陳海冰

陳海冰，女，同濟大學附屬第十人民醫院內分泌代謝科副主任，主任醫師，教授，博士生導師。

基本介紹

• 中文名：陳海冰
• 臨床職稱：主任醫師
• 執業地點：同濟大學附屬第十人民醫院
• 性別：女

研究方向

高尿酸血症，痛風。

著作譯作

文章發表

1. Liu F, Chen S, Hu Z, Chen J, Jiang L, Qu S*, Chen H*. Musculoskeletal ultrasound features-based scoring system can evaluate the severity of gout and asymptomatic hyperuricaemia. Ther Adv Musculoskel Dis. 2021, 2021 May 12;13:1759720X211006985. doi: 10.1177/1759720X211006985. eCollection 2021.（IF: 5.3）

2. Chen X, Wu M, Liang N, Lu J, Qu S*, Chen H*. Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production. Front. Cell Dev. Biol. 2021 Apr 1;9:636802. doi: 10.3389/fcell.2021.636802. eCollection 2021. （IF: 6.68）

3. Wu M, Ma Y, Chen X, Liang N, Qu S*, Chen H*. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Dis Model Mech. 2021 Mar 24;14(3): dmm 048041. doi: 10.1242/dmm.048041. （IF: 5.76）

4. Guo K, Pan P, Wu M, Ma Y, Lu J, Chen H*. Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes via β1 Integrin/FAK signaling in diabetic nephropathy. Mol Cell Endocrinol. 2020 Jan 22:110730. doi: 10.1016/j.mce.2020.110730. [Epub ahead of print] （IF: 4.1）

5. Wu M, Liu F, Chen J, Chen L, Wei C, Hu Z, Han Y, Lu J, Jiang L*, Chen H*.Prevalence and factors associated with bone erosion in patients with gout. Arthritis Care Res (Hoboken). 2019 Dec;71(12):1653-1659. doi: 10.1002/acr.23816. [Epub ahead of print] （IF: 4.53）

6. Wu M, Zhang M, Ma Y, Liu F, Chen S, Lu J, Chen H*. Chaetocin attenuates gout in mice through inhibiting HIF-1α and NLRP3 inflammasome-dependent IL-1β secretion in macrophages. Arch Biochem Biophys. 2019, 670, July 30(19): 94-103. doi: 10.1016/j.abb.2019.06.010.（IF: 3.559）

7. Yu H, Zhang M, Ma Y, Lu J, Pan J, Pan P, Chen H*, Jia W*. 5-ALA ameliorates hepatic steatosis through AMPK signaling pathway. J Mol Endocrinol. 2017 Aug;59(2):121-128. （IF: 3.297）

8. Han Y, Zhang M, Lu J, Zhang L, Han J, Zhao F, Chen H*, Bao Y, Jia W*. Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes. Sci Rep. 2017 Jun 19;7(1):3802. （IF: 4.122）

9. Guo K, Zhang L, Lu J, Yu H, Wu M, Bao Y, Chen H*, Jia W*. Non-alcoholic fatty liver disease is associated with late but not early atherosclerotic lesions in Chinese inpatients with type 2 diabetes. J Diabetes Complications. 2017 Jan;31(1):80-85. doi: 10.1016/j.jdiacomp.2016.09.008. Epub 2016 Sep 27. （IF: 2.792）

10. Zhang L, Guo K, Lu J, Zhao F, Yu H, Han J, Bao Y, Chen H*, Jia W*. Nonalcoholic Fatty Liver Disease is Associated with Increased Carotid Intima-Media Thickness in Type 1 Diabetic Patients. Sci Rep. 2016 May 26;6:26805. doi: 10.1038/srep26805. （IF: 4.259）

11. Guo K, Zhang L, Zhao F, Lu J, Pan P, Yu H, Bao Y, Chen H*, Jia W*. Prevalence of chronic kidney disease and associated factors in Chinese individuals with type 2 diabetes: Cross-sectional study. J Diabetes Complications. 2016 Jul;30(5):803-10. doi: 10.1016/j.jdiacomp.2016.03.020. Epub 2016 Mar 17 （IF: 2.734）

12. Guo K, Yu H, Lu J, Bao Y, Chen H*, Jia W*. Decreased serum betatrophin levels correlate with improved fasting plasma glucose and insulin secretion capacity after Roux-en-Y gastric bypass in obese Chinese patients with type 2 diabetes: a 1-year follow-up. Surg Obes Relat Dis. 2016 Jan 29. pii: S1550-7289(16)00029-0. doi: 10.1016/j.soard.2016.01.024. [Epub ahead of print] . （IF：4.496）

13. Zhao S, Li T, Li J, Lu Q, Han C, Wang N, Qiu Q, Cao H, Xu X, Chen H*, Zheng Z*. miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signaling pathway. Diabetologia, 2016, 59(3), 644-654. （IF: 6.08）

14. Zhao F, Zhang L, Lu J, Guo K, Wu M, Yu H, Zhang M, Bao Y, Chen H*, Jia W*. The Chronic Kidney Disease Epidemiology Collaboration equation improves the detection of hyperfiltration in Chinese diabetic patients. Int J Clin Exp Med, 2015, 8(12):22084-22097. （IF: 1.075）

15. Guo K, Lu J, Kou J, Wu M, Zhang L, Yu H, Zhang M, Bao Y, Chen H*, Jia W*. Increased urinary Smad3 is significantly correlated with glomerular hyperfiltration and a reduced glomerular filtration rate and is a new urinary biomarker for diabetic nephropathy. BMC Nephrology , 2015, 16 (10):159. （IF: 2.289）

