《基礎藥物化學》是2014年科學出版社出版的圖書，作者是周成合。
基本介紹
- 中文名：基礎藥物化學
- 作者：周成合
- 出版社：科學出版社
- ISBN：9787030412751
內容簡介,圖書目錄,
內容簡介
本書內容包括：中樞神經系統藥物、麻醉藥物、非甾體消炎藥物、作用於呼吸系統的藥物、抗過敏藥物和消化系統的藥物、心血管系統藥物、抗糖尿病藥物、作用於血液及血系統的藥物、抗腫瘤藥物、抗微生物藥物、抗寄生蟲藥物、維生素等。
圖書目錄
- 封面
- 基礎藥物化學
- 內容簡介
- 編委會
- 前言
第1章緒論(Introduction)1
1.1藥物化學的發展簡史(Development History of Medicinal Chemistry)2
1.1.1天然藥物時期(Period of Natural Drugs)2
1.1.2合成藥物時期(Period of Synthetic Drugs)3
1.1.3藥物設計時期(Period of Drug Design)4
1.2藥物化學發展新趨向(New Trends in Medicinal Chemistry)5
1.3化學藥物的命名(Nomenclature of Drugs)6
1.3.1通用名稱(Generic Name)7
1.3.2商品名稱(Trade Name)7
1.3.3系統名稱(Systematic Name)8
1.4藥物作用基礎(Background of Drug Interactions)11
1.4.1藥物作用靶點(Drug Targets)11
1.4.2藥物的化學結構與活性的關係(StructureActivity Relationships)13
1.4.3藥物代謝動力學(Drug Pharmacokinetics)15
1.5藥物設計的原理與方法(Principles and Methods of Drug Design)18
1.5.1先導化合物的發現(Lead Discovery)19
1.5.2先導化合物的最佳化(Lead Optimization)21
1.5.3計算機輔助藥物設計(Computer Aided Drug Design)25
1.6新藥研究與開發概論(Brief Introduction of New Drug Research andDevelopment)26
1.6.1新藥研究與開發過程和方法(Process and Method of New Drug Research andDevelopment)27
1.6.2藥物質量標準(Drug Quality Standards)29
習題30
參考文獻31
第2章中樞神經系統藥物(Drugs for Central Nervous System)32
2.1鎮靜催眠藥物(SedativeHypnotics)32
2.1.1巴比妥類(Barbiturates)32
2.1.2苯二氮類(Benzodiazepines)36
2.1.3其他類(Others)42
2.2抗癲癇藥物(Antiepileptics)45
2.2.1環內酯脲結構類(Macrolide Ureas)46
2.2.2二苯並氮雜類(Dibenzodiazepines)48
2.2.3脂肪酸類(Fatty Acids)49
2.2.4其他類(Others)50
2.3抗驚厥藥物(Anticonvulsants)51
2.4抗精神病藥物(Antipsychotics)52
2.4.1吩噻嗪類(Phenothiazines)53
2.4.2丁醯苯類(Butyrophenones)54
2.4.3硫雜蒽類(Thioxanthenes)57
2.4.4新型抗精神病藥物(New Types of Antipsychotics)58
2.5抗抑鬱藥(Antidepressants)59
2.5.1單胺氧化酶抑制劑(Monoamine Oxidase Inhibitors)60
2.5.25HT重攝取抑制劑(5HTReuptake Inhibitors)61
2.5.3去甲腎上腺素重攝取抑制劑(NorepinephrineReuptake Inhibitors)62
2.6抗焦慮藥(Antianxietics)63
2.6.1苯二氮類(Benzodiazepines)63
2.6.2氨甲酸酯類(Carbamates)63
2.6.3二苯甲烷類(Diphenylmethanes)64
2.6.4其他類(Others)64
2.7促智藥(Nootropics)65
2.8抗躁狂藥物(Antimanics)65
2.9中樞興奮藥物(Central Stimulants)67
2.9.1主要興奮大腦皮質的藥物(Drugs Mainly Exciting Cerebral Cortex)67
2.9.2主要興奮延髓呼吸中樞的藥物(Drugs Mainly Exciting Medullary Respiratory
Center)69
2.9.3主要興奮脊髓的藥物(Drugs Mainly Exciting Spinal Cord)72
2.10抗帕金森病藥(Antiparkinsonism Drugs)73
2.11抗阿爾茨海默病藥物(AntiAlzheimer Drugs)74
2.12鎮痛藥物(Analgesics)77
2.12.1阿片類(Opiums)77
2.12.2合成鎮痛藥(Synthetic Analgesics)79
習題82
參考文獻84
第3章麻醉藥物(Anesthetics)86
3.1全身麻醉藥物(General Anesthetics)86
3.1.1吸入性全身麻醉藥(Inhalation Anesthetics)87
3.1.2靜脈麻醉藥(Intravenous Anesthetics)89
3.2局部麻醉藥物(Local Anesthetics)92
3.2.1芳酸酯類(Aromatic Esters)92
3.2.2醯胺類(Amides)93
3.2.3氨基酮類(Aminoketones)94
3.2.4氨基醚類(Amino Ethers)94
3.2.5其他類型(Others)95
3.2.6局部麻醉藥的構效關係(StructureActivity Relationships of Local Anesthetics)95
習題96
參考文獻97
第4章非甾體消炎藥物(Nonsteroidal Antiinflammatory Drugs)98
4.1解熱鎮痛藥物(Antipyretic Analgesics)99
4.1.1苯胺類(Anilines)99
4.1.2水楊酸類(Salicylic Acids)100
4.1.3吡唑酮類(Pyrazolons)102
4.2環氧化酶抑制劑(Cycloxygenase Inhibitors)104
4.2.1吡唑烷酮類(Pyrazolidones)104
4.2.2苯並噻嗪類(Benzothiazines)105
4.2.3芳基烷酸類(Aralkyl Acids)106
4.2.4滅酸類(Fenamates)109
4.2.5COX2抑制劑(COX2 Inhibitors)110
4.3抗風濕病藥(Antirheumatics)111
4.4抗痛風藥物(Gout Suppressants)113
4.4.1急性痛風關節炎藥物(Acute Gouty Arthritis Drugs)114
4.4.2糖皮質激素(Glucocorticoid，GCS)114
4.4.3作用於尿酸代謝的藥物(Drugs Affecting Uric Acid Metabolism)115
4.4.4其他類(Others)117
4.5抗偏頭痛藥(Antimigraines)119
習題120
參考文獻121
第5章作用於呼吸系統的藥物(Drugs Affecting the Respiratory System)122
5.1鎮咳藥物(Antitussives)122
5.1.1中樞性鎮咳藥(Central Antitussives)122
5.1.2外周性鎮咳藥(Peripheral Antitussives)125
5.2祛痰藥(Expectorants)127
5.3平喘藥(Antiasthmatics)129
5.3.1β腎上腺素受體激動劑(βAdrenergic Receptor Agonists)129
5.3.2嘌呤類(Purines)131
5.3.3抗膽鹼類(Cholinolytics)132
5.3.4消炎平喘類(Antiinflammatory Antiasthmatics)133
5.3.5抗過敏性平喘類(Ananaphylaxis Antiasthmatics)133
習題134
參考文獻135
