基本介紹
- 中文名：廖 瑛
- 國籍：中國
- 民族：漢族
- 出生地：浙江省
- 出生日期：1975年10月
- 職業：研究員
- 畢業院校：新加坡南洋理工大學
人物經歷,科學研究,代表文章與著作,
人物經歷
1993.9-1997.6 | 華東師範大學 | 生物學 學士 |
2002.8-2006.8 | 新加坡南洋理工大學 | 分子與細胞生物學 博士 |
2006.8-2009.8 | 新加坡南洋理工大學 | 博士後 |
2009.8-2010.8 | 新加坡科技局分子與細胞生物研究所 | 博士後 |
2010.8-2014.2 | 新加坡南洋理工大學 | 高級博士後研究員 |
2014年 | 中國農業科學院上海獸醫研究所 | 博士生導師 |
科學研究
長期以來，從事動物病毒學研究，已發表SCI論文30多篇。研究領域包括病毒入侵宿主細胞的分子機制，病毒的複製機理，病毒對宿主細胞蛋白翻譯系統的調控，病毒感染引起的內質網應激,宿主抗病毒天然免疫反應的啟動機制，病毒感染引起的細胞死亡，病毒膜孔蛋白的功能，鑑定抗病毒的靶標等。主要開展禽類病毒，包括冠狀病毒，禽副黏病毒，IBDV的相關工作。
代表文章與著作
1.Liao Y#*, Wang HX#, Mao X, Fang H, Wang H, Li Y, Sun Y, Meng C, Tan L, Song C, Qiu X, Ding C*.RIP1 is a central signaling protein in regulation of TNF-α/TRAIL mediated apoptosis and necroptosis during Newcastle disease virus infection.Oncotarget. 2017 Jun 27;8(26):43201-43217.
2.Fan XX, Han SC, YanD, GaoY, WeiYQ, LiuXT,Liao Y,Guo HC, Sun SQ. Foot-and–mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3C. 2017. Cell Death & Disease. 19;8(1): e2561.
3.Wang X, Wang R, Luo M, Li C, Wang HX, Huan CC, Qu YR,Liao Y*,Mao X*. (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017 May16;8(20):33197-33213.
4.Fung TS,Liao Y*,Liu DX*. Regulation of Stress Responses and Translational Control by Coronavirus.Viruses.2016 Jul 4;8(7). pii: E184. doi: 10.3390/v8070184.
5..Liao Y,Gu F, Mao X, Niu Q, Wang H, Sun Y, Song C, Qiu X, Tan L, Ding C. 2016. Regulation of de novo Translation of Host Cells by Manipulation of PERK/PKR and GADD34-PP1 Activity during Newcastle Disease Virus Infection. J Gen Virol.2016 Apr;97(4):867-79.doi: 10.1099/jgv.0.000426.
6.Liao Y,Zhang SM, Neo TL, Tam JP. 2015. Tryptophan-dependent membrane interaction and heteromerization with the internal fusion peptide by the membrane proximal external region of SARS-CoV spike protein. Biochemistry. 54(9):1819-30.
7.Liao Y, Fung TS, Huang M, Fang SG, Zhong YX, Liu DX.2014.RNA Isolation and Northern Blot Analysis. Bio-protocol. Vol 4, Iss6
8.Liao Y, Fung TS, Huang M, Fang SG, Zhong Y, Liu DX. 2013. Up-regulation of CHOP/GADD153duringCoronavirusInfectiousBronchitisVirusInfectionModulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway. J Virol. 87(14):8124-34. May15.
9.Liao Y,Wang X, Huang M, Tam JP, Liu DX. 2011. Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus. Virology. 420 (2):106-16.
10.Wang, X.X.#,Liao,Y.#, Yap PL, Png KJ, Tam JP, Liu DX. Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells. J Virol. 2009. 83(23):12462-72.
11.Liao, Y.,Yuan, Q., Torres, J., Tam, J. P., and Liu, D. X. 2006. Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein. Virology. 349:264-275.
12.Liao, Y.,Lescar, J., Tam, P. J., and Liu, D. X. 2004. Expression of SARS-coronavirus envelope protein in Escherichia coli cells alters membrane permeability. BBRC. 325: 374-380.
13.Liao,Y.,Tam,J.P.,andLiu,D.X.2005.ViroporinactivityofSARS-CoVEprotein. Adv. Exp. Med.Biol.199-202.
14.Fung TS,Liao Y,Liu DX. The endoplasmic reticulum stress sensor IRE1α protects cells from apoptosis induced by the coronavirus infectious bronchitis virus. J Virol. 2014 Nov; 88(21):12752-64.
15.Tan L,Liao Y,Fan J, Zhang Y, Mao X, Sun Y, Song C, Qiu X, Meng C, Ding C. Prediction and identification of novel IBV S1 protein derived CTL epitopes in chicken. Vaccine. 2016 Jan 12;34 (3):380-6.
