松胞菌素B

松胞菌素B,針狀結晶。通常情況下穩定。不溶於水。熔點218~221℃。有毒。本品應密封於0℃以下乾燥保存。

基本介紹

  • 中文名:松胞菌素B
  • 外文名:Cytochalasin B
  • 中文別名:細胞鬆弛素B
  • 分子式:C29H37NO5
基本信息,化學式,

基本信息

中文名稱:松胞菌素B
中文別名:細胞鬆弛素B
英文名稱:Cytochalasin B
英文別名:(E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione; 24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-; 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-; 7,20-Dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-(14)cytochalas-6(12),13,21-trien-23-one; BRN 1096207; CCRIS 9284; HSDB 3479; Phomin; 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E)-(5S,9R,12aS,13S,15S,15aS,16aS,18aS)-; 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-; 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-; 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,23-dione; 16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione; (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione; (3E,5S,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione; (3E,5S,9R,11E,12aS,13S,15S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione

化學式

CAS:14930-96-2
EINECS:239-000-2
分子式:C29H37NO5
分子量:479.6078
CB = cytochalasin B
松胞菌素B;松胞素B;細胞分裂抑素B;針狀結晶。通常情況下穩定。不溶於水。熔點218~221℃。有毒。本品應密封於0℃以下乾燥保存。C29H37NO3。從真菌類Helminthosporium de-mariodeum中分離得到的代謝產物。是以希臘語的cytos(細胞)和chalasis(鬆弛)組合而命名的。在許多動植物細胞的細胞運動中,特別是可逆地抑制同微絲系有關的現象。例如在0.5—1.0微克/毫升濃度下作用24小時,會使鼠的培養纖維芽細胞只進行核分裂,而細胞質的分裂受到抑制,從而成為多核細胞。5微克/毫升可阻止蛙的受精卵的卵裂溝的形成,致使不能進行正常的卵裂,也抑制淋巴球、海膽卵、肺上皮細胞等的細胞質分裂,還阻止原腸陷入(海膽、螠蟲等),雞的第五天的雛雞輸卵管的管狀腺的形成,唾液腺的形成,阻止因胚神經索的生長圓錐的運動引起的伸長等,阻止發育、形態形成等過程。此外,還阻害游離細胞的移動,分離胚細胞的相互選別,阻止細胞向玻璃面上粘著和白血球的吞食作用、血小板的凝集、血餅的收縮、生長激素的釋放、甲狀腺素的分泌等。對於植物來說,30微克/毫升,1小時以內可以使燕麥的孑葉鞘和車軸藻的原生質流動完全停止。在這些情況下,用電子顯微鏡觀察,常能見到微絲的鏡相變化,其他已知細胞鬆弛素B還可抑制糖的輸送,可以考慮細胞鬆弛素B與細胞膜間的相互作用。此外還分離出數種具有類似結構和功能的物質,分別命名為細胞鬆弛素A、C、D、E、F。

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