第6章抗過敏藥物和消化系統的藥物(Drugs for Allergy & Gastrointestinal
Diseases)136
6.1抗過敏藥物(Antiallergic Drugs)136
6.1.1經典的H1受體拮抗劑(Classical H1Receptor Antagonists)138
6.1.2非鎮靜H1受體拮抗劑(Nonsedative H1Receptor Antagonists)143
6.1.3過敏介質釋放抑制劑(Allergic Medicator Release Inhibitors)145
6.1.4過敏介質拮抗劑(Allergic Mediator Antagonists)146
6.1.5鈣通道阻斷劑(Calcium Channel Blockers)146
6.2抗潰瘍藥物(Antiulcer Drugs)146
6.2.1抗酸藥物(Antiacids)147
6.2.2抑制胃酸分泌藥物(Antigastric Acid Secretion Drugs)147
6.2.3抗微生物藥物(Antimicrobials)150
6.3瀉藥與止瀉藥物(Cathartics and Antidiarrheals)151
6.3.1瀉藥(Cathartics)152
6.3.2止瀉藥物(Antidiarrheals)155
6.4止吐藥物與催吐藥物(Antemetics and Emetics)157
6.4.1止吐藥物(Antemetics)157
6.4.2催吐藥物(Emetics)159
6.5助消化藥物(Digestants)160
6.5.1消化液的主要成分(Essential Components of Digestive Juice)161
6.5.2促消化液分泌藥(Drugs for Promoting the Secretion of Digestive Juice)162
6.6促動力藥物(Prokinetics)162
6.7肝膽藥物及其輔助治療藥物(Hepatobiliary Drugs and Their
Adjuvants)168
6.7.1肝病藥物及其輔助治療藥(Hepatic Drugs and Their Adjuvants)168
6.7.2膽病藥物及其輔助治療藥(Biliary Drugs and Their Adjuvants)171
習題171
參考文獻173
第7章心血管系統藥物(Drugs Affecting the Cardiovascular System)174
7.1抗慢性心力衰竭藥物(Drugs for Chronic Heart Failure)174
7.1.1強心苷類(Cardiac Glycosides)175
7.1.2β受體激動劑類(βReceptor Agonists)177
7.1.3磷酸二酯酶抑制劑(Phosphodiesterase Inhibitors)178
7.1.4鈣敏化藥 (Calcium Sensitizers)178
7.2抗心律失常藥物(Antiarrhythmic Drugs)178
7.2.1Ⅰ類鈉通道阻斷劑(ⅠSodium Channel Blockers)179
7.2.2β受體阻斷劑和鈣拮抗劑(βReceptor Blockers and Calcium Antagonists)183
7.2.3鉀通道阻斷劑(Potassium Channel Blockers)183
7.3抗心絞痛藥物(Antianginal Drugs)184
7.3.1硝酸酯類及亞硝酸酯類藥物(Nitrates and Nitrites Drugs)184
7.3.2鈣拮抗劑(Calcium Antagonists)185
7.3.3β受體阻斷劑(βReceptor Blockers)186
7.3.4其他類(Others)186
7.4抗高血壓藥物(Antihypertensive Drugs)187
7.4.1β受體阻斷劑(βReceptor Blockers)188
7.4.2鈣拮抗劑(Calcium Antagonists)192
7.4.3血管緊張素轉換酶抑制劑(Angiotensin Converting Enzyme Inhibitors，
ACEI)195
7.4.4血管緊張素Ⅱ受體拮抗劑(Angiotensin Ⅱ Receptor Antagonists，ARB)197
7.4.5α1受體阻斷劑(α1Receptor Blockers)199
7.4.6其他類(Others)200
7.5抗腦血管疾病藥物(Drugs for Cerebrovascular Diseases)201
7.5.1腦血管擴張藥物(Cerebral Vasodilators)202
7.5.2改善腦部血液循環類藥物(Drugs Improving Cerebral Blood Circulation)204
7.5.3中成藥(Chinese Patent Drugs)205
7.6抗休克藥物(Antishock Drugs)206
7.6.1強心類藥物(Cardiotonic Drugs)206
7.6.2血管擴張類藥(Vasodilator Drugs)207
7.6.3血管收縮類藥(Vasoconstrictor Drugs)208
7.6.4調節代謝類藥(Drugs for Metabolic Regulation)209
7.6.5中成藥(Chinese Patent Drugs)209
7.7利尿藥物(Diuretics)209
7.7.1碳酸酐酶抑制劑(Carbonic Anhydrase Inhibitors)209
7.7.2滲透性利尿藥(Osmotic Diuretics)210
7.7.3Na+Cl-協轉運抑制藥(Na+Cl- Cotransport Inhibitors)211
7.7.4Na+K+2Cl-協轉運抑制藥(Na+K+2Cl- Cotransport Inhibitors)213
7.7.5阻斷腎小管上皮Na+通道藥物(Drugs Blocking Luminal Sodium Channels)215
7.7.6鹽皮質激素受體阻斷藥(Mineralocorticoid Receptor Antagonists)216
7.8降血脂藥物(Antilipemic Drugs)217
7.8.1苯氧乙酸類(Phenoxy Acetic Acids)218
7.8.2羥甲戊二醯輔酶A還原酶抑制劑(HMGCoA Reductase Inhibitors)219
7.8.3煙酸及其衍生物(Nicotinic Acid and Their Derivatives)220
7.8.4其他類(Others)221
習題222
參考文獻223
第8章抗糖尿病藥物(Antidiabetics)226
8.1胰島素製劑(Insulin Agents)226
8.2胰島素分泌促進劑(Insulin Secretagogues Agents)227
8.2.1磺醯脲類(Sulfonylureas)227
8.2.2非磺醯脲類(Nonsulfonylureas)229
8.3胰島素增敏劑(Insulin Enhancers)230
8.3.1雙胍類(Biguanides)230
8.3.2噻唑烷二酮類(Thiazolidinediones)231
8.4α葡萄糖苷酶抑制劑(αGlucosidase Inhibitors)233
8.5醛糖還原酶抑制劑(Aldose Reductase Inhibitors)233
8.6其他類(Others)235
8.6.1胰高血糖素樣多肽1受體激動劑(Glucagonlike Peptide1 Receptor Agonists)235
8.6.2二肽基肽酶Ⅳ抑制劑(Dipeptidyl Peptidase Ⅳ Inhibitors)235
8.6.3胰淀素類似物(Amylin Analogues)236
8.6.4升血糖藥物(Hyperglycemics)237
習題237
參考文獻238
第9章作用於血液及血系統的藥物(Drugs Affecting the Blood and Blood
System)240
9.1抗貧血藥物(Antianemia Drugs)240
9.1.1鐵製劑(Iron Preparations)240
9.1.2葉酸(Folic Acid)241
9.1.3維生素B12(Vitamin B12)242
9.1.4亞葉酸鈣(Calcium Folinate)243
9.1.5重組紅細胞生成素(Erythropoietin)243
9.2抗凝血藥物(Anticoagulant Drugs)244
9.2.1凝血酶間接抑制劑(Indirect Thrombin Inhibitors)244
