《醫學免疫學》是2006年科學出版社出版的圖書，作者是譚錦泉。
基本介紹
- 中文名：醫學免疫學
- 作者：譚錦泉
- 出版時間：2006年3月
- 出版社：科學出版社
- ISBN：7030165683
內容簡介,圖書目錄,
內容簡介
本教材以面向21世紀課程教材，龔非力主編的“醫學免疫學”的內容和結構為藍本，在“Medical Immunolgy”中進行相應的英文摘編。本教材主要包括三大內容：基礎免疫學、臨床免疫學、套用免疫學。
圖書目錄
GENERAL INTRODUCTION
Section 1 Fundaments of Immunology
Chapter 1 Immunity
Innate Immunity
Adaptive Immunity
Chapter 2 Immune Cells
Phagocytes
Lymphocytes
Antigen Presenting Cells
Chapter 3 Lymphoid Tissues and Organs
Primary Lymphoid Organs
Secondary（peripheral） Lymphoid Tissues and Organs
Lymphocyte Traffic and Recirculation
Chapter 4 Pathological Immunity and Im-mune Diseases
Section 2 Brief History and Prospect of Immunology
Chapter 1 Empirical Immunology
Chapter 2 Scientific Immunology
Discovery of Pathogens and Application of Vaccines
Discovery and Application of Antibodies
Cellular Immunity
Immunological Tolerance
Chapter 3 Modern Immunology
Diversity of Antigen Receptors
Discovery of Signal Transduction Pathway
Discovery of Programmed Cell Death
Hematogenesis and Development of Im-mune Cells
Immunological Application
Prospect of Immunology
IMMUNE MOLECULES
Section 3 Antigen
Chapter 1 Properties of Antigen
Chapter 2 Characteristics of Antigen
Specificity
Foreignness
Chapter 3 Factors Influencing Immunogeni-city
Physicochemical Properties of Antigens
Effect of Host
Mode of Contact
Chapter 4 Classification of Antigens
TD-Ag and TI-Ag
Classification Based on Relationship with Host
Chapter 5 Non-specific Stimulators
Super Antigen
Adjuvant
Mitogen
Section 4 Immunoglobulins
Chapter 1 Organization of Immunoglobulins
Molecular Structure of Immunoglobulins
J Chain and Secretory Component
Enzymatic Digestion Products of Immu-noglobulins
Chapter 2 Immunoglobulin Classes and Sub-classes
Immunoglobulin Classes， Subclasses and Types
Isotypes， Allotypes and Idiotypes of Im-munoglobulins
Chapter 3 Biological Activities of Immuno-globulins
Activities of Variable Regions
Activities of Constant Regions
Chapter 4 Biological Properties and Func-tions of Immunoglobulin Classes
IgG
IgA
IgM
IgD
IgE
Chapter 5 Antibody Technology
Section 5 The Complement System
Chapter 1 Introduction
Component of Complement System
Nomenclature
Chapter 2 Pathways of Complement Activa-tion
Classical Pathway
The Lectin Pathway
Alternative Pathway
Terminal Sequence and the Membrane Attack Complex
Chapter 3 Regulation of Complement System Activation
Self-regulation
Fluid-Phase Regulator
Solid-Phase Regulator
Chapter 4 Biological Consequences of Com-plement Activation
Cell Lysis
Opsonization and Phagocytosis
Viral Neutralization
Inflammation
Regulation of Cells
Clearance of Immune Complex
Section 6 Cytokines
Chapter 1 Introduction
Chapter 2 Classification and Biological Activities of Cytokines
Interleukins
Tumor Necrosis Factor
Interferon
Hematopoietic Colony-Stimulating Factors
Transforming Growth Factor
Chemokines
Chapter 3 Cytokine Receptors
IL-1 Recepto
TNF-αReceptors
IL-2 Receptor
Chemokine Receptor
Chapter 4 Clinical Application
Section 7 Major Histocompatible Complex
Chapter 1 Structure and Genetics of MHC
Classical MHC Gene Complex
MHC Molecules
Other MHC Genes
Chapter 2 MHC Polymorphism
Concept of Polymorphism
Linkage Disequilibrium and Haplotype
Generation and Significance of MHC Poly-morphism
Chapter 3 Peptide-MHC Interaction
Molecular Basis
Characteristics
Chapter 4 HLA and Clinical Medicine
HLA and Graft Rejection
HLA Related-Diseases
HLA and Diseases
Section 8 Leukocyte Differentiation Anti-gens and Adhesion Molecules
Chapter 1 Leukocyte Differentiation Anti-gens
Concept of Leukocyte Differentiation Antigens
Concept of Cluster of Differentiation
Chapter 2 Cell Adhesion Molecules
Intergrin Family
Selectin Family
Immunoglobulin Superfamily
Functions of Cell Adhesion Molecules
Chapter 3 Clinical Application of CD Mole-cules，Cam and Monoclonal Antibodies Against CD Molecules and Cam
Elucidation of Pathogenesis
Diagnosis and Prognosis in Clinical Use
Prevention and Treatment for Diseases
IMMUNE CELLS
Section 9 Hematopoietic Stem Cells
Chapter 1 Origin and Surface Markers of Hematopoietic Stem Cells
Origin of Hematopoietic Stem Cells
Surface Markers of Hematopoietic Stem Cells
