人物履歷
1982.1畢業廈門大學動物學專業,學士學位;
1985.1畢業廈門大學生物化學專業,碩士學位;
1999.7畢業清華大學生物化學與分子生物學專業,理學博士學位;
2000.1~2002.2在美國加州Berkeley大學工作2年。
1998年至今,廈門大學生命科學學院,教授;
研究方向
酶的結構與功能、酶作用動力學、抑制動力學、失活動力學、激活動力學、酶活力調控機理、抑制作用機理;酶產品及酶抑制劑的開發套用;蛋白質摺疊與去摺疊;抗癌多肽;癌變機理;蛋白質組學。
主要貢獻
主持或參加國家自然科學基金7項,省市基金5項,發表研究論文228篇,其中在國際SCI源學術刊物發表92篇。近5年發表研究論文83篇,其中SCI論文39篇(JCR一區16篇、二區7篇),申請9個專利,其中8個已獲得證書。
1. Huang GF, Wu XB*, Bai LP, Liu K, Jiang LJ, Long MN,Chen QX*. Improved O2-tolerance in variants of a H2-evolving [NiFe]-hydrogenase from Klebsiella oxytoca HP1.FEBS Lett.2015, 589(8): 910-8.
2. Gui-Li Huang1, Wei Zhang2, Hong-Yue Ren3, Xue-Ying Shen1,Qing-Xi Chen*and Dong-Yan Shen*. Retinoid X receptor α enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/β-catenin and nuclear factor-kB pathways.Cancer Science. 2015, 106(11): 1515–1523.
3. Cui Y, Liang G, Hu YH, Shi Y, Cai YX, Gao HJ,Chen QX, Wang Q*. Alpha-substituted derivatives of cinnamaldehyde as tyrosinase inhibitors: inhibitory mechanism and molecular analysis.J. Agric. Food Chem. 2015, 63(2): 716–722.
4. Feng Yu, Yu-Long Jia, Hui-Fang Wang, Jing Zheng, Yi Cui, Xin-Yu Fang, Lin-Min Zhang, andQing-Xi Chen*. Synthesis of Triazole Schiff's Base Derivatives and Their Inhibitory Kinetics on Tyrosinase Activity.PLoS One. 2015, 10(9): e0138578.
5. Wei Song, Ling Tian, Shan-Shan Li, Dong-Yan Shen,Qing-Xi Chen. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells.FEBS Letters. 2014, 588(3): 422–428.
6. Zhizhen Pan, Lian Xu, Yujing Zhu, Huai Shi, Zheng Chen, Meichun Chen,Qingxi Chen*,Bo Liu*. Characterization of a new cry2Ab gene of Bacillus thuringiensis with high insecticidal activity against Plutella xylostella L.World Journal of Microbiology and Biotechnology. 2014, 30(10): 2655-2662.
7.Apoptosis Induced by Aqueous Extracts of Crocodile Bile in Human Heptacarcinoma SMMC-7721.Wei Song, Shan-Shan Li, Ping-ping Qiu, Dong-Yan Shen, Ling Tian, Qiu-Yan Zhang, Long-Xing Liao,Qing-Xi Chen*.Applied Biochemistry and Biotechnology. 2013, 170(1): 15-24.
8. Huang GL1, Luo Q, Rui G, Zhang W, Zhang QY,Chen QX, Shen DY*. Oncogenic Activity of Retinoic Acid Receptor γ Is Exhibited through Activation of the Akt/NF-κB and Wnt/β-Catenin Pathways in Cholangiocarcinoma.Mol Cell Biol. 2013, 33(17): 3416-25.
9. Huang QS, Xie XL, Liang G, Gong F, Wang Y, Wei XQ, Wang Q, Ji ZL,Chen QX*. The GH18 Family of Chitinases: their domain architectures, functions, and evolutions.Glycobiology. 22: 23-34, 2012. (*Corresponding author).
10. Chai WM, Shi Y, Feng HL, Qiu L, Zhou HC, Deng ZW, Yan CL,Chen QX*. NMR, HPLC-ESI-MS, and MALDI-TOF MS analysis of condensed tannins from (Bojer ex Hook.) Raf. and their bioactivities.J Agric Food Chem.2012, 60: 5013-5022.
11. Pan ZZ , Li HL , Yu XJ , Zuo QX , Zheng GX , Shi Y, Liu X, Lin YM , Liang G, Wang Q,Chen QX*. Synthesis and Antityrosinase Activities of Alkyl 3,4-Dihydroxybenzoates.J Agric Food Chem. 2011, 59: 6645-6649.
12. Zhang JP, Hu YH, Wang Q, Wang W, Wang Y, Yan JH,Chen QX*. Inhibitory kinetics of β-N-Acetyl-D-glucosaminidase from green crab (Scylla Serrata) by Zinc ion.J Agric Food Chem. 2010, 58: 8763-8767.
13. Huang QS, Yan JH, Tang JY, Tao YM,Xie XL, Wang Y, Wei XQ, Yan QH,Chen QX*. Cloning and tissue expressions of seven chitinase family genes in L. vannamei.Fish Shellfish Immunol. 2010, 29: 76-82.
14. Han P, Kang JH, Li HL, Hu SX, Lian HH, Qiu PP, Zhang J, Li WG,Chen QX*. Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression.Biochem Biophys Res Commun. 2009, 385: 251-256.
獲獎記錄
項目“鋸緣青蟹鹼性磷酸酶活力調控的分子機理研究”獲得2002年教育部提名國家科技獎-自然科學二等獎;“養殖環境污染對長毛對蝦磷酸酯酶活力的影響” 獲得2003年度福建省科學技術進步獎三等獎;研究論文曾獲得2003年和2006年福建省自然科學優秀論文二等獎。