9.2.2凝血酶直接抑制劑(Direct Thrombin Inhibitors)245
9.2.3維生素K拮抗藥物(Vitamin K Antagonists)247
9.2.4體外抗凝血藥物(In Vitro Anticoagulants)248
9.3抗血小板藥物(Antiplatelet Drugs)248
9.3.1抑制血小板花生四烯酸代謝的藥物(Drugs Inhibiting the Metabolism of
Platelet Arachidonic Acid)249
9.3.2增高血小板內環核苷酸含量的藥物(Drugs Increasing the Content of Platelet
Cyclic Nucleotide)249
9.3.3特異抑制ADP活化血小板的藥物(Drugs Inhibiting the ADP Activating
Platelet)250
9.3.4血小板膜纖維蛋白原受體拮抗藥物(Platelet Fibrinogen Receptor Antagonists)250
9.4抗血栓藥物(Antithrombotics)251
9.4.1纖溶酶原啟動藥物(Plasminogen Activators)251
9.4.2去纖維蛋白原藥物(Defibrinogenating Drugs)251
9.5促凝血藥物和止血藥物(Coagulants and Hemostatics)252
9.5.1促進凝血因子活性的藥物(Drugs Promoting the Coagulation Factor
Activity)252
9.5.2凝血因子製劑(Preparation of Coagulation Factor)252
9.5.3抑制纖維蛋白溶解的藥物(Fibrinolytic Inhibitors)253
9.5.4作用於血管的止血藥物(Vasoactive Hemostyptics)253
9.5.5局部止痛藥物(Local Analgesics)254
9.6促白細胞增生藥物(Drugs Promoting Leucocyte Proliferation)254
9.6.1粒細胞集落刺激因子(Granulocyte ColonyStimulating Factor)254
9.6.2粒細胞/巨噬細胞集落刺激因子(Granulocyte/Macrophage Colony
Stimulating Factor)255
習題255
參考文獻256
第10章抗腫瘤藥物(Antineoplastic Drugs)257
10.1烷化劑(Alkylating Agents)258
10.1.1氮芥類(Nitrogen Mustards)258
10.1.2乙撐亞胺類(Ethylene Imines)265
10.1.3甲磺酸酯類及多元醇類(Methanesulfonates and Polyhydric Alcohols)266
10.1.4甲基化劑類(Methylating Agents)267
10.2金屬類抗癌藥物(Metallic Anticancer Drugs)268
10.2.1過渡金屬配合物(Transition Metal Complexes)268
10.2.2非過渡金屬配合物(Nontransition Metal Complexes)272
10.3抗代謝藥物(Antimetabolites)273
10.3.1嘧啶拮抗物(Pyrimidine Antagonists)274
10.3.2嘌呤拮抗物(Purine Antagonists)276
10.3.3葉酸拮抗物(Antifolates)278
10.4抗腫瘤抗生素(Anticancer Antibiotics)280
10.4.1多肽類抗生素(Polypeptide Antibiotics)280
10.4.2蒽醌類抗生素(Anthraquinone Antibiotics)281
10.5抗腫瘤的植物藥有效成分及其衍生物(Antitumor Compounds
from Plants and Their Derivatives)283
10.5.1喜樹鹼類(Camptothecins)283
10.5.2鬼臼生物鹼類(Podophyllotoxin Alkaloids)286
10.5.3長春鹼類(Vinblastines)287
10.5.4紫杉醇類(Taxols)289
10.5.5秋水仙鹼(Colchicine)289
10.5.6三尖杉酯鹼(Harringtonine)290
10.5.7靛玉紅(Indirubin)290
10.6激素類藥物(Hormone Drugs)291
10.6.1芳香酶抑制劑(Aromatase Inhibitors)291
10.6.2激素治療和激素拮抗劑治療(Hormone and Hormone Antagonists
Therapy)293
習題295
參考文獻297
第11章抗微生物藥物(Antimicrobial Drugs)299
11.1抗生素(Antibiotics)299
11.1.1β內醯胺類(βLactams)300
11.1.2氨基糖苷類(Aminoglycosides)312
11.1.3大環內酯類(Macrolides)317
11.1.4四環素類(Tetracyclines)320
11.1.5其他類(Others)323
11.1.6抗生素的合理使用(Rational Use of Antibiotics)325
11.2抗細菌藥物(Antibacterial Drugs)326
11.2.1磺胺類(Sulfonamides)326
11.2.2喹諾酮類(Quinolones)330
11.2.3唑烷酮類(Oxazolidinones)334
11.2.4咪唑類(Imidazoles)335
11.2.5其他類(Others)337
11.3抗真菌藥物(Antifungal Drugs)338
11.3.1唑類(Azoles)339
11.3.2多烯類(Polyenes)344
11.3.3丙烯胺類(Allylamines)345
11.3.4硫代氨基甲酸類(Thiocarbamic Acids)347
11.3.5其他類(Others)347
11.4抗結核藥物(Antitubercular Drugs)350
11.4.1合成抗結核藥物(Synthetic Antitubercular Drugs)350
11.4.2抗結核抗生素(Antitubercular Antibiotics)353
11.4.3其他類(Others)355
11.5抗麻風病藥(Antileprotic Drugs)355
11.5.1結核樣型麻風病(Tuberculoid Leprosy)356
11.5.2瘤型麻風病(Lepromatous Leprosy)356
11.5.3常用藥物(Normal Drugs)357
11.6抗病毒藥物(Antiviral Drugs)359
11.6.1金剛烷胺類(Amantadines)359
11.6.2核苷類(Nucleotides)360
11.6.3非核苷類(Nonnucleotides)363
11.6.4其他類(Others)366
11.7抗微生物中藥(Antimicrobial Chinese Patent Drugs)367
11.7.1黃連(Coptis)368
11.7.2黃芩(Scutellaria)368
11.7.3魚腥草(Heartleaf Houttuynia Herb)369
11.7.4穿心蓮(Andrographis Paniculata)370
11.7.5金銀花(Honeysuckle)370
11.7.6大蒜(Garlic)371
11.8消毒防腐藥物(Disinfectants and Antiseptics)372
11.8.1醇類(Alcohols)372
11.8.2酚類(Phenols)373
11.8.3醛類(Aldehydes)374
11.8.4酸類(Acids)375
11.8.5鹵化物類(Halogenides)377
11.8.6氧化劑類(Oxidants)378
11.8.7染料類(Dyestuffs)379
11.8.8重金屬化合物類(Heavy Metallic Compounds)380
11.8.9表面活性劑類(Surface Active Drugs)381
習題382
參考文獻384
第12章抗寄生蟲藥物(Antiparasitics)388
12.1抗瘧藥物(Antimalarial Drugs)388
12.1.1喹啉類(Quinolines)389
12.1.2青蒿素類(Artemisinins)391
12.1.3嘧啶類(Miazines)393
12.2驅腸蟲藥(Anthelmintics)393