Chapter 2 Differentiation of Hematopoietic Stem Cells
The Factors Affect Differentiation of He-matopoietic Stem Cells
Development of Lineage-Committed Pro-genitors
Section 10 Cells of Innate Immunity
Chapter 1 Phase of Innate Immunity
Chapter 2 Cells of Innate Immunity
Epithelials
Phagocytes
Neutrophils
Mononuclear Phagocytes:the Monocyte-Macrophage System
NK Cells
γ:δ T Cells
B1 B Cells
NK T Cells
Chapter 3 Receptors of Innate Cells
Pattern-Recognition Receptors
Toll Like Receptors
Section 11 T Lymphocytes
Chapter 1 T Cell Ontogeny
Stages of Thymocyte Development
Positive and Negative Selection of Thym-ocytes
Chapter 2 Surface Proteins of T Lymph-ocytes
TCR-CD3 Complex
CD4 and CD8 Coreceptors
Costimulatory Molecules
Mitogen Receptors
Chapter 3 T Lymphocytes Subsets and Functions
Helper T Lymphocytes
Cytotoxic T Lymphocytes
Memory T Cells
Regulatory T Cells
Section 12 B Lymphocytes
Chapter 1 Development of B Lymphocytes
The B Cells Development in the Bone Marrow
The B Cells Maturation in Germinal Centers
Chapter 2 Surface Markers of B Lympho-cytes
BCR Complex
Surrogate BCR Complex
Other Surface Markers
Chapter 3 Subsets and Functions of B Lymphocytes
B1 Cells and Their Functions
B2 Cells and Their Functions
Immune Regulation
Section 13 Organization and Diversity of Antigen Receptor Genes
Chapter 1 Structure of Antigen Receptor Genes
The Gene Structure of BCR
The Gene Structure of TCR
Chapter 2 Rearrangement of Antigen Receptor Genes
Chapter 3 The Diversity Antigen Recep-tor Genes
BCR
TCR
IMMUNE RESPONSE
Section 14 Innate Immune Response
Chapter 1 Components Involved in Innate Immune Response
The Skin and the Mucosal Surfaces
Immune Cells Involved in Innate Immune Response
Humoral Proteins of Innate Immunity
Chapter 2 The Recognition Mechanism of Innate Immune Response
Pathogen Associated Molecular Pattersn（PAMPs）
Pattern Recognition Receptor（PRR）
Chapter 3 The Biological Significance of Innate Immune Response
Section 15 Antigen Presentation
Chapter 1 Antigen Presenting Cells
MPS
Antigen Processing and Presentation by Dendritic Cells
Antigen Processing and Presentation by B Lymphocytes
Chapter 2 Antigen Processing and Prese-ntation
Processing of Exogenous and EndogenousAntigens
MHC and Antigen Processing and Pre-sentation
CD1 Related Antigen Presentation
Section 16 T Cells Recognitions and Res-ponses of Antigens
Chapter 1 T Cells Recognition of Antigens
Chapter 2 Signals for T Cells Activation
Stimulators of T Cells Activation
Double Signals for T Cells Activation
Chapter 3 Signal Transduction of T Cell Activation
Receptor Cross-Iinking
Cytoplamic Signaling by TCR
Chapter 4 Transcription Factor Activation and Gene Expression
Chapter 5 Functions of Effector T Cells
Functions of CD4 +TH1 Cells
Functions of CD8+ Cytotoxic T Cells
Section 17 B Cell Recognition and Resp-onse of Antigens
Chapter 1 B Cell Response to T Cell-Dependent Antigen
Clonal Selection and Antigen Recogni-tion of B Cells
Signaling by BCR Complex and B Cell Coreceptors
Effects of TH Cells and Interaction Between TH and B Cells
Development and Differentiation of B Cells in Germinal Centers
Chapter 2 B Cell Response to T Cell-Independent-Antigen
B Cell Response to Type 1 of TI Anti-gens
B Cell Response to Type 2 of TI Anti-gens
Chapter 3 Rules of Antibody Production
Immunoglobulin Secretion
Primary and Secondary Response
Chapter 4 Mucosal Immune Response
Mucosa-Associated Lymphoid Tissue
Secretory Ig and Transcytosis
Section 18 Immunoregulation
Chapter 1 Role of Antigen， Antibody and Complement
Role of Antigen
Role of Antibody
Role of Complement
Chapter 2 Role of Signaling Components and Molecules
Role of Activating Signaling Components and Molecules
Role of Suppressing Signaling Compo-nents and Molecules
Chapter 3 Role of Cells
Role of T Cell Subtypes
Role of the Idiotypic Network
Role of Apoptosis
Chapter 4 Neuroendocrine Immune Sys-tem Regulation
Role of Neuroendocrine System
Immunoregulation Among Population
Section 19 Immune Tolerance
Chapter 1 The Development and Repre-sentation of Immune Tolerance
Innate Tolerance
Acquired Tolerance
Chapter 2 Mechanisms of Immune Tole-rance
Central Tolerance
