薛雷，北京大學生物系學士，中國科學院上海細胞生物學研究所碩士，瑞士蘇黎世大學分子生物學研究所博士，美國耶魯大學醫學院博士後。 歷任耶魯大學醫學院副研究員 (Associate Research Scientist)，霍華德修斯醫學研究院 (Howard Hughes Medical Institute) 研究專家 (Research Specialist)，自2008年9月起任同濟大學生命科學與技術學院教授，博導，首席科學家。
基本介紹
- 中文名：薛雷
- 畢業院校：瑞士蘇黎世大學分子生物學研究所
- 學位/學歷：博士
- 專業方向：腫瘤發生的分子遺傳學機制
- 職務：博士生導師
研究方向,研究領域,發布論文,
研究方向
1.腫瘤發生的分子遺傳學機制
The molecular and genetic mechanism of tumorigenesis.
2. 細胞凋亡的分子生物學機制
The molecular mechanism of apoptosis.
3.阿爾茨海默病的分子生物學機制
The molecular mechanism of Alzheimer's disease.
4.Pax基因對胚胎髮育和器官形成的調控作用及機制
Genetic regulation of embryonic development and organogenesis by Pax genes.
5.治療腫瘤遷移和神經退行性疾病的中藥篩選
A screen for Chinese herbal medicines against tumor metastasis and neurodegenerative diseases.
2. 細胞凋亡的分子生物學機制
The molecular mechanism of apoptosis.
3.阿爾茨海默病的分子生物學機制
The molecular mechanism of Alzheimer's disease.
4.Pax基因對胚胎髮育和器官形成的調控作用及機制
Genetic regulation of embryonic development and organogenesis by Pax genes.
5.治療腫瘤遷移和神經退行性疾病的中藥篩選
A screen for Chinese herbal medicines against tumor metastasis and neurodegenerative diseases.
研究領域
JNK信號通道在細胞增殖、遷移、凋亡、應激反應和個體衰老中起著至關重要的作用，其失調可導致發育缺陷和過早衰老，並和腫瘤發生和遷移、免疫失調、阿爾茲海默症及多種重要疾病的發生與發展密切相關。
我們以果蠅為模式動物進行遺傳篩選，找到了JNK信號通道上30多個新的基因，已分析鑑定其中部分基因，成果發表在DevelopmentalCell和Science等國際頂級學術雜誌。我們將繼續研究其餘的基因，探索它們在JNK信號通道中的分子功能，闡明其在細胞凋亡、個體衰老、癌症及阿爾茲海默症中的作用機制。
選擇是一種行為，也代表著智慧，其調控分子和作用機制仍有待破解。我們利用果蠅的擇偶方式和取向，研究選擇的分子機制以及調控選擇的遺傳因素。
我們還建立了癌症和阿爾茲海默症的果蠅模型，並利用這些疾病模型篩選和檢驗各類中藥成分對延緩衰老、治療癌症和老年痴呆症等疾病的效果。
發布論文
1.S Zhang, X Guo, H Wu, Y Sun, X Ma, J Li, Q Xu, C Wu, Q Li, C Jiang, W Li, MS Ho, Z Lv, and L Xue* (2019) Wingless modulates activator protein-1-mediated tumor invasion. Oncogene. doi: 10.1038/s41388-018-0629-x
2.Y Sun, D Zhang, X Guo, W Li, C Li, J Luo, M Zhou and L Xue* (2019) MKK3 modulates JNK-dependent cell migration and invasion. Cell Death Dis. 10:149.
3.Y Sun, D Zhang, C Li, J Huang, W Li, Y Qiu, A Mao, M Zhou and L Xue* (2019) Lic regulates JNK‐mediated cell death in Drosophila. Cell Proliferation. e12593
4.X Ma, X Guo, HE Richardson, T Xu and L Xue* (2018) POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation. PNAS115:2150-2155.
5.X Wang, X Huang, C Wu and L Xue* (2018) Pontin/Tip49 acts as a novel regulator of JNK pathway. Cell Death Disease9: 978.
6.X Wang, X Huang, C Wu and L Xue* (2018) Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila.Cell Death Discov.4:74.
7.X Wang, X Guo, Y Ma, C Wu, W Li and L Xue* (2018) APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. BioMed Research International: Article ID 7469714.
8.X Ma, H Wang, J Ji, W Xu, Y Sun, W Li, X Zhang, J Chen and L Xue* (2017) Hippo Signaling Promotes JNK-dependent Cell Migration. PNAS114:1934-1939.
