曹日暉 （Rihui Cao）, 男，1970年8月出生，籍貫湖南新化，理學博士，中山大學化學與化學工程學院講師，碩士生導師。中山大學生命科學院生物技術專業博士，化學與化學工程學院有機化學博士後。
基本介紹
- 中文名：曹日暉
- 出生地：湖南新化
- 出生日期：1970年8月
- 職業：理學博士，中山大學化學與化學工程學院講師
個人簡介,教育經歷,工作經歷,論著一覽,科研工作,科研項目,
個人簡介
近五年來，先後在國際學術刊物《Current Medicinal Chemistry》、《International Journal of Cancer》、《Biochemical & Biophysical Research Communication》、《Bioorganic & Medicinal Chemistry》、《Bioorganic & Medicinal Chemistry Letters》、《Cancer Biology Therapy》、《European Journal of Medicinal Chemistry》、《Food Chemistry》、《Chemical & Pharmaceutical Bulletin》、《Acta Pharmacologica Sinica》等上發表SCI收錄論文32篇，其中第一作者（含通訊作者）19篇，IF >3.0的16篇，IF >4.5的2篇。現擔任國際學術刊物《European Journal of Medicinal Chemistry》、《Applied Biochemistry and Biotechnology》和《Letters in Drug Design and Discovery》審稿人。
教育經歷
· 1989.9－1993.6 湖南師範大學生命科學學院生物學系 學士
· 1993.9－1996.6 武漢大學生命科學學院病毒學系 碩士
· 2001.9－2004.6 中山大學生命科學學院生物化學系 博士
工作經歷
· 1996.7－2000.11 珠海金沙製藥有限公司藥物研究所
· 2000.12－2001.3 深圳雲大科技實業開發有限公司技術部 項目經理
· 2001.4－2001.8 深圳創新慧生物技術開發有限公司 項目經理
· 2004.8－2007.11 中山大學化工學院/新疆華世丹藥物研究有限公司 博士後
· 2007.12－至今 中山大學化學與化學工程學院有機研究所 副教授
目前主講本科生必修課程《細胞生物學》、研究生必修課程《結構生物學》。《基礎有機化學實驗》《綜合化學實驗》-化學生物學專題實驗。
論著一覽
1. Chunming Ma, Rihui Cao*, Buxi Shi, Xiantai Zhou, Qin Ma, Jie Sun, Liang Guo, Wei Yi, Zhiyong Chen, Huacan Song*. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines. European Journal Medicinal Chemistry. 2010, 45, 5513-5519. (通訊作者,SCI收錄，IF=3.269).
2. Zhiyong Chen, Rihui Cao*, Liang Yu, Buxi Shi, Jie Sun, Liang Guo, Qin Ma, Wei Yi, Xiao Song, Huacan Song*. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives. European Journal Medicinal Chemistry. 2010, 45, 4740-4745. (通訊作者,SCI收錄，IF=3.269).
3. Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Huacan Song. Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58 (9), 1216-1220. (SCI收錄，IF=1.698 ).
4. Zhiyong Chen, Rihui Cao*, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren, Wenlie Peng. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3876-3879. (通訊作者,SCI收錄，IF=2.650).
5. Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Wenlie Peng, Huacan Song*. Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3254-3258. (SCI收錄，IF=2.650).
6. Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Huan Wen, Qin Yan, Lin Ma and Huacan Song*. Rational Design and Synthesis of 4-O-Substituted Phenylmethylenethiosemicarbazones as Novel Tyrosinase Inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58, 752-754. (SCI收錄，IF=1.698 ).
7. Zhiyong Chen, Rihui Cao, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren*. Synthesis and Biological Evaluation of Novel β-Carbolines as Potent Cytotoxic and DNA Intercalating Agents. Chemical & Pharmaceutical Bulletin. 2010, 58 (7), 901-907. (SCI收錄，IF=1.698 ).
8. Rihui Cao*, Xiangdong Guan, Buxi Shi, Zhiyong Chen, Zhenhua Ren, Wenlie Peng, Huacan Song. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents. European Journal Medicinal Chemistry. 2010, 45 (6) 2503-2515. (通訊作者,SCI收錄，IF=3.269).
