蔣序林(Xulin Jiang)，出生於1967年3月，博士、教授，武漢大學化學學院生物醫用高分子材料教育部重點實驗室博士生導師。
基本介紹
- 中文名：蔣序林
- 國籍：中國
- 民族：漢族
- 出生日期：1967年3月
- 職業：教師
- 畢業院校：成都科技大學
- 學位/學歷：博士
- 專業方向： 高分子化學與物理、生物醫用高分子、高分子分離與表征
- 職務：教授
基本情況,學習工作簡歷,主授課程,主要研究領域與項目,研究領域,科研項目：,學術論文,
基本情況
學習工作簡歷
1985,9-1989,7 成都科技大學優秀生試點班, 高分子材料系, 學士
1989,9-1992,6 成都科技大學高分子材料工程國家重點實驗室，碩士 (導師：徐僖院士，鄭邦乾教授)
1992,7-2000,9 上海交通大學化學化工學院高分子材料系 助教，講師，副教授
2000,9-2004,5 荷蘭阿姆斯特丹大學高分子分析組, 博士 (導師: Prof. Dr. P. J. Schoenmakers)
2004,6-2006,10 荷蘭烏特勒支大學藥學院藥劑系博士後 (導師: Prof. Dr. W.E. Hennink)
2006,11-至今：武漢大學化學學院生物醫用高分子材料教育部重點實驗室（教授，博導）
主授課程
有機結構分析、功能高分子
主要研究領域與項目
研究領域
1. 可控高分子的合成、改性及共軛技術的研究
2. 基因藥物用新型可降解高分子載體的研究
3. 熱敏性可降解高分子藥物靶向載體的研究（抗腫瘤藥物、多肽蛋白質藥物）
4. HPLC分離與表征功能高分子
科研項目：
1 國家自然科學基金項目21174109 長循環-靶向-逃逸-示蹤-多功能高分子膠束藥物載體及其細胞相互作用的研究（資助時間2012.01-2015.12, 60萬）
2 國家自然科學基金項目21074100 穩定化熱敏腫瘤靶向高分子納米膠束載藥系統的研究（資助時間 2011.01-2013.12, 37萬)
3 國家自然科學基金項目20774068 點擊化學合成降解梳形聚合物及用於基因載體的研究（資助時間 2008.01-2010.12, 29萬）
4 20744002 HPLC用於新型生物醫用高分子的分離與表征
5 博士點基金新教師項目 點擊化學可控合成基因載體用新型可降解星形陽離子高分子
學術論文
1. J. Liu, Y.-L. Xu, Q.-Z. Yang, C. Li, W. E. Hennink, R.-X. Zhuo,X.-L. Jiang*, Reduction Biodegradable Brushed PDMAEMA Derivatives Synthesized by ATRP and Click Chemistry for Gene Delivery, Acta Biomater, 2013, 9, 7758-7766.
2. Y.-Y. Ma, X.-L. Jiang*, R.-X. Zhuo, Biodegradable and Thermosensitive Micelles of Amphiphilic Polyaspartamide Derivatives Containing Aromatic Groups for Drug Delivery, J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3917-3924.
3. X.-G. Huang, X.-L. Jiang*, Q.-Z. Yang, Y.-F. Chu, G.-Y. Zhang, B. Yang, R.-X. Zhuo, Triple-Stimuli (pH/Thermo/Reduction) Sensitive Copolymers for Intracellular Drug Delivery, J. Mater. Chem. B, 2013,1, 1860-1868.
4. G.-Y. Zhang, J. Liu, Q.-Z. Yang, R.-X. Zhuo, X.-L. Jiang*, Disulfide-Containing Brushed Polyethylenimine Derivative Synthesized by Click Chemistry for Nonviral Gene Delivery, Bioconjugate Chem. 2012, 23, 1290-1299.
5. X.-L. Jiang*, L.-H. Li, J. Liu, W. E. Hennink, R.-X. Zhuo，Facile Fabrication of Thermo-Responsive and Reduction-Sensitive Polymeric Micelles for Anticancer Drug Delivery, Macromol. Biosci. 2012, 12, 703-711.
6. X.-G. Huang, X.-L. Jiang*, R.-X. Zhuo, Microwave-assisted solid-phase synthesis of pH-responsive polyaspartamide derivatives, Carbohydrate Polymers, 2012, 89,788-794
7. X.-L. Jiang*, J. Liu, L. Xu, R.-X. Zhuo，Disulfide-Containing Hyperbranched Polyethylenimine Derivative via Click Chemistry for Nonviral Gene Delivery，Macromol. Chem.Phys., 2011, 212, 64-71.
8. X.-L. Jiang*, Y.-F. Chu, J. Liu, G.-Y. Zhang and R.-X. Zhuo，Aqueous SEC Analysis of Cationic Polymers ass Gene Carriers，Chinese Journal of Polymer Science 2011, 29(4), 421-426
9. 蔣序林, 劉佳, 張光彥, 楊奇志, 卓仁禧, 可還原降解的梳型高分子基因載體及其製備方法, 中國發明專利, ZL201110020684.8
10. X.-L. Jiang*, L.-H. Li, J. Liu, R.-X. Zhuo, Reduction-responsive polymeric micelles for anticancer drug delivery, J. Control. Release, 2011, 152 S1, e36-e37.
