張雷，男，漢族，出生年月：1971-05， 博士，教授，華南理工大學生物科學與工程學院博士生導師 。
基本介紹
- 中文名：張雷
- 國籍：中國
- 民族：漢族
- 出生日期：1971-05
- 職業：華南理工大學生物科學與工程學院教授
人物經歷,學習經歷,工作經歷,社會兼職,研究方向,主要貢獻,科研項目,科研成果,論文,
人物經歷
學習經歷
工作經歷
2000.11-2001.11 法國原子能委員會/Grenoble 大學博士後
2001.12-2003.12 日本Kanazawa 大學 JSPS 外國人特別研究員
2004.03-2011.06華南理工大學化學與化工學院 製藥工程系主任（期間於2004.03任副教授，碩士生導師，2008.12晉升為教授，2010年被評聘為博士生導師）
2010.07-至今 華南理工大學生物科學與工程學院 生物製藥系主任（期間於2011.06—2011.10赴法國狄德龍大學（巴黎第七大學）高級訪問學者。）
2001.12-2003.12 日本Kanazawa 大學 JSPS 外國人特別研究員
2004.03-2011.06華南理工大學化學與化工學院 製藥工程系主任（期間於2004.03任副教授，碩士生導師，2008.12晉升為教授，2010年被評聘為博士生導師）
2010.07-至今 華南理工大學生物科學與工程學院 生物製藥系主任（期間於2011.06—2011.10赴法國狄德龍大學（巴黎第七大學）高級訪問學者。）
社會兼職
研究方向
製藥工程
主要貢獻
科研項目
承擔國家自然科學基金、省部產學研項目、省科技計畫和國際合作項目等10多項。
科研成果
1）新藥研究與開發 主要進行藥物的結構改造和前藥研究；以及從天然產物發酵液中分離製備活性物質。已經從普伐他汀發酵液中分離得到了高活性的四氫普伐他汀，並完成了其合成工藝和結構鑑定，完成了初步的藥學和毒性研究。
2）藥物多晶型與質量控制 主要進行了非布索坦藥物新晶型、氯吡格雷藥物新晶型以及他汀類藥物新晶型的研究，建立了藥物轉晶製備新晶型的研究和評價平台。對頭孢類和克林黴素類等抗生素進行了相關物質的研究，合成開發了7個新的相關物質對照品。
3）新型醫用材料與螢光免疫分析試劑 主要進行了新型生物醫用膠黏劑和螢光標記抗體的開發，該類研究主要套用於醫療器械和診斷試劑盒。
3）新型醫用材料與螢光免疫分析試劑 主要進行了新型生物醫用膠黏劑和螢光標記抗體的開發，該類研究主要套用於醫療器械和診斷試劑盒。
論文
發表論文60多篇，其中SCI收錄50篇, 被他人引用超過500次。
申請發明專利8件，其中2件已經獲得授權。
代表論文：
.1. Lei Zhang* Zhiping Huang, Xiaoran Wan, Jing Li, and Jing Liu，Measurement and Correlation of the Solubility of Febuxostat in Four Organic Solvents at Various Temperatures，J. Chem. Eng. Data, OI: 10.1021/je300647k.
2. Jing Li, Huan Li, Lei Zhang*，Synthesis, crystal structure and biological evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA reductase inhibitor，Letters in Drug Design & Discovery, 2011, 8(9), 884-888。
3. 李晶，李環，張雷*，4,7-二氫普伐他汀的分離、結構解析與活性研究，中國抗生素雜誌，2011，36(7)，526-529.
4. Yun Ling, Lei Zhang*, Jing Li and Miao Du, A robust porous PtS-type Cu(II) metal–organic framework: single-crystal-to-single-crystal transformation with reversible guest intercalation accompanied by colour change, CrystEngComm, 2011, 13, 768-770.
5. Lei Zhang*, Wang-Wei Chen, Yuan-Yuan Ge, Yun Ling, Xin-Ping Ouyang, Jing Li, Miao Du, Anion-directed supramolecular assembly of cobalt(II)-fluconazole coordination polymers: Structural diversity, fluorescent and magnetic properties, Inorg. Chim. Acta, 2010, 363, 866-876.
6. Lei Zhang*, Yun Ling, Dan-Jun Li, Jing Li, Miao Du，Synthesis, crystal structures and properties of novel zinc(II) and cadmium(II) polymeric and cyclic bimetallic complexes with fluconazole and dicarboxylate co-ligands, Inorg. Chim. Acta, 2010, 363, 1031-1038.
7. Yun Ling, Lei Zhang*, Jing Li, Shuan-Shi Fan and Miao Du, Thiocyanate-induced conformational transformation of a flexible fluconazole ligand in Cd(II) coordination polymers, CrystEngComm, 2010, 12, 604-611.
8. Lei Zhang*, Yun Ling, Ai-Xi Hu, Ting-Ting Yao, Jing Li, Four novel Co(II) and Mn(II) coordination polymers with triazolyl derivate: syntheses, crystal structures and magnetic properties, Inorg. Chim. Acta, 2009, 362, 4867-4874.
9. 楊亞勇，張雷，鄒任賢，線上顆粒度分析儀在美伐他汀結晶工藝過程中的套用研究，中國抗生素雜誌，2009，34(8)，475-480.
10. Yun Ling, Lei Zhang*, Jing Li, and Ai Xi Hu, Three-fold-Interpenetrated Diamondoid Coordination Frameworks with Torus Links Constructed by Tetranuclear Building Blocks, Cryst. Growth Des., 2009, 9 (5), 2043-2046.
