梁斌，男，博士，雲南大學生命科學學院研究員。
基本介紹
- 中文名：梁斌
- 國籍：中國
- 畢業院校：復旦大學
- 學位/學歷：博士
- 專業方向：脂滴生物學、脂肪肝發病機理及治療
- 職務：雲南大學博士生導師
人物經歷,研究方向,主要論文,
人物經歷
1990.09-1994.06 雲南大學生物系，獲學士學位。
1994.07-1999.08 雲南省農業科學院農作物品種資源站，研究實習員、助理研究員。
1999.09-2001.07 雲南大學生化學院，獲碩士學位。
2001.09-2004.07 復旦大學生命科學院遺傳所，獲博士學位。
2004.04-2004.11 雲南省農業科學院農作物品種資源站, 助理研究員, 所長助理。
2004.12-2006.07 美國加州大套多學爾灣分校(University of California, Irvine), 博士後。
2006.07-2006.10 美國愛因斯坦醫學院(Albert Einstein College of Medicine of Yeshiva University)。
2006.10-2010.07 美國華盛頓州立大學(Washington State University), 博士後，研究助理教授(Assistant Research Professor)。
2010.08-2019 中科院昆明動物研究所“脂類代謝與疾病”學科組負責人，研究員，博導中科院和雲南省“動物模型與人類疾病機理重點實驗室”副主任（2016-2019年）、中科院昆明動物研究所工會副主席（2016-2019年）。
2019-至今雲南大學探笑府生命科學中心/生命科堡姜放符學學院，研究員，博士生導師。
2010年入選中科院“百人計畫”人才項目，2016年入選“雲南省高端科技人才”。政協昆明市第十三屆委員會常委。中國生物物理學會理事，生物漏腿承學分會理事、副秘書長，膜生物學分會理事。Zoological Research、Metabolism Open、《生物化學與生物物理進展》等期刊編委。以通訊作者或第一作者在Cell Metabolism、Nature Communications、Journal of Lipid Research、Oncogene、iScience、Genetics等國際著名期刊發表SCI論文20多篇。
研究方向
1. 脂滴生物學
脂滴是重要的細胞器，存在於所有真核生物中。脂滴與其它細胞器互作，回響胞內外環境變化，動態調節細胞的脂類代謝和能量平衡，參與生物體的生長、發育、生殖、衰老、抗逆境等。脂滴在脂肪組織和非脂肪組織（如肝臟）中大量沉積，導致肥胖、脂肪肝、糖尿病等代謝性疾病。我們利用秀麗線蟲和小鼠等模式生物，結合細胞生物學、遺傳學、生物化學及分子生物學、代謝流等方法和技術，重點研究：1）脂類合成調控及其生物學功能；2）脂滴起源和增大機理；3）不同生理或病理條件下脂滴與其它細胞器互作維持能量平衡機理，進而揭示脂代謝紊亂相關疾病如脂肪肝和糖尿病等代謝性疾病的發病機理，並尋找新的疾病標誌物和治療靶標。
2. 脂肪肝發病機理及治療
肝臟是重要的代謝器官。臨床上，當肝臟中多於5%的肝細胞出現脂滴積累時，即為肝臟脂肪變性。隨著肝臟中脂肪過多的積累，脂毒性、胰島素抵抗等多種因素作用下，出現小葉炎症和肝細胞損傷等，肝臟脂肪變性發展為脂肪性肝炎；如果脂肪性肝炎中出現膠原沉積則發展形成肝臟纖維化，繼續惡化則導致肝硬化和肝癌。
建立了樂漏承境脂肪肝的細胞、小鼠、樹鼩和獼猴模型。發現樹鼩是一種新型的非肥胖型脂肪肝（non-obese fatty liver）動物模型，篩選到一些自發性肥胖、脂肪肝和糖尿病獼猴。基於上述脂肪肝細胞和動物模型，甩多屑利用轉錄組、蛋白質組、尋背和代謝組等，開展脂肪肝的發病機理研究，尋找新的疾病標誌物和治療靶標；同時開展減肥降脂藥物的篩選、評價和作用機理研究。
主要論文
（#通訊作者，按發表年代排序):
1.Shuang Wang*, Ning Wang*, Bin Yu, Mingxing Cao, Yanlong Wang, Yuqi Guo, Yanli Zhang, Ping Zhang, Bin Liang#,Xin Li# and Yingjie Wu#. Circulating IGF-1 Promotes Prostate Adenocarcinoma via FOXO3A/BIM Signaling in a Double Transgenic Mouse Model.Oncogene.2019. (*Equal contribution)
2.Liyuan Ran*, Xiaoshuang Wang*, Ai Mi, Yanshuang Liu, Jin Wu, Meihua Guo, Jie Sun, Bo Liu,Youwei Li, Dan Wang, Rujiao Jiang, Ning Wang, Wenting Gao, Li Zeng, Li Huang, Xiaoli Chen, Bin Liang#, Xin Li#, and Yingjie Wu#. Loss of Adipose GHR in Mice Enhances Local Fatty Acid Trapping and Impairs BAT Thermogenesis.iScience.2019. (*Equal contribution)
3.Mengqiao Cui, Rong Ying, Xue Jiang, Gang Li, Xuanjun Zhang, Jun Zheng, Kin Tam, Bin Liang, Anbing Shi, Verena Gobel#, and Hongjie Zhang#. A model of hereditary sensory and autonomic neuropathy type 1 reveals a role of glycosphingolipids in neuronal polarity.Journal of Neuroscience.2019.
