基本介紹
教育經歷,研究方向,主持項目,代表性論文,
教育經歷
1995-1999 內蒙古大學生命科學學院生物技術專業獲得學士學位
1999-2004 南京農業大學生命科學學院獲得生物化學與分子生物學博士學位
2004-2008 天津大學藥物科學與技術學院化學工程與技術專業從事博士後研究
2008-至今天津商業大學生物工程系副教授，夜糠贈符教授
2015年美國賓夕法付達婚尼亞大學醫學院微生物系訪問學者
研究方向
2、微生物來源功能酶的開發和利用。側重於新型微生物功能酶的篩選、分離、純化、鑑定及其在原核和真核細胞中的表達與套用。
3、微生物多糖、膠原蛋白等生物質提判院想取、合成與加工技術。
主持項目
1、主持國家自然科學基金面上項目一項（2019.01-2022.12，No.31870122）。
2、主持完成國家自然科學基金項目2項（2011.01-2013.12，No.81101220；元旋她踏2016.01-2016.12，No.31540066）。
3、主持完成天津市自然科學基金1項（霉設采12JCQNJC08100）以及教育部科學技術研究重點項目1項（210010）。
4、主持完成天津市十二五總投“中青年骨幹教師培養項目”1項。
代表性論文
（1）Hai-Hua Ruan(#*), Zhen Zhang, Su-ying Wang, Logan M.Nickels, Li Tian, Jian-jun Qiao(*), Zhu Jun. Tumor necrosis factor receptor-1 associated factor 6 (TRAF6) mediates ubiquitination-dependent STAT3 activation upon Salmonella Typhimurium infection. Infection and Immunity, 2017, 85:e00081-17. DOI:10.1128/IAI.00081-17.
（2）Hong-yu Zhang, Qiu-ling Zhou, Ting-ting Lou, Su-yingWang, Hai-Hua Ruan(*). Draft genome sequence of broad-spectrum antibiotic sparsomycin-producing Streptomyces sparsogenes ATCC 25498 from the American Type Culture Collection. Journal of global antimicrobial resistance, 2017, (11): 159-160.
（3）Hai-Hua Ruan(#*), Jing-Yue Xu, Ling-Ling Wang, Zhen-Yu Zhao, Ling-Qin Kong, Bei Lan, Xi-Chuan Li. The prognostic value of p62 in solid tumor patients: a meta-analysis. Oncotarget, 2018, 9(3): 4258-4266.
（4）Hai-Hua Ruan(#*), Shuang-Yan Hu, Hong-Yu Zhang, Gang Du, Xiao-Ting Li, Xiao-Bo Li, Xi-Chuan Li. Upregulated SOX9 expression indicates worse prognosis in solid tumors: a systematic review and meta-analysis. Oncotarget, 2017, 8(68):113163-113173.
（5）Hai-Hua Ruan(#*), Ye Li, Xi-Xuan Zhang, Qiang Liu, He Ken, Kun-Sheng, Zhang, Hui Zhao(*). Identification of TRAF6 as a ubiquitin ligase engaged in the ubiquitination of SopB, a virulence effector protein secreted by Salmonella typhimurium, Biochemical and Biophysical Research Communications, 2014, 447(1):172-177.
（6）Hai-Hua Ruan (#*), Zhen Zhang, Li Tian, Su-Ying Wang, Shuang-Yan Hu, Jian-Jun Qiao(*). The Salmonella effector SopB prevents ROS-induced apoptosis of epithelial cells by retarding TRAF6 recuitment to mitochondria. Biochemical and Biophysical Research Communications, 2016, 478(2):618-623.
（7）Chun-Ze Zhang, Xiao-Ting Li, Dan Gao, Hai-Hua Ruan, Zhen-Zhen Lin, Xiao-Bo Li, Guang Liu, Zhi-cheng Ma, Xi-chuan Li. The prognostic value of over-expressed TrkB in solid tumors: a systematic review and meta-analysis. Oncotarget, 2017, 8(59): 99394-99401.
（3）Hai-Hua Ruan(#*), Jing-Yue Xu, Ling-Ling Wang, Zhen-Yu Zhao, Ling-Qin Kong, Bei Lan, Xi-Chuan Li. The prognostic value of p62 in solid tumor patients: a meta-analysis. Oncotarget, 2018, 9(3): 4258-4266.
（4）Hai-Hua Ruan(#*), Shuang-Yan Hu, Hong-Yu Zhang, Gang Du, Xiao-Ting Li, Xiao-Bo Li, Xi-Chuan Li. Upregulated SOX9 expression indicates worse prognosis in solid tumors: a systematic review and meta-analysis. Oncotarget, 2017, 8(68):113163-113173.
（5）Hai-Hua Ruan(#*), Ye Li, Xi-Xuan Zhang, Qiang Liu, He Ken, Kun-Sheng, Zhang, Hui Zhao(*). Identification of TRAF6 as a ubiquitin ligase engaged in the ubiquitination of SopB, a virulence effector protein secreted by Salmonella typhimurium, Biochemical and Biophysical Research Communications, 2014, 447(1):172-177.
（6）Hai-Hua Ruan (#*), Zhen Zhang, Li Tian, Su-Ying Wang, Shuang-Yan Hu, Jian-Jun Qiao(*). The Salmonella effector SopB prevents ROS-induced apoptosis of epithelial cells by retarding TRAF6 recuitment to mitochondria. Biochemical and Biophysical Research Communications, 2016, 478(2):618-623.
（7）Chun-Ze Zhang, Xiao-Ting Li, Dan Gao, Hai-Hua Ruan, Zhen-Zhen Lin, Xiao-Bo Li, Guang Liu, Zhi-cheng Ma, Xi-chuan Li. The prognostic value of over-expressed TrkB in solid tumors: a systematic review and meta-analysis. Oncotarget, 2017, 8(59): 99394-99401.
