王孝偉

王孝偉，女，博士，北京大學藥學院副教授，碩士生導師。

基本介紹

• 中文名：王孝偉
• 畢業院校：北京醫科大學
• 職業：教師
• 專業方向：HIV、HBV病毒作用的靶點、抑制劑的作用機理、構構關係及耐藥問題
• 任職院校：北京大學藥學院
• 職稱：副教授

個人經歷

1988年畢業於北京醫科大學藥學院，同年留校從事有機化學的教學與科研工作。歷任北京大學藥學院助教、講師、副教授。2008年在日本進修。在此期間，參與了多項課題的研究。

研究方向

對HIV、HBV病毒作用的靶點、抑制劑的作用機理、構構關係及耐藥問題進行研究。結合計算機輔助藥物設計、分子模擬等技術，設計多種類型的單靶點及多靶點抑制劑，希望從中找到各項性能更為優良的抗耐藥性的抗病毒先導化合物。

1. 抗HIV-1單靶點及雙靶點抑制劑的設計合成及活性評估，

2. 基於對宿主STING蛋白激動劑的研究，從而尋找抗HIV病毒新思路，

3. 抗HBV病毒藥物的設計合成及活性評估。

學術成果

科研項目

1.國家自然科學基金“環庚駢嘧啶類新型非核苷抗愛滋病藥物的設計合成及活性研究”

2.博士點基金“環更並嘧啶類新型非核苷抗愛滋病藥物的設計合成和活性研究”

3.國家自然科學基金“基於DAPY/S-DABO結構的新型非核苷類逆轉錄酶抑制劑的研究”

4.北京大學綜合性創新藥物研究技術大平台新藥品種“嘧啶酮類抗HIV藥物的臨床前研究”

5.北大方正創新藥物研究基金“抗HIV藥物的研發”

6. 國家重點實驗室自主課題“抗HBV藥物的研究”

代表性論文

Amin Li, Yabo Ouyang, Ziyun Wang, Yuanyuan Cao, Xiangyi Liu, Li Ran, Chao Li, Li Li, Liang Zhang, Kang Qiao, Weisi Xu, Yang Huang, Zhili Zhang, Chao Tian, Zhenming Liu, Shibo Jiang, Yiming Shao, Yansheng Du, Liyang Ma*, Xiaowei Wang*, and Junyi Liu* Novel Pyridinone Derivatives As Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI-Resistant HIV-1 Strains . Journal of Medicinal Chemistry

Xiaowei Wang, Jianfang Zhang, Yang Huang, Ruiping Wang, Liang Zhang, Kang Qiao, Li Li, Chang Liu, Yabo Ouyang, Weisi Xu, Zhili Zhang, Liangren Zhang, Shibo Jiang, Yimin Shao, Liying Ma* and Junyi Liu*. Design, Synthesis and Biological Evaluation of 1-[(2-benzyloxyl/alkoxyl) methyl]-5-halo-6–aryl uracils as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Drug Resistance Profile. Journal of Medicinal Chemistry

Xianling Ning, Ying Guo, Xiaowei Wang, Xiaoyan Ma, Chao Tian, Xueqi Shi, Renzong Zhu, Can Cheng, Yansheng Du, Zhizhong Ma, zhili Zhang,* and Junyi Liu* Design, Synthesis, and Biological Evaluation of (E)？3,4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents.J. Med. Chem.

Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Bernard T. Golding, Roger J. Griff, Yansheng Du, Junyi Liu*. Mechanism-based Design, Synthesis and Biological Studies of N5-Substituted Tetrahydrofolate Analogues as Inhibitors of Cobalamin-dependent Methionine Synthase and Potential Anticancer Agents. Euro. J. Med. Chem.

Yuanyuan Cao, Yu Zhang, Shaotong Wu, Quanzhi Yang, Xuefeng Sun, Jianxiong Zhao, Fen Pei, Ying Guo , Chao Tian , Zhili Zhang , Haining Wang, Liying Ma, Junyi Liu*, Xiaowei Wang*. Synthesis and biological evaluation of pyridinone analogues as Novel potent HIV-1 NNRTIs. Bioorg. Med. Chem.

Yu Zhang, Xuefeng Sun,Ningning Fan,Jianxiong Zhao,Jing Tu,Xiangmei Chen,Junyi Liu* and Xiaowei Wang*. 5-Iodo-2-arylalkyl thio-6-aryl pyrimidin-4(3H)-ones as non-nucleoside anti-HBV agents. Med. Chem. Commun.

Shaotong Wu, Qianqian Yin, Liang Zhao, Ningning Fan, Xiaowan Tang, Jianxiong Zhao, Tao Sheng, Ying Guo, Chao Tian, Zhili Zhang, Weisi Xu, Zhenming Liu, Shibo Jiang, Liying Ma,* Junyi Liu* and Xiaowei Wang*, A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2 (2H)-ones as potency inhibitors of HIV-1 variants. Org. Biomol. Chem.2015

Weisi Xu,Jianxiong Zhao, Jianping Sun, Qianqian Yin,Yan Wang, Yang Jiao, Junyi Liu, ShiboJiang, Yiming Shao, Xiaowei Wang,* and Liying Ma.* The HEPT analogue, 1-((benzyloxy) methyl)-6-(3, 5-dimethylbenzyl)-5- iodopyrimidine-2, 4(1H, 3H)-dione (WPR-6), is active against a broad spectrum of HIV-1 strains of different subtypes with drug-resistance. Antimicrob. Agents Chemother.

