牛效迪

牛效迪，男，1978年12月出生，博士，吉林大學食品科學與工程學院教授，博士生導師。主要從事抗食源性病原菌藥物設計、食品安全檢測及分子藥理學等研究，成功建立中藥抗菌成分作用靶標及分子作用機制的分析和驗證平台。主持和參與了多項國家級項目，包括國家自然科學基金面上項目、國家自然基金重點項目及科技部973項目等。目前，在國際期刊上發表SCI論文20餘篇，其中影響因子5以上論文5篇。

基本介紹

• 中文名：牛效迪
• 出生日期：1978年12月
• 畢業院校：中科院長春套用化學研究所
• 學位/學歷：博士
• 專業方向：抗食源性病原菌藥物設計、食品安全檢測等
• 職務：博士生導師

個人經歷

1998～汽戒甩請獄幾蘭2002年在東北師範大學化學學院學習，獲學士學危和轎元位。

2002～2005年在東北師範大學化學學院學習，獲碩士學位。

2005～2008年在中科院長春套用化學研究所學習辣迎，獲博士學位。

2008～至今 在吉林大學軍需科技學院工作，講師、副教授，碩士生導師。

2009～2011年進入軍事醫學科學院基礎獸醫學專業博士後流動站。

學術任職

吉林省食品學會理事

在研項目

[1] 國家自然科學基金面上項目，《木犀草素抗李斯特菌感染的分子機制》，31572566，2016/01-2019/12，77.2萬元，在研，主持

[2]中國博士後一等面上資助，8萬元，在研，主持

[3]中國博士後特別資助，15萬元，在研，主持

[4] 國家自然基金重點項目子課題項目-《溶組兆棄血素-藥物小分子複合物分子動力學模擬》(3A2110026603)

[5] 科技部973項目子課題項目-《抗金葡萄溶血素天然化合物篩選》(3F012J606201)

[6] 吉林大學博士科研啟動基金-《食源性腿敬境多酚類抗氧化劑活性機制研究》

發表論文

[1] Wang, Jianfeng ，Qiu, Jiazhang ，Tan, Wei，Zhang, Yu，Wang, Hongshu，Zhou, Xuan，Liu, Shui，Feng, Haihua，Li, Wenhua，Niu, Xiaodi(*)，Deng, Xuming(*)，Fisetin Inhibits Listeria monocytogenes Virulence by InterferingWith the Oligomerization of Listeriolysin O.，The Journal of Infectious Diseases，2015，211：1376-1387。(影響因子：6.288)

[2] Wang, Jianfeng ，Zhou, Xuan ，Liu, Shui ，Li, Gen，Zhang, Bing，Deng, Xuming(*)，Niu, Xiaodi(*)，Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin via protein-ligand modeling，Scientific Reports，2015，5：8864。(影響因子：5.228)

[3] Li, Hongen ，Zhao, Xiaoran ，Wang, Jianfeng，Dong, Yu，Meng, Song，Li, Rui，Niu, Xiaodi(*)，Deng, Xuming(*)，beta-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection，Scientific Reports，2015，5：17668。(影響因子：5.228)

[4] Xiaoran Zhao ，Hongen Li，Jianfeng Wang，Yan Guo，Bowen Liu，Xuming Deng(*)，Niu, Xiaodi(*)，Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers，MOLECULAR PHARMACOLOGY，2016，89：376–387。(影響因子：3.931)

[5] Wang, Jianfeng ，Zhou, Xuan ，Liu, Shui，Li, Gen，Shi, Lei，Dong, Jing，Li, Wenhua，Deng, Xuming(*)，Niu, Xiaodi(*)，Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of α-hemolysin，Journal of Applied Microbiology，廈承兆2015，118：753-763。(影響因子：2.156)

[6] Wang, Lin ，Bi, Chongwei ，Cai, Hongjun，Liu, Bingrun，Zhong, Xiaobo，Deng, Xuming，Wang, Tiedong，Xiang, Hua，Niu, Xiaodi(*)，Wang, Dacheng(*)，The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition，Frontiers in Microbiology，2015，6：1031。(影響因子：3.989)

[7] Liu, Bingrun ，Chen, Fuguang ，Bi, Chongwei ，Wang, Lin，Zhong, Xiaobo，Cai, Hongjun，Deng, Xuming，Niu, Xiaodi(*)，Wang, Dacheng(*)，Quercitrin, an Inhibitor of Sortase A, Interferes with the Adhesion of Staphylococcal aureus，Molecules，2015，20：6533-6543 (影響因子：2.416)

