基本介紹
- 中文名：汪海健
- 國籍：中國
- 民族：漢族
- 出生日期：1974-08-24
- 畢業院校：湖北農學院
- 職稱：副教授
個人簡歷,研究方向,獲獎情況,代表性論文和專著,
個人簡歷
2006.4-至今，復旦大學生命科學學院與生物醫學研究院，副教授；
2004.7-2006.3，復旦大學生命科學學院與生物醫學研究院，講師；
2003.7-2004.6，國家人類基因組北方研究中心，研究助理；
2000.9-2003.6，軍事醫學科學院放射與輻射醫學研究所，細胞生物學專業人類與醫學遺傳學方向博士生，獲理學博士學位；
1997.9-2000.6, 南京農業大學動物醫學院，預防獸醫學專業分子病毒學方向碩士生，獲農學碩士學位；
研究方向
研究領域包括複雜疾病的遺傳易感性，比較與進化藥物基因組學，以及分子水平人類適應性進化。目前研究方向為P450和ABC轉運體等藥物代謝酶的進化與功能基因組學。對疾病的遺傳分析，不僅需要從橫向的空間上分析不同群體或個體的遺傳變異對疾病譜和易感性的影響，而且需要在縱向的進化歷史中，把疾病的自然史和人類的分子適應性進化結合起來，考察人類起源遷移的群體歷史中，動態變化的環境風險因素對疾病相關基因的達爾文分子選擇。運用群體遺傳學與分子進化的原理與方法，結合分子與細胞生物學的實驗手段，以及基於家系或群體的疾病連鎖與關聯分析，從多個水平研究“疾病遺傳與人類進化”，不僅對探詢人類進化的自然史有重要理論意義，而且對了解包括腫瘤與心腦血管疾病等重大複雜疾病的病因學，以及疾病譜和藥物反應性的群體差異，並最終促進疾病群體預防和個體化治療，亦有重大現實意義。
獲獎情況
2005年全國優秀博士論文提名;
2005年軍隊科技進步一等獎（第五完成人）；
2005年北京市科技進步一等獎（第八完成人）；
2005年中華醫學科技二等獎（第八完成人）；
2005年第八屆“北京青年優秀科技論文”一等獎；
1998年南京農業大學“品學兼優研究生”
代表性論文和專著
（以發表時間為序，* 並列第一作者; §並列通訊作者）：
1. Haijian Wang*, Keyue Ding*, Yang Zhang, Li Jin, Iftikhar J. Kullo, Fuchu He. Comparative and Evolutionary Pharmacogenetics of ABCB1: Complex Signatures of Positive Selection on Coding and Regulatory Regions. (Pharmacogenet Genomics 2007, in press; SCI 2005 IF = 5.882)
2. Haijian Wang, Bingtao Hao, Xiaoping Chen, Naiqing Zhao, Gang Cheng, Yan Jiang, Yang Liu, Chengzhao Lin, Wen Tan, Daru Lu, Qingyi Wei, Li Jin, Dongxin Lin§, and Fuchu He§. Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: A case-control study in a Chinese population. Cancer Lett. 2006; 240: 297-305. (SCI 2005 IF = 3.049)
3. Haijian Wang, Yan Jiang, Yang Liu, Chengzhao Lin, Gang Cheng, Xiaoping Chen, Bingtao Hao, Wen Tan, Dongxin Lin§, and Fuchu He§. CYP2J2*7 single nucleotide polymorphism in a Chinese population. Clin Chim Acta 2006, 365:125-8. (SCI 2005 IF = 2.149)
4. Xiaoping Chen, Haijian Wang, Weimin Xie, Renxiang Liang, Zhongliang Wei, Lianteng Zhi, Xiumei Zhang, Bingtao Hao, Shaofei Zhong, Gangqiao Zhou, Lingqiang Zhang, Xue Gao, Yunping Zhu and Fuchu He. Association of CYP1A2 genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a high-risk region of China. Pharmacogenet Genomics 2006; 16:219-227. (SCI 2005 IF = 5.882)
5. Bingtao Hao, Xiaoping Miao, Yi Li, Xuemei Zhang, Tong Sun, Gang Liang, Yanlin Zhao, Yifeng Zhou, Haijian Wang, Xiaoping Chen, Lingqiang Zhang, Wen Tan, Qingyi Wei, Dongxin Lin, and Fuchu He. A Novel T-77C Polymorphism in XRCC1 Contributes to Diminished Promoter Activity and Increased Lung Cancer Susceptibility. (Oncogene 2006; 25: 3613-20, SCI 2005 IF = 6.872)
6. Xiaoping Chen, Liqing Wang, Lianteng Zhi, Gangqiao Zhou, Haijian Wang, Xiumei Zhang, Bingtao Hao, Yunping Zhu Zeneng Cheng, Fuchu He. The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population. Clin Pharmacol Ther. 2005; 78: 249-59. (SCI 2005 IF = 7.526)
7. Haijian Wang, Bingtao Hao, Kaixin Zhou, Xiaoping Chen, Songfeng Wu, Gangqiao Zhou, Yunping Zhu, and Fuchu He. Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: implications for pharmacogenomic association study. Ann Hum Genet. 2004, 68: 563-573. (SCI 2003 IF = 3.102)
8. Bingtao Hao, Haijian Wang, Kaixin Zhou, Yi Li, Xiaoping Chen, Gangqiao Zhou, Yunping Zhu, Xiaoping Miao, Wen Tan, Qingyi Wei, Dongxin Lin§, and Fuchu He§. Identification of Genetic Variants in Base Excision Repair Pathway and Their Associations with Risk of Esophageal Squamous Cell Carcinoma. Cancer Res. 2004, 64(12): 4378-4384. (SCI 2003 IF = 8.649)
9. Haijian Wang*, Wen Tan*, Bingtao Hao, Xiaoping Miao, Gangqiao Zhou, Fuchu He§, and Dongxin Lin§. Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active Cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. Cancer Res. 2003, 63(22): 8057-8061. (SCI 2002 IF = 8.318)
10. Guo-Lin Chen*, Haijian Wang*, Wei Wang, Zhen-Hua Xu, Gan Zhou, Fuchu He§, and Hong-Hao Zhou§. Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocyte. Pharmacogenet; 2003, 13 (7): 389-397. (SCI 2002 IF = 5.540)
11. Heyi Yang, Haijian Wang, Jie Wang, Yun Cai, Gangqiao Zhou, Fuchu He and Xiaohong Qian. Multiplex single-nucleotide polymorphism genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem 2003; 314(1): 54-62. (SCI 2002 IF = 2.370)
12. 汪海健, 賀福初. 生物異源物感測系統研究進展. 生命的化學. 2003; 23(2): 97-99.
