10: Wu Y, Lou QY, Ge F, Xiong Q.*. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Scientific Reports. 2017; 7(1):4022.（*通訊作者）
11: Ren S, Yang M, Li Y, Zhang F, Chen Z, Zhang J, Yang G, Yue Y, Li S, Ge F*, Wang S.*. Global Phosphoproteomic Analysis Reveals the Involvement of Phosphorylation in Aflatoxins Biosynthesis in the Pathogenic Fungus Aspergillus flavus. Scientific Reports. 2016; 6: 34078.（*通訊作者）
12: Siting Li, Minghai Chen, Qian Xiong, Jia Zhang, Zongqiang Cui, Feng Ge*. Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer Cells. Journal of Proteome Research. 2016, 7;15(10):3741-3751. （*通訊作者）
13: 楊明坤；林小煌；馬炎炎；王炎；葛峰*. 藍藻的蛋白質翻譯後修飾研究進展. 水生生物學報，2016 (05)，1056-1067. (*通訊作者)
14: Ming-kun Yang, Yao-hua Yang, Zhuo Chen, Jia Zhang, Yan Lin, Yan Wang, Qian Xiong, Tao Li*, Feng Ge*, Donald A. Bryant, and Jin-dong Zhao. Proteogenomic analysis and global discovery of post-translational modifications in prokaryotes. Proceedings of the National Academy of Sciences of the United States of America，2014，111（52）：E5633-E5642（*通訊作者）
15: Peng Zheng，Qian Xiong，Ying Wu，Ying Chen，Zhuo Chen，Joy Fleming，Ding Gao，Lijun Bi，Feng Ge*，Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Non-coding RNA HOTAIR in HeLa Cells，Molecular & Cellular Proteomics, 2015, 14 (5) :1447-63. （*通訊作者）
16: Feng Ge, Weichao Huang, Zhuo Chen, Chunye Zhang, Qian Xiong, Chris Bowler, Juan Yang, Jin Xu, and Hanhua Hu. Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum Plant Cell 2014; 26(4):1681-1697.
17: Ziyad Tariq Muhseen, Qian Xiong, Zhuo Chen and Feng Ge*. Proteomics studies on stress responses in diatoms. Proteomics. 2015;15(23-24):3943-53.（*通訊作者）
18: Zhuo Chen, Jiao Zhan, Ying Chen, Mingkun Yang, Chenliu He, Feng Ge*, Qiang Wang*. Effects of Phosphorylation of β Subunits of Phycocyanins on State Transition in the Model Cyanobacterium Synechocystis sp. PCC 6803. Plant and Cell Physiology. 2015, 56 (10): 1997-2013. （*通訊作者）
19: Qian Xiong, Zhuo Chen, Feng Ge*. Proteomic analysis of post translational modifications in cyanobacteria. Journal of Proteomics. 2016; 134:57-64.（*通訊作者）
20: Mingkun Yang, Yan Wang, Ying Chen, Zhongyi Cheng, Jing Gu, Jiaoyu Deng, Lijun Bi, Chuangbin Chen, Ran Mo, Xude Wang, and Feng Ge*. Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis H37Rv. Molecular & Cellular Proteomics，2015，14 (4): 796-811（*通訊作者）
21: Qian Xiong，Jie Feng，Si-ting Li，Gui-ying Zhang，Zhi-xian Qiao，Zhuo Chen，Ying Wu，Hui Huang，Yan Lin，Tao Li*，Feng Ge*，Jin-dong Zhao*. Integrated Transcriptomic and Proteomic Analysis of the Global Response of Synechococcus sp. PCC 7002 to High Light Stress. Molecular & Cellular Proteomics，2015; 14(4): 1038-53（*通訊作者）
22: Yang, Yaohua，Feng, Jie，Li, Tao*，Feng Ge*，Zhao, Jindong. CyanOmics: an integrated database of omics for the model cyanobacterium Synechococcus sp. PCC 7002. Database (Oxford)，2015 Jan 28;2015. pii: bau127. doi: 10.1093/database/bau127. （*通訊作者）
23: Ran Mo, Mingkun Yang, Zhuo Chen, Zhongyi Cheng, Xingling Yi, Chongyang Li, Chenliu He, Qian Xiong, Hui Chen, Qiang Wang*, and Feng Ge*. Acetylome Analysis Reveals the Involvement of Lysine Acetylation in Photosynthesis and Carbon Metabolism in the Model Cyanobacterium Synechocystis sp. PCC 6803. Journal of Proteome Research 2015，14（2）: 1275-1286（*通訊作者）