[8] Jing Dong, Jiazhang Qiu, Yu Zhang, Chongjian Lu, Xiaohan Dai, Jianfeng Wang, Hongen Li,Xin Wang, Wei Tan, Mingjing Luo, Xiaodi Niu (通訊作者), Xuming Deng. Oroxylin A Inhibits Hemolysis via Hindering the Self-Assembly of a-Hemolysin Heptameric Transmembrane Pore. PLoS Computational Biology, 2013, 21: e1002869 (影響因子：5.216)

[9] Xiaodi Niu, Jiazhang Qiu, Xin Wang, Xiaohan Gao, Jing Dong, Jianfeng Wang, Hongen Li, Yu Zhang, Xiaohan Dai, Chongjian Lu, Xuming Deng. Molecular insight into the inhibition mechanism of cyrtominetin to a-hemolysin by molecular dynamics simulation. European Journal of Medicinal Chemistry, 2013, 62: 320-328 (影響因子：3.346)

[10] Yu Zhang, Jian-feng Wang, Jing Dong, Jing-yuan Wei, Ya-nan Wang, Xiao-han Dai, Xin Wang, Ming-jing Luo, Wei Tan, Xu-ming Deng, Xiao-di Niu(通訊作者). Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia. Fitoterapia, 2013, 86,92-99. (影響因子：1.848)

[11] XinWang, Jing Dong, Xiaohan Dai, Yu Zhang, JianfengWang, Hongen Li, Chongjian Lu,Wei Tan, Xiaohan Gao, Xuming Deng, Shijin Bu, Xiaodi Niu(通訊作者). Silibinin In Vitro Protects A549 Cells from Staphylococcus aureus-Mediated Injury and In Vivo Alleviates the Lung Injury of Staphylococcal Pneumonia. Planta Med, 2013, 79: 110–115 (影響因子：2.153)

[12] Xiaodi Niu, Jing Dong, Dacheng Wang, Jianfeng Wang, Hongen Li, Mingjing Luo, Shentao Li, Haihua Feng, and Xuming Deng. Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via Inhibition of the Cytolytic Activity of α-Hemolysin. The Journal of Infectious Diseases, 2012, 206:292–301 (影響因子：6.288)

[13] Xiaodi Niu, Jianfeng Wang, Yan Xing, Bingfeng Leng, Jing Dong, Hongen Li, Mingjing Luo, Yu Zhang, Xiaohan Dai, Yonghuang Luo, Xuming Deng. Capsaicin Protects Mice from Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonia. PLoS ONE, 2012, 7:e33032 (影響因子：4.092)

[14] Hongsu Wang, Xiaohan Gao, Yanan Wang, Jinglong Tang, Cancan Sun, Xuliang Deng, Xiaodi Niu(通訊作者). Bio-templated synthesis of mesoporous bioactive glass with a hierarchical pore structure. Materials Letters, 2012, 76:237-239 (影響因子：2.307)

[15] Xiaodi Niu, Xiaohan Gao, Hongsu Wang, Xin Wang, Song Wang. Insight into the dynamic interaction between different flavonoids and bovine serum albumin using molecular dynamics simulations and free energy calculations. J. Mol. Model. 2013, 19:1039-1047 (影響因子：1.797)

[16] Xiaodi Niu, Xin Wang, Hongsu Wang, Xiaohan Gao, Yanan Wang, Song Wang. Insights into the specific binding site of adenosine to the Stx2, the protein toxin from Escherichia coli O157:H7 using molecular dynamics simulations and free energy calculations. Molecular Simulation, 2013, DOI:10.1080/08927022.2012.713483 (影響因子：1.328)

[17] Hongsu Wang, XiaohanGao, YananWang, JianfengWang, Xiaodi Niu(通訊作者), XuliangDeng. Effect of amine functionalization of SBA-15 on controlled baicalin drug release. Ceramics International, 2012, 38: 6931-6935 (影響因子：1.751)

[18] Xiaodi Niu, Hongsu Wang, Jingbo Liu. Efficient green-phosphorescent light-emitting diodes based on polymeric binary-host systems. Journal of Luminescence. 2011, 131: 2589-2592 (影響因子：2.102)

[19] Han Weiwei, Wang Ye, Luo Quan, Xiaodi Niu (通訊作者). INSIGHTS INTO A 3D HOMOLOGY MODEL OF ARYLESTERASE: THE KEY RESIDUES UPON PROTEIN-LIGAND DOCKING AND MM-PBSA CALCULATIONS. JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY, 2011, 10: 165-177 (影響因子：0.561)

