張琨，女，博士，上海交通大學環境科學與工程學院副教授。
基本介紹
- 中文名：張琨
- 畢業院校：瑞士西北套用科技大學
- 學位/學歷：博士
- 專業方向：環境科學與工程
- 任職院校：上海交通大學
人物經歷,研究方向,學術成果,研究成果,榮獲獎項,
人物經歷
2003-2007 北京大學，城市與環境學院 環境科學， 理學學士
2007-2012 北京大學，城市與環境學院 環境地理學， 理學博士
2012-2015 加拿大阿爾伯塔大學， 實驗醫學與病理學系， 博士後
2015-2016 瑞士西北套用科技大學，生態環境研究所， 博士後
2017-2018 美國哈佛醫學院/布萊根婦女醫院，高級研究助理
研究方向
研究領域： 環境分析監測，環境污染物行為，環境健康
現階段主要研究方向：
環境中新型污染物的分析監測及其來源和環境行為解析
環境中未知污染污染物的非靶標篩查和鑑定
環境污染物質對健康，特別是對神經發育的影響
學術成果
Zhang, K.; Zhao, Y. B.*Reduced Zebrafish Transcriptome Atlas toward Understanding the Environmental Neurotoxicants. Environ. Sci. Technol.2018, 52 (12), 7120-7130.
Zhang, K.; Fent, K. Determination of two progestin metabolites (17α-hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, corticosteroids, progestins) in rivers and wastewaters by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Sci. Total Environ.2018, 610, 1164-1172.
Zhang, K.; Zhao, Y.; Fent, K. Occurrence and ecotoxicological effects of free, conjugated and halogenated steroids of 17α-hydroxypregnanolone and pregnanediol in Swiss wastewater and surface water. Environ. Sci. Technol., 2017, 51 (11), 6498–6506.
Zhang, K.; Wiseman, S. B.; Giesy, J. P.; Martin, J. W. Bioconcentration of Dissolved Organic Compounds from Oil Sands Process-Affected Water by Medaka (Oryzias latipes): Importance of Partitioning to Phospholipids. Environ. Sci. Technol. 2016, 50 (12), 6574–6582.
Zhang, K.; Pereira, A. S.; Martin, J. W. Estimates of Octanol–Water Partitioning for Thousands of Dissolved Organic Species in Oil Sands Process-Affected Water. Environ. Sci. Technol. 2015, 49 (14), 8907-8913.
Zhang, K.; Wan, Y.; Jones, P. D.; Wiseman, S.; Giesy, J. P.; Hu, J. Y. Occurrences and Fates of Hydroxylated Polybrominated Diphenyl Ethers in Marine Sediments in Relation to Trophodynamics. Environ. Sci. Technol. 2012, 46 (4), 2148?2155
Zhang, K.; Wan, Y.; Giesy, J. P.; Lam, MHW; Wiseman, S.; Jones, P. D.; Hu, J. Y. Tissue Concentrations of Polybrominated Compounds in Chinese Sturgeon (Acipenser sinensis): Origin, Hepatic Sequestration, and Maternal Transfer. Environ. Sci. Technol. 2010, 44 (15), 5781-5786.
Zhang, K.; Wan, Y.; An, L. H.; Hu, J. Y. Trophodynamics of Polybrominated Diphenyl Ethers and Methoxylated Polybrominated Diphenyl Ethers in a Marine Food Web. Environ. Toxicol. Chem. 2010, 29 (12), 2792-2799.
Siegenthaler, P. F.; Zhao, Y.; Zhang, K.; Fent, K. Reproductive and transcriptional effects of the antiandrogenic progestin chlormadinone acetate in zebrafish (Danio rerio). Environ. Pollut. 2017, 223, 346-356.
Morandi, G. D.; Zhang, K.; Wiseman, S. B.; Pereira, A. d. S.; Martin, J. W.; Giesy, J. P. Effect of Lipid Partitioning on Predictions of Acute Toxicity of Oil Sands Process Affected Water to Embryos of Fathead Minnow (Pimephales promelas). Environ. Sci. Technol. 2016, 50 (16), 8858-8866.
Zhao, Y.; Zhang, K.; Fent, K. Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations. Environ. Sci. Technol. 2016, 50 (18), 10245-10254.
Rossier, N. M.; Chew, G.; Zhang, K.; Riva, F.; Fent, K. Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo. Aquat. Toxicol. 2016, 174, 109-122.
Zhao, Y. ; Zhang, K.; Giesy, J. P.; Hu, J. Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective. Scientific reports 2015, 5, 8554.
Peng, H.; Wan, Y.; Zhang, K.; Sun, J. X.;Hu, J. Y. Trophic Transfer of Dechloranes in the Marine Food Web of Liaodong Bay, North China. Environ. Sci. Technol. 2014, 48 (10), 5458?5466
Wan, Y.; Zhang, K.; Dong, Z. M.; Hu, J. Y. ; Distribution is a Major Factor Affecting Bioaccumulation of Decabrominated Diphenyl Ether: Chinese Sturgeon (Acipenser sinensis) as an Example. Environ. Sci. Technol. 2013, 47 (5), 2279?2286
Peng, H.; Zhang, K.; Wan, Y.; Hu, J. Y. Tissue Distribution, Maternal Transfer, and Age-Related Accumulation of Dechloranes in Chinese Sturgeon. Environ. Sci. Technol. 2012, 46 (18), 9907?9913
Wan, Y.; Jones, P. D.; Wiseman, S.; Chang, H.; Chorney, D.; Kannan, K.; Zhang, K.; Hu, J. Y.; Khim, J. S.; Tanabe, S.; Lam, MHW; Giesy, J. P.Contribution of Synthetic and Naturally Occurring Organobromine Compounds to Bromine Mass in Marine Organisms. Environ. Sci. Technol. 2010, 44 (16), 6068-6073.
Wan, Y.; Hu, J. Y. ; Zhang, K.; An, L. H. Trophodynamics Of Polybrominated Diphenyl Ethers in the Marine Food Web of Bohai Bay, North China. Environ. Sci. Technol. 2008, 42 (4), 1078-1083.
研究成果
近年來主要致力於環境污染物質的環境行為研究。利用氣相/超高效液相質譜聯用檢測技術結合體外微粒體暴露，微生物降解，PBPK模型模擬，野外樣品採集分析對環境污染物質的來源降解和在不同結構的食物網中的生物富集差異及受污染物藥代行為學的影響等一系列環境行為開展了獨創性的研究工作。同時，利用超高分辨質譜非靶向檢測技術結合生物模擬和魚體暴露等方法開發了對環境中複合有機污染物的毒性和生物富集性評估方法平台，並將其成功套用於油砂廢水中獲得污染物優先控制名單。以上研究成果共發表SCI 論文18 篇，其中13篇發表在環境科學權威雜誌Environ. Sci. Technol.（IF 6.2）上。一作文章8 篇，6篇發表在Environ. Sci. Technol.上。
榮獲獎項
2010 陶氏可持續發展創新學生挑戰賽學生獎
2009 林超地理學獎學金
