湯富酬

湯富酬

湯富酬，男，1998年及2003年分別獲北京大學生物學專業理學學士、博士學位。2004年-2010年在英國劍橋大學Gurdon研究所做博士後研究工作，現任北京大學生物動態光學成像中心 (BIOPIC中心) 研究員、清華大學-北京大學生命科學聯合中心研究員、北京大學未來基因診斷高精尖創新中心研究員。

2016年8月獲國家傑出青年科學基金資助，2016年11月獲第九屆談家楨生命科學創新獎。

基本介紹

個人經歷,榮譽獲獎,科學研究,研究領域,代表性論文,

個人經歷

2016年8月至今，北京大學未來基因診斷高精尖創新中心，研究員
2015年至今，清華大學-北京大學生命科學聯合中心，研究員
2010年至今，北京大學生物動態光學成像中心(BIOPIC中心)，研究員
2004年-2010年，英國劍橋大學Gurdon研究所，博士後
2003年，北京大學，生物學，理學博士
1998年，北京大學，生物學，理學博士

榮譽獲獎

2018, "人類胚胎髮育機制研究取得新進展"項目成果入選“2017年度中國十大醫學科技新聞”
2017, 拜爾學者獎
2016，第九屆談家楨生命科學創新獎
2016，第二屆普洛麥格生物化學獎
2016，國家自然科學基金委，傑出青年基金
2016，“揭示人類原始生殖細胞基因表達與表觀遺傳調控特徵”項目成果入選“2015年度中國科學十大進展”
2015，“顧孝誠講座獎”
2015，“精確推演母源基因組信息”入選"2014年度中國科學十大進展"
2013，國家自然科學基金委，優秀青年基金

科學研究

研究領域

具有自我更新能力和分化潛能的幹細胞是哺乳動物胚胎髮育過程中以及成體中的關鍵種類的細胞，對各種幹細胞進行深入研究是理解哺乳動物發育、生長機制的關鍵，也是將幹細胞套用於臨床再生醫學、治療人類疾病的前提。
課題圍繞人類早期胚胎髮育、研究多能幹細胞的自我更新能力和多能性調控的分子機理，特別是表觀遺傳學調控機理，以及相關的原始生殖細胞發育過程中的表觀遺傳學重編程機理。
利用單細胞功能基因組學分析技術（單細胞 RNA-Seq 轉錄組分析技術、單細胞 DNA甲基化組測序技術、單細胞多組學平行測序技術等），以及基因編輯技術、少量細胞染色體免疫共沉澱-高通量測序技術、單細胞基因組測序技術、小鼠胚胎顯微操作技術和胚胎幹細胞體外定向分化等技術在單細胞和單鹼基解析度深入分析人類早期胚胎、生殖系細胞、以及多能性幹細胞中基因表達網路的表觀遺傳學調控機理。