4.Shimeng Xu*, Fei Zou*, Zhiqing Diao*, Shuyan Zhang, Yaqin Deng, Xiaotong Zhu, Liujuan Cui, Jinhai Yu, Zhiguang Zhang, Adekunle Toyin Bamigbade, Hongchao Zhang, Xuan Wei, Xuelin Zhang, Bin Liang#,and Pingsheng Liu#. Perilipin 2 and lipid droplets provide reciprocal stabilization.Biophysics Reports.2019. (*Equal contribution)
5.Junlong Wang*, Linqiang Zhang*, Ruyue Xiao, Yunhai Li, Shasha Liao, Zhiguo Zhang, Wenhui Yang, Bin Liang#. Plasma lipidomic signatures of spontaneous obese rhesus monkeys.Lipids in Health and Disease.2019.18:8.https://doi.org/10.1186/s12944-018-0952-9.(*Equal contribution)
6.Jieyu Wu *, Xue Jiang*, Yamei Li, Tingting Zhu, Jingjing Zhang, Zhiguo Zhang, Lingqiang Zhang , Yuru Zhang , Yanli Wang, Xiaoju Zou#, Bin Liang#.PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans.Nature Communications.2018 (*Equal contribution) 10.1038/s41467-018-03531-2.
7.Jinhai Yu*, Linqiang Zhang*, Yunhai Li, Xiaotong Zhu, Shimeng Xu, Xiao-Ming Zhou, Haizhen Wang, Hongchao Zhang,Bin Liang#,and Pingsheng Liu#. The Adrenal Lipid Droplet is a New Site for Steroid Hormone Metabolism.Proteomics. 2018,18, 1800136. DOI: 10.1002/pmic.20180013(*Equal contribution)（封面文章）
8.Junlong Wang*, Shimeng Xu*, Jing Gao*, Linqiang Zhang, Zhiguo Zhang, Wenhui Yang, Hu Zhou#, Pingsheng Liu#, and Bin Liang#.SILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys.Am J Physiol Endocrinol Metab.doi.org/10.1152/ajpendo.00016.2018. (*Equal contribution)
9.Baoshen He*, Jingjing Zhang*, Yanli Wang, Yamei Li, Xiaoju Zou#, Bin Liang#.Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD.BBA-Mol Cell Biol Lipids 1863(2018)235–246 (*Equal contribution)
10.Zhang JJ, Hao JJ, Zhang YR, Wang YL, Li MY, Miao HL, Zou XJ#, Liang B#.Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans.Journal of Lipid Research.2017 58:(9) 1845-1854.（封面文章）
11.Yanli Wang*, Cangsang Xie*, Zhiqing Diao and Bin Liang#.Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans.Molecules. 2017, 22, 1062; doi:10.3390. (*Equal contribution)
12.Haizhen Wang*, Xue Jiang*, Jieyu Wu, Linqiang Zhang, Jingfei Huang, Yuru Zhang, Xiaoju Zou#, Bin Liang#.Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.Genetics.2016. doi: 10.1534/genetics.116. 186742 (*Equal contribution) (Comments by GENES to GENOMES)
13.Linqiang Zhang*, Xiaoyun Wu*, Shasha Liao*, Yunhai Li, Zhiguo Zhang, Qing Chang, Ruyue Xiao, and Bin Liang#.Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease.Biology Open. (2016) 5: 1545-1552; doi:10.1242/bio.020875 (*Equal contribution).