11. Ling Yun, Li Jing, Hu Ai-Xi, Zhang Lei*, Syntheses, Crystal Structures and Fluorescence Properties of Two triazolyl Derivatives with Biphenyl Links, Chinese J. Struct. Chem., 2009, 28(4), 461-466.
12. Yun Ling, Lei Zhang*, Crystal Structure and Magnetic Property of a Two-Dimensional Copper(II) Complex with Dual EO- and Single EE-Azide Bridges, Polish J Chem., 2009, 83, 547-554.
13. Lei Zhang*, Yun Ling, Jing Li, Hong-Yun Gao, Supramolecular self-assembly of two Cu(II) complexes with 1,2,4-triazole derivatives: syntheses, crystal structures and magnetic properties, Struct. Chem, 2008, 19(6), 911–916.
14. Lei Zhang*, Yun Ling, Miao Du, Synthesis, crystal structures and in vitro anti-fungal activities of two silver(I) coordination polymers with fluconazole, Inorg. Chim. Acta, 2007, 360, 3182-3188.
15. Lei Zhang*, Yun Ling, Feng Peng, Miao Du, Anion-tuned self-assembly of zinc(II)-fluconazole complexes: crystal structures, luminescent and thermal properties, J. Mol. Struct., 2007, 829, 161-167
代表論文：
.1. Lei Zhang* Zhiping Huang, Xiaoran Wan, Jing Li, and Jing Liu，Measurement and Correlation of the Solubility of Febuxostat in Four Organic Solvents at Various Temperatures，J. Chem. Eng. Data, OI: 10.1021/je300647k.
2. Jing Li, Huan Li, Lei Zhang*，Synthesis, crystal structure and biological evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA reductase inhibitor，Letters in Drug Design & Discovery, 2011, 8(9), 884-888。
3. 李晶，李環，張雷*，4,7-二氫普伐他汀的分離、結構解析與活性研究，中國抗生素雜誌，2011，36(7)，526-529.
4. Yun Ling, Lei Zhang*, Jing Li and Miao Du, A robust porous PtS-type Cu(II) metal–organic framework: single-crystal-to-single-crystal transformation with reversible guest intercalation accompanied by colour change, CrystEngComm, 2011, 13, 768-770.
5. Lei Zhang*, Wang-Wei Chen, Yuan-Yuan Ge, Yun Ling, Xin-Ping Ouyang, Jing Li, Miao Du, Anion-directed supramolecular assembly of cobalt(II)-fluconazole coordination polymers: Structural diversity, fluorescent and magnetic properties, Inorg. Chim. Acta, 2010, 363, 866-876.
6. Lei Zhang*, Yun Ling, Dan-Jun Li, Jing Li, Miao Du，Synthesis, crystal structures and properties of novel zinc(II) and cadmium(II) polymeric and cyclic bimetallic complexes with fluconazole and dicarboxylate co-ligands, Inorg. Chim. Acta, 2010, 363, 1031-1038.
7. Yun Ling, Lei Zhang*, Jing Li, Shuan-Shi Fan and Miao Du, Thiocyanate-induced conformational transformation of a flexible fluconazole ligand in Cd(II) coordination polymers, CrystEngComm, 2010, 12, 604-611.
8. Lei Zhang*, Yun Ling, Ai-Xi Hu, Ting-Ting Yao, Jing Li, Four novel Co(II) and Mn(II) coordination polymers with triazolyl derivate: syntheses, crystal structures and magnetic properties, Inorg. Chim. Acta, 2009, 362, 4867-4874.
9. 楊亞勇，張雷，鄒任賢，線上顆粒度分析儀在美伐他汀結晶工藝過程中的套用研究，中國抗生素雜誌，2009，34(8)，475-480.
10. Yun Ling, Lei Zhang*, Jing Li, and Ai Xi Hu, Three-fold-Interpenetrated Diamondoid Coordination Frameworks with Torus Links Constructed by Tetranuclear Building Blocks, Cryst. Growth Des., 2009, 9 (5), 2043-2046.
11. Ling Yun, Li Jing, Hu Ai-Xi, Zhang Lei*, Syntheses, Crystal Structures and Fluorescence Properties of Two triazolyl Derivatives with Biphenyl Links, Chinese J. Struct. Chem., 2009, 28(4), 461-466.
12. Yun Ling, Lei Zhang*, Crystal Structure and Magnetic Property of a Two-Dimensional Copper(II) Complex with Dual EO- and Single EE-Azide Bridges, Polish J Chem., 2009, 83, 547-554.
13. Lei Zhang*, Yun Ling, Jing Li, Hong-Yun Gao, Supramolecular self-assembly of two Cu(II) complexes with 1,2,4-triazole derivatives: syntheses, crystal structures and magnetic properties, Struct. Chem, 2008, 19(6), 911–916.
14. Lei Zhang*, Yun Ling, Miao Du, Synthesis, crystal structures and in vitro anti-fungal activities of two silver(I) coordination polymers with fluconazole, Inorg. Chim. Acta, 2007, 360, 3182-3188.
15. Lei Zhang*, Yun Ling, Feng Peng, Miao Du, Anion-tuned self-assembly of zinc(II)-fluconazole complexes: crystal structures, luminescent and thermal properties, J. Mol. Struct., 2007, 829, 161-167
