《醫學免疫學》是2017年清華大學出版社出版的圖書。
基本介紹
- 中文名：醫學免疫學
- 作者：[印度] 蘇尼爾·庫馬爾·莫漢蒂
- 出版時間：2017年3月1日
- 出版社：清華大學出版社
- ISBN：9787302463085
內容簡介,圖書目錄,作者簡介,
內容簡介
醫學免疫學是一門獨立的學科，是研究免疫系統的組織結構和功能的科學。它從不同的角度和水平來揭示免疫系統識別並消除抗原性異物的應答過程和規律，並套用這些規律來闡明免疫相關疾病發生髮展的機制，達到防治相關疾病的目的。醫學免疫學進展迅速，知識量大，本教材基於*基本的理論和知識，介紹了抗原、免疫器官和免疫細胞、免疫分子（抗體、補體、細胞因子、黏附分子和MHC等）、免疫應答、免疫預防、免疫治療、免疫診斷、免疫耐受、免疫相關疾病以及感染免疫等。本教材適用於醫學專業外國留學生的醫學免疫學英文教學和本科雙語教學。
圖書目錄
Chapter 1 Introduction......................................... 1
A BRIEF OVERVIEW OF IMMUNOLOGY................. 1
HIST ORY OF IMMUNOLOGY................................... 10
STUDY QUESTIONS.................................................... 13
Suggested readingS .......................................... 13
Chapter 2 Antigen.................................................... 14
DEFINITION................................................................. 14
Epitopes...................................................................... 14
Classification of Antigens BASED ON
IMMUNE RESPONSE............................................. 15
DETERMINANTS OF IMMUNOGENICITY............ 15
ANTIGEN RECEPTORS.............................................. 16
ANTIGENIC SPECIFICITY......................................... 17
STUDY QUESTIONS ................................................... 18
Suggested readingS........................................... 18
Chapter 3 Antigen Recognition Molecules
....................................................................... 19
ANTIBODIES—IMMUNOGLOBULINS................... 20
Major Histocompatibility Complex ......... 25
STUDY QUESTIONS.................................................... 28
Suggested ReadingS........................................... 28
Chapter 4 The Complement System............ 29
Complement Activation................................. 29
Regulation of the Complement
System ................................................................. 31
Biological Consequences of
Complement Activation.............................. 32
Defects in the Complement System........... 34
STUDY QUESTIONS ................................................... 34
Suggested readingS........................................... 35
Chapter 5 Organs and Tissues of the
Immune System................................. 36
LYMPHOID ORGANS................................................. 36
Contents
STUDY QUESTIONS.................................................... 39
Suggested ReadingS........................................... 39
Chapter 6 Immune Cells...................................... 41
Lymphocytes........................................................... 41
Phagocytic Cells................................................. 47
Dendritic Cells .................................................... 48
STUDY QUESTIONS.................................................... 48
Suggested ReadingS........................................... 48
Chapter 7 Immune Response............................ 49
AN TIGEN PROCESSING AND
PRESENTATION................................................... 49
AC TIVATION OF HELPER T LYMPHOCYTES.......... 51
HU MORAL IMMUNE RESPONSE
(HUMORAL IMMUNITY).................................... 55
PRIMARY AND SECONDARY RESPONSE ........... 58
FA CTORS INFLUENCING ANTIBODY
PRODUCTION........................................................ 59
CE LL-MEDIATED IMMUNE RESPONSE
(CELL-MEDIATED IMMUNITY).......................... 60
CYTOKINES.................................................................. 64
THEORIES OF IMMUNE RESPONSE....................... 71
STUDY QUESTIONS.................................................... 73
SUGGESTED READINGS........................................... 75
Chapter 8 Immunological Tolerance........... 76
CE NTRAL T CELL TOLERANCE TO SELFANTIGENS...............................................................
76
PE RIPHERAL T CELL TOLERANCE TO SELFANTIGENS...............................................................
