基本介紹
- 中文名：尹艷慧
- 國籍：中國
- 畢業院校：白求恩醫科大學
- 學位/學歷：碩士
- 專業方向：腫瘤的免疫細胞治療
研究方向,學術成果,基金,學術論文,
研究方向
1.腫瘤的免疫細胞治療
2.腫瘤抗原在腫瘤微環境形成中的作用及其機制
學術成果
獲2008年度“北京大學醫學部優秀青年學者”稱號；作為主要參與人，完成的“新的腫瘤相關抗原的發現及其套用前景研究”，獲國家教育部自然科學獎一等獎，中華醫學科技獎二等獎，北京市科學技術獎二等獎；三項國內發明專利已獲授權；作為主要參與人申請的腫瘤-睪丸抗原NY-ESO-1抗原肽疫苗獲得中國FDA批准用於肝癌患者免疫治療的Ⅰ期臨床試驗。
基金
科技部863專項課題1 項 （課題負責人）
國家自然科學基金面上課題5項 （課題負責人）
北京市自然科學基金課題2項 （課題負責人）
方正藥物創新研究基金1 項 （課題負責人）
學術論文
近五年代表性論文（責任作者）：
1. Song X, Guo C, Zheng Y, Wang Y, Jin Z, Yin Y*. Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells. BMC Cancer. 2018, 18: 971-980.
2. Zeng P, Wang Y, Zheng Y, Song X, Yin Y*. Cancer-testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells. Mol Med Rep. 2018; 17: 3226-3231.
3. Song X, Hao J, Wang J, Guo C, Wang Y, He Q, Tang H, Qing X, Li Y, Zhang Y*, Yin Y*. The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signling. Oncogene. 2017; 36, 1476–1486.
4. Wang J, Song X, Guo C, Wang Y, Yin Y*. Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells.Cancer Sci. 2016; 107(12): 1888-1897.
5. Xiao Song, Wenjie Song, Ying Wang, Jingjing Wang, Yan Li, Xiaoping Qian, Xuewen Pang, Yu Zhang, Yanhui Yin*. MicroRNA-874 functions as a tumor suppressor by targeting cancer/testis antigen HCA587/MAGE-C2.J Cancer. 2016 ;7(6):656-663..
6. Hao J, Song X, Wang J, Guo C, Li Y, Li B, Zhang Y*, Yin Y*. Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Oncotarget. 2015, 6(19):42028-42039.
7. Li X, Peng J, Pang Y, Yu S, Yu X, Chen P, Wang W, Han , Zhang J,Yin Y*, Zhang Y*. Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma. Sci Rep. 2015, 5:14757.
8. Sun X, Jin Z, Song X, Wang J, Li Y, Qian X, Zhang Y, Yin Y*. Evaluation of KF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma. BMC Cancer. 2015, 15:961.
9. Jiaqing Hao, Rui Shen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2014, 449(4): 386-391.
10. Lijie Zhang, Juanjuan Chen, Xiao Song, Weigang Wen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer/Testis antigen HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model. Oncol Res. 2014,21(4):193-200.
