張定校，男，博士，湖南大學生物學院教授、嶽麓學者、博士生導師。
基本介紹
- 中文名：張定校
- 畢業院校：韓國忠北國立大學
- 學位/學歷：博士
- 專業方向：分子胚胎髮育學
- 任職院校：湖南大學
人物經歷,教育經歷,工作經歷,研究領域,科研項目,學術成果,
人物經歷
教育經歷
1999.09 – 2003.06 華中農業大學 動物科學 本科
2003.09 – 2006.06 華中農業大學 動物分子生物學 碩士
2006.09 – 2010.02 韓國忠北國立大學 分子胚胎髮育學 博士
工作經歷
2010.04 – 2012.02 美國University of Cincinnati College of Medicine 博士後
2012.02 – 2015.03 美國MD Anderson Cancer Center 博士後
2015.04 – 2016.05 美國MD Anderson Cancer Center 講師 (Instructor)
2016.06 – 2016.09 美國Roswell Park Cancer Center 青年研究員 (Affiliate Member)
2016.09 – 2018.12 美國Roswell Park Cancer Center 助理教授 (Assistant Professor of Oncology)
2018.09 – 2019.07 華中農業大學 生物醫學中心 (和動科動醫學院) 教授
2019.07 – 至今 湖南大學 生物學院 教授
研究領域
以性激素敏感型癌症 (主要是前列腺癌和乳腺癌) 為模型，研究癌症發生、發展以及藥物治療抵抗的機理，以尋找潛在新的癌症治療靶點和臨床治療方案。目前研究方向有：癌症功能基因組學 (結合臨床樣本和生物組學大數據), 癌症幹細胞的維持和分化，和癌症 (幹細胞) 的治療。
科研項目
1. 2018, NIH/NCI – R21 前列腺癌幹細胞與臨床治療, $47.2萬，主持
2. 2019, 武漢市前資助科技計畫項目 – 生物醫學專項, 50萬, 主持
3. …….To be updated.
學術成果
Zhang D.,* Hu Q., Li XY., Kirk J., Tang DG*. The Landscape of Aberrant Splicing in Prostate Cancer Development and Progression Identifies Therapeutics Vulnerability. BioRxiv (2019)
Zhao C, Xie S, Wu H, Luan Y, Hu S, Ni J, Lin R, Zhao S, Zhang D*, Li X*. Quantification of allelic differential expression using a simple Fluorescence primer PCR-RFLP-based method. Scientific Reports (5yr-IF=4.525) 2019 Apr 19;9(1):6334
Zhang D.,* Zhao SH., Li XY., Kirk J., Tang DG*. Prostate Luminal Progenitors in Development and Cancer. Trends in Cancer (5yr-IF=8.884), 2018, 4(11):769-783.
Zhang D*, Tang DG. "Splice" a way towards neuroendocrine prostate cancer. EBioMedicine (5yr-IF=6.486) 2018, pii: S2352-3964(18)30331-1.
Zhang D.,* Tang DG* and Rycaj K*. Cancer stem cells: Regulation programs, immunological properties and immunotherapy. Seminars in Cancer Biology (5yr-IF=10.023), 2018, (17)30280-8
Zhang D*., Gong S., Lu Y., Jeter C., Tang DG*. Histone 2B-GFP Label-Retaining Prostate Luminal Cells Possess Progenitor Cell Properties and Are Intrinsically Resistant to Castration. Stem Cell Reports (5yr-IF=7.181), 2018, 10(1):228–242.
Zhang, D*., Lin, K., Lu, Y., Rycaj, K., Zhong, Y., Chao, H.P., Davis, T., Shen, J., and Tang, D.G*. Developing a novel 2D culture system to enrich human prostate luminal progenitors that can function as a cell of origin for prostate cancer. Stem Cells Translational Medicine (5yr-IF=5.962), 2017, 6(3): 748-760.
Zhang, D*., Park, D., Zhong, Y., Lu, Y., Gong, S., Chen, X., Liu, X., Chao, H.P., Whitney, P., Davis, T., Takata, Y., Shen, J., Iyer, V.R., Tang, D.G*. Stem cell and neurogenic gene expression profiles link prostate basal cells to aggressive prostate cancer. Nature Communications (5yr-IF=13.811), 2016, 7:10798.
Liu C#., Liu R#., Zhang D., Deng Q., Liu B., Chao HP., Rycaj K., Takata Y., Lin K., Lu Y., Zhong Y., Krolewski J., Shen J., and Tang D*. MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes. Nature Communications (5yr-IF=13.811), 2017, 8:14270.
Li Q, Deng Q, Chao HP, Liu X, Lu Y, Lin K, Liu B, Tang GW, Zhang D, Tracz A, Jeter C, Rycaj K, Calhoun-Davis T, Huang J, Rubin MA, Beltran H, Shen J, Chatta G, Puzanov I, Mohler JL, Wang J, Zhao R, Kirk J, Chen X, Tang DG. Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nature Communications (5yr-IF=13.811). 2018 Sep 6;9(1):3600.
Chen X, Li Q, Liu X, Liu C, Liu R, Rycaj K, Zhang D, Liu B, Jeter C, Calhoun-Davis T, Lin K, Lu Y, Chao HP, Shen J, Tang DG. Defining a population of stem-like human prostate cancer cells that can generate and propagate castration-resistant prostate cancer. Clinical Cancer Research (5yr-IF=9.174), 2016, 22(17): 4505-16.