12.2.1哌嗪類(Piperazines)394
12.2.2咪唑類(Imidazoles)395
12.2.3嘧啶類(Pyrimidines)397
12.2.4天然藥物(Natural Drugs)398
12.3抗滴蟲病藥(Antitrichomoniasis Drugs)399
12.4抗血吸蟲藥物(Antischistosomal Drugs)401
12.5抗絲蟲病藥(Antifilarial Drugs)404
12.6抗阿米巴病藥(Antiamebiasis Drugs)404
12.7抗黑熱病藥(Antikalaazar Drugs)406
習題407
參考文獻408
第13章維生素(Vitamins)409
13.1脂溶性維生素(FatSoluble Vitamins)409
13.1.1維生素A(Vitamin A)類409
13.1.2維生素D(Vitamin D)類411
13.1.3維生素E(Vitamin E)類412
13.1.4維生素K(Vitamin K)類413
13.2水溶性維生素(WaterSoluble Vitamins)415
13.2.1維生素B(Vitamin B)類415
13.2.2維生素C(Vitamin C)類421
習題422
參考文獻423
第14章激素類藥物(Hormone Drugs)424
14.1甾體激素類藥物(Steroid Hormone Drugs)424
14.1.1雄激素、同化激素與抗雄激素類藥物(Androgens，Anabolic Hormones
and Androgen Antagonists)425
14.1.2雌激素和抗雌激素類(Estrogens and Antiestrogens)429
14.1.3孕激素和抗孕激素類藥物(Progestogens and Antiprogestogens)434
14.1.4腎上腺皮質激素(Adrenocorticoids)436
14.2甲狀腺激素及抗甲狀腺激素(Thyroid and Antithyroid
Hormones)442
14.2.1甲狀腺激素類藥物(Thyroid Hormone Drugs)443
14.2.2抗甲狀腺激素類藥物(Antithyroid Hormone Drugs)443
14.3前列腺素(Prostaglandins)445
14.3.1PGE1類衍生物(PGE1Derivatives)445
14.3.2PGE2類衍生物(PGE2Derivatives)446
14.4肽類激素(Peptide Hormones)446
習題448
參考文獻450
第15章作用於自主神經系統的藥物(Drugs Affecting Autonomic Nervous
System)451
15.1作用於膽鹼受體的藥物(Drugs Affecting Cholinergic
Receptor)451
15.1.1擬膽鹼藥(Cholinomimetic Agents)453
15.1.2抗膽鹼藥(Anticholinergic Agents)461
15.2作用於腎上腺素受體的藥物(Drugs Affecting Adrenergic
Receptor)470
15.2.1擬腎上腺素藥物(Adrenergic Agents)471
15.2.2抗腎上腺素藥物(Adrenergic Antagonists)483
習題493
參考文獻494
第16章作用於生殖系統的藥物(Drugs Affecting Reproductive System)496
16.1女性生殖系統藥物(Female Reproductive System Drugs)496
16.1.1子宮肌活動調節藥(Uterine Muscle Activity Regulators)496
16.1.2終止妊娠藥和引產藥(Drugs for Termination of Pregnancy and
Odinopoeia)501
16.1.3促宮頸成熟藥(Drugs Promoting Cervical Ripening)504
16.1.4抑制乳汁分泌藥(Antigalactagogues)504
16.1.5調經藥、促排卵藥和子宮內膜異位症用藥(Antidysmenorrheics，
Ovulation Stimulants and Drugs for Endometriosis)505
16.1.6更年期、絕經期綜合徵用藥(Drugs for Syndrome of Climacteric and
Menopause)507
16.2男性生殖系統藥(Male Reproductive System Drugs)508
16.2.1抗前列腺增生藥(Prostatic Hyperplasia Inhibitors)508
16.2.2促進精子發生和活力的藥物(Drugs Promoting Spermatogenesis and
Vitality)511
16.2.3治療陽痿的藥物(Drugs for Impotence)512
16.3生殖健康及生育調節藥(Reproductive Health and Procreation
Regulators)513
習題519
參考文獻519
第17章解毒藥(Detoxicants)521
17.1金屬中毒解毒藥(Detoxicants for Metal Poisoning)521
17.2有機磷農藥中毒解毒藥(Detoxicants for Organophosphorus
Pesticide Poisoning)522
17.3氰化物中毒解毒藥(Detoxicants for Cyanide Poisoning)524
17.4有機氟中毒解毒藥(Detoxicants for Organofluorine Poisoning)525
17.5有毒動物蜇傷解毒藥(Detoxicants for Poisonous Animals
Poisoning)526
17.6解酒藥(Antialcoholic Drugs)527
17.6.1化學製劑(Chemical Formulas)528
17.6.2中成藥(Chinese Patent Drugs)529
17.6.3保健品(Health Care Products)529
17.7戒毒藥(Treatment Drugs for Addiction)530
17.7.1阿片受體拮抗劑(Opiate Receptor Antagonists)530
17.7.2阿片受體激動劑(Opiate Receptor Agonists)531
17.8其他解毒藥(Other Detoxicants)532
17.8.1一氧化碳中毒解毒藥(Detoxicants for Carbon Monoxide Poisoning)532
17.8.2甲醇中毒解毒藥(Detoxicants for Methanol Poisoning)533
17.8.3四季豆中毒解毒藥(Detoxicants for Phaseolus Poisoning)534
習題534
參考文獻535
第18章其他藥物(Other Drugs)536
18.1抗衰老藥物(Antiaging Drugs)536
18.1.1自由基清除劑(Free Radical Scavengers)536
18.1.2免疫功能調節劑(Immunologic Function Regulators)537
18.1.3激素療法(Hormonotherapy)537
18.2減肥藥物(Antiobesity Drugs)538
18.3殺蟲劑(Pesticides)540
18.3.1乙醯膽鹼酯酶抑制劑(Acetylcholine Esterase Inhibitors)540
18.3.2擬除蟲菊酯類(Pyrethroids)541
18.3.3沙蠶毒素類(Nereistoxins)541
18.3.4有機氯類(Organochlorines)542
18.4毒鼠藥物(Ratsbanes)543
18.5診斷用藥(Diagnostic Drugs)545
18.5.1器官功能檢查藥(Agents for Organ Functional Examination)545
18.5.2X線造影劑(Xray Contrast Medias)547
18.5.3磁共振顯像造影劑(MRI Contrast Medias)548
習題548
參考文獻549
附錄參考書目及手冊550
第1章緒論(Introduction)1
1.1藥物化學的發展簡史(Development History of
Medicinal Chemistry)2
1.1.1天然藥物時期(Period of Naturally Occurring Drugs)2
