專業特長
糖尿病自體骨髓幹細胞移植治療
糖尿病與腫瘤
NRF2與糖尿病併發症
學術成就
重慶市第五屆人大代表、重慶市傑青、重慶市高校重點實驗室主任、軍隊院校育才銀獎、軍隊優秀專業技術人才崗位津貼獲得者,博士生導師,SCI雜誌CSTT、IJBS、SDI、CDR、Genes Diseases編委與審稿人,UpToDate臨床顧問,中華內分泌代謝雜誌委員、第三軍醫大學學報常委。中華醫學會內分泌專委會高尿酸學組委員,中華醫學會內分泌專委會青年委員,白求恩醫學專家委員會糖尿病專業委員會副秘書長,中華醫學會重慶分會糖尿病專委會副主任委員,中國醫師協會重慶分會內分泌代謝科醫師分會副會長,中華醫學會重慶分會內分泌專委會委員,國家自然科學基金委生命科學部/醫學科學部同行評議專家。主持國家自然科學基金(4項)、國家自然科學基金海外合作項目、教育部留學歸國基金、重慶市傑青、重慶市自然科學基金重點項目等各類課題10餘項。獲2013年中華醫學科技獎二等獎(5)、2006年度重慶市科技進步一等獎(7)、2007年度全軍醫療成果三等獎(1)。主研方向:氧化應激/Nrf2在糖尿病並發血管病變中的機制及干預,糖尿病與腫瘤。在Science Transl Med、Cell系列Trends Endocrin Met、Diabetes、JCEM、Nat Commun、Kidney Int等本領域高影響因子SCI期刊發表論文多篇。
代表論著:
1、Wang H#,Liu XF#,Long M#,Huang Y#,Zhang LL,Zhang R,Zheng Y,Liao XY,Wang YR,Liao Q,Li WJ,Tang ZL,Tong Q,Wang XC,Fang F,Rojo de la Vega M,Ouyang Q,Zhang DD*,Yu SC*,Zheng HT*.NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis,Science Transl Med,2016,8(334):334ra51.
【被Cell Metab,2016 Jun 14;23(6):959-60專文述評】
2、Wang H,Rojo de la Vega M,Zhang DD*,Yu SC*,Zheng HT*.Multiple factors may affect the outcome of diabetic patients with cancer treated with antioxidant antidiabetic agents,Science Transl Med,2016,8(349):349lr1.
3、Min Long#,Xing Li#,Li Li#,Matthew Dodson,Donna D. Zhang,Hongting Zheng*. Multifunctional p62 Effects Underlie Diverse Metabolic Diseases,Trends Endocrin Met,2017,28(11):818-830. doi: 10.1016/j.tem.2017.09.001.
4、Long Min#,Cai Leiqin#,Li Wenjie,Zhang Linlin,Guo Shaodong,Zhang Rui,Zheng Yi,Liu Xiufei,Wang Min,Zhou Xianli,Wang Hui,Li Xing,Li Ling,Zhu Zhiming,Yang Gangyi,Zheng Hongting*.DPP-4 Inhibitors Improve Diabetic Wound Healing via Direct and Indirect Promotion of Epithelial-Mesenchymal Transition and Reduction of Scarring,Diabetes,2017,Dec 18. pii: db170934. doi: 10.2337/db17-0934.
5、Long M,Rojo de la Vega M,Wen Q,Bharara M,Jiang T,Zhang R,Zhou SW,Wong PK,Wondrak GT*,Zheng HT*,Zhang DD*.An essential role of NRF2 in diabetic wound healing,Diabetes,2016,65(3):780-793.
6、Zheng HT,Whitman SA,Wu W,Wondrak GT,Wong PK,Fang DY,Zhang DD*.Therapeutic Potential of Nrf2 Activators in Streptozotocin -Induced Diabetic Nephropathy,Diabetes,2011,60(11):3055-3066.
7、Tong Q#,Duan L#,Xu ZH,Wang H,Wang XC,Li ZJ,Zhang WZ,Zheng HT*.Improved Insulin Secretion Following Intrapancreatic UCB Transplantation in Patients With T2DM,J Clin Endocrinol Metab,2013,98(9):E1501-E1504.
8、Zhang JL,Liu GK,Ruan Y,Wang JL,Zhao K,Wan Y,Liu B,Zheng HT,Peng T,Wu W,He P,Hu FQ*,Jian R*.Dax1 and Nanog act in parallel to stabilize mouse embryonic stem cells and induced pluripotency,Nature Commun,2014,Oct 6; 5:5042. .doi:10.1038/ncomms6042 .
9、Jiang T*,Tian F,Zheng HT,Whitman SA,Lin YF,Zhang ZG,Zhang N,Zhang DD*.Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-kappaB-mediated inflammatory response,Kidney Int,2014,85(2):333-343 .