14.Yuru Zhang*, Haizhen Wang* , Jingjing Zhang* ,Ying Hu*, Linqiang Zhang, Xiaoyun Wu, Xiong Su, Tingting Li, Xiaoju Zou#, Bin Liang#.Cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans.BBA-Mol Cell Biol Lipids.2016.1861(4):310-319. doi: 10.1016/j.bbalip.2016.01.009. (*Equal contribution)
15.Xiao, R.-Y.; Hao, J.; Ding, Y.-H.; Che, Y.-Y.; Zou, X.-J#.;Liang, B#.Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans.Molecules.2016, 21, 1379; doi:10.3390.
16.Xiaoyun Wu*, Haibo Xu*, Zhiguo Zhang, Qing Chang, Shasha Liao, Linqiang Zhang, Yunhai Li, Dongdong Wu# and Bin Liang#.Transcriptome profiles using next generation sequencing reveal liver changes in the early stage of diabetes in tree shrew (Tupaia belangeri chinensis).Journal of Diabetes Research. Volume 2016. doi:10.1155/2016/6238526 (*Equal contribution)
17.Linqiang Zhang*, Zhiguo Zhang*, Yunhai Li*, Shasha Liao, Xiaoyun Wu, Qing Chang & Bin Liang#.Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease.Scientific.Reports.5, 15970; doi: 10.1038/srep15970 (2015). (*Equal contribution) (*Equal contribution)
18.鄒飛*,刁志清*,張紅超,徐式孟,劉平生,梁斌#,魏璇#.骼肌細胞中UBXD8的敲除及其對脂質代謝的影響.生物化學與生物物理進展.2015,42(10): 926~934.(*Equal contribution)(*Equal contribution)（封面文章）
19.YiHong Ding*, XiaoJu Zou#*, Xue Jiang, JieYu Wu, YuRu Zhang, Dan Chen,Bin Liang#.Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans.PLoS ONE(2015) 10(2): e0113815. doi:10.1371/journal.pone.0113815. (*Equal contribution)
20.胡英，肖麗霞，梁斌#.秀麗線蟲硬脂醯輔酶A去飽和化酶的研究進展.生物物理學報.2015,Feb.31(1)13-23.
21.Shi X*, Li J*, Zou X, Greggain J, Rodkaer SV, Faergeman NJ, Liang B#,Watts JL#. (2013). Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase.Journal of Lipid Research.2504–2514. (*Equal contribution)
22.Yuru Zhang, Xiaoju zou, Yihong Ding, Haizhen Wang, Xiaoyun Wu, Bin Liang#.(2013). Comparative Genomics and Functional Study of Lipid Metabolic Genes in Caenorhabditis elegans.BMC Genomics.14:164. doi:10.1186/1471-2164-14-164.(Highly accessed)
23.Wu X*, Zou X*, Chang Q, Zhang Y, Li Y, Zhang L, Huang J, Liang B#.(2013). The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes.BioMed Research International.doi:10.1155/2013/856521. (*Equal contribution)
24.X. Wu*, Q. Chang*, Y. Zhang*, X. Zou, L. Chen, L. Zhang, L. Lv，andB. Liang#.(2013). Relationships between body weight, fasting blood glucose, sex and age in tree shrews (Tupaia belangeri chinensis).J Anim Physiol Anim Nutr.January 22. doi: 10.1111/jpn.12036. (*Equal contribution)
25.Yu Fan, Zhi-Yong Huang, Chang-Chang Cao, Ce-Shi Chen, Yuan-Xin Chen, Ding-Ding Fan, Jing He, Hao-Long Hou, Li Hu, Xin-Tian Hu, Xuan-Ting Jiang, Ren Lai,Yong-Shan Lang, Bin Liang, Sheng-Guang Liao, Dan Mu, Yuan-Ye Ma, Yu-Yu Niu, Xiao-Qing Sun, Jin-Quan Xia, Jin Xiao, Zhi-Qiang Xiong, Lin Xu, Lan Yang, Yun Zhang, Wei Zhao, Xu-Dong Zhao, Yong-Tang Zheng, Ju-Min Zhou, Ya-Bing Zhu, Guo-Jie Zhang, Jun Wang & Yong-Gang Yao. (2013). Genome of the Chinese Tree Shrew. Nature Communications.Volume:4, DOI: doi: 10.1038 /ncomms2416.