77
B C ELL TOLERANCE TO SELF-ANTIGENS........... 78
AR TIFICIALLY INDUCED TOLERANCE IN
VIVO......................................................................... 79
STUDY QUESTIONS.................................................... 80
SUGGESTED READINGS........................................... 80
Contents
目 錄
XIV 醫學免疫學Meeddiiccaall IImmuunnoollooggyy
Chapter 9 Hypersensitivity................................ 81
DEFINITION................................................................. 81
GELL AND COOMBS CLASSIFICATION................ 81
IMMEDIATE TYPE I HYPERSENSITIVITY.............. 81
TY PEⅡ HYPERSENSITIVITY REACTION
(ANTIBODY-DEPENDENT CYTOTOXICITY)........ 89
TY PEⅢ HYPERSENSITIVITY REACTION
(IMMUNE COMPLEX-MEDIATED).................... 93
TY PE Ⅳ CELL-MEDIATED (DELAYED)
HYPERSENSITIVITY.............................................. 96
STUDY QUESTIONS.................................................. 101
SUGGESTED READINGS......................................... 101
Chapter 10 Autoimmunity................................ 102
PR OBABLE MECHANISMS OF
AUTOIMMUNITY................................................ 102
AUTOIMMUNE DISEASES...................................... 107
STUDY QUESTIONS.................................................. 109
Suggested readings......................................... 110
Chapter 11 Immunodeficiency Disorders...... 111
PRIMARY IMMUNoDeFICIENCIES...................... 111
SE CONDARY (ACQUIRED) IMMUNodEFICIENCIES
.................................................................................. 117
STUDY QUESTIONS.................................................. 125
SUGGESTED READINGs......................................... 125
Chapter 12 Tumor Immunology......................... 126
CANCER: ORIGIN..................................................... 126
TUMOR ANTIGENS.................................................. 129
Cancer Immunotherapy................................ 134
STUDY QUESTIONS.................................................. 136
SUGGESTED READINGs......................................... 137
Chapter 13 Transplantation Immunology...... 138
Graft Rejection................................................... 138
FACTORS FAVORINGALLOGRAFT SURVIVAL...... 140
Mechanism Involved in Graft Rejection
................................................................................ 142
Tempo of Rejection............................................ 145
STUDY QUESTIONS.................................................. 147
SUGGESTED READINGS......................................... 147
Chapter 14 Immunological Techniques.......... 149
ST AGES OF ANTIGEN-ANTIBODY
INTERACTIONS.................................................... 149
ME ASUREMENT OF ANTIGEN AND ANTIBODY
................................................................................ 149
PrecipitationReactions................................. 149
Agglutination Reaction............................. 154
MO NOCLONAL ANTIBODIES AND
HYBRIDOMA TECHNIQUE............................. 167
STUDY QUESTIONS.................................................. 170
SUGGESTED READINGs......................................... 171
Chapter 15 Immunoprophylaxis &
Immunotherapy............................... 172
IMMUNOPROPHYLAXIS........................................ 172
IMMUNOTHERAPY.................................................. 179
STUDY QUESTIONS.................................................. 183
SUGGESTED READINGs......................................... 183
Chapter 16 Immunity in Viral, Bacterial,
Fungal, and Parasitic
Infections............................................. 184
IMMU NITY IN VIRALINFECTIONS...................... 184
IMMU NITY IN BACTERIAL INFECTIONS........... 188
IMMU NITY IN FUNGAL INFECTIONS................ 197
IMMU NITY IN PARASITIC INFECTIONS............ 198
STUDY QUESTIONS.................................................. 204
SUGGESTED READINGs......................................... 204
作者簡介
姚智教授，現任天津醫科大學基礎醫學院免疫學系主任、天津醫科大學病原生物與免疫學學科學術帶頭人、天津醫科大學黨委書記等職務。任第十七屆世界支原體聯盟常務理事，中華微生物學及免疫學會主任委員，中國免疫學會理事，中國醫藥生物技術協會臨床套用委員會常務理事，中國細胞生物學與分子生物學學會臨床分會常務理事，中華醫學會天津分會檢驗學會主任委員等學術職務。任中國檢驗醫學雜誌英文版主編，中國免疫學雜誌編委，中國腫瘤臨床（英文版）編委，中草藥編委等植物。曾獲天津市教書育人十大標兵、天津市衛生系統科技先進個人；他領導的課題組獲天津市衛生系統科技先進集體、天津市“十五”立功先進集體；天津市“五一”立功先進集體，他本人榮獲天津市“八五”“九五”“十五”立功獎章、天津市勞動模範、天津市科技明星、天津市第四屆青年科技獎；為國務院特殊津貼專家；天津市“131工程”人才培養*層次人選；衛生部有突出貢獻中青年專家；天津市授銜專家；2006年入選“新世紀百千萬人才工程”*人選。
