蒲雪梅, 女，理學博士，四川大學化學學院教授，博士生導師，四川省學術和技術帶頭人後備人選。
基本介紹
- 中文名：蒲雪梅
- 畢業院校：四川大學
- 學位/學歷：理學博士
個人簡介,研究方向,主要業績,承擔項目,主要著 作,
個人簡介
蒲雪梅, 女，理學博士，四川大蘭閥學教授，博士生導師，四川省學術和技術帶頭人後備人選。1987-1991年在四川理工學院獲得工業分析學士學位，1991-1995年在中國天府可樂集團公司工作，1995-1998年獲得四川大學分析化學專業碩士學位，2000-2004年獲得四川大學物舟朽慨理化學專業博士學位，2002-2003年在香港浸會大學作訪問學者。1998年至今在四川大學化學學院工作。
研究方向
蛋白質結構與功能的理論研究及計算機輔助藥物設計
光電材料功能化合物的分子設計與結構性能的研究
高能物質結構性能的研究及波譜解析
主要業績
科研工駝鑽轎作：利用多學科交叉技術在蛋白質和功能材料領域的複雜體系和複雜數據的快速準確解析方面開展了一系列的研究工作，所建立的計算和實驗相結合的一些計算機輔助分析和設計系統已在相關單位和研究所得到實際套用和推廣。近五年作為負責人主持了三項國家自然科學基金和兩項四川省科技項目，發表了五十餘篇SCI論文，獲得一項國家計算機軟體著作權，並申請了兩項專利，第十一批四川省學術和技術帶頭人後備人選。
教學獄祖頸工作：承擔本科生 "分析化學"和"儀器分析"的教學任務，是四川省精品課程《大學化學實驗》和《分析化學》的第一主講教師，主持了七項校級教改項目，並參加了多項省部級教改項目。近五年發表教改論文十餘篇，主編出版了兩本教材(四川省十二五規劃教材和四川大學優秀教材)，獲得了四川省教學成果三等獎和四川大學校級教學成果一等獎各一項，榮獲四川大學優秀教師，唐立新教學名師，青年骨幹教師的稱號。
承擔項目
1. 2013-2016，一些重要A族G蛋白偶聯受體激活機制采汗射符及其配體影響作用的理論研究，國家自然科學基金，項目負責人
2. 2013-2015，基於PBX 炸藥波譜結構解析的化學計量學方法研甩廈殼煉究，國家自然科學基金，項目負責人
3. 2010-2012. 水量調控有機相絲氨酸蛋白酶催化活性分子機制的理論研究，國家自然科學基金，項目負責人
4. 2015-2016，炸藥快速識別和測定的新方法及計算機專家智慧型系統的構建，四川省科技支撐項目，項目負責人
5. 2011-2013. 非水相蛋白酶在手性藥物拆分中催化性能的分子機制研究，四川省國際合作項目，項目負責人
主要著 作
1. 陳華，蒲雪梅主編，大學化學實驗，化學工業出版社，2010
2. 李夢龍，蒲雪梅主編，分析化學數據速查手冊，化擊鞏妹學工業出版社，2009
代表性成果 （獲獎成果、專著、論文、專利）
1. Liyun Zhang, Xiuchan Xiao, Yuan Yuan, Yanzhi Guo, Menglong Li, Xuemei Pu,* Probing Immobilization Mechanism of alpha-chymotrypsin onto Carbon Nanotube in Organic Media by Molecular Dynamics Simulation, Sci. Rep., 2015, 5: 9297
2. Xiuchan Xiao, Xiaojun Zeng, Yuan Yuan, Nan Gao, Yanzhi Guo, Xuemei Pu*, Menglong Li*, Understanding the conformation transition in the activation pathway of β2 adrenergic Receptor via Target Molecular Dynamics Simulation. Phys. Chem. Chem. Phys. 2015, 17, 2512 – 2522
3. Yunqing Chen, Yi Wang, Yuan Yuan, Yan Jiao, Xuemei Pu,* and Zhiyun Lu,* Deactivation Mechanism of a Novel AIE-active Naphthalimide Derivative in More Polar Solutions. Phys. Chem. Chem. Phys., 2015, 17, 1309 – 1316
4. Tao Lu, Yuan Yuan, Xuan He, Menglong Li, Xuemei Pu*, Tao Xu*, Zhining Wen, Simultaneous determination of multicomponent in explosives using ultraviolet spectrophotometry and partial least square method, RSC adv., 2015, 5, 13021 – 13027
5. Jian Hu, Qian Luo, Zhanyuan Zhang, Yan Huang*, Daobin Yang, Xuemei Pu* and Zhiyun Lu*, Self-assembled nanopillar arrays by simple spin coating from blending systems comprising PC61BM and conjugated polymers with special structure, RSC Adv., 2014,4, 24316-24319
6. Yanyan Zhu, Yuan Yuan, Xiuchan Xiao, Liyun Zhang, Yanzhi Guo, Xuemei Pu*, Understanding effects of D130N mutation on constitutive activation of β2 adrenergic receptor and drug binding via Molecular Dynamics Simulation, J. Mol. Model, 2014, 20, 2491
7. Dongbing Zhao, Gaocan Li, Di Wu, Xurong Qin, Patrik Neuhaus, Yangyang Cheng, Shuaijun Yang, Zhiyun Lu, Xuemei Pu, Chao Long, and Jingsong You,* Regiospecific N-Heteroarylation of Amidines for Full-Color-Tunable Boron Difluoride Dyes with Mechanochromic Luminescence, Angew. Chem. 2013, 125, 13921 –13925
