吳建國(武漢大學生命科學學院教授)

吳建國，男，“長江學者”病毒學特聘教授，武漢大學生命科學學院教授、博導、生物技術系主任，武漢大學微生物學國家重點學科帶頭人，“211工程”病毒學國家重點建設項目負責人，“985”二期工程高校國家科技創新平台建設項目負責人，湖北省病毒疾病工程技術中心副主任，病毒學教育部重點實驗室主任，病毒學國家重點實驗室主任。

基本介紹

• 中文名：吳建國
• 外文名：JianGuo Wu
• 民族：漢族
• 職業：武漢大學生命科學學院教授
• 畢業院校：美國普林斯頓大學
• 主要成就：論文30餘篇，出版著作1部，成果鑑定1項，專利4項
• 人物簡介：男,“長江學者”病毒學特聘教授

人物經歷

1982年獲武漢大學微生物學學士學位，1985年獲武漢大學病毒學碩士學位，1992獲美國愛達華大學生物化學博士學位，1993～1996年為美國普林斯頓大學博士後。曾先後在中科院微生物所田波院士實驗室（代培研究生）、美國喬治亞大學Miller院士實驗室（訪問研究員）、美國普林斯頓大學美國微生物學院院士Newton教授實驗室（研究員）、美國多瑞瑪斯研究所（資深研究員）、美國塞普特藥物公司（顧問）、美國國防部海軍健康研究中心分子生物學實驗室（主任）做科研工作。

學術兼職

1. 病毒學國家重點實驗室學術委員會，副主任委員。
2. 農業微生物國家重點實驗室學術委員會，副主任委員。
3. 湖北省生物工程學會，理事長。
4. 湖北省微生物學會，副理事長。
5. 中國生物工程學會，理事。
6. 中國微生物學會病毒專業委員會，理事。

研究方向

（1）人類重要病毒致病和致癌的分子機理研究；

（2）抗病毒和抗腫瘤新藥物研發；

（3）呼吸道病毒的分子生物學與流行病學研究；

（4）人體細胞核受體新藥物的研究和開發；

（5）致病真菌遺傳基因組的結構與功能研究；

（6）信息傳導系統在調控細胞分裂與分化中的作用機理研究；

（7）基因轉錄調控的分子機理研究；

（8）真菌生長與發育的機理研究等。

主要貢獻

在重要學術刊物上發表學術論文30餘篇，出版著作1部，成果鑑定1項，專利4項。

科研項目

主持國家科技重大專項、國家科技部973計畫項目、國家自然科學基金重點項目等多項。

學術論文

1.Chen YN, Chen JB, Wang H, Shi JJ, Wu KL, Liu S, Liu YL, Wu JG (2013). HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog 9(4):e1003248. (IF:9.629)

2.Xia C, Chen YC, Gong H, Zeng WB, Vu GP, Trang P, Lu SW, Wu JG, Liu FY (2013). Inhibition of hepatitis B virus gene expression and replication by ribonuclease P. Mol Ther 21(5):995-1003. (IF:6.284)

3.Cao YH, Zhang W, Yu Y, Zhu CL, Zhang R, Song Y, Wang Q, Bai L, Liu YL, Wu KL, Wu JG (2013). IL-27, a cytokine, and IL-29, a type III interferon, are coordinated to regulate virus replication in a manner similar to type I interferon. J Immunol (Accepted) (IF:5.745)

4.Xu P, Huang ZX, Gao XD, Michel FJ, Hirsch G, Hogan RJ, Sakamoto K, Ho WZ, Wu JG, He B (2013). Infection of mice, ferrets, and rhesus macaques with a clinical mumps virus isolate. J Virol 87(14):8158-8168. (IF:5.189)

5.Yu Y, Cao YH, Sun ZC, Zhang W, Wu KL, Wu JG (2013). Hepatitis B e antigen activates the suppressor of cytokine signaling-2 to antagonize type I and type III interferon and mediate viral immune evasion. Eur J Immunol (In reversion) (IF:4.970)

6.Zhang Z, Vu GP, Gong H, Xia C, Chen YC, Liu FY, Wu JG, Lu SW (2013). Engineered external guide sequences are highly effective in inhibiting gene expression and replication of hepatitis B virus in cultured cells. PLoS One 8(6):e65268. (IF:4.411)

7.Liu S, Hao Q, Wang Y, Yue X, Peng NF, Chen YN, Wu JG, Zhu Y (2012). Major vault protein: A virus-induced host factor against viral replication through the induction of type-I interferon. Hepatology 56(1):57-66. (IF:11.665)

8.Yue X, Wang H, Zhao F, Liu S, Wu JG, Ren W, Zhu Y (2012). Hepatitis B virus-induced calreticulin protein is involved in interferon resistance. J Immunol 189(1):279-286. (IF:5.745)

9.Liu L, Cao ZY, Chen J, Li R, Cao YH, Zhu CL, Wu KL, Wu JG, Liu F, Zhu Y (2012). Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. J Biol Chem 287(15):11899-11910. (IF:5.328)

10.Li YX, Zhang Q, Liu Y, Luo Z, Kang L, Qu J, Liu WY, Xia XS, Liu YL, Wu KL, Wu JG (2012). Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. J Virol 86(23):12531-12543. (IF:5.189)

11.Zhang Q, Gong R, Qu J, Zhou YJ, Liu WY, Chen MZ, Liu YL, Zhu Y, Wu JG (2012). Activation of the Ras/Raf/MEK pathway facilitates HCV replication via attenuation of the INF-JAK-STAT pathway. J Virol 86(3):1544-1554. (IF:5.189)

12.Fang JL, Liu L, Li YK, Wu JG, Huo XX, Zhu Y (2012). Epigenetic changes mediated by miR29 activate cyclooxygenase-2 and interferon-1 production during viral infection. J Virol 86(2):1010-1020. (IF:5.189)

13.Xu P, Luthra PY, Li Z, Fuentes S, D’Andrea J, Wu JG, Rubin S, Rota P, He B (2012). The V protein of mumps virus plays a critical role in pathogenesis. J Virol 86(3):1768-1776. (IF:5.189)

14.Zeng WB, Chen YC, Bai Y, Trang P, Vu GP, Lu SW, Wu JG, Liu FY (2012). Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme. PLoS One 7(12):e51855. (IF:4.411)

15.Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Circadian rhythms of fetal liver transcription persist in the absence of canonical circadian clock gene expression rhythms in vivo. PLoS One 7(2): e30781. (IF:4.411)

16.Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Transcriptome comparison between fetal and adult mouse livers: Implications for circadian clock mechanisms. PLoS One 7(2): e31292. (IF:4.411)

17.Chen YN, Shen A, Rider PJ, Yu Y, Wu KL, Mu YX, Hao Q, Liu YL, Gong H, Zhu Y, Liu FY, Wu JG (2011). A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. FASEB J 25(12):4511-4521. (IF:6.515)

18.Yu Y, Gong R, Mu YX, Chen YN, Zhu CL, Sun ZC, Chen MZ, Liu YL, Zhu Y, Wu JG (2011). Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, interleukin-29, interleukin-8, and cyclooxygenase-2. J Immunol 187(9):4844-4860. (IF:5.745)

19.Liu QY, Chen JW, Liu L, Zhang J, Wang DF, Ma L, He YM, Liu YL, Liu ZS, Wu JG (2011). The X protein of HBV inhibits apoptosis in hepatoma cells through enhancing MAT2A expression and reducing SAM production. J Biol Chem 286(19):17168-17180. (IF:5.328)

20.Liu QY, Liu L, Zhao YH, Zhang J, Wang DF, Chen JW, He YM, