羅開珺，女，博士，雲南大學教授。
基本介紹
- 中文名：羅開珺
- 國籍：中國
- 畢業院校：中山大學
- 學位/學歷：博士
- 專業方向：細胞生物學
人物經歷,研究方向,教授課程,學術論文,
人物經歷
2018年評為東陸學者
2017年晉升為三級教授
2016年榮獲伍達觀優秀教師獎先進獎
2010年雲南省引進高層次人才
2010/08 – 至今，雲南大學，生命科學學院，教授
2019/01 - 2020/01, 美國德州大學，聖安東尼奧健康醫學中心，訪問學者
2013/03 - 2013/06, 法國馬賽大學，法國國家免疫研究中心，高級訪問學者
2006/10 - 2009/07, 美國克萊蒙森大學，昆蟲系，博士後
2001/09 - 2006/06，中山大學，生命科學學院，碩博連讀
2003/07 - 2006/07, 雲南省農業科學院，農業資源與環境研究所，副研究員
1998/07 - 2003/06, 雲南省農業科學院，植物保護研究所，助理研究員
1992/07 - 1998/06, 雲南省農業科學院，植物保護研究所，實習研究員
1988/09 - 1992/06, 雲南師範大學，生物系，理學學士
研究方向
細胞表面的Innexin_hemichannel是一個信號傳遞的通道，維繫細胞的完整性，介導細胞內在的先天免疫反應。
研究使用的研究體系：繭蜂/繭蜂病毒/寄主
Microplitis bicoloratus / M. bicoloratus bracovirus (MbBV) / Spodoptera litura
研究圍繞3個具體的科學問題開展：
(1)Innexin_hemichannel在細胞內在的先天免疫反應中傳遞凋亡信號；
(2)MbBV在免疫抑制中調控細胞的凋亡信號通路；
(3)MbBV調控Innexin_hemichannel，破壞細胞的完整性，形成凋亡小體。
教授課程
本科生課程：《Lehninger Principles of Biochemistry》，《Principles of Virology》 (校級雙語課)， 《食品安全縱橫談》；研究生課程：《Molecular Genetics》。
學術論文
Ji-Hui Cui, Shu-Mei Dong, Chang-Xu Chen, Wei Xiao, Qiu-Cheng Cai, Li-Dan Zhang, Hao-Juan He, Wei Zhang, Xue-Wen Zhang, Tian Liu, Lei Ding, Yang Yang, Jian-Hua Lai, Qi-Shun Zhu, , and Kai-Jun Luo. (2019) Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura. Dev. Comp. Immunol.95, 101-107.
Hang-YuTian, Yan Hu , Pan Zhang, , Wen-Xi Xing, Cui-Xian Xu, Dan Yu, Yang Yang, Kai-Jun Luo, and Ming Li. (2019) Spodoptera litura cyclophilin A is required for Microplitis bicoloratus bracovirus-induced apoptosis during insect cellular immune response. Arch. Insect Biochem. Physiol. arch.21534
Li-Dan Zhang#, Qiu-Cheng Cai#, Ji-Hui Cui #, Wei Zhang #, Shu-Mei Dong #, Wei Xiao#, Jiang Li, Tian-Chao Kou, Xue-Wen Zhang, Hao-Juan He, Lei Ding, Yang Yang, Jian-Hua Lai, Ming Li, Qi-Shun Zhu, Kai-Jun Luo*. (2019)A secreted-Cu/Zn superoxide dismutase from Microplitis bicoloratus reduces reactive oxygen species triggered by symbiotic bracovirus. Developmental & Comparative Immunology， 92,129-139，
Ji-Hui Cui #, Yan-Bin Chen #, Ming Li #, Qiu-Cheng Cai, Li-Dan Zhang, Zi-Yun Lu, Jian-Cheng Li, Qi-Shun Zhu, Gang Ji *, Kai-Jun Luo*. (2018) Cryo-EM structure reveals cylindrical nucleocapsids from two polydnaviruses. Archives of Virology, DOI: 10.1007/s00705-018-3958-8.
Wei Zhang #, Meng-Wei Liu #, Ming Li#, Wei Xiao #, Xue-Wen Zhang Hao-Juan He, Yan-Bin Chen, Lei Ding, Kai-Jun Luo*. (2018) Unexpected link between insect innexins and apoptosis of HeLa cells. Arch. Insect Biochem. Physiol., e21473.
Shu-Mei Dong, Ji-Hui Cui, Wei Zhang, Xue-Wen Zhang, Tian-Chao Kou, Qiu-Chen Cai, Sha Xu, Dong-Shuai Yu, Lei Ding, Jian-Hua Lai, Ming Li, Kai-Jun Luo*. (2017). Inhibition of translation initiation factor eIF4A is required for apoptosis mediated by Microplitis bicoloratus bracovirus. Arch. Insect Biochem. Physiol. e21423,
Tian-Chao Kou#, Yue-Tong Liu#, Ming Li #, Yang Yang#, Wei Zhang, Ji-Hui Cui, Xue-Wen Zhang, Shu-Mei Dong, Sha Xu, Shan You, Dong-Shuai Yu, Zun-Yu Pang, Kai-Jun Luo*. (2017). Identification of β-chain of FoF1-ATPase in apoptotic cell population induced by Microplitis bicoloratus bracovirua and its role in the development of Spodoptera litura. Arch. Insect Biochem. Physiol. 95, e21389
Dong-Shuai Yu#, Ya-Bin Chen#, Ming Li#, Ming-Jun Yang, Yang Yang, Jian-Sheng Hu,Kai-Jun Luo*. (2016). A polydnaviral genome of Microplitis bicoloratus bracovirus and molecular interactions between the host and virus involved in NF-κB signaling. Arch Virol 161, 3095-3125.
Ya-Bin Chen#, Wei Xiao#, Ming Li#, Yan Zhang, Yang Yang, Jian-Sheng Hu, Kai-Jun Luo*. (2016). N-terminally elongated SpliInx2 and SpliInx3 reduce baculovirus-triggered apoptosis via hemichannel closure. Arch Insect Biochem Physiol 92, 24-37.
Lin-E Guo#, Jun-Feng Zhang#, Xin-Yi Liu, Li-Mei Zhang, Hong-Li Zhang, Jian-Hua Chen, Xiao-Guang Xie, Ying Zhou*, Kai-Jun Luo*, Ju-Yong Yoon*. (2015) Phosphate ion targeted colorimetric and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell. Anal Chem 87, 1196-1201.
Zunyu Pang#，Ming Li#，Dongshuai Yu#，Yan Zhang，Xinyi Liu，Xinglai Ji，Yang Yang，Jiansheng Hu，Kaijun Luo*. (2015). Two innexins of Spodoptera litura influences hemichannel and gap junction functions in cellular immune responses，Arch. Insect Biochem. Physiol90, 43-57.
Ming Li#，Zunyu Pang#，Wei Xiao#，Xinyi Liu，Yan Zhang，Minjun Yang，Yang Yang，Jiansheng Hu，Kaijun Luo*. (2014). A Transcriptome analysis Suggests apoptosis-related signaling pathways in hemocytes of Spodoptera litura after parasitization by Microplitis bicoloratus，PLoS ONE 9(10),1-18, e110967.
Tian Liu#，Ming Li#，Yan Zhang，Zunyu Pang，Wei Xiao，Yang Yang，Kaijun Luo*. (2013). A role for Innexin2 and Innexin3 proteins from Spodoptera litura in apoptosis, PLoS ONE, 8(7), e70456.
