許小娟

許小娟

許小娟,博士,教授,武漢大學化學與分子科學學院教授,

基本介紹

  • 中文名:許小娟
  • 國籍中國
  • 畢業院校武漢大學
  • 學位/學歷:博士
  • 職業:教師
  • 專業方向:高分子化學與物理、多糖化學生物學
  • 職稱:教授
人物經歷,研究領域,科研項目,發表論文,

人物經歷

教育與研究經歷
1993.9-1997.6,理學學士,武漢大學化學學院
1997.9-2002.6,理學博士,武漢大學化學與分子科學學院
2000.4-2001.3,特別研究生,日本大阪大學理學部高分子科學系(從事多糖溶液性質研究)
2001.7-,助教、講師、副教授、教授/博導,武漢大學化學與分子科學學院
2008.11-2010.10,日本學術振興會(JSPS)外國人特別研究員,日本神戶大學(從事多糖生物學研究)
2022年10月28日,中國化學會高分子材料分析技術與表征方法專業委員會成立大會線上上召開。武漢大學許小娟教授聘任為秘書長。
教學情況
本科生課程:《高分子導論》、《高分子合成與表征》
研究生課程:《高分子物理近代研究方法》、《高分子科學進展》

研究領域

一、多糖溶液
1、多糖鏈構象及表征方法
2、多糖溶液行為(聚集、溶液-凝膠轉變、自組裝、流變行為等)
3、多糖納米複合物的構建、功能及構效關係
二、多糖生物學
1、多糖與DNA/RNA的相互作用
2、多糖及其衍生物的生物活性及構效關係
3、多糖及其衍生物誘導的細胞內信號轉導

科研項目

1、教育部新世紀優秀人才支持計畫(NCET-13-0442),2014-2016。(主持)
2、國家自然科學重點基金(21334005),2014.1-2017.12。(參加)
3、武漢市“黃鶴英才計畫”,2013.1-2016.12。(主持)
4、國家自然科學基金(21274114),2013.1-2016.12。(主持)
5、國家自然科學基金(20874078),2009.1~2011.12。(主持)
6、武漢市青年科技晨光計畫(200950431193), 2009.1-2011.12。(主持)
7、國家自然科學基金(20404010),2005.1-2007.12。(主持)
8、湖北省自然科學基金, 2005.1-2006.12。(主持)

發表論文

1. Liu Q., Cao Y., Xu H., Li M., Xu X., Zhang L., Transfection efficiency and internalization of the gene carrier prepared from a triple helical b-glucan and polydeoxyadenylic acid in macrophage RAW264.7 cells, J. Mater. Chem. B, 2015, 3, 3789-3798.
2. Fang Y., Duan B., Lu A., Liu M., Liu H., Xu X., Zhang L., Intermolecular interaction and the extended wormlike chain conformation of chitin in NaOU/urea aqueous solution, Biomacromolecules, 2015,16,1410-1417.
3. Liu Q., Wang C., Cao Y., Xu X.*, Zhang L., A novel gene delivery system prepared from beta-glucan and polydeoxyadenylic acid via disulfide bonds. J. Mater. Chem. B, 2014, 2, 933-944. (cover paper)
4. Jia X., Xu X.*, Zhang L. Synthesis and Stabilization of Gold Nanoparticles Induced by Denaturation and Renaturation of Triple Helical b-Glucan in Water. Biomacromolecules, 2013,14, 1787-1794.
5. Xu S., Lin Y., Huang J., Li Z., Xu X.*, Zhang L.*, Construction of high strength hollow fibers by self-assembly of a stiff polysaccharide with short branches in water. J. Mater., Chem. A, 2013, 1, 4198-4206.
6. Liu Q., Xu X.*, Zhang L., Luo X., Liang Y., Assembly of single-stranded polydeoxyadenylic acid and b-Glucan probed by the sensing platform of graphene oxide based on the fluorescence resonance energy transfer andfluorescence anisotropy. Analyst, 2013, 138, 2661-2668.
7. Xu X.*, Yasuda M., Mizuno M., Ashida H.* β-Glucan from Saccharomyces cerevisiae reduces lipopolysaccharide-induced inflammatory responsesin RAW264.7 macrophages. Biochim. Biophys. Acta, 2012, 1820, 1656-1663.
8. Xu X.*, Yasuda M., Nakamura-Tsuruta S., Mizuno M., Ashida H.*, b-glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-a and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide stimulated murine RAW 264.7 macrophages. J. Biol. Chem., 2012, 287, 871-878.
9. Xu X.*, Chen P., Zhang L., Ashida H., Immunomodulatory b-glucan from Lentinus edodes activates mitogen-activated protein kinases and nuclearfactor-kB in murine RAW 264.7 macrophages. J. Biol. Chem., 2011, 286, 31194-31198.
10.Xu S., Xu X.*, Zhang L.* Branching structure and chain conformation of water-soluble glucan extracted from Auricularia Auricula-Judae. J. Agric. Food Chem.2012, 60, 3498-3506.
11. Li S., Zhang Y., Xu X., Zhang L., Triple helical polysaccharide-induced good dispersion of silver nanoparticles in water. Biomacromolecules, 2011, 12, 2864-2871
12.Zhang Y, Xu X.*, Zhang L., Dynamic viscoelastic behavior of triple helical Lentinan in water. Effects of concentration and molecular weight.Polymer, 2007, 48, 6681-6690.
13.Xu X., Zhang X., Zhang L., Wu C., Collapse and association of denatured lentinan in water / dimethylsulfoxide solution, Biomacromolecules, 2004,5, 1893-189

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