代表性論文

28. Guo H, Hu B, Yan L, Yong J, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Tang F and Qiao J. DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells. Cell Res. 2017;27:165-183.
27. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Izpisua Belmonte JC, Qu J, Tang F and Liu GH. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res. 2017;27:1178-1181.
26. Yang L, Ma Z, Cao C, Zhang Y, Wu X, Lee R, Hu B, Wen L, Ge H, Huang Y, Lao K and Tang F. MR-seq: measuring a single cell’s transcriptome repeatedly by RNA-seq. Science Bulletin. 2017;62:391-398.
25. Liu J, Liu W, Yang L, Wu Q, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J, Tang F and Wang X. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. Cell Stem Cell. 2017;21:635-649 e8.
24. Wen L and Tang F. Single cell epigenome sequencing technologies. Mol Aspects Med. 2018;59:62-69.
23. Zhu C, Gao Y, Guo H, Xia B, Song J, Wu X, Zeng H, Kee K, Tang F and Yi C. Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution. Cell Stem Cell. 20:720-731.e5.
22. Zhu P, Guo H, Ren Y, Hou Y, Dong J, Li R, Lian Y, Fan X, Hu B, Gao Y, Wang X, Wei Y, Liu P, Yan J, Ren X, Yuan P, Yuan Y, Yan Z, Wen L, Yan L, Qiao J and Tang F. Single-cell DNA methylome sequencing of human preimplantation embryos. Nat Genet. 2018;50:12-19.
21. Guo F, Li L, Li J, Wu X, Hu B, Zhu P, Wen L and Tang F. Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells. Cell Res. 2017;27:967-988.
20. Li L, Dong J, Yan L, Yong J, Liu X, Hu Y, Fan X, Wu X, Guo H, Wang X, Zhu X, Li R, Yan J, Wei Y, Zhao Y, Wang W, Ren Y, Yuan P, Yan Z, Hu B, Guo F, Wen L, Tang F and Qiao J. Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions. Cell Stem Cell. 2017;20:891-892.
19. Zhou F, Li X, Wang W, Zhu P, Zhou J, He W, Ding M, Xiong F, Zheng X, Li Z, Ni Y, Mu X, Wen L, Cheng T, Lan Y, Yuan W*, Fuchou Tang*, Liu B*. Tracing haematopoietic stem cell formation at single-cell resolution. Nature, 533: 487-492 (2016) (*: Co-corresponding authors).
18. Guo H, Hu B, Yan L, Yong J, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Fuchou Tang*, Qiao J*. DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells. Cell Research, doi: 10.1038/cr.2016.128 (2016) (*: Co-corresponding authors).
17. Wen L*, Tang Fuchou*. Single-cell sequencing in stem cell biology. Genome Biology 17: 71 (2016) (*: Co-corresponding authors) (Review).
16. Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y*, Tang Fuchou*, Qiao J*. Tracing the expression of circular RNAs in human pre-implantation embryos. Genome Biology 17: 130 (2016) (*: Co-corresponding authors).
15. Hou Y, Guo H, Cao C, Li X, Hu B, Zhu P, Wu X, Wen L, Tang Fuchou*, Huang Y*, Peng J*. Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas. Cell Research 26: 304-319 (2016) (*: Co-corresponding authors).
14. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang Fuchou*, Liu GH*. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Research 26: 190-205 (2016) (*: Co-corresponding authors).
13. Zhou F, Li X, Wang W, Zhu P, Zhou J, He W, Ding M, Xiong F, Zheng X, Li Z, Ni Y, Mu X, Wen L, Cheng T, Lan Y, Yuan W*, Fuchou Tang*, Liu B*. Tracing haematopoietic stem cell formation at single-cell resolution. Nature, 533: 487-492 (2016) (*:共同通訊作者).
12. Fan X, Zhang X, Wu X, Guo H, Hu Y, Tang Fuchou*, Huang Y*. Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos. Genome Biology 16: 148 (2015) (*:共同通訊作者).
11. Guo H, Zhu P, Guo F, Li X, Wu X, Fan X, Wen L*, Tang Fuchou*. Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing. Nature Protocols 10: 645-659 (2015) (*:共同通訊作者).
10. Wen L*, Tang Fuchou*, How to catch rare cell types. Nature 2015; doi:10.1038/nature15204 (*: Co-corresponding authors) (Preview).
9. Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang Fuchou*, Qiao J*. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell 2015; 161: 1437-1452 (*: Co-corresponding authors).
8. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang Fuchou*, Liu GH*, Belmonte JC*. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 2015; 348: 1160-1163 (*: Co-corresponding authors).
7. Wen L*, Tang Fuchou*, Charting a Map through the Cellular Reprogramming Landscape. Cell Stem Cell 2015; 16: 215-216 (*: Co-corresponding authors) (Preview).
6. Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang Fuchou*, Qiao J*. The DNA methylation landscape of human early embryos. Nature 2014; 511: 606-610 (*: Co-corresponding authors).
5. Guo F, Li X, Liang D, Li T, Zhu P, Guo H, Wu X, Wen L, Gu TP, Hu B, Walsh CP, Li J*, Tang Fuchou*, Xu GL*. Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote. Cell Stem Cell 2014; 15: 447-458 (*: Co-corresponding authors).
4. Wen L, Tang Fuchou*, Reconstructing Complex Tissues from Single-Cell Analyses. Cell 2014; 157: 771-773 (*: Corresponding author).
3. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang Fuchou*, Xie XS*, Qiao J*. Genome Analyses of Single Human Oocytes. Cell 2013; 155: 1492-1506 (*: Co-corresponding authors).
2. Guo H, Zhu P, Wu X, Li X, Wen L, Tang Fuchou*. Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Research 2013; 23: 2126-2135 (*: Corresponding author).
1. Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R*, Qiao J*, Tang Fuchou*. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nature Structural & Molecular Biology 2013; 20: 1131-1139 (*: Co-corresponding authors).

相關詞條

熱門詞條

聯絡我們