人物履歷
1990.9 - 1994.7
湖南師範大學生物系 理學學士
1994.9 - 1997.7
上海水產大學漁業學院 農學碩士
1997.9 - 2000.7
中國科學院上海昆蟲研究所 理學博士
2000.8 - 2001.7
義大利Universita of Basilicatà生物系 博士後
2001.8 - 2004.12
美國Illinois State University生物系 博士後
2005.1 - 2006.8 美國Johns Hopkins University醫學院分子生物學和遺傳學系 博士後
學術兼職
套用昆蟲學報 編委
Journal of Insect Physiology 編委
Journal of Insect Science 編委
Insect Science 編委
中國昆蟲學會理事
中國昆蟲學會上海昆蟲學會理事長
中國昆蟲學會昆蟲發育與遺傳專業委員會主任
獲獎情況
2000年,中國科學院彭蔭光獎學金一等獎
2006年,中國科學院“百人計畫”入選;
2007年獲中國科學院百人計畫和上海市浦江人才擇優支持、終期評估均為優秀;
2010年獲SA-SIBS優秀青年人才獎勵基金;
2011年獲國家傑出青年基金、終期評估優秀;
2011年獲上海市明治生命科學獎優秀獎;
2012年遴選為上海市優秀學術帶頭人;
2013年獲中國遺傳學會李汝祺動物遺傳獎;
2014年入選全國優秀科技工作者、上海市科技類黨外優秀人才;
2015年獲評中國科學院特聘研究員。
研究工作
長期從事昆蟲發育遺傳學研究,整合果蠅遺傳發育和家蠶生理生化優勢,在昆蟲發育生物學研究領域的三項相輔相成的研究工作(JH和20E協同調控變態發育的分子機制;脂肪體重建的激素和營養調控;家蠶絲腺發育的遺傳調控)中取得了一系列進展。作為通訊作者在Autophagy, Cell Research, Development,Journal of Biological Chemistry和PLoS Genetics等國際知名期刊上發表論文;作為第一作者在Annual Review of Entomology, Biochemical Journal和Insect Biochemistry and Molecular Biology等重要期刊上發表論文;多篇論文遴選為封面論文或者作為專題評論。組織和承擔了多項基金委重點和面上、973、863、轉基因專項等國家項目和課題。多次應邀在重大國際會議(如2011年在荷蘭舉行的第6屆國際分子昆蟲科學大會上)做主題和大會報告,多次擔任國際大會(如2011年的國際昆蟲生理生化和分子生物學會議、2010和2013年的國際蛻皮激素會議、2014年的國際保幼激素會議)主席和組委員成員。
近年代表性研究論文(*通訊作者)
1. Wen, D., Rivera-Perez, C., Abdou, M., Jia, Q., He, Q., Liu, X., Zyann, O., Xu. J., Bendena, W.G., Tobe, S.S., Noriega, F.G., Palli, S.R., Wang, J., Li, S.*, 2015. Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. PLoS Genetics, 11:e1005038. (IF 8.167)
2. Liu, X., Dai, F., Guo, E., Li, K., Ma, L., Tian, L., Cao, Y., Palli, S.R., Li, S.*, 2015. 20-Hydroxyecdysone (20E) primary-response gene E93 modulates 20E signaling to promote Bombyx larval-pupal metamorphosis. Journal of Biological Chemistry, 290:27370-27383. (IF 4.68)
3. Li, K., Guo, E., Hossain, M., Li, Q., Cao, Y., Tian, L., Yang, W.Y., Li, S.*, 2015. Bombyx E75 isoforms display stage- and tissue-specific response to 20-hydroxyecdysone. Scientific Reports, 5:12114. (IF 5.578)
4. Xie, K., Tian, L., Guo, X., Li, K., Li, J., Deng, X., Li, Q., Xia, Q., Zhong, Y., Huang, Z., Liu, J., Li, S.*, Yang, W., Cao, Y., 2015. BmATG5 and BmATG6 mediate the initiation of apoptosis in response to autophagy induced by 20-hydroxyecdysone or starvation. Autophagy, in press. (IF 11.423)
5. He, Q., Cui, C., Wen, D., Wang, J., Palli, S.R., Li, S.*, 2014. Hsp83 facilitates Met nuclear import to modulate juvenile hormone signaling. Journal of Biological Chemistry 289:27874-27885. (IF 4.68)
6. Jia, Q., Liu, Y., Liu, H., Li, S.*, 2014. MMP1 and MMP2 cooperatively induce Drosophila fat body cell dissociation with distinct roles. Scientific Reports, 4:7535. (IF 5.578)