1.1.2合成藥物時期(Period of Synthetic Drugs)3
1.1.3藥物設計時期(Period of Drug Design)4
1.2藥物化學發展新趨向(New Trends in Medicinal Chemistry)5
1.3化學藥物的命名(Nomenclature of Drugs)6
1.3.1通用名稱(Generic Name)7
1.3.2商品名稱(Trade Name)7
1.3.3系統名稱(System Name)8
1.4藥物作用基礎(Background of Drug Interactions)11
1.4.1藥物作用靶點(Drug Targets)11
1.4.2藥物的化學結構與活性的關係(StructureActivity Relationships)13
1.4.3藥物代謝動力學(Drug Pharmacokinetics)15
1.5藥物設計的原理與方法(Principles and Methods of Drug Design)18
1.5.1先導化合物的發現(Lead Discovery)19
1.5.2先導化合物的最佳化(Lead Optimization)21
1.5.3計算機輔助藥物設計(Computer Aided Drug Design)25
1.6新藥研究與開發概論(Brief Introduction of New Drug Research and Development)26
1.6.1新藥研究與開發過程和方法(Process and Method of New Drug Research and Development)27
1.6.2藥物質量標準(Drug Quality Standards)29
1.6.3新藥研發的新技術(New Techniques of New Drug Research)30
1.7我國新藥管理(The Administration of New Drugs in P.R.China)32
1.8新藥的專利和專利權(The Patents and Patent
Rights of New Drugs)33
1.8.1專利和專利權(Patents and Patent Rights)34
1.8.2醫藥發明專利的種類(The Categories of Medicinal Patent of Invention)34
1.8.3藥品專利的保護對象及條件(The Protect Object and Requirements
of Medicinal Patents)35
1.8.4專利的保護(Patent Protection)35
習題35
參考文獻36
第2章中樞神經系統藥物(Drugs for Central Nervous System)38
2.1鎮靜催眠藥物(SedativeHypnotics)38
2.1.1巴比妥類藥(Barbiturates)38
2.1.2苯二氮類藥物(Benzodiazepines)42
2.1.3其他類鎮靜催眠藥(Others)48
2.2抗癲癇藥物(Antiepileptics)51
2.2.1環內酯脲結構類(Macrolide Ureas)52
2.2.2二苯並氮雜類(Dibenzodiazepines)54
2.2.3脂肪酸類(Fatty Acids)55
2.2.4其他類(Others)56
2.3抗驚厥藥物(Anticonvulsants)57
2.4抗精神病藥物(Antipsychotics)58
2.4.1吩噻嗪類(Phenothiazines)59
2.4.2丁醯苯類(Butyrophenones)60
2.4.3硫雜蒽類(Thioxanthenes)63
2.4.4新型抗精神病藥(New Types of Antipsychotics)64
2.5抗抑鬱藥(Antidepressants)65
2.5.1單胺氧化酶抑制劑(Monoamine Oxidase Inhibitors)66
2.5.25HT重攝取抑制劑(5HTReuptake Inhibitors)67
2.5.3去甲腎上腺素重攝取抑制劑(NorepinephrineReuptake Inhibitors)68
2.6抗焦慮藥(Antianxietics)69
2.6.1苯二氮類(Benzodiazepines)69
2.6.2氨甲酸酯類(Carbamates)69
2.6.3二苯甲烷類(Diphenylmethanes)70
2.6.4其他類(Others)70
2.7促智藥(Nootropics)71
2.8抗躁狂藥物(Antimanics)71
2.9中樞興奮藥物(Central Stimulants)73
2.9.1主要興奮大腦皮質的藥物(Drugs Mainly Exciting Cerebral Cortex)73
2.9.2主要興奮延髓呼吸中樞的藥物(Drugs Mainly Exciting Medullary Respiratory Center)75
2.9.3主要興奮脊髓的藥物(Drugs Mainly Exciting Spinal Cord)78
2.10抗帕金森病藥(Antiparkinsonism Drugs)79
2.11抗阿爾茨海默病藥物(AntiAlzheimer Drugs)80
2.12鎮痛藥物(Analgesics)83
2.12.1阿片類(Opiums)83
2.12.2合成鎮痛藥(Synthetic Analgesics)85
習題88
參考文獻90
第3章麻醉藥物(Anesthetics)92
3.1全身麻醉藥物(General Anesthetics)92
3.1.1吸入性全身麻醉藥(Inhalation Anesthetics)93
3.1.2靜脈麻醉藥(Intravenous Anesthetics)95
3.2局部麻醉藥物(Local Anesthetics)98
3.2.1芳酸酯類(Aromatic Esters)98
3.2.2醯胺類(Amides)99
3.2.3氨基酮類(Aminoketones)100
3.2.4氨基醚類(Amino Ethers)100
3.2.5其他類型(Others)101
3.2.6局部麻醉藥的構效關係(StructureActivity Relationships of
Local Anesthetics)101
習題102
參考文獻103
第4章非甾體抗炎藥物(Nonsteroidal AntⅡnflammatory Drugs)104
4.1解熱鎮痛藥物(Antipyretic Analgesics)105
4.1.1苯胺類(Anilines)105
4.1.2水楊酸類(Salicylic Acids)106
4.1.3吡唑酮類(Pyrazolons)108
4.2非甾體抗炎藥物(Nonsteroidal AntⅡnflammatory Drugs)110
4.2.1吡唑烷酮類(Pyrazolidones)110
4.2.2苯並噻嗪類(Benzothiazines)111
4.2.3芳基烷酸類(Aralkyl Acids)112
4.2.4滅酸類(Fenamates)115
4.2.5COX2抑制劑(COX2 Inhibitors)116
4.3抗風濕病藥(Antirheumatics)117
4.4抗痛風藥物(Gout Suppressants)119
4.4.1急性痛風關節炎藥物(Acute Gouty Arthritis Drugs)120
4.4.2糖皮質激素(Glucocorticoid，GCS)120
4.4.3作用於尿酸代謝的藥物(Drugs Affecting Uric Acid Metabolism)121
4.4.4其他類(Others)123
4.5抗偏頭痛藥(Antimigraines)125
習題126
參考文獻127
第5章作用於呼吸系統的藥物(Drugs Affecting the Respiratory System)128
5.1鎮咳藥物(Antitussives)128
5.1.1中樞性鎮咳藥(Central Antitussives)128
5.1.2外周性鎮咳藥(Peripheral Antitussives)131
5.2祛痰藥(Expectorants)133
5.3平喘藥(Antiasthmatics)135
5.3.1β腎上腺素受體激動劑(βSympathomimetics)135
5.3.2嘌呤類(Purines)137
5.3.3抗膽鹼類(Cholinolytics)138
5.3.4抗炎平喘類(Antiinflammatory Antiasthmatics)139
5.3.5抗過敏性平喘類(Ananaphylaxis Antiasthmatics)139