8. Xue Tian, Lin Jiang, Yuan Yuan, Minqi Wang, Yanzhi Guo, Xiaojun Zeng, Menglong Li, Xuemei Pu*, Effects of water content on the tetrahedral intermediate of chymotrypsin -rifluoromethylketone in polar and non-polar media: observations from molecular dynamics simulation, J. Mol. Model, 2013, 19, 2025-2038
9. Yanyan Meng, Yuan Yuan, Yanyan Zhu, Yanzhi Guo, Menglong Li, Zhimeng Wang, Xuemei Pu,* Lin Jiang,* Effects of organic solvents and substrate binding on trypsin in acetonitrile and hexane media, J. Mol. Model, 2013, 19, 3749-3766
10. Wei Yang, Li-yun Zhang, Meng-long Li, Xue-mei Pu*, Nan-rong Zhao*, Effects of Non-specific and Specific Solvation on Adsorption of BPTI on Au Surface: Insight from Molecular Dynamics Simulation, Chinese Journal of Chemical Physics, 2013, 26, 558-568
11. Xiaojiao Yang, Yanzhi Guo*, Jiesi Luo,Xuemei Pu, Menglong Li, Effective Identification of Gram-Negative Bacterial Type III Secreted Effectors Using Position-Specific Residue Conservation Profiles, Plos One, 2013, 8:e84439
12. Lijuan Zhu, Wei Yang, YanYan Meng, Yanzhi Gao, Xuemei Pu*, Menglong Li, Effects of organic solvent and the crystal water on γ-chymotrypsin in acetonitrile media: observations from molecular dynamics simulation and DFT calculation, J. Phys .Chem. B, 2012, 116, 3292-3304
13. Xiuchan Xiao, Ying Tan, Lijuan Zhu, Yanzhi Guo, Zhining Wen, Menglong Li,Xuemei Pu*, Anmin Tian, Effects of the position and manner of hydration on the stability of solvated N-methylacetamides and the strength of binding between N-methylacetamide and water clusters: a computational study, J. Mol. Model, 2012, 138, 1389-1399
14. Ming Li, Hui Zeng, Yanyan Meng, Huiqin Sun, Song Liu, Zhiyun Lu, Yan Huanga, Xuemei Pu*, Fine tuning of emission color of iridium(III) complexes from yellow to red via substituent effect on 2-phenylbenzothiazole ligands: synthesis, photophysical,electrochemical and DFT study, Dalton Trans., 2011, 40, 7153-7164
15. Ying Tan, Lijuan Zhu, Xiuchan Xiao， Yanzhi Guo, Menglong Li, Anmin Tian, Xuemei Pu,*, A Comparative study of Meta/Para Substitution effects on the Hydrogen-Bonded Complex of Aniline-H2O：Observations from Computation, J.Theor.Comput. Chem.,2011, 10, 567-579
2. Xiuchan Xiao, Xiaojun Zeng, Yuan Yuan, Nan Gao, Yanzhi Guo, Xuemei Pu*, Menglong Li*, Understanding the conformation transition in the activation pathway of β2 adrenergic Receptor via Target Molecular Dynamics Simulation. Phys. Chem. Chem. Phys. 2015, 17, 2512 – 2522
3. Yunqing Chen, Yi Wang, Yuan Yuan, Yan Jiao, Xuemei Pu,* and Zhiyun Lu,* Deactivation Mechanism of a Novel AIE-active Naphthalimide Derivative in More Polar Solutions. Phys. Chem. Chem. Phys., 2015, 17, 1309 – 1316
4. Tao Lu, Yuan Yuan, Xuan He, Menglong Li, Xuemei Pu*, Tao Xu*, Zhining Wen, Simultaneous determination of multicomponent in explosives using ultraviolet spectrophotometry and partial least square method, RSC adv., 2015, 5, 13021 – 13027