11. J. Liu, L. Xu,X.-L. Jiang*, W. E. Hennink, X.-M. Wang, R.-X. Zhuo, Disulfide-containing cross-linked PEI derivative synthesized by click chemistry for non-viral gene delivery, J. Control. Release, 2011, 152, S1, e157-e159
12. Y. Chen, L.-Z. Zhou, Y. Pang, W. Huang, F. Qiu, X.-L. Jiang, X.-Y. Zhu,D.-Y. Yan, and Q. Chen, Photoluminescent Hyperbranched Poly(amido amine) Containing β-Cyclodextrin as a Nonviral Gene Delivery, Bioconjugate Chem. 2011, 22, 1162-1170.
13. J. Liu, X.-L. Jiang*, L. Xu, X.-M. Wang, W. E. Hennink, R.-X. Zhuo，Novel Reductive Crosslinked Polyethylenimine Derivative by Click Chemistry for Nonviral Gene Delivery, Bioconjugate Chem. 2010, 21(10), 1827-1835.
14. 蔣序林, 劉佳, 徐麗, 卓仁禧, 還原敏感性聚乙烯亞胺衍生物及其製備方法和套用，中國發明專利， ZL201010154628.9
15. L.-H. Li,X.-L. Jiang*, R.-X. Zhuo, Synthesis and Characterization of Thermoresponsive Polymers Containing Reduction-Sensitive Disulfide Linkage, J Polym Sci Part A: Polym Chem 2009, 47: 5989-5997.
蔣序林, 李麗花, 卓仁禧, 還原敏感性的兩親性嵌段共聚物及其膠束 , 中國發明專利, ZL200910273157.0
16. X.-L. Jiang, M. C. Lok, C. F. van Nostrum, W. E. Hennink, Degradable-Brushed pHEMA-pDMAEMA
Synthesized via ATRP and Click Chemistry for Gene Delivery, Bioconjugate Chem., 2007, 18(6), 2077-2084.
17. D. F. Vlugt-Wensink, X.-L. Jiang, G. Schotman, G. Kruijtzer, A. Vredenberg, J.T. Chung, Z. Zhang, C. Versluis, D. Ramos, R. Verrijk, W. Jiskoot, D. J. A. Crommelin, W. E. Hennink, “In Vitro Degradation Behavior of Microspheres Based on Cross-Linked Dextran”, Biomacromolecules,2006,7(11), 2983-2990.
18.X.-L. Jiang, A. van der Horst, M.J. van Steenbergen, N. Akeroyd, C.F. van Nostrum, P.J. Schoenmakers and W.E. Hennink, “Aqueous size-exclusion chromatography of cationic polymers for gene delivery”,J. Controlled Release, 2006, 116(2), e69-e71.
19. C. Hiemstra, Z.Y. Zhong, X.-L. Jiang, W.E. Hennink, P.J. Dijkstra and J. Feijen, “PEG–PLLA and PEG–PDLA multiblock copolymers: Synthesis and in situ hydrogel formation by stereocomplexation”,J. Controlled Release, 2006, 116(2), e17-e19.
20. C. Lin, Z.-Y. Zhong, M. C. Lok, X.-L. Jiang, W. E. Hennink, J. F. and Johan F.J. Engbersen，“Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: Synthesis and in vitro gene transfer properties”,J. Controlled Release, 2006, 116(2), 130-137.
21. X.-L. Jiang, A. van der Horst, M. J. van Steenbergen, C. F. van Nostrum, P. J. Schoenmakers, W. E. Hennink, “Molar-Mass Characterization of Cationic Polymers for Gene Delivery by Aqueous SEC with Online Multi-Angle Light Scattering Detection”, Pharmaceut. Res., 2006，23(3), 595-603.
22. X.-L. Jiang, A. van der Horst, V. Lima, P. J. Schoenmakers, “Comprehesive Two-Dimentional Liquid Chromatography for the Characterization of Functional Acrylate Polymers”, J. Chromatogr. A, 2005, 1076(1-2), 51-61.
23. V. Lima V, X.-L. Jiang, J. Brokken-Zijp, P. J. Schoenmakers, B. Klumperman, R. Van Der Linde, “Synthesis and characterization of telechelic polymethacrylates via RAFT polymerization”m, J. Polym. Sci.: Polym. Chem., 2005, 43(5), 959-973.
24. X.-L. Jiang,P. J. Schoenmakers, X.-W. Lou, V. Lima, J. L. J. van Dongen, and J. Brokken-Zijp, “Separation and Characterization of Functional Poly(n-Butyl Acrylate) by Critical Liquid Chromatography”, J. Chromatogr. A, 2004, 1055(1-2), 123-133.
25. H.-Q. Zhang,X.-L. Jiang, R. van der Linde, “Synthesis of Hydroxyl End-Capped Telechelic Polymers with Poly(Methyl Methacrylate)-block-Poly(n-Butyl Acrylate) Backbones via Atom-Transfer Radical Polymerisation”, Polymer, 2004, 45 (5), 1445-1466.
26. X.-L. Jiang, P. J. Schoenmakers, J. L.M van Dongen, X.W. Lou, V. Lima, J. Brokken-Zijp, “Mass-Spectrometric Characterization of Functional Poly(Methyl Methacrylate) in Combination with Critical Liquid Chromatography”, Anal. Chem., 2003, 75(20), 5517-5524.