習題140
參考文獻141
第6章抗過敏藥物和消化系統的藥物(Drugs for Allergy & Gastrointestinal
Diseases)142
6.1抗過敏藥物(Antiallergic Drugs)142
6.1.1經典的H1受體拮抗劑(Classical H1Receptor Antagonists)144
6.1.2非鎮靜H1受體拮抗劑(Nonsedative H1Receptor Antagonists)149
6.1.3過敏介質釋放抑制劑(Allergic Medicator Release Inhibitors)151
6.1.4過敏介質拮抗劑(Allergic Mediator Antagonists)152
6.1.5鈣通道阻斷劑(Calcium Channel Blockers)152
6.2抗潰瘍藥物(Antiulcer Drugs)152
6.2.1抗酸藥物(Antiacids)153
6.2.2抑制胃酸分泌藥物(Antigastric Acid Secretion Drugs)153
6.2.3抗微生物藥物(Antimicrobials)156
6.3瀉藥與止瀉藥物(Cathartics and Constipating Remedies)157
6.3.1瀉藥(Cathartics)158
6.3.2止瀉藥物(Constipating Remedies)161
6.4止吐藥物與催吐藥物(Antemetics and Emetics)163
6.4.1止吐藥物(Antemetics)163
6.4.2催吐藥物(Emetics)165
6.5助消化藥物(Digestants)166
6.5.1消化液的主要成分(Essential Components of Digestive Juice)167
6.5.2促消化液分泌藥(Drugs for Promoting the Secretion of Digestive Juice)168
6.6促動力藥物(Prokinetics)168
6.7肝膽藥物及其輔助治療藥物(Hepatobiliary Drugs and Their
Adjuvants)174
6.7.1肝病藥物及其輔助治療藥(Hepatic Drugs and Their Adjuvants)174
6.7.2膽病藥物及其輔助治療藥(Biliary Drugs and Their Adjuvants)177
習題177
參考文獻179
第7章心血管系統藥物(Drugs Affecting the Cardiovascular System)180
7.1抗慢性心力衰竭藥物(Drugs for Chronic Heart Failure)180
7.1.1強心苷類(Cardiac Glycosides)181
7.1.2木β受體激動劑類(βReceptor Agonists)183
7.1.3磷酸二酯酶抑制劑(Phosphodiesterase Inhibitors)184
7.2抗心律失常藥物(Antiarrhythmic Drugs)184
7.2.1Ⅰ類鈉通道阻滯劑(ⅠSodium Channel Blockers)185
7.2.2β受體阻斷劑和鈣離子拮抗劑(βReceptor Blockers and Calcium Antagonists)189
7.2.3鉀通道阻斷劑(Potassium Channel Blockers)189
7.3抗心絞痛藥物(Antianginal Drugs)190
7.3.1硝酸酯類及亞硝酸酯類藥物(Nitrates and Nitrites Drugs)190
7.3.2鈣離子拮抗劑(Calcium Antagonists)191
7.3.3β受體阻斷劑(βReceptor Blockers)192
7.3.4其他類(Others)192
7.4抗高血壓藥物(Antihypertensive Drugs)193
7.4.1β受體阻滯劑(βReceptor Blockers)194
7.4.2鈣離子拮抗劑(Calcium Channel Blockers)198
7.4.3血管緊張素轉換酶抑制劑(Angiotensin Converting Enzyme Inhibitors，
ACEI)201
7.4.4血管緊張素Ⅱ受體拮抗劑(Angiotensin Ⅱ Receptor Antagonists，ARB)203
7.4.5α1受體阻滯劑(α1Receptor Blockers)205
7.4.6其他類(Others)206
7.5抗腦血管疾病藥物(Drugs for Cerebrovascular Diseases)207
7.5.1腦血管擴張藥物(Cerebral Vasodilator)208
7.5.2改善腦部血液循環類藥物(Drugs Improving Cerebral Blood Circulation)210
7.5.3中成藥(Chinese Patent Drugs)211
7.6抗休克藥物(Antishock Drugs)212
7.6.1強心類藥物(Cardiotonic Drugs)212
7.6.2血管擴張類藥(Vasodilator Drugs)213
7.6.3收縮血管類藥(Vasoconstrictor Drugs)214
7.6.4調節代謝類藥(Drugs for Metabolic Regulation)215
7.6.5中成藥(Chinese Patent Drugs)215
7.7利尿藥物(Diuretics)215
7.7.1碳酸酐酶抑制劑(Carbonic Anhydrase Inhibitors)215
7.7.2滲透性利尿藥(Osmotic Diuretics)216
7.7.3Na+Cl-協轉運抑制藥(Na+Cl- Contransport Inhibitors)217
7.7.4Na+K+2Cl-協轉運抑制藥(Na+K+2Cl- Contransport Inhibitors)219
7.7.5阻斷腎小管上皮Na+通道藥物(Drugs Blocking Luminal Sodium
Channels)221
7.7.6鹽皮質激素受體阻斷藥(Mineralocorticoid Receptor Antagonists)222
7.8降血脂藥物(Antilipemic Drugs)223
7.8.1苯氧乙酸類(Phenoxy Acetic Acids)224
7.8.2羥甲戊二醯輔酶A還原酶抑制劑(HMGCoA Reductase Inhibitors)225
7.8.3煙酸及其衍生物(Nicotinic Acid and Their Derivatives)226
7.8.4其他類(Others)227
習題228
參考文獻229
第8章抗糖尿病藥物(Antidiabetics)232
8.1胰島素製劑(Insulin Agents)232
8.2胰島素分泌促進劑(Insulin Secretagogues Agents)233
8.2.1磺醯脲類(Sulfonylureas)233
8.2.2非磺醯脲類(Nonsulfonylureas)235
8.3胰島素增敏劑(Insulin Enhancers)236
8.3.1雙胍類(Biguanides)236
8.3.2噻唑烷二酮類(Thiazolidinediones)237
8.4α葡萄糖苷酶抑制劑(αGlucosidase Inhibitors)239
8.5醛糖還原酶抑制劑(Aldose Reductase Inhibitors)239
8.6其他類(Others)241
8.6.1胰高血糖素樣多肽1受體激動劑(Glucagonlike Peptide1 Receptor
Agonists)241
8.6.2二肽基肽酶Ⅳ抑制劑(Dipeptidyl Peptidase Ⅳ Inhibitors)241
8.6.3胰淀素類似物(Amylin Analogues)242
8.6.4升血糖藥物(Hyperglycemics)243
習題243
參考文獻244
第9章作用於血液及血系統的藥物(Drugs Affecting the Blood and Blood System)246
9.1抗貧血藥物(Antianemia Drugs)246
9.1.1鐵製劑(Iron Preparations)246
9.1.2葉酸(Folic Acid)247
9.1.3維生素B12(Vitamin B12)248
9.1.4亞葉酸鈣(Calcium Folinate)249
9.1.5重組紅細胞生成素(Erythropoietin)249
9.2抗凝血藥物(Anticoagulant Drugs)250
9.2.1凝血酶間接抑制劑(Indirect Thrombin Inhibitors)250