26.徐林,張雲,梁斌,呂龍寶,陳策實,陳勇彬,周巨民,姚永剛.實驗動物樹鼩和人類疾病的樹鼩模型研究概述.動物學研究.2013,Apr. 34(2): 59−69.
28.Rong-Xia Li, Wei Xu, Zhen Wang, Bin Liang, Jia-Rui Wu, Rong Zeng. (2012). Proteomic characteristics of liver and muscle of Chinese tree shrew (Tupaia belangeri chinensis).Protein & Cell.3(9): 691-700.
29.鄒曉菊,丁毅弘,梁斌#.普洱茶減肥、降脂機制的探討.動物學研究. 2012,Aug. 33(4): 1−6.
30.Gholamali Jafari*, Yusu Xie*, Andrey Kullyev, Bin Liang, and Ji Ying Sze.(2011).Regulation of extra-synaptic 5-HT by SERT function in 5-HT-absorbing neurons underscores adaptation behavior in C. elegans.Journal of Neuroscience,31(24):8948-8957.
31.梁斌#，吳曉雲.非人靈長類糖尿病動物模型研究進展.動物學研究. 2011,Feb. 32(1): 91−96.
32.Bin Liang, Kim Ferguson, Lisa Kadyk, and Jennifer L. Watts (2010) .The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. PLoS One, 5(3) e9869.
33.Kyleann K. Brooks, Bin Liang, Jennifer L. Watts (2009) .The influence of bacterial diet on fat storage in C. elegans.PLoS One,4(10) e7545.
34.Bin Liang, Mustapha Moussaif, Chih-Jen Kuan, J. Jay Gargus and Ji Ying Sze. (2006) Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses.Cell Metabolism,Dec;4(6):429-440.(Preview in Cell Metabolism, 2006 Dec; 4(6):415-417.)
建立了脂肪肝的細胞、小鼠、樹鼩和獼猴模型。發現樹鼩是一種新型的非肥胖型脂肪肝（non-obese fatty liver）動物模型，篩選到一些自發性肥胖、脂肪肝和糖尿病獼猴。基於上述脂肪肝細胞和動物模型，利用轉錄組、蛋白質組、代謝組等，開展脂肪肝的發病機理研究，尋找新的疾病標誌物和治療靶標；同時開展減肥降脂藥物的篩選、評價和作用機理研究。
主要論文
（#通訊作者，按發表年代排序):
1.Shuang Wang*, Ning Wang*, Bin Yu, Mingxing Cao, Yanlong Wang, Yuqi Guo, Yanli Zhang, Ping Zhang, Bin Liang#,Xin Li# and Yingjie Wu#. Circulating IGF-1 Promotes Prostate Adenocarcinoma via FOXO3A/BIM Signaling in a Double Transgenic Mouse Model.Oncogene.2019. (*Equal contribution)
2.Liyuan Ran*, Xiaoshuang Wang*, Ai Mi, Yanshuang Liu, Jin Wu, Meihua Guo, Jie Sun, Bo Liu,Youwei Li, Dan Wang, Rujiao Jiang, Ning Wang, Wenting Gao, Li Zeng, Li Huang, Xiaoli Chen, Bin Liang#, Xin Li#, and Yingjie Wu#. Loss of Adipose GHR in Mice Enhances Local Fatty Acid Trapping and Impairs BAT Thermogenesis.iScience.2019. (*Equal contribution)
3.Mengqiao Cui, Rong Ying, Xue Jiang, Gang Li, Xuanjun Zhang, Jun Zheng, Kin Tam, Bin Liang, Anbing Shi, Verena Gobel#, and Hongjie Zhang#. A model of hereditary sensory and autonomic neuropathy type 1 reveals a role of glycosphingolipids in neuronal polarity.Journal of Neuroscience.2019.
4.Shimeng Xu*, Fei Zou*, Zhiqing Diao*, Shuyan Zhang, Yaqin Deng, Xiaotong Zhu, Liujuan Cui, Jinhai Yu, Zhiguang Zhang, Adekunle Toyin Bamigbade, Hongchao Zhang, Xuan Wei, Xuelin Zhang, Bin Liang#,and Pingsheng Liu#. Perilipin 2 and lipid droplets provide reciprocal stabilization.Biophysics Reports.2019. (*Equal contribution)
5.Junlong Wang*, Linqiang Zhang*, Ruyue Xiao, Yunhai Li, Shasha Liao, Zhiguo Zhang, Wenhui Yang, Bin Liang#. Plasma lipidomic signatures of spontaneous obese rhesus monkeys.Lipids in Health and Disease.2019.18:8.https://doi.org/10.1186/s12944-018-0952-9.(*Equal contribution)
6.Jieyu Wu *, Xue Jiang*, Yamei Li, Tingting Zhu, Jingjing Zhang, Zhiguo Zhang, Lingqiang Zhang , Yuru Zhang , Yanli Wang, Xiaoju Zou#, Bin Liang#.PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans.Nature Communications.2018 (*Equal contribution) 10.1038/s41467-018-03531-2.