Peripheral Tolerance
Chapter 3 Immune Tolerance and Clinical Medicine
Establishment and Maintenance of Im-mune Tolerance
Abrogation of Immune Tolerance
CLINICAL IMMUNOLOGY
Section 20 Hypersensitivity
Chapter 1 Type I Hypersensitivity
Component and Cells
Immune Pathogenesis
Type I Hypersensitivity-Associated Diseases
Therapy for Type I Hypersensitivity
Chapter 2 Type II Hypersensitivity
Immune Pathogenesis
Type II Hypersensitivity-Associated Diseases
Chapter 3 Type III Hypersensitivity
Immune Pathogenesis
Type III Hypersensitivity-Associated Diseases
Chapter 4 Type IV Hypersensitivity
Immune Pathogenesis
Diseases caused by Delayed-Type Hypersensitivity
Section 21 Autoimmunity and Autoimmune Diseases
Chapter 1 Introduction
Autoimmunity
Autoimmune Disease
Classification
Characteristics
Chapter 2 Immunologic Pathogenesis and Typical Diseases
Autoantibodies Directly Mediated Tissue Damage
Autoantibodies Modulate Cell Function
Autoantibodies form Damaging Immune Complexes
Cell Mediated Immunity in Pathogenesis
Chapter 3 Factors in Development of Autoimmune
Autoantigens
Abnormal Immunoregulation
Abnormal Expression of Fas/FasL
Genetic Factors
Infections
Chapter 4 Treatment of Autoimmune Disease
Section 22 Immunodeficiency Diseases
Chapter 1 Introduction
Chapter 2 Primary/Congenital Immuno-deficiency Diseases
Congenital B Cell Immunodeficiency Disorders
Congenital T Cell/Cellular Immuno-deficiency Disorders
Combined Immunodeficiency Disorders
Complement Deficiencies
Phagocytic Defects
Chapter 3 Secondary Immunodeficiency
HIV and AIDS
Chapter 4 Treatment of Immunodefici-ency
Section 23 Tumor Immunology
Chapter 1 Tumor Antigens
Classification by Specificity of Antigen
Classification by Origin and Nature of Antigen
Chapter 2 Mechanisms of Anti-tumor Effects
Cellular Immunity
Humoral Immunity
Chapter 3 Mechanisms of Tumor Escape
Tumor Cell-Associated Factors
Host Immune System-associated Factors
Chapter 4 Tumor Immunodiagnosis
Chapter 5 Tumor Immunotherapy
Cellular Immunotherapy
Humoral Immunotherapy
Tumor Vaccines
Section 24 Transplantation Immunology
Chapter 1 Immunologic Basis of Allograft Rejection
Attributes of Allograft Rejection
Target Antigens of Allograft Rejection
Cell Basis of Allograft Rejection
Recognition of Alloantigens
Chapter 2 Allograft Rejection Types and Mechanisms
HVGR
GVHR
Chapter 3 Prevention and Treatment of Allograft Rejection
Donor Selection
Immunosuppressive Agents
Specific Tolerance to Transplantation Antigens
Section 25 Immunodiagnosis
Chapter 1 Detection of Antigens and Antibodies
Principles of Antigen-Antibody Reaction
Detection of Antigens and Antibodies
Chapter 2 Detection of Cellular Immunity
Lymphocyte Isolation and Phenotyping
Lymphocyte Function Assays
Phagocyte Function Assays
Chapter 3 Clinical Analysis of Immune System by Molecular Genetic Techn-iques
Hybridization
Polymerase Chain Reaction
Genome Sequencing
Chapter 4 Application of Immunologic Tests
Selection and Evaluation of Immune-Tests
Clinical Application of Immune-Tests
Section 26 Immunotherapy
Chapter 1 Definition and Classification
Chapter 2 Molecular Immunotherapy
Molecular Vaccines
Antibody Immunotherapy
Cytokine Therapy
Microbe Antigen Vaccine
Chapter 3 Cellular Immunotherapy
Adoptive Immunotherapy
Stem Cells Transplantation
Chapter 4 BRMs and Immunosupressors
BRMs
Immunosupressor
Section 27 Immunoprevention
Chapter 1 Artificial Immunization
Artificial Active Immunization
Artificial Passive Immunization
Planned Immunization
Chapter 2 Development of New Vaccines
Basic Requirements for Vaccines
Development of New Vaccines
Chapter 3 Application of Vaccines
Prevention of Infectious Diseases
Prevention of Tumor
Others
Appendix
English-Chinese Comparison
Attached Compact Discs
Animator:Si Chuanping
Narrator:Sean Mcnulty（Ireland）
Script：
Immunoglobulins:Si Chuanping
Cytokines:Meng Fanping
Major Histocompatible Complex:Ding Jianbing
The Mechanism by which Neutrophils engulf and digest microorganisms:Li Jintao
Antigen Presentation:Liu Ying
T Cell Recognition and Response to Antigens:Zhang Chongjie
B Cell Recognition and Response to Antigens:Ji Xiaohui
Immunoregulation:Han Mei