9.2.2凝血酶直接抑制劑(Direct Thrombin Inhibitors)251
9.2.3維生素K拮抗藥物(Vitamin K Antagonists)253
9.2.4體外抗凝血藥物(In Vitro Anticoagulants)254
9.3抗血小板藥物(Antiplatelet Drugs)254
9.3.1抑制血小板花生四烯酸代謝的藥物(Drugs Inhibiting the Metabolism
of Platelet Arachidonic Acid)255
9.3.2增高血小板內環核苷酸含量的藥物(Drugs Increasing the Content
of Platelet Cyclic Nucleotide)255
9.3.3特異抑制ADP活化血小板的藥物(Drugs Inhibiting the ADP Activating
Platelet)256
9.3.4血小板膜纖維蛋白原受體拮抗藥物(Platelet Fibrinogen Receptor
Antagonists)256
9.4抗血栓藥物(Antithrombotics)257
9.4.1纖溶酶原啟動藥物(Plasminogen Activators)257
9.4.2去纖維蛋白原藥物(Defibrinogenating Drugs)257
9.5促凝血藥物和止血藥物(Coagulants and Hemostatics)258
9.5.1促進凝血因子活性的藥物(Drugs Promoting the Coagulation Factor
Activity)258
9.5.2凝血因子製劑(NiaStates)258
9.5.3抑制纖維蛋白溶解的藥物(Fibrinolytic Inhibitors)259
9.5.5局部止痛藥物(Local Analgesics)260
9.6促白細胞增生藥物(Drugs Promoting Leucocyte Proliferation)260
9.6.1粒細胞集落刺激因子(Granulocyte ColonyStimulating Factor)260
9.6.2粒細胞/巨噬細胞集落刺激因子(Granulocyte/Macrophage Colony
Stimulating Factor)261
習題261
參考文獻262
第10章抗腫瘤藥物(Antineoplastic Drugs)263
10.1烷化劑(Alkylating Agents)264
10.1.1氮芥類(Nitrogen Mustards)264
10.1.2乙撐亞胺類(Ethylene Imines)271
10.1.3甲磺酸酯類及多元醇類(Methanesulfonates and Polyhydric Alcohols)272
10.1.4甲基化劑類(Methylating Agents)273
10.2金屬類抗癌藥物(Metallic Anticancer Drugs)274
10.2.1過渡金屬配合物(Transition Metal Complexes)274
10.2.2非過渡金屬配合物(Nontransition Metal Complexes)278
10.3抗代謝藥物(Antimetabolites)279
10.3.1嘧啶拮抗物(Pyrimidine Antagcnists)280
10.3.2嘌呤拮抗物(Purine Antagcnists)282
10.3.3葉酸拮抗物(Antifolates)284
10.4抗腫瘤抗生素(Anticancer Antibiotics)286
10.4.1多肽類抗生素(Polypeptide Antibiotics)286
10.4.2蒽醌類抗生素(Anthraquinone Antibiotics)287
10.5抗腫瘤的植物藥有效成分及其衍生物(Antitumor Compounds
from Plants and Their Derivatives)289
10.5.1喜樹鹼類(Camptothecins)289
10.5.2鬼臼生物鹼類(Podophyllotoxin Alkaloids)292
10.5.3長春鹼類(Vinblastines)293
10.5.5秋水仙鹼(Colchicine)295
10.5.6三尖杉酯鹼(Harringtonine)296
10.5.7靛玉紅(Indirubin)296
10.6激素類藥物(Hormone Drugs)297
10.6.1芳香酶抑制劑(Aromatase Inhibitors)297
10.6.2激素治療和激素拮抗劑治療(Hormone and Hormone Antagonists
Therapy)299
習題301
參考文獻303
第11章抗微生物藥物(Antimicrobial Drugs)305
11.1抗生素(Antibiotics)305
11.1.1β內醯胺類(βLactams)306
11.1.1.1β內醯胺類抗生素的結構特點及其分類(Structure Characteristic and Classification of βLactam Antibiotics)306
11.1.1.2β內醯胺類抗生素的抗菌作用機制(Antibacterial Mechanism Action
of βLactam Antibiotics)306
11.1.2氨基糖苷類(Aminoglycosides)318
11.1.3大環內酯類(Macrolides)323
11.1.4四環素類(Tetracyclines)326
11.1.5其他類(Others)329
11.1.6抗生素的合理使用(Rational Use of Antibiotics)331
11.2抗細菌藥(Antibacterial Drugs)332
11.2.1磺胺類(Sulfonamides)332
11.2.2喹諾酮類(Quinolones)336
11.2.3唑烷酮類(Oxazolidinones)340
11.2.4咪唑類(Imidazoles)341
11.2.5其他類(Others)343
11.3抗真菌藥物(Antifungal Drugs)344
11.3.1唑類(Azoles)345
11.3.2多烯類(Polyenes)350
11.3.3丙烯胺類(Allylamines)351
11.3.4硫代氨基甲酸類(Thiocarbamic acids)353
11.3.5其他類(Others)353
11.4抗結核藥物(Antitubercular Drugs)356
11.4.1合成抗結核藥物(Synthetic Antitubercular Drugs)356
11.4.2抗結核抗生素(Antitubercular Antibiotics)359
11.4.3其他類(Others)361
11.5抗麻風病藥(Antileprotic Drugs)361
11.5.1結核樣型麻風病(Tuberculoid Leprosy)362
11.5.2瘤型麻風病(Lepromatous Leprosy)362
11.5.3其他類(Others)363
11.6抗病毒藥物(Antiviral Drugs)365
11.6.1金剛烷胺類(Amantadines)365
11.6.2核苷類(Nucleotides)366
11.6.3非核苷類(Nonnucleotides)369
11.6.4其他類(Others)372
11.7抗微生物中藥(Antimicrobial Chinese Patent Drugs)373
11.7.1黃連(Coptis)374
11.7.2黃芩(Scutellaria)374
11.7.3魚腥草(Heartleaf Houttuynia Herb)375
11.7.4穿心蓮(Andrographis Paniculata)376
11.7.5金銀花(Honeysuckle)376
11.7.6大蒜(Garlic)377
11.8消毒防腐藥物(Disinfectants and Antiseptics)378
11.8.1醇類(Alcohols)378
11.8.2酚類(Phenols)379
11.8.3醛類(Aldehydes)380
11.8.5鹵化物類(Halogenides)383
11.8.6氧化劑類(Oxidants)384
11.8.7染料類(Dyestuffs)385
11.8.8重金屬化合物類(Heavy Metallic Compounds)386
11.8.9表面活性劑類(Surface Active Drugs)387
習題388
參考文獻390
第12章抗寄生蟲藥物(Antiparasitics)394
12.1抗瘧藥物(Antimalarial Drugs)394