9.X Ma, J Huang, Y Tian,Y Chen, Y Yang, X Zhang*, F Zhang*and L Xue*(2017) Myc Suppresses Tumor Invasion and Cell Migration by inhibiting JNK Signaling. Oncogene36：3159-3167
10.X Wang, Y Sun, S Han, C Wu, Y Ma, Y Zhao, Y Shao, Y Chen, L Kong, W Li, F Zhang, L Xue*(2017) Amyloid precursor like protein-1 promotes JNK-mediated cell migration in Drosophila. Oncotarget8:49725-49734.
11.J Huang, Y Feng, X Chen, W Li and L Xue* (2017) Myc inhibits JNK-mediated cell death in vivo. Apoptosis22:479-490
12.P Ren, W Li and L Xue* (2017) GLYAT regulates JNK-mediated cell death in Drosophila.Scientific Reports7:5183.
13.L Zhuang, Y Sun, M Hu, C Wu, X La, X Chen, Y Feng, X Wang, Y Hu*and L Xue*(2016) Or47b plays a role in Drosophila males’ preference for younger mates. Open Biology6: 160086.
14.S Zhang, X Guo, C Chen, Y Chen, J Li, Y Sun, C Wu, Y Yang, C Jiang, W Li* and L Xue*(2016) dFoxO promotes Wingless signaling in Drosophila. Scientific Reports6:22348.
15.X Ma, Y Chen, S Zhang, W Xu, Y Shao, Y Yang, W Li, M Li*and L Xue* (2016) Rho1–Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.Oncogene35, 846–855.
16.X Ma, Y Chen, W Xu, N Wu, M Li, Y Cao, S Wu, Q Li and L Xue* (2015) Impaired Hippo signaling promotes Rho1-JNK-dependent growth. PNAS112:1065-70.
17.C Wu, Y Chen, F Wang, C Chen, S Zhang, C Li, W Li, S Wu and L Xue* (2015) Pelle Modulates dFoxO-Mediated Cell Death in Drosophila. PLOS Genetics11:e1005589.
18.F Peng, Y Zhao, X Huang, C Chen, L Sun, L Zhuang and L Xue* (2015) Loss of Polo ameliorates APP-induced Alzheimer’s disease-like symptoms in Drosophila. Scientific Reports5:16816/DOI: 10.1038/srep16816.
19.Y Hu, Y Han, Y Shao, X Wang, Y Ma, E Ling and L Xue* (2015) Gr33a Modulates Drosophila Male Courtship Preference. Scientific Reports5:7777
20.X Ma, W Xu, D Zhang, Y Yang, W Li and L Xue*(2015) Wallenda regulates JNK-mediated cell death in Drosophila. Cell Death Disease6, e1737.
21.S Zhang, C Chen, C Wu, Y Yang, W Li and L Xue*(2015) The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila. Cell Death Disease6, e1713.
22.C Wu, C Chen, J Dai, F Zhang, Y Chen, W Li, J Pastor-Pareja and L Xue*(2015) Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila. Open Biology5: 140171
23.L Li, P Li and L Xue* (2015) The RED domain of Paired is specifically required for Drosophila accessory gland maturation. Open Biology5: 140179
24.J Huang and L Xue*(2015) Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMed Research International: Article ID 623573.
25.X Wang, Y Ma, Y Zhao, Y Chen, Y Hu, C Chen, Y Shao and L Xue* (2015) APLP1 promotes dFoxO-dependent cell death in Drosophila. Apoptosis 20, 778-786.
26.X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014）FoxO Mediates APP-Induced AICD-Dependent Cell Death. Cell Death Disease5, e1233.
27.Y Hu, Y Han, X Wang and L Xue* (2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging35, 2174-2178.
28.X Ma, W Li, H Yu, Y Yang, M Li, L Xue*and T Xu* (2014) Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Diff.21, 407-415.
29.H Yang, W Li, H Yu, R Yuan, Y Yang, K Pung, P Li and L Xue*(2013) Physiological Effects of L-Theanine on Drosophila melanogaster. Molecules18,13175-13187.
30.X Ma, Y Shao, H Zheng, M Li, W Li* and L Xue* (2013) Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Disease 4, e864.
31.X Ma, L Yang, Y Yang, M Li, W Li* and L Xue* (2013) dUev1aModulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Dev. Biol.380, 211-221.
32.W Li, S Li, S Zhang and L Xue* (2012) A Broad Expression Profile of the GMR-GAL4 driver in Drosophila melanogaster. Genet. Mol. Res.11, 1997-2002.
33.X Ma, J Huang, YYang, W Li and L Xue* (2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Research22, 425-431.