7.Jinhai Yu*, Linqiang Zhang*, Yunhai Li, Xiaotong Zhu, Shimeng Xu, Xiao-Ming Zhou, Haizhen Wang, Hongchao Zhang,Bin Liang#,and Pingsheng Liu#. The Adrenal Lipid Droplet is a New Site for Steroid Hormone Metabolism.Proteomics. 2018,18, 1800136. DOI: 10.1002/pmic.20180013(*Equal contribution)（封面文章）
8.Junlong Wang*, Shimeng Xu*, Jing Gao*, Linqiang Zhang, Zhiguo Zhang, Wenhui Yang, Hu Zhou#, Pingsheng Liu#, and Bin Liang#.SILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys.Am J Physiol Endocrinol Metab.doi.org/10.1152/ajpendo.00016.2018. (*Equal contribution)
9.Baoshen He*, Jingjing Zhang*, Yanli Wang, Yamei Li, Xiaoju Zou#, Bin Liang#.Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD.BBA-Mol Cell Biol Lipids 1863(2018)235–246 (*Equal contribution)
10.Zhang JJ, Hao JJ, Zhang YR, Wang YL, Li MY, Miao HL, Zou XJ#, Liang B#.Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans.Journal of Lipid Research.2017 58:(9) 1845-1854.（封面文章）
11.Yanli Wang*, Cangsang Xie*, Zhiqing Diao and Bin Liang#.Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans.Molecules. 2017, 22, 1062; doi:10.3390. (*Equal contribution)
12.Haizhen Wang*, Xue Jiang*, Jieyu Wu, Linqiang Zhang, Jingfei Huang, Yuru Zhang, Xiaoju Zou#, Bin Liang#.Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.Genetics.2016. doi: 10.1534/genetics.116. 186742 (*Equal contribution) (Comments by GENES to GENOMES)
13.Linqiang Zhang*, Xiaoyun Wu*, Shasha Liao*, Yunhai Li, Zhiguo Zhang, Qing Chang, Ruyue Xiao, and Bin Liang#.Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease.Biology Open. (2016) 5: 1545-1552; doi:10.1242/bio.020875 (*Equal contribution).
14.Yuru Zhang*, Haizhen Wang* , Jingjing Zhang* ,Ying Hu*, Linqiang Zhang, Xiaoyun Wu, Xiong Su, Tingting Li, Xiaoju Zou#, Bin Liang#.Cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans.BBA-Mol Cell Biol Lipids.2016.1861(4):310-319. doi: 10.1016/j.bbalip.2016.01.009. (*Equal contribution)
15.Xiao, R.-Y.; Hao, J.; Ding, Y.-H.; Che, Y.-Y.; Zou, X.-J#.;Liang, B#.Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans.Molecules.2016, 21, 1379; doi:10.3390.
16.Xiaoyun Wu*, Haibo Xu*, Zhiguo Zhang, Qing Chang, Shasha Liao, Linqiang Zhang, Yunhai Li, Dongdong Wu# and Bin Liang#.Transcriptome profiles using next generation sequencing reveal liver changes in the early stage of diabetes in tree shrew (Tupaia belangeri chinensis).Journal of Diabetes Research. Volume 2016. doi:10.1155/2016/6238526 (*Equal contribution)
17.Linqiang Zhang*, Zhiguo Zhang*, Yunhai Li*, Shasha Liao, Xiaoyun Wu, Qing Chang & Bin Liang#.Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease.Scientific.Reports.5, 15970; doi: 10.1038/srep15970 (2015). (*Equal contribution) (*Equal contribution)
18.鄒飛*,刁志清*,張紅超,徐式孟,劉平生,梁斌#,魏璇#.骼肌細胞中UBXD8的敲除及其對脂質代謝的影響.生物化學與生物物理進展.2015,42(10): 926~934.(*Equal contribution)(*Equal contribution)（封面文章）
19.YiHong Ding*, XiaoJu Zou#*, Xue Jiang, JieYu Wu, YuRu Zhang, Dan Chen,Bin Liang#.Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans.PLoS ONE(2015) 10(2): e0113815. doi:10.1371/journal.pone.0113815. (*Equal contribution)
20.胡英，肖麗霞，梁斌#.秀麗線蟲硬脂醯輔酶A去飽和化酶的研究進展.生物物理學報.2015,Feb.31(1)13-23.