[20] Xiaodi Niu, Baohua Zhang, Zhiyuan Xie, Yanxiang Cheng, and Lixiang Wang. Balanced charge transport and enhanced white electroluminescence from a single white emissive polymer via thermal annealing. APPLIED PHYSICS LETTERS, 2010, 96: 073303 (影響因子：3.844)

[21] Xiaodi Niu, Jingbo Liu, Zhiyuan Xie. Efficient white polymer light-emitting diodes based on the control of a emissive polymer morphology through solvent processing. Organic Electronics, 2010, 11, 1273-1276 (影響因子：4.047)

[22] Xiaodi Niu, Chuanjiang Qin, Baohua Zhang, Junwei Yang, Zhiyuan Xie. Efficient multilayer white polymer light-emitting diodes with aluminum cathodes. APPLIED PHYSICS LETTERS, 2007, 90: 203513 (影響因子：3.844)

[23] Xiaodi Niu, Liang Ma, Bing Yao, Junqiao Ding, Zhiyuan Xie. white polymeric light-emitting diodes with high color rendering index. APPLIED PHYSICS LETTERS, 2006, 89: 213508 (影響因子：3.844)

[24] 牛效迪，劉靜波，王嵩，王虹蘇. 以膦酸酯聚芴作為陰極界面修飾層的高效聚合物紅光電致發光器件. 高等學校化學學報，2010,9：1-4.

[25] Zhuo Lv, Hong S. Wang, Xiao D. Niu*. Molecular dynamics simulations reveal insight into key structural elements of aaptamines as sortase inhibitors with free energy calculations. Chemical Physics Letters, 2013, 585, 171-177. (影響因子：2.147)

[4] Xiaoran Zhao ，Hongen Li，Jianfeng Wang，Yan Guo，Bowen Liu，Xuming Deng(*)，Niu, Xiaodi(*)，Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers，MOLECULAR PHARMACOLOGY，2016，89：376–387。(影響因子：3.931)

[5] Wang, Jianfeng ，Zhou, Xuan ，Liu, Shui，Li, Gen，Shi, Lei，Dong, Jing，Li, Wenhua，Deng, Xuming(*)，Niu, Xiaodi(*)，Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of α-hemolysin，Journal of Applied Microbiology，2015，118：753-763。(影響因子：2.156)

[6] Wang, Lin ，Bi, Chongwei ，Cai, Hongjun，Liu, Bingrun，Zhong, Xiaobo，Deng, Xuming，Wang, Tiedong，Xiang, Hua，Niu, Xiaodi(*)，Wang, Dacheng(*)，The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition，Frontiers in Microbiology，2015，6：1031。(影響因子：3.989)

[7] Liu, Bingrun ，Chen, Fuguang ，Bi, Chongwei ，Wang, Lin，Zhong, Xiaobo，Cai, Hongjun，Deng, Xuming，Niu, Xiaodi(*)，Wang, Dacheng(*)，Quercitrin, an Inhibitor of Sortase A, Interferes with the Adhesion of Staphylococcal aureus，Molecules，2015，20：6533-6543 (影響因子：2.416)

[8] Jing Dong, Jiazhang Qiu, Yu Zhang, Chongjian Lu, Xiaohan Dai, Jianfeng Wang, Hongen Li,Xin Wang, Wei Tan, Mingjing Luo, Xiaodi Niu (通訊作者), Xuming Deng. Oroxylin A Inhibits Hemolysis via Hindering the Self-Assembly of a-Hemolysin Heptameric Transmembrane Pore. PLoS Computational Biology, 2013, 21: e1002869 (影響因子：5.216)

[9] Xiaodi Niu, Jiazhang Qiu, Xin Wang, Xiaohan Gao, Jing Dong, Jianfeng Wang, Hongen Li, Yu Zhang, Xiaohan Dai, Chongjian Lu, Xuming Deng. Molecular insight into the inhibition mechanism of cyrtominetin to a-hemolysin by molecular dynamics simulation. European Journal of Medicinal Chemistry, 2013, 62: 320-328 (影響因子：3.346)

[10] Yu Zhang, Jian-feng Wang, Jing Dong, Jing-yuan Wei, Ya-nan Wang, Xiao-han Dai, Xin Wang, Ming-jing Luo, Wei Tan, Xu-ming Deng, Xiao-di Niu(通訊作者). Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia. Fitoterapia, 2013, 86,92-99. (影響因子：1.848)

[11] XinWang, Jing Dong, Xiaohan Dai, Yu Zhang, JianfengWang, Hongen Li, Chongjian Lu,Wei Tan, Xiaohan Gao, Xuming Deng, Shijin Bu, Xiaodi Niu(通訊作者). Silibinin In Vitro Protects A549 Cells from Staphylococcus aureus-Mediated Injury and In Vivo Alleviates the Lung Injury of Staphylococcal Pneumonia. Planta Med, 2013, 79: 110–115 (影響因子：2.153)