5. Jian Hu, Qian Luo, Zhanyuan Zhang, Yan Huang*, Daobin Yang, Xuemei Pu* and Zhiyun Lu*, Self-assembled nanopillar arrays by simple spin coating from blending systems comprising PC61BM and conjugated polymers with special structure, RSC Adv., 2014,4, 24316-24319
6. Yanyan Zhu, Yuan Yuan, Xiuchan Xiao, Liyun Zhang, Yanzhi Guo, Xuemei Pu*, Understanding effects of D130N mutation on constitutive activation of β2 adrenergic receptor and drug binding via Molecular Dynamics Simulation, J. Mol. Model, 2014, 20, 2491
7. Dongbing Zhao, Gaocan Li, Di Wu, Xurong Qin, Patrik Neuhaus, Yangyang Cheng, Shuaijun Yang, Zhiyun Lu, Xuemei Pu, Chao Long, and Jingsong You,* Regiospecific N-Heteroarylation of Amidines for Full-Color-Tunable Boron Difluoride Dyes with Mechanochromic Luminescence, Angew. Chem. 2013, 125, 13921 –13925
8. Xue Tian, Lin Jiang, Yuan Yuan, Minqi Wang, Yanzhi Guo, Xiaojun Zeng, Menglong Li, Xuemei Pu*, Effects of water content on the tetrahedral intermediate of chymotrypsin -rifluoromethylketone in polar and non-polar media: observations from molecular dynamics simulation, J. Mol. Model, 2013, 19, 2025-2038
9. Yanyan Meng, Yuan Yuan, Yanyan Zhu, Yanzhi Guo, Menglong Li, Zhimeng Wang, Xuemei Pu,* Lin Jiang,* Effects of organic solvents and substrate binding on trypsin in acetonitrile and hexane media, J. Mol. Model, 2013, 19, 3749-3766
10. Wei Yang, Li-yun Zhang, Meng-long Li, Xue-mei Pu*, Nan-rong Zhao*, Effects of Non-specific and Specific Solvation on Adsorption of BPTI on Au Surface: Insight from Molecular Dynamics Simulation, Chinese Journal of Chemical Physics, 2013, 26, 558-568
11. Xiaojiao Yang, Yanzhi Guo*, Jiesi Luo,Xuemei Pu, Menglong Li, Effective Identification of Gram-Negative Bacterial Type III Secreted Effectors Using Position-Specific Residue Conservation Profiles, Plos One, 2013, 8:e84439
12. Lijuan Zhu, Wei Yang, YanYan Meng, Yanzhi Gao, Xuemei Pu*, Menglong Li, Effects of organic solvent and the crystal water on γ-chymotrypsin in acetonitrile media: observations from molecular dynamics simulation and DFT calculation, J. Phys .Chem. B, 2012, 116, 3292-3304
13. Xiuchan Xiao, Ying Tan, Lijuan Zhu, Yanzhi Guo, Zhining Wen, Menglong Li,Xuemei Pu*, Anmin Tian, Effects of the position and manner of hydration on the stability of solvated N-methylacetamides and the strength of binding between N-methylacetamide and water clusters: a computational study, J. Mol. Model, 2012, 138, 1389-1399
14. Ming Li, Hui Zeng, Yanyan Meng, Huiqin Sun, Song Liu, Zhiyun Lu, Yan Huanga, Xuemei Pu*, Fine tuning of emission color of iridium(III) complexes from yellow to red via substituent effect on 2-phenylbenzothiazole ligands: synthesis, photophysical,electrochemical and DFT study, Dalton Trans., 2011, 40, 7153-7164
15. Ying Tan, Lijuan Zhu, Xiuchan Xiao， Yanzhi Guo, Menglong Li, Anmin Tian, Xuemei Pu,*, A Comparative study of Meta/Para Substitution effects on the Hydrogen-Bonded Complex of Aniline-H2O：Observations from Computation, J.Theor.Comput. Chem.,2011, 10, 567-579
