《星型膠質細胞分泌谷氨酸及其機制研究》是周專為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：星型膠質細胞分泌谷氨酸及其機制研究
- 項目類別 ：面上項目
- 依託單位 ：北京大學
- 項目負責人：周專
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo | 期刊論文 | Wang, CH|Li, WL|Zhang, K|Zhou, Z| |
2 | Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons | 期刊論文 | Shang SJ, Zhang XY, Xu HD, Teng SS, Liu B|Kuo ST, Liu W, Li ML, Zhou L, Jiao RY|Wang CH, Wang SR, Yang H, Zhang B|Zhou Z, Xu ZD| |
3 | Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta-cells | 期刊論文 | C. C. Chen|I. C. Bruce|X. Yu|Z. Zhou| |
4 | Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice | 期刊論文 | Zuo, PL|Wang, CH|Wang, SR|Zhou, ZA| |
5 | Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo | 期刊論文 | Kang, XJ|Xiong, W|Wang, CH|Zhou, ZA| |
6 | Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices | 期刊論文 | S. Guo|H. Zheng|C. X. Zhang|Z. Zhou| |
7 | Gain-of-function mutations in SCN11A cause familial episodic pain | 期刊論文 | Z. Zhou|J. Yao|X. Zhang|J. Y. Liu| |
8 | Nicotine dynamically modulates dopamine clearance in rat striatum in vivo | 期刊論文 | X. J. Kang|C. L. Fu|Z. Zhou|B. Zhang| |
9 | Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells | 期刊論文 | Dai, JX|Wang, CH|Zheng, LH|Zhou, Z| |
10 | Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo | 期刊論文 | W. Liu, F. Zhu, Q. Li, S. Guo, J. Gu|Q. Lei, J. Lu, Y. Mu, M. Jin, S. Wang|W. Jiang, K. Liu, C. Wang, W. Li|K. Zhang, Z. Zhou| |
11 | Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo | 期刊論文 | Zhang, Claire Xi|Kang, Xin-Jiang|Zhou, Zhuan|Zhang, Bo| |
12 | Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis | 期刊論文 | Huang Rong|Han Weiping|Zhang, Claire Xi|Zhou Zhuan| |
13 | Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells | 期刊論文 | Zhang, C|Wang, LC|Xiong, W|Zhou, Z| |
14 | Extracellular Ca2？ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells | 期刊論文 | Qihui Wu, Quanfeng Zhang, Wei Liu|Lianghong Zheng, Huadong Xu, Xinjiang Kang, Xiaoyu|Yeshi Wang, Hui Zheng,Shirong Wang, Wei Xiong|Tao Liu, Zhuan Zhou| |
15 | Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice | 期刊論文 | Feipeng Zhu, Xinjiang Kang, Bin Liu|Sasa Teng, QihuiWu, Mingli Li|Haiqiang Dou, Panli Zuo, ChangheWang|ShirongWang, Zhuan Zhou| |
16 | Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells | 期刊論文 | Meiqin Hu , Yeshi Wang ,Li Wang|Yi Wu , Shujiang Shang , Xinjiang Kang , Lianghong|Jin Zhang, Matthieu Raoux, Jochen Lang|Qing Li ,Jing Su , Xiao Yu ,Liangyi Chen , Zhuan Z| |
17 | Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo | 期刊論文 | Zhang, CX|Kang, XJ|Zhou, Z|Zhang, B| |
18 | Modulation of dopamine release from the striatum by physiologically-relevant levels of nicotine | 期刊論文 | Li ML, Liu W, Xu HD|Zhou L, Jiao RY, Dou HQ, Zuo PL|Zhang XY, Zheng LH, Wang SR|Wang CH, Zhou Z| |
19 | Extracellular Ca2+ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells | 期刊論文 | Wang, SR|Xiong, W|Liu, T|Zhou, Z| |
20 | Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons | 期刊論文 | H. Yang|B. Zhang|Z. Zhou|Z. Q. Xu| |
21 | Effect of cocaine on ion channels and glutamatergic EPSCs in noradrenergic locus coeruleus neurons | 期刊論文 | Wang SR|Zhang B|Zhou Z|Xu ZQ| |
22 | Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus | 期刊論文 | X. W. Chen|Z. Q. Xu|C. X. Zhang|Z. Zhou| |
23 | Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells | 期刊論文 | C. Zhang|L. C. Wang|W. Xiong|Z. Zhou| |
24 | Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine | 期刊論文 | Zheng, LH|Wang, SR|Wang, CH|Zhou, ZA| |
25 | Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells | 期刊論文 | Su J|Yu X|Chen LY|Zhou Z| |
項目摘要
神經膠質細胞和神經元一起，是構成神經系統的基本細胞。膠質細胞不僅對神經元起營養和支持作用，而且通過分泌遞質主動調節神經信號傳遞。谷氨酸是最重要的興奮性神經遞質，也是膠質細胞分泌的主要遞質之一。關於膠質細胞分泌谷氨酸的機制（是否通過鈣離子介導的囊泡）問題有長期爭論。2005年我們套用電化學微電極和FM螢光成像發現了海馬星形膠質細胞釋放谷氨酸的一種新模式：鈣離子依賴性囊泡kiss-and-run（J Neurosci，2005；Neuroscientists, 2006），成為該領域研究熱點。為研究膠質細胞中谷氨酸囊泡分泌的調控機制，本申請將研究膠質細胞分泌囊泡的分子類型，以及已知兩種囊泡（溶酶體和20nm囊泡）被誘導釋放的動力學。這項研究的重要生理意義是，膠質細胞如何通過鈣離子依賴性谷氨酸囊泡釋放來主動調控神經信號傳遞。