Tong-Bo Zhang,Yuan-Yuan Cao, Shao-Tong Wu, Yu Zhang, Ying Guo,Jian-Xiong Zhao, Xue-Feng Sun,Quan-Zhi Yang,Zhi-Li Zhang, Chao Tian, Jun-Yi Liuand Xiao-Wei Wang.An approach to synthesis of pyrimido[b]azepines via Ruthenium-catalyzed ring-closing metathesis. Synthesis

Zhang Tongbo, Wu Shaotong, Cao Yuanyuan, Fu Yuhong, Guo Ying, Zhang Liang, Li Li, Zhou Han, Liu Xiangyi, Li Chao, Tang Xiaowan, Zhang Zhili, Tian Chao, Wang Xiaowei*,Liu Junyi*. Rapid Access to 10-(Cyclohexylimino)-7,9-diazaspiro[4.5]decane-6,8-dione Derivatives for HIV-1 Reverse Transcriptase Inhibition via Ruthenium-Catalyzed Ring-Closing Metathesis . Synthesis.

Liang Zhang, Xiaowan Tang, Yuanyuan Cao, Shaotong Wu, Yu Zhang , Jianxiong Zhao, Ying Guo, Chao Tian , Zhili Zhang , Junyi Liu,* and Xiaowei Wang*. Synthesis and Biological Evaluation of Novel 2-Arylalkylthio-5-iodine-6-substituted- benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor. Molecules

Yang Huang# , Xiaowei Wang#, Xiaoling Yu, Lin Yuan, Ying Guo, Weisi Xu, Tiejun Liu, Junyi Liu, Yiming Shao* and Liying Ma*.Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors. Virology Journal

Gong Li, Xiaowei Wang*, Chao Tian, Tongbo Zhang, Zhili Zhang, Junyi Liu*. Rapid access to multi-substituted pyrimido[4,5-b][1,4] diazepine-2,4,6-trione and pyrimido[4,5-b][1,4]diazepine-2,4-dione as novel and versatile scaffolds for drug discovery. Tetrahedron Letters53

Hua Qin, Jianfang Zhang, Chang Liu, Ying Guo, Siwei Zhang, Zhili Zhang, Xiaowei Wang, Liangren Zhang, Junyi Liu*, Synthesis and biological evaluation of novel 2-arylalkylthio-4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors, Bioorganic Medicinal Chemistry Letter.

Hua Qin, Chang Liu, Ying Guo, Ruiping Wang, Jianfang Zhang, Liying Ma, Zhili Zhang, Xiaowei Wang, Yuxin Cui, Junyi Liu*. Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry

Xiao Lu, Yanli Chen, Ying Guo, Zhenming Liu, Yawei Shi, Yang Xu, Xiaowei Wang and Junyi Liu, The Design and Synthesis of N-1 alkylated 5-aminoaryalkyl substituted 6-methyluracils as potential non-nucleoside HIV-1 RT Inhibitors Bioorganic Medicinal Chemistry

Xiaowei Wang, Qinghua Lou, Ying Guo, Yang Xu, Zhili Zhang and Junyi Liu，The design and synthesis of 9-phenylcyclohepta[d] pyrimidine-2, 4-dione derivatives as potent non- nucleoside inhibitors of HIV reverse transcriptase.Organic & Biomolecular Chemistry

Li Li, Liying Ma, Xiaowei Wang*, Junyi Liu*. New efficient and flexible synthetic route to Emivirine and its analogs.Journal of Heterocyclic Chemistry

謝欣，王孝偉*，劉俊義*。免疫途徑抗HIV信號通路: cGAS-STING研究進展。國際藥學研究雜誌，2014年10月，底41卷，第5期，525頁。

授權專利

1. 王孝偉；張建芳；劉俊義 新型HEPT類HIV-1逆轉錄酶抑制劑的製備及其套用

2. 李阿敏；王孝偉；馬麗英；邵一鳴；劉俊義 新型吡啶酮類HIV-1逆轉錄酶抑制劑的製備及其套用

3. 李立；高宇；王孝偉；劉俊義。 6-苄基-1-乙氧甲基-5-異丙基脲嘧啶(Emivirine)及其類似物的新合成方法。

4. 劉俊義，寧顯玲，張志麗，郭瑩，王孝偉，田超，E-3,4-二羥苯乙烯基磺醯胺磺酸酯類化合物的製備方法及其作為神經保護藥物的套用。

申請專利

1. 劉俊義，張亮，王孝偉，具有抗HBV病毒且兼具抗HIV和HCV病毒作用的新一類非核苷S-DABOs嘧啶酮衍生物的製備和套用

2. 劉俊義，王孝偉，曹源源，張志麗，郭瑩，田超，3,4-二取代-6-苯乙基吡啶酮類HIV-1逆轉錄酶抑制劑的製備及其套用

3. 劉俊義；李超；王孝偉；張志麗；郭瑩；田超，HIV逆轉錄酶/整合酶雙靶點抑制劑6-苯甲醯基取代尿嘧啶類化合物的製備及套用

4. 王孝偉；劉俊義；張羽，2,5,6位取代嘧啶酮衍生物的製備方法及其作為抗B肝病毒藥物的套用

5. 王孝偉，劉俊義，趙劍雄，2-芳基硫代-5-碘代嘧啶酮類衍生物的製備方法及其作為抗B肝病毒藥物的套用

榮譽獎項

我國HIV耐藥檢測技術平台的建立及推廣套用, 中華預防醫學會科學技術獎，二等獎，2013年