基本介紹
- 中文名：洪鳴凰
- 畢業院校：復旦大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：工業藥學
- 任職院校：華東理工大學
個人經歷,研究方向,學術成果,
個人經歷
教育經歷
2009.06 復旦大學藥學院 理學博士
2004.06 復旦大學藥學院 理學學士
工作經歷
2014.01-今 華東理工大學藥學院 副研究員
2010.08-2013.12 上海醫藥工業研究院 副研究員
2009.07-2010.07 上海開拓者醫藥發展有限公司 研究員
研究方向
第一部分 工業藥學——處方前研究和製劑學研究
研究方向：1. 藥物晶型研究，包括晶型篩選、鹽型篩選、共晶、離子液體、固態表征及質量標準制定
2. 固體藥物製劑開發
3. 製劑研發中的晶型問題，包括製劑中藥用晶型的判定、晶型轉化及質量標準
第二部分 基礎研究——腫瘤靶向納米載藥系統
研究方向：以納米載藥系統（包括脂質體、納米粒、非粒子表面活性劑泡囊和共軛物）為載體，將抗腫瘤藥物遞送至腫瘤部位而實現靶向治療。
學術成果
發表文章
Hao Wu, Zhaizhu Deng, Bijian Zhou, Minghui Qi, Minghuang Hong⁎, Guobin Ren⁎. Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties, J. Mol. Liq., 2019,
Minghuang Hong, Sai Guo, Kai Wang, Lei Ma⁎, Guobin Ren⁎, Influence factor investigation on the solution-mediated polymorphic transformation of Baricitinib phosphate, Z. Anorg. Allg. Chem., 2018,
Minghuang Hong#, Jingyan Chen#, Hui Zhou, Hao Xu, Guobin Ren⁎, Investigation of a solution-mediated phase transformation of pranlukast DMF solvate to hemihydrate, Cryst. Res. Technol., 2017,
Minghuang Hong#, Shiwang Wu#, Minghui Qi, Guobin Ren⁎, Solubility correlation and thermodynamic analysis of two forms of metaxalone in different pure solvents, Fluid Phase Equilib., 2016,
Ming-Hui Qi#, Ming-Huang Hong#, Yan Liu, En-Fu Wang, Fu-Zheng Ren, Guo-Bin Ren⁎, Estimating thermodynamic stability relationship of polymorphs of sofosbuvir, Cryst. Growth Des., 2015,
Minghuang Hong#, Lehui Xu#, Guobin Ren⁎, Jinyao Chen, Minghui Qi, Solubility of lansoprazole in different solvents, Fluid Phase Equilib., 2012,
Minghuang Hong, Saijie Zhu, Yanyan Jiang, Guotao Tang, Chang Sun, Chao Fang, Bin Shi, and Yuanying Pei⁎, Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles, J Control Release, 2010
Minghuang Hong, Saijie Zhu, Yanyan Jiang, Guotao Tang, and Yuanying Pei⁎, Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin, J Control Release,2009,
Guo-Bin Ren⁎, Ming-Huang Hong, Jia-Liang Zhong, Dong-Xu Yi, Le-Hui Xu, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole monohydrate, Acta Cryst., 2011,
Saijie Zhu, Minghuang Hong, Guotao Tang, Lili Qian, Jiayuan Lin, Yanyan Jiang, and Yuanying Pei⁎, Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style, Biomaterials, 2010,
Saijie Zhu, Minghuang Hong, Lihong Zhang, Guotao Tang, Yanyan Jiang, and Yuanying Pei⁎, PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation, and in vivo tumor accumulation, Pharm. Res-Doror., 2010,
Saijie Zhu, Minghuang Hong, Chen Liu, and Yuanying Pei⁎, Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation. Pharm. Dev. Technol., 2009,
Jinju Ma, Ming-Hui Qi, Ming-Huang Hong, Jie Lu, Guo-Bin Ren⁎, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole propan-2-ol monosolvate: a second monoclinic polymorph, Acta Cryst., 2012,
Yu-Feng Chen, Jin-Yao Chen, Ming-Huang Hong, Jie Lu, Guo-Bin Ren⁎, 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methylsulfanyl}-1H-benzimidazole monohydrate: a monoclinic polymorph, Acta Cryst., 2012,
Wenhua Chen, Ne Guo, Minghui Qi, Haiying Dai, Minghuang Hong, Longfei Guan, Xiajuan Huan, Shanshan Song, Jinxue He, Yingqing Wang, Yong Xi, Xinying Yang, Yanyan Shen, Yi Su, Yiming Sun, Yinglei Gao, Yi Chen, Jian Ding, Yun Tang, Guobin Ren, Zehong Miao, Jian Li⁎,Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy, Eur. J. Med. Chem., 2017,
Saijie Zhu, Lili Qian, Minghuang Hong, Lihong Zhang, Yuanying Pei, and Yanyan Jiang⁎, RGD-Modified PEG-PAMAM-DOX Conjugate: In vitro and in vivo targeting to both tumor neovascular endothelial cells and tumor cells. Adv. Mater., 2011,
Saijie Zhu, Rongqin Huang, Minghuang Hong, Yanyan Jiang, Zhuohan Hu, Chen Liu, Yuanying Pei⁎, Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur. J Pharm. Sci., 2009,