21.Shi X*, Li J*, Zou X, Greggain J, Rodkaer SV, Faergeman NJ, Liang B#,Watts JL#. (2013). Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase.Journal of Lipid Research.2504–2514. (*Equal contribution)
22.Yuru Zhang, Xiaoju zou, Yihong Ding, Haizhen Wang, Xiaoyun Wu, Bin Liang#.(2013). Comparative Genomics and Functional Study of Lipid Metabolic Genes in Caenorhabditis elegans.BMC Genomics.14:164. doi:10.1186/1471-2164-14-164.(Highly accessed)
23.Wu X*, Zou X*, Chang Q, Zhang Y, Li Y, Zhang L, Huang J, Liang B#.(2013). The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes.BioMed Research International.doi:10.1155/2013/856521. (*Equal contribution)
24.X. Wu*, Q. Chang*, Y. Zhang*, X. Zou, L. Chen, L. Zhang, L. Lv，andB. Liang#.(2013). Relationships between body weight, fasting blood glucose, sex and age in tree shrews (Tupaia belangeri chinensis).J Anim Physiol Anim Nutr.January 22. doi: 10.1111/jpn.12036. (*Equal contribution)
25.Yu Fan, Zhi-Yong Huang, Chang-Chang Cao, Ce-Shi Chen, Yuan-Xin Chen, Ding-Ding Fan, Jing He, Hao-Long Hou, Li Hu, Xin-Tian Hu, Xuan-Ting Jiang, Ren Lai,Yong-Shan Lang, Bin Liang, Sheng-Guang Liao, Dan Mu, Yuan-Ye Ma, Yu-Yu Niu, Xiao-Qing Sun, Jin-Quan Xia, Jin Xiao, Zhi-Qiang Xiong, Lin Xu, Lan Yang, Yun Zhang, Wei Zhao, Xu-Dong Zhao, Yong-Tang Zheng, Ju-Min Zhou, Ya-Bing Zhu, Guo-Jie Zhang, Jun Wang & Yong-Gang Yao. (2013). Genome of the Chinese Tree Shrew. Nature Communications.Volume:4, DOI: doi: 10.1038 /ncomms2416.
26.徐林,張雲,梁斌,呂龍寶,陳策實,陳勇彬,周巨民,姚永剛.實驗動物樹鼩和人類疾病的樹鼩模型研究概述.動物學研究.2013,Apr. 34(2): 59−69.
28.Rong-Xia Li, Wei Xu, Zhen Wang, Bin Liang, Jia-Rui Wu, Rong Zeng. (2012). Proteomic characteristics of liver and muscle of Chinese tree shrew (Tupaia belangeri chinensis).Protein & Cell.3(9): 691-700.
29.鄒曉菊,丁毅弘,梁斌#.普洱茶減肥、降脂機制的探討.動物學研究. 2012,Aug. 33(4): 1−6.
30.Gholamali Jafari*, Yusu Xie*, Andrey Kullyev, Bin Liang, and Ji Ying Sze.(2011).Regulation of extra-synaptic 5-HT by SERT function in 5-HT-absorbing neurons underscores adaptation behavior in C. elegans.Journal of Neuroscience,31(24):8948-8957.
31.梁斌#，吳曉雲.非人靈長類糖尿病動物模型研究進展.動物學研究. 2011,Feb. 32(1): 91−96.
32.Bin Liang, Kim Ferguson, Lisa Kadyk, and Jennifer L. Watts (2010) .The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. PLoS One, 5(3) e9869.
33.Kyleann K. Brooks, Bin Liang, Jennifer L. Watts (2009) .The influence of bacterial diet on fat storage in C. elegans.PLoS One,4(10) e7545.
34.Bin Liang, Mustapha Moussaif, Chih-Jen Kuan, J. Jay Gargus and Ji Ying Sze. (2006) Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses.Cell Metabolism,Dec;4(6):429-440.(Preview in Cell Metabolism, 2006 Dec; 4(6):415-417.)