7. Xia, Q., Li, S., Feng, Q., 2014. Advances in silkworm studies accelerated by the Bombyx genome. Annual Review of Entomology, 59:213-236. (# equal contribution; * an invited review). (IF 13.021)
8. Tian, L., Ma, L., Guo, E., Deng, X., Ma, S., Xia, Q., Cao, Y., Li, S.*, 2013. 20-hydroxyecdysone upregulates Atg genes to induce autophagy in the Bombyx fat body. Autophagy, 9:1167-1182. (IF 11.423)
9. Ma, L., Shi, M., Chen, X-X., Li, S.*, 2013. Ras1 upregulates bcpi for inhibiting cathepsin activity to prevent tissue destruction of the Bombyx posterior silk gland. Journal of Proteome Research, 12:1924-1934. (IF 5.001)
10. Wang, S., Wang, J., Sun, Y., Song, Q., Li, S.*, 2012. PKC-mediated USP phosphorylation at Ser35 modulates 20-hydroxyecdysone signaling in Drosophila. Journal of Proteome Research, 11:6187-6196. (IF 5.001)
11. Ma, L., Xu, H., Zhu, J., Ma, S., Liu, Y., Jiang, R-J., Xia, Q, Li, S.*, 2011. Ras1 overexpression in the posterior silk gland improves silk yield. Cell Research, 21:934-943. (IF 11.981)(Highlighted by Belles, X. 2011 Cell Research 21:862-863)
12. Huang, J., Tian, L., Abdou, M., Wen, D., Wang, Y.,Li, S.*, Wang, J., 2011. DPP-mediated TGF-β signaling regulates juvenile hormone biosynthesis by upregulating expression of JH acid methyltransferase.Development, 138:2283-2291. (IF 6.273)
13. Li. S.*, 2010. Identification of iron-loaded ferritin as an essential mitogen for cell proliferation and postembryonic development in Drosophila. Cell Research, 20:1148-1157. (IF 11.981)
14. Wang, S., Liu, S., Liu, H., Wang, J., Zhou, S., Liu, Y., Jiang, R-J., Bendena, W.G.,Li, S.*, 2010. The insect steroid hormone 20-hydroxyecdysone reduces food consumption resulting in fat body lipolysis during molting and pupation. Journal of Molecular Cell Biology, 2:128-138. Cover Story (IF 8.432)
15. Tian, L., Guo, E., Diao, Y., Wang, S., Liu, S., Cao, Y., Jiang, R-J., Ling, E., Li, S.*,2010. Developmental regulation of glycolysis by 20-hydroxyecdysone and juvenile hormone in fat body tissues of the silkworm, Bombyx mori. Journal of Molecular Cell Biology, 2:255–263. (IF 8.432)
16. Liu, Y., Sheng, Z., Liu, H., Wen, W., He, Q., Wang, S., Shao, W., Jiang, R-J., An, S., Sun, Y., Bendena, W.G., Wang, J., Gilbert, L.I., Wilson, T.G., Song, Q., Li, S.*, 2009. Juvenile hormone counteracts the bHLH-PAS transcriptional factor MET and GCE to prevent caspase-dependent programmed cell death in Drosophila. Development 136: 2015-2025. (IF 6.273)