胡凱，南京鼓樓醫院眼科行政副主任，主任醫師，教授，南京大學醫學院博士生導師，中華醫學會江蘇省眼科學分會委員，中國醫師協會江蘇眼科分會基礎研究與臨床轉化學組副組長，美國視覺與眼科學研究協會會員，擅長白內障、斜弱視、角膜眼表及視網膜疾病的診治及手術。
基本介紹
著作譯作,科研成果,擅長領域,出診時間,科研項目,
著作譯作
Shen W, Wang C, Jiang J, He Y, Liang Q, Hu K*. Targeted delivery of herpes simplex virus glycoprotein D to CD169+ macrophages using ganglioside liposomes alleviates herpes simplex keratitis in mice. Journal of Controlled Release.2023; 365:208-218.
Liang Q, Guo R, Tsao JR, He Y, Wang C, Jiang J, Zhang D, Chen T, Yue T, Hu K*. Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway. Int Immunopharmacol, 2023, 121:110397.
Guo R, Liang Q, He Y, Wang C, Jiang J, Chen T, Zhang D, Hu K*. Mesenchymal stromal cells-derived extracellular vesicles regulate dendritic cell functions in dry eye disease. Cells, 2023, 12: 33.
Guo R, Jiang J, Zhang Y, Liang Q, Chen T, Hu K*. Evaluation of corneal dendritic cell density and subbasal nerve density in contact lens wearers using IVCM: A systematic review and meta-analysis. Front Med (Lausanne), 2023, 10:1149803.
Yun He, Chenchen Wang, Qi Liang, Rongjie Guo, Jiaxuan Jiang, Wenhao Shen, Kai Hu*. PKHB1 Peptide Induces Antiviral Effects Through Induction of Immunogenic Cell Death in Herpes Simplex Keratitis. Frontiers in Pharmacology. 2022, 13: 1048978
Chenchen Wang, Qi Liang, Dong Sun, Yun He, Jiaxuan Jiang, Rongjie Guo, Tejsu Malla, Pedram Hamrah, Xun Liu*, Zhenping Huang*, Kai Hu*. Nectin-1 and Non-muscle Myosin Heavy Chain-ⅡB: Major Mediators of Herpes Simplex Virus-1 Entry Into Corneal Nerves. Frontiers in Microbiology. 2022, 13:830699.
Qin Q, Hu K, He Z, Chen F, Zhang W, Liu Y, Xie Z. Resolvin D1 protects against Aspergillus fumigatus keratitis in diabetes by blocking the MAPK-NF-κB pathway. Exp Eye Res, 2022, 216:108941.
Wenting Cheng, Lei Zhou, Kai Hu(共同第一), Dehua Kong, Wei Huang, Chuanjun Xu, Hao Li, Jinlong Li. Enzyme-Initiated Assembly of an Extracellular-Like Two-Dimensional Nanonetwork as a Method to Detect Procancerous Activity. ACS Sens. 2021, 6(5):1815-1822.
Arsia Jamali, Kai Hu（共同第一）,Victor G. Sendra, Tomas Blanco, Maria J. Lopez, Gustavo Ortiz, Yureeda Qazi,Lixin Zheng, Aslihan Turhan, Deshea L. Harris, Pedram Hamrah*. Characterizationof Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role inHerpes Simplex Keratitis. Cell Reports , 2020, 32: 108099.
Jinlong li, Kai Hu（共同第一）,Yongchen Zhang, Zhaoli Zhang, Yongfeng Yang. A Highly Sensitive ElectrochemicalSensor Based on DNA Y-Junction for Detection of Estrogen Receptor Using TargetProtein Protection Strategy. AnalyticaChimica Acta, 2019, 1086:110-115.
Jinlong Li, Kai Hu（共同第一）, ZhaoliZhang, Xiaoyan Teng, Xia Zhang. Click DNA cycling in combination with goldnanoparticles loaded with quadruplex DNA motifs enable sensitiveelectrochemical quantitation of the tuberculosis-associated biomarker CFP-10 insputum. Microchimica Acta, 2019, 186(9):662.
Jinlong Li*, Jiehua Ma, Yongchen Zhang, ZhaoliZhang, Kai Hu* . Highly sensitive electrochemical analysis oftelomerase activity based on magnetic bead separation and exonuclease III-aidedtarget recycling amplification. Bioelectrochemistry.2019, 130:107341.
Kai Hu*, Jinlong Li, Xianwen Yuan. MicroRNA-411plays a protective role in Diabetic Retinopathy through Targeted RegulatingRobo4. European Review for Medical andPharmacological Sciences. 2019, 23: 9171-9179.
Jinlong Li*, Kai Hu, Yongchen Zhang, Zhaoli Zhang, Hao Li. Highlysensitive detection of Smoothened based on the drug binding and rolling cycleamplification. Analytical andBioanalytical Chemistry. 2019, 411（22）:5721-5727.
Tejsu Malla, Jing Jiang, KaiHu*. Clinicaloutcome of combined conjunctival autograft transplantation and amniotic membranetransplantation in pterygium surgery. InternationalJournal of Ophthalmology. 2018, 11(03) :395-400.
Ru Tang, Yujia Zhai, Lili Dong, Tejsu Malla, Kai Hu*. Immunization with dendriticcell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplexvirus keratitis. Immunotherapy. 2018,10(03) :189-200.
Lili Dong, Ru Tang,Yujia Zhai, Tejsu Malla,KaiHu*. DNA vaccineexpressing herpes simplex virus 1 glycoprotein C and D protects mice againstherpes simplex keratitis. InternationalJournal of Ophthalmology. 2017, 10(11)：1633-1639.
KaiHu*, Tejsu Malla, Yujia Zhai, Lili Dong, Ru Tang. Topical Administration Is APromising Inoculating Route versus Intramuscular Inoculation for The Nanoparticle-CarriedDNA Vaccine to Prevent Corneal Infections. OphthalmicResearch. 2016, 55(2):99-110.
Kai Hu, Deshea L.Harris, Takefumi Yamaguchi, Ulrich von Andrian, Pedram Hamrah*. A Dual Role forCorneal Dendritic Cells in Herpes Simplex Keratitis: Local Suppression ofCorneal Damage and Promotion of Systemic Viral Dissemination. Plos one. 2015; 10(9):e0137123.
科研成果
共發表SCI論文20餘篇，包括 Cell Reports、 Analytica Chimica Acta、Bioelectrochemistry、Vaccine、Immunotherapy等著名期刊。
已獲授權國家發明專利2項（201510362141.2；201510362541.3）。
擅長領域
1994年開始從事眼科專業，精通眼科常見病、多發病的診治，在疑難複雜疾病的診療上有較豐富的經驗。尤其擅長白內障、斜弱視、角膜眼表及視網膜疾病的診治及手術。
出診時間
周一上午（南京鼓樓醫院江北院區眼科）
周二、周三上午（南京鼓樓醫院眼科）
科研項目
國家自然科學基金（2019）
江蘇省自然科學基金（2020）
江蘇省自然科學基金（2014）
南京市衛生健康委員會重點項目（2020）