9. Chunming Ma, Rihui Cao*, Buxi Shi, Shaoxue Li, Zhiyong Chen, Wei Yi, Wenlie Peng, Zhenhua Ren, Huacan Song*. Synthesis and cytotoxic evaluation of N2-benzylated quaternary β-carboline amino acid ester conjugates. European Journal Medicinal Chemistry. 2010, 45：1515-1523. (通訊作者,SCI收錄，IF=3.269).
10. Wei Yi, Rihui Cao*, Wenlie Peng, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. European Journal Medicinal Chemistry. 2010, 45，639-646. (通訊作者,SCI收錄，IF=3.269).
11. Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Lin Ma, Huacan Song*. Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors. Chemical & Pharmaceutical Bulletin. 2009, 57, 1273-1277. (SCI收錄，IF=1.698 ).
12. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Discovery of 4-functionalized phenyl-O-β-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 6157-6160. (通訊作者,SCI收錄，IF=2.650).
13. Qin Yan, Rihui Cao*, Wei Yi, Liang Yu, Zhiyong Chen, Lin Ma, Huacan Song*. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-D-glycosides as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 4055-4058. (通訊作者,SCI收錄，IF=2.650).
14. Qin Yan, Rihui Cao*, Wei Yi, Zhiyong Chen, Huan Wen, Lin Ma, Huacan Song*. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities. European Journal Medicinal Chemistry. 2009, 44, 4235-4243. (通訊作者,SCI收錄，IF=3.269).
15. Yi Wei, Xiaoqin Wu, Rihui Cao, Huacan Song, Lin Ma*. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants. Food Chemistry. 2009, 117, 381-386. (SCI收錄，IF=3.146 ).
16. Jinbing Liu, Rihui Cao*, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song*. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds. European Journal Medicinal Chemistry. 2009, 44: 1773-1778. (通訊作者,SCI收錄，IF=3.269).
17. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Yiqian Wan, Lin Ma, Huacan Song*. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008, 18: 6490-6493. (通訊作者,SCI收錄，IF=2.650).
18. Jinbing Liu, Rihui Cao, Qifeng Wu, Chunming Ma, Zihou Wang, Wenlie Peng, Huacan Song*. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives. European Journal Medicinal Chemistry. 2009, 44: 1737-1744. (SCI收錄，IF=3.269).
19. Qifeng Wu, Rihui Cao*, Manxiu Feng, Xiangdong Guan, Chunming Ma, Jinbing Liu, Huacan Song, Wenlie Peng*. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives. European Journal Medicinal Chemistry. 2009, 44, 533-540. (通訊作者，SCI收錄，IF=3.269).
20. Rihui Cao*, Wei Yi, Qifeng Wu, Xiangdong Guan, Manxiu, Feng, Chunming Ma, Zhiyong Chen, Huacan Song, Wenlie Peng*. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry Letters. 2008, 18 : 6558-6561. (通訊作者，SCI收錄，IF=2.650).
21. Rihui Cao, Wenlie Peng, Zihou Wang，Anlong Xu*. β-Carboline alkaloids: Biochemical & pharmacological functions. Current Medicinal Chemistry. 2007, 14 : 479-500. (SCI收錄，IF=4.708).
22. Rihui Cao, Wenlie Peng, Hongsheng Chen，Yan Ma, Xiaodong Liu, Xuerui Hou, Huaji Guan, Wenlie Peng, Anlong Xu*. DNA binding properties of 9-substituted harmine derivatives. Biochemical and Biophysical Research Communication. 2005, 338: 1157-1563. (SCI收錄，IF=2.548).
23. Rihui Cao, Wenlie Peng, Hongsheng Chen, Xuerui Hou, Huaji Guan, Qi Chen, Yan Ma, Anlong Xu*. Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted beta-carboline derivatives. European Journal Medicinal Chemistry. 2005, 40: 249 -257. (SCI收錄，IF=3.269).
24. Rihui Cao, Qi Chen, Xuerui Hou, Hongsheng Chen, Huaji Guan, Yan Ma, Wenlie Peng, Anlong Xu*. Synthesis, acute toxicities and antitumor effects of novel 9-substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry. 2004, 12: 4613- 4623. (SCI收錄，IF=2.822).
