2009年12月25日下午，由中國科學院上海生命科學研究院研究生部主辦的“第一作者講壇”第47期報告在中科大廈一樓報告廳舉行。營養所方靖研究員指導的博士生薛婧作了題為“Prolyl Hydroxylase-3 Is Downregulated in Colorectal Cancer Cells and Inhibits IKKβ, Independent of Hydroxylase Activity”的精彩報告，給大家送上了一份特殊的聖誕禮物。 結直腸癌是人類常見的消化道腫瘤，與生活方式及膳食結構密切相關。全球每年新增病例數達94萬，每年有近50萬人死於結直腸癌，居癌症死因第3位。在我國，結直腸癌居惡性腫瘤發病率第4位，且呈明顯上升趨勢。薛婧等通過分析結直腸癌臨床樣本，發現腫瘤中ProlylHydroxylase-3 (PHD3)的表達水平明顯低於正常結直腸組織，且PHD3的表達水平與腫瘤的分級和轉移呈負相關。細胞和動物實驗顯示抑制PHD3表達可以顯著加速腫瘤細胞的生長和腫瘤的生成。進一步的研究提示，PHD3可能通過抑制IKKβ/NF-kB信號通路發揮作用，並且這一作用不依賴於其羥基化酶的活性。研究結果揭示了PHD3的新功能，有助於認識結直腸癌的生長機制以及尋找治療新靶標。該研究成果於今年9月被消化系統研究領域的權威雜誌《胃腸病學》(Gastroenterology)線上發表。左二為博士生薛婧
Dr. Bruce N. Ames is a Professor of Biochemistry and Molecular Biology at the University of California, Berkeley, and also Senior Scientist, Children's Hospital of Oakland Research Institute. He is a member of the National Academy of Sciences and he was on their Commission on Life Sciences.
T. Colin Campbell, Ph.D., Professor
美國康耐爾大學人類生態學院名譽教授
Dr. Campbell is a Jacob Gould Schurman Professor Emeritus of nutritional biochemistry at Cornell University. He has received more than 70 grant-years of peer-reviewed research funding and authored more than 300 research papers. His legacy, The China Study, is the most comprehensive study of health and nutrition ever conducted.
Ting-Kai Li is the director of the Indiana Alcohol Research Center at the IU Medical Center. He is also Adjunct Professor of Nursing (School of Nursing). Li is one of the nation's leading researchers in the area of alcoholism and genetics and serves on the medical advisory council of the Alcoholic Beverage Medical Research Foundation.
Akitane Mori, Professor
日本岡山大學
Dr. Akitane Mori, M.D. and Ph.D., is a Professor Emeritus of Okayama University and Visiting Professor of the Department of Anti-Aging Food Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. He's illustrious career, spanning half a century, has helped shape the development of the field of neurosciences.
左二為博士生薛婧