基本介紹
- 中文名：陳娟
- 國籍：中國
- 民族：漢
- 職業：教師
- 畢業院校：香港中文大學
- 學位/學歷：博士
- 職務：研究員
個人簡介,代表性成果,通訊作者論文,第一作者論文,獲獎情況,
個人簡介
陳娟，重慶醫科大學教授，博士生導師，國家優秀青年基金獲得者，重慶市高校創新群體負責人，重慶市高等學校巴渝學者特聘教授。近年來在Hepatology、Oncogene、Clinical Cancer Research、Journal of Virology等國際期刊正式發表發表SCI收錄論文30餘篇(具體參見代表性成果部分)，單篇最高IF 14.07 分。申請人先後主持國家自然科學基金6 項（國際合作項目1項）、重慶市自然科學基金計畫項目3 項、獲第五批重慶市高校支持計畫資助、帶領的團隊獲得重慶市“高校創新研究群體”；作為研究骨幹參加國家科技部傳染病“十二五”、“十三五”重大專項。Frontiers in Pharmacology 期刊編委，Journal of Virology、Frontiers in Pharmacology 等多個SCI 雜誌審稿人。
代表性成果
通訊作者論文
[1]L Zhou, JH Ren, ST Cheng, HM Xu, WX Chen, DP Chen, VKW Wong, BYK Law, Y Liu, XF Cai, H Tang, HB Yu, JL Hu, Y Hu, HZ Zhou, F Ren, L He, ZW Hu, H Jiang, HY Xu, AL Huang, J Chen*. A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein. Hepatology 2019 May;69(5):1885-1902.
[2] Ren JH, Hu JL, Cheng ST, Yu HB, Wong VKW, Law BYK, Yang YF, Huang Y, Liu Y, Chen WX, Cai XF, Tang H, Hu Y, Zhang WL, Liu X, Long QX, Zhou L, Tao NN, Zhou HZ, Yang QX, Ren F, He L, Gong R, Huang AL, Chen J. SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases. Hepatology 2018 Oct;68(4):1260-1276.
[3] LK Ran, Y Chen, ZZ Zhang, NN Tao, JH Ren, L Zhou, H Tang, X Chen, K Chen, WY Li, ALHuang，J Chen.SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinomavia BCL2-associated X protein-dependent apoptotic pathway.Clinical Cancer Research2016 ;22(13):3372-3382.
[4] CL Song, H Tang, LK Ran, BC Ko, ZZ Zhang, X Chen, JH Ren, NN Tao, WY Li, AL Huang ,J Chen.Sirtuin 3 inhibits hepatocellular carcinoma growth throughthe glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway.Oncogene 2016 ;35(5):631-641.
[5] JH Ren, Y Tao, ZZ Zhang, WX Chen, K Chen, CL Song, LK Ran, WY Li, AL Huang,J Chen.Sirtuin1 (SIRT1) regulates HBV transcription and replication by targeting transcription factor AP-1.Journal of Virolgoy2014; 88(5):2442-2451.
[6] CL Song, JH Ren, LK Ran, YG Li , XS Li ,X Chen, WY Li , AL Huang,J Chen. Cyclin D2 plays a regulatory role in HBV replication.Virology2014, 462-463: 149–157.
[7] YW Wang, XF Shan, Z Liang,YL Shan, W Huang, D Zhang, AZ Zen, X Zhou,Y Zhao, XY Gong,G Xu,X Zhang, J Chen, AL Huang. Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy.PLoS ONE2015;10(6):e0131337.
[8] ST Cheng, H Tang, JH Ren, X Chen, AL Huang,J Chen. Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo.PLoS One2017;12(6):e0179605.
[9] JH Ren, X Chen, L Zhou, NN Tao, HZ Zhou, B Liu, WY Li, AL Huang,J Chen. Protective Role of Sirtuin3 (SIRT3) in Oxidative Stress Mediated by Hepatitis B Virus X Protein Expression.PLoS ONE2016 ;11(3):e0150961.
[10] Q He, WY Li, JH Ren, Y Huang, Q Hu,J Chen, WX Chen. ZEB2 inhibits HBV transcription and replication by targeting its core promoter.Oncotarget2016,7(13):16003-16011.
[11] NN Tao, JH Ren, H Tang, LK Ran, HZ Zhou, B Liu, AL Huang,J Chen. Deacetylation ofKu70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.Biochem BiophysRes Commun2017;485(4):713-719.
[12] ST Cheng, H Ren, XF Cai,H Jiang,J Chen. HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis.Biochem Biophys Res Commun2018 Jan 22 [Epub ahead of print].
[13] ST Cheng, D Yuan, Y Liu, Y Huang, X Chen, HB Yu, L He, H Jiang, JH Ren,J Chen. Interleukin-35 Level Is Reduced in Patients with Chronic Hepatitis B Virus Infection.International Journal of Medical Sciences2018; 15(2): 188-194.
[14] WY Li, JH Ren, NN Tao, LK Ran, X Chen, HZ Zhou, B Liu, XS Li, AL Huang,J Chen.The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.ArchivesVirology2016 ;161(3):621-630.
[15] L Xu, Z Tu, G Xu, Y Wang, WL Pan, X Zhan, Q Luo, Y Huang,J Chen, AL Huang. Epirubicin directly promotes hepatitis B virus (HBV)replication in stable HBV-expressing cell lines:a novelmechanism of HBV reactivation following anticancer chemotherapy.Molecular Medicine Reports2014 ;9(4):1345-1350.
第一作者論文
[1]J Chen, AW Chan,KF To, W Chen, Z Zhang, JH Ren,CL Song, YS Cheung, PB Lai, SH Cheng, MH Ng, AL Huang, BCKo. SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by Protein Kinase B/Glycogen Synthase Kinase-3β/β-Catenin Signaling.Hepatology2013 ;57(6):2287-2298.
[2] J Chen, B Zhang, N Wong, WI Lo, KF To, WH Chan, HL Ng, YS Ho, SH Cheng, BS Lai, J Yu, HK Ng, MT Ling, AL Huang, XF Cai, and BC Ko. Sirtuin 1 (SIRT1) is upregulated in a subset of hepatocellular carcinoma and is essential for tumor cell growth. Cancer Research2011,71(12),4138-4149.
[3] L Wang, J Chen, Y Zeng, JWei, JJ Jing, G Li, L Su, XJ Tang, TC Wu, L Zhou. Functional Variant in the SLC22A3-LPAL2-LPA Geneluster Contributes to the Severity of Coronary Artery Disease. Arteriosclerosis Thrombosis and Vascular Biology 2016 ;36(9):1989-1996.
[4] C Zou,J Chen,K Chen, S Wang, YY Cao, J Zhang, Y Sheng, AL Huang, H Tang. Functional analysis of miR-181a and Fas involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.Experimental Cell Research2015 ;331(2):352-361.
[5] Q Fu, X Tang, J Chen, L Su, MZhang, L Wang, J Jing, L Zhou. Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.PLoS ONE2015;10(9):e0138652.
[6] ZZhang,J Chen,YHe,XZhan,RZhao,YHuang,HXu,ZZhu,QLiu. miR-125b inhibits hepatitis B virus expression in vitro throughtargeting of the SCNN1A gene. Archives of Virology 2014;159(12):3335-3343.
獲獎情況
[1] 研究論文入選重慶市科協首屆自然科學優秀學術論文,2016（見公示附屬檔案）
[2] 研究論文入選重慶市科協自然科學優秀學術論文,2017（見公示附屬檔案）