25. Rihui Cao, Hongsheng Chen, Wenlie Peng, Yan Ma, Xuerui Hou, Huaji Guan, Xiaodong Liu, Anlong Xu*. Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives. European Journal Medicinal Chemistry. 2005, 40: 991-1001. (SCI收錄，IF=3.269).
26. Qi Chen, Rihui Chao, Hongsheng Chen, Xuerui Hou, Huifang Yan, Shufeng Zhou, Wenlie Peng, Anlong Xu*. Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. International Journal of Cancer, 2004, 114 : 675-682 (並列第一作者, SCI收錄，IF=4.722).
27. Jing Zhang, Yan Li, Liang Guo, Rihui Cao, Pei Zhao, Wei Jiang, Qin Ma, Hong Yi, Zhuorong Li, Jiandong Jiang, Jialin Wu, Yanchang Wang, Shuyi Si*. DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1. Cancer Biology Therapy. 2009, 8: 2374-2383. (SCI收錄，IF=2.711).
28.Yan Li, Fengshan Liang, Wei Jiang, Fusheng Yu, Rihui Cao, Qinghe Ma, Xiuyong Dai, Jiandong Jiang, Yanchang Wang*, Shuyi Si*. DH334, a β-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer Biology Therapy. 2007, 6: 1193-1199. (SCI收錄，IF=2.711).
29. Huaji Guan, Hongsheng Chen, Wenlie Peng, Yan Ma, Rihui Cao, Xiaodong Liu, Anlong Xu*. Design of β-carboline derivatives as DNA-targeting antitumor agents. European Journal Medicinal Chemistry. 2006, 41:1167-1179. (SCI收錄，IF=3.269).
30. Huaji Guan, Xiaodong Liu, Wenlie Peng, Rihui Cao, Yan Ma, Hongsheng Chen, Anlong Xu*. β-carboline derivatives－Novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochemical and Biophysical Research Communication. 2005, 342: 894-901. (SCI收錄，IF=2.548).
31. Xue-rui HOU, Qi CHEN, Ri-hui CAO, Wen-lie PENG, An-long XU*. A comparative molecular field analysis of cytotoxic beta-carboline analogs. Acta Pharmacologica Sinica. 2004；25 (7): 959-965. (SCI收錄，IF=1.783).
32. Huan Wen, Chonglan Lin, Ling Que, Hui Ge, Lin Ma, Rihui Cao, Yiqian Wan, Wenlie Peng, Zihou Wang, Huacan Song*. Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry 2008, 43: 166-173. (SCI收錄，IF=3.269).
科研工作
主要從事天然來源活性單體的分子設計、化學合成、活性篩選及分子機理等研究。曾主持或參與鹽酸氮卓斯汀、羅格列酮、格列美脲、纈沙坦、伊貝沙坦、坎地沙坦酯等多個國家二類和四類新藥的成功開發，主持並完成了中國博士後科學基金項目《去氫駱駝蓬鹼結構改造與抗腫瘤構效關係的初步研究》、中山大學有害生物防治與資源利用國家重點實驗室開放式課題《去氫駱駝蓬鹼衍生物抗腫瘤作用機理初步研究》。
科研項目
1. 基於拓撲異構酶I靶點的新型抗腫瘤化合物β-咔啉鹼的最佳化設計、合成及構效關係研究 （項目負責人 教育部高等學校青年培育項目 2009.1-2011.12）
2. 新型拓撲異構酶I抑制劑β-咔啉鹼的分子設計與生物活性研究 （項目負責人 教育部博士點基金新教師基金 2011.1-2013.12）
3. 基於魚腥草素結構最佳化的新型抗菌藥物研究 （項目負責人 廣東省科技計畫項目 2010.1-2012.12）
4. 高性能氯化聚丙烯改性樹脂的研發 (項目負責人 廣東省科技廳省部產學研項目 2009.1－2010.12)
5. 去氫駱駝蓬鹼結構改造與抗腫瘤構效關係研究 （項目負責人 中國博士後科學基金 2005.1－2007.12）
6. 香豆素衍生物構效關係研究 (項目負責人 企業橫向課題 2009.9 -2010.10)
7. 去氫駱駝蓬鹼結構改造與抗腫瘤構效關係研究 （項目負責人 企業橫向課題 2008.1-2008.12）