24: Fengying Liu, Mingkun Yang, Xude Wang, Shanshan Yang, Jing Gu, Jie Zhou, Xian-En Zhang*, Jiaoyu Deng*, and Feng Ge*. Acetylome analysis reveals diverse functions of lysine acetylation in Mycobacterium tuberculosis. Molecular & Cellular Proteomics 2014; 13(12):3352-66 （*通訊作者）
25: Zhuo Chen, Ming-kun Yang, Chong-yang Li, Yan Wang, Jia Zhang, Dian-bing Wang, Xian-en Zhang*, and Feng Ge*. Phosphoproteomic Analysis Provides Novel Insights into Stress Responses in Phaeodactylum tricornutum, a Model Diatom. Journal of Proteome Research 2014; 13(5): 2511-23 （*通訊作者）
26: Miao Tian, Xiulan Chen, Qian Xiong, Jie Xiong, Chuanle Xiao, Feng Ge*, Fuquan Yang*, and Wei Miao*. Phosphoproteomic analysis of protein phosphorylation networks in Tetrahymena thermophila, a Model Single-Celled Organism. Molecular & Cellular Proteomics 2014;13(2):503-19. （*通訊作者）
27: Ying Chen, Li-Na Yang, Li Cheng, Shun Tu, Shu-Juan Guo, Huang-Ying Le, Qian Xiong, Ran Mo, Chong-Yang Li, Jun-Seop Jeong, Lizhi Jiang, Seth Blackshaw, Li-Jun Bi, Heng Zhu*, Sheng-Ce Tao*, and Feng Ge*. BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Molecular & Cellular Proteomics 2013;12(10):2804-19. （*通訊作者）
28: Ming-kun Yang, Zhi-xian Qiao, Wan-yi Zhang, Qian Xiong, Jia Zhang, Tao Li*, Feng Ge*, and Jin-dong Zhao*. Global phosphoproteomic analysis reveals diverse functions of Serine/Threonine/Tyrosine phosphorylation in the model cyanobacterium synechococcus sp. strain PCC 7002. Journal of Proteome Research 2013, 12 (4), 1909–1923. （*通訊作者）
29: Chongyang Li, Qian Xiong, Jia Zhang, Feng Ge* and Li-Jun Bi. Quantitative Proteomic Strategies for the Identification of MicroRNA Targets. Expert Review of Proteomics 2012;9(5):549-59 （*通訊作者）
30: Qian Xiong, Qiu Zhong, Jia Zhang, Mingkun Yang, Chongyang Li, Peng Zheng, Li-Jun Bi*, and Feng Ge*. Identification of Novel miR-21 Target Proteins in Multiple Myeloma Cells by Quantitative Proteomics. Journal of Proteome Research 2012; 11(4):2078-90 （*通訊作者）
31: Peng Zheng, Qiu Zhong, Qian Xiong, Mingkun Yang, Jia Zhang, Chongyang Li, Li-Jun Bi*, Feng Ge*. QUICK identification and SPR validation of signal transducers and activators of transcription 3 (Stat3) interacting proteins. Journal of Proteomics 2012; 75(3):1055-66. （*通訊作者）
32: Jia Zhang, Fangjin Chen, Wenliang Li, Qian Xiong, Mingkun Yang, Peng Zheng, Chongyang Li, Jianfeng Pei*, Feng Ge*. 14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells. PLoS One 2012;7(1):e29554. （*通訊作者）
33: Qian Xiong, Feng Ge*. Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients. Expert Review of Proteomics 2011;8(4):439-42 （*通訊作者）
34: Feng Ge*, Li-Jun Bi, Sheng-Ce Tao, Xudong Xu, Zhi-Ping Zhang, Kaio Kitazato and Xian-En Zhang*. Proteomic analysis of multiple myeloma: current status and future perspectives. Proteomics Clin Appl 2011; 5:30-37. （*通訊作者）
35: Feng Ge*, Shengce Tao, Lijun Bi, Zhiping Zhang, and Xianen Zhang*. Proteomics: addressing the challenges of multiple myeloma. Acta Biochim Biophys Sin (Shanghai) 2011; 43:89-95. （*通訊作者）
36: Feng Ge*, Liang Zhang, Sheng-Ce Tao, Kaio Kitazato, Zhi-Ping Zhang, Xian-En Zhang, and Li-Jun Bi*. Quantitative proteomic analysis of tumor reversion in multiple myeloma cells. Journal of Proteome Research 2011;10(2):845-55. （*通訊作者）
37: Feng Ge*, Wen-Liang Li, Li-Jun Bi, Sheng-Ce Tao, Zhi-Ping Zhang, and Xian-En Zhang. Identification of novel 14-3-3ζ interacting proteins by quantitative immunoprecipitation combined with knockdown (QUICK). Journal of Proteome Research 2010 Nov 5;9(11):5848-58. （*通訊作者）
