研究方向
K.C.Nicolaou教授的研究興趣涉及化學、生物學和藥學等多個方面。
學術成果
他領導的研究小組致力於結構新穎且具有重要
生物活性的天然產物全合成,並通過發展新合成策略和合成方法將新合成技術套用於生物學和新藥研發。作為第一作者或合作者,K.C.Nicolaou教授已發表超過725篇科研論文及綜述,申請專利79項(56個獲批,23個待批),並撰寫5本專著。包括:
[1]InvigoratingEducation,K.C.Nicolaou,Angew.Chem.Int.Ed.2011,50,63–74.
[2]SynthesisoftheC'D'E'F'DomainofMaitotoxin,KC.Nicolaou,J.H.Seo,T.Nakamura,R.J.Aversa,J.Am.Chem.Soc.2011,133,214–219.
[3]SynthesisoftheWXYZA'DomainofMaitotoxin,KC.Nicolaou,T.M.Baker,T.Nakamura,J.Am.Chem.Soc.2011,133,220–226.
[4]TotalSynthesisandBiologicalEvaluationofMonorhizopodinand16-epi-Monorhizopodin,K.C.Nicolaou,X.Jiang,P.J.Lindsay-Scott,A.Corbu,S.Yamashiro,A.Bacconi,V.M.Fowler,Angew.Chem.Int.Ed.2011,50,1139–1144
[5]TotalSynthesisandBiologicalEvaluationofMarinopyrroleAandAnalogs,K.C.Nicolaou,N.L.Simmons,J.S.Chen,N.M.Haste,V.Nizet,TetrahedronLett.2011,52,2041–2043.
[6]Design,SynthesisandBiologicalEvaluationofaBiyouyanaginLibrary,K.C.Nicolaou,S.Sanchini,D.Sarlah,G.Lu,D.K.Nomura,B.F.Cravatt,B.Cubitt,J.C.delaTorre,A.J.Hessell,D.R.Burton,Proc.Natl.Acad.Sci.U.S.A.2011,108,6715–6720.
[7]AddressingtheStereochemistryofComplexOrganicMoleculesbyDensityFunctionalTheory-NMR:VannusalBinRetrospective,G.Saielli,K.C.Nicolaou,A.Ortiz,H.Zhang,A.Bagno,J.Am.Chem.Soc.2011,133,6072–6077.
[8]AnExpedientSynthesisofaFunctionalizedCoreStructureofBielschowskysin,K.C.Nicolaou,V.A.Adsool,C.R.H.Hale,Angew.Chem.Int.Ed.2011,50,5149–5152.
[9]EnantioselectiveDichlorinatoinofAllylicAlcohols,K.C.Nicolaou,N.L.Simmons,Y.Ying,P.M.Heretsch,J.S.Chen,J.Am.Chem.Soc.2011,133,8134–8137.
[10]TotalSynthesisofEpicoccinG,K.C.Nicolaou,S.Totokotsopoulos,D.Giguère,Y.Sun,D.Sarlah,J.Am.Chem.Soc.2011,133,8150–8153.