12.1.1喹啉類(Quinolines)395
12.1.2青蒿素類(Artemisinins)397
12.1.3嘧啶類(Miazines)399
12.2驅腸蟲藥(Anthelmintics)399
12.2.1哌嗪類(Piperazines)400
12.2.2咪唑類(Imidazoles)401
12.2.3嘧啶類(Miazines)403
12.2.4天然藥物(Naturally Occurring Drugs)404
12.3抗滴蟲病藥(Antitrichomoniasis Drugs)405
12.4抗血吸蟲藥物(Antischistosomal Drugs)407
12.5抗絲蟲病藥(Antifilarial Drugs)410
12.6抗阿米巴病藥(Antiamebiasis Drugs)410
12.7抗黑熱病藥(Antikalaazar Drugs)412
習題413
參考文獻414
第13章維生素(Vitamins)415
13.1脂溶性維生素(FatSoluble Vitamins)415
13.1.1維生素A(Vitamin A)類415
13.1.2維生素D(Vitamin D)類417
13.1.3維生素E(Vitamin E)類418
13.1.4維生素K(Vitamin K)類419
13.2水溶性維生素(WaterSoluble Vitamins)421
13.2.1維生素B(Vitamin B)類421
13.2.2維生素C(Vitamin C)427
習題428
參考文獻429
第14章激素類藥物(Hormone Drugs)430
14.1甾體激素類藥物(Steroid Hormone Drugs)430
14.1.1雄激素、同化激素與抗雄激素類藥物(Androgens，Anabolic Hormones
and Androgen Antagonists)431
14.1.2雌激素和抗雌激素類(Estrogens and Antiestrogens)435
14.1.3孕激素和抗孕激素類藥物(Progestogens and Antiprogestogens)440
14.1.4腎上腺皮質激素(Adrenocorticoid)442
14.2甲狀腺激素及抗甲狀腺激素(Thyroid and Antithyroid
Hormones)448
14.2.1甲狀腺激素類藥物(Thyroid Hormone Drugs)448
14.2.2抗甲狀腺激素類藥物(Antithyroid Hormone Drugs)449
14.3前列腺素(Prostaglandins)450
14.3.1PGE1類衍生物(PGE1Derivatives)451
14.3.2PGE2類衍生物(PGE2Derivatives)451
14.4肽類激素(Peptide Hormones)452
習題454
參考文獻455
第15章作用於自主神經系統的藥物(Drugs Affecting Autonomic Nervous
System)457
15.1作用於膽鹼能受體的藥物(Drugs Affecting Cholinergic
Receptor)457
15.1.1擬膽鹼藥(Cholinomimetics)459
15.1.2抗膽鹼藥(Anticholinergic Agents)467
15.2作用於腎上腺素受體的藥物(Drugs Affecting Adrenergic
Receptor)476
15.2.1擬腎上腺素藥物(Adrenergic Agonists)477
15.2.2抗腎上腺素藥物(Adrenergic Antagonists)489
習題499
參考文獻500
第16章作用於生殖系統的藥物(Drugs Affecting Reproductive System)502
16.1女性生殖系統藥物(Female Reproductive System Drugs)502
16.1.1子宮肌活動調節藥(Uterine Muscle Activity Regulators)502
16.1.2終止妊娠藥和引產藥(Drugs for Termination of Pregnancy and
Odinopoeia)507
16.1.3促宮頸成熟藥(Drugs Promoting Cervical Ripening)510
16.1.4抑制乳汁分泌藥(Antigalactagogues)510
16.1.5調經藥、促排卵藥和子宮內膜異位症用藥(Antidysmenorrheics，
Ovulation Stimulants & Drugs for Endometriosis)511
16.1.6更年期、絕經期綜合徵用藥(Drugs for Syndrome of Climacteric and
Menopause)513
16.2男性生殖系統藥(Male Reproductive System Drugs)514
16.2.1抗前列腺增生藥(Prostatic Hyperplasia Inhibitors)514
16.2.2促進精子發生和活力的藥物(Drugs Promoting Spermatogenesis and
Vitality)517
16.2.3治療陽痿的藥物(Drugs for Impotence)518
16.3生殖健康及生育調節藥(Reproductive Health and Procreation
Regulators)519
習題525
參考文獻525
第17章解毒藥(Detoxicants)527
17.1金屬中毒解毒藥(Detoxicants for Metal Poisoning)527
17.2有機磷農藥中毒解毒藥(Detoxicants for Organophosphorus
Pesticide Poisoning)528
17.3氰化物中毒解毒藥(Detoxicants for Cyanide Poisoning)530
17.4有機氟中毒解毒藥(Detoxicants for Organofluorine Poisoning)531
17.5有毒動物蜇傷解毒藥(Detoxicants for Poisonous Animals
Poisoning)532
17.6解酒藥(Antialcoholic Drugs)533
17.6.1化學製劑(Chemical Preparations)534
17.6.2中成藥(Chinese Patent Drugs)535
17.6.3保健品(Health Care Products)535
17.7戒毒藥(Detoxification Drugs)536
17.7.1阿片受體拮抗劑(Opiate Receptor Antagonists)536
17.7.2阿片受體激動劑(Opiate Receptor Agonists)537
17.8其他解毒藥(Others)538
17.8.1一氧化碳中毒解毒藥(Detoxicants for Carbon Monoxide Poisoning)538
17.8.2甲醇中毒解毒藥(Detoxicants for Methanol Poisoning)539
17.8.3四季豆中毒解毒藥(Detoxicants for Phaseolus Poisoning)540
習題540
參考文獻541
第18章其他藥物(Other Drugs)542
18.1抗衰老藥物(Antiaging Drugs)542
18.1.1自由基清除劑(Free Radical Scavengers)542
18.1.2免疫功能調節劑(Immunologic Function Regulators)543
18.1.3激素療法(Hormonotherapy)543
18.2減肥藥物(Antiobesity Drugs)544
18.3殺蟲劑(Pesticides)546
18.3.1乙醯膽鹼酯酶抑制劑(Acetylcholine Esterase Inhibitors)546
18.3.2擬除蟲菊酯類(Pyrethroids)547
18.3.3沙蠶毒素類(Nereistoxins)547
18.3.4有機氯類(Organochlorines)548
18.4毒鼠藥物(Ratsbanes)549
18.5診斷用藥(Diagnostic Drugs)551
18.5.1器官功能檢查藥(Agents for Organ Functional Examination)551
18.5.2X線造影劑(Xray Contrast Medias)553
18.5.3磁共振顯像造影劑(MRI Contrast Medias)554
習題554
參考文獻555
附錄1參考書目及手冊556
附錄2習題參考答案558
附錄 參考書目及手冊
- 封底