[12] Xiaodi Niu, Jing Dong, Dacheng Wang, Jianfeng Wang, Hongen Li, Mingjing Luo, Shentao Li, Haihua Feng, and Xuming Deng. Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via Inhibition of the Cytolytic Activity of α-Hemolysin. The Journal of Infectious Diseases, 2012, 206:292–301 (影響因子：6.288)

[13] Xiaodi Niu, Jianfeng Wang, Yan Xing, Bingfeng Leng, Jing Dong, Hongen Li, Mingjing Luo, Yu Zhang, Xiaohan Dai, Yonghuang Luo, Xuming Deng. Capsaicin Protects Mice from Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonia. PLoS ONE, 2012, 7:e33032 (影響因子：4.092)

[14] Hongsu Wang, Xiaohan Gao, Yanan Wang, Jinglong Tang, Cancan Sun, Xuliang Deng, Xiaodi Niu(通訊作者). Bio-templated synthesis of mesoporous bioactive glass with a hierarchical pore structure. Materials Letters, 2012, 76:237-239 (影響因子：2.307)

[15] Xiaodi Niu, Xiaohan Gao, Hongsu Wang, Xin Wang, Song Wang. Insight into the dynamic interaction between different flavonoids and bovine serum albumin using molecular dynamics simulations and free energy calculations. J. Mol. Model. 2013, 19:1039-1047 (影響因子：1.797)

[16] Xiaodi Niu, Xin Wang, Hongsu Wang, Xiaohan Gao, Yanan Wang, Song Wang. Insights into the specific binding site of adenosine to the Stx2, the protein toxin from Escherichia coli O157:H7 using molecular dynamics simulations and free energy calculations. Molecular Simulation, 2013, DOI:10.1080/08927022.2012.713483 (影響因子：1.328)

[17] Hongsu Wang, XiaohanGao, YananWang, JianfengWang, Xiaodi Niu(通訊作者), XuliangDeng. Effect of amine functionalization of SBA-15 on controlled baicalin drug release. Ceramics International, 2012, 38: 6931-6935 (影響因子：1.751)

[18] Xiaodi Niu, Hongsu Wang, Jingbo Liu. Efficient green-phosphorescent light-emitting diodes based on polymeric binary-host systems. Journal of Luminescence. 2011, 131: 2589-2592 (影響因子：2.102)

[19] Han Weiwei, Wang Ye, Luo Quan, Xiaodi Niu (通訊作者). INSIGHTS INTO A 3D HOMOLOGY MODEL OF ARYLESTERASE: THE KEY RESIDUES UPON PROTEIN-LIGAND DOCKING AND MM-PBSA CALCULATIONS. JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY, 2011, 10: 165-177 (影響因子：0.561)

[20] Xiaodi Niu, Baohua Zhang, Zhiyuan Xie, Yanxiang Cheng, and Lixiang Wang. Balanced charge transport and enhanced white electroluminescence from a single white emissive polymer via thermal annealing. APPLIED PHYSICS LETTERS, 2010, 96: 073303 (影響因子：3.844)

[21] Xiaodi Niu, Jingbo Liu, Zhiyuan Xie. Efficient white polymer light-emitting diodes based on the control of a emissive polymer morphology through solvent processing. Organic Electronics, 2010, 11, 1273-1276 (影響因子：4.047)

[22] Xiaodi Niu, Chuanjiang Qin, Baohua Zhang, Junwei Yang, Zhiyuan Xie. Efficient multilayer white polymer light-emitting diodes with aluminum cathodes. APPLIED PHYSICS LETTERS, 2007, 90: 203513 (影響因子：3.844)

[23] Xiaodi Niu, Liang Ma, Bing Yao, Junqiao Ding, Zhiyuan Xie. white polymeric light-emitting diodes with high color rendering index. APPLIED PHYSICS LETTERS, 2006, 89: 213508 (影響因子：3.844)

[24] 牛效迪，劉靜波，王嵩，王虹蘇. 以膦酸酯聚芴作為陰極界面修飾層的高效聚合物紅光電致發光器件. 高等學校化學學報，2010,9：1-4.

[25] Zhuo Lv, Hong S. Wang, Xiao D. Niu*. Molecular dynamics simulations reveal insight into key structural elements of aaptamines as sortase inhibitors with free energy calculations. Chemical Physics Letters, 2013, 585, 171-177. (影響因子：2.147)