16. Guo K, Lu J, Huang Y, Wu M, Zhang L, Yu H, Zhang M, Bao Y, He JC*, Chen H*, Jia W*. Protective Role of PGC-1α in Diabetic Nephropathy Is Associated with the Inhibition of ROS through Mitochondrial Dynamic Remodeling. Plos one. 2015;10(4):e0125176. （IF: 3.057）

17. Guo K, Lu J, Yu H, Zhao F, Pan P, Zhang L, Chen H*, Bao Y, Jia W*. Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals. Obesity (Silver Spring). 2015 ;23(4):793-7. （IF: 3.614）

18. Chen HB, Jia WP. Biomarkers for diabetes prediction, diagnosis and personalized therapy. Chin Med J (Engl). 2012; 125(23):4163-4166. （IF:0.901）

19. Huang Y, Yu H, Lu J, Guo K, Zhang L, Bao Y, Chen H*, Jia W. Oral Supplementation with Cholecalciferol 800 IU Ameliorates Albuminuria in Chinese Type 2 Diabetic Patients with Nephropathy. Plos one. 2012; 7(11):e50510.（IF: 3.73）

20. Chen H, Lu J, Chen X, Yu H, Zhang L, Bao Y, Lu F, Tang J, Gu C, Jia W. Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes. J Mol Cell Biol. 2012 Aug;4(4):256-7.（IF: 7.667）

21. Chen H, Zheng Z, Huang Y, Guo K, Lu J, Zhang L, Yu H, Bao Y, Jia W. A microalbuminuria threshold to predict the risk for the development of diabetic retinopathy in type 2 diabetes mellitus patients. Plos one. 2012; 7(5):e36718. （IF: 3.73）

22. Zheng Z, Chen HB#, Wang H, Ke BL, Zheng BQ, Li Q, Li PY, Su L, Gu Q, Xu X. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial ROS pathway mediated by PGC-1α. Diabetes. 2010; 59,2315-2325.（IF: 8.889）

23. Chen HB, Zheng Z, Li RX, Lu JX, Bao YQ, Ying XF, Zeng R, Jia WP. Urinary pigment epithelium-derived factor as a marker of diabetic nephropathy. Am J Nephrol. 2010 ;32(1):47-56.（IF: 2.658）

24. Zheng Z, Chen HB#, Zhao H, Liu K, Luo DW, Chen YD, Chen YH, Yang XL, Gu Q, Xu X. Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro. Invest Ophthalmol Vis Sci. 2010,51(1):64-71.（IF: 3.466）

25. Zheng Z, Chen HB#, Ke GJ, Fan Y, Zou HD, Sun XD, Gu Q, Xu X, Ho PC. The protective effect of perindopril on diabetic retinopathy is associated with decreased VEGF/PEDF ratio: involvement of a mitochondria-ROS pathway. Diabetes. 2009,58(4):954-964.（IF: 8.889）

26. Chen HB, Lu JX, Li Q, Bao YQ, Tang JL, Lu HJ, Xiang KS, Jia WP. The protective effect of the RAS inhibitor on diabetic patients with nephropathy in the context of VEGF suppression. Acta Pharmacol Sin. 2009 Feb;30(2):242-50. （IF: 1.909）

27. Chen H, Jia W, Xu X, Fan Y, Zhan D, Wu H, Xie Z, Zheng Z. Upregulation of PEDF expression by PARP inhibition contributes to the decrease in hyperglycemia-induced apoptosis in HUVECs. Biochem Biophys Res Commun. 2008,369:718-724.（IF: 2.76）

28. Li RX, Chen HB#, Tu K, Zhao SL, Zhou H, Li SJ, Dai J, Li QR, Nie S, Li YX, Jia WP, Zeng R, Wu JR. Localized-statistical quantification of human serum proteome associated with type 2 diabetes. PLoS One. 2008 Sep 16;3(9):e3224. （IF: 4.411）

29. Chen H, Ren A, Hu S, Mo W, Xin X, Jia W. The significance of tumor necrosis factor-alpha in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Res Clin Pract. 2007,75 : 327-332. （IF: 2.134）

知網論文

《葡萄糖在目標範圍內時間的研究進展 》

《青少年高尿酸血症和痛風的流行現狀、病因及臨床特徵》

科研成果

1.人工基因迴路設計、構建及其用於代謝疾病智慧型診療的研究，子課題1負責人：代謝性疾病分子機制解析及元件開發，國家重點研發計畫子課題，2019YFA090451，398萬元，2020.01-2024.1

2.心理應激促進脂肪組織生成尿酸及致高尿酸血症機，2018年國家自然基金面上項目負責人，81870616，經費57萬元，負責人，2019-01 2022-12

3.LAMTOR1調節的足細胞自噬在糖尿病腎病發病中的作，2016年國家自然基金面上項目負責人，81670737，經費58萬元，2017-01 2020-12

4.代謝性炎症對慢性腎臟病進展和腎纖維化的促進作用及其機制（973計畫研究專項課題，2012CB517700，經費50.4萬元，學術骨幹，2012-2016）

5.Role of PGC-1α-mediated mitochondrial ROS pathway in nephropathy in type 2 diabetes，歐洲糖尿病研究基金會項目負責人，經費Euro 10萬， 2011－2013

6.PGC-1α調控的線粒體ROS通路在2型糖尿病腎病早期發病中的作用，2010年國家自然基金面上項目負責人，81070649，經費32萬元，2011－2013

7.色素上皮源因子在氧化應激導致的胰島β細胞損傷中作用機制及意，2008年國家自然基金面上項目負責人，30871204，經費33萬元，2009－2011

學術任職

1. 亞太痛風聯盟，常委 2017-2020

2. 中華醫學會內分泌學會高尿酸學組，委員

3. 上海市醫學會內分泌學會委員

4. 高尿酸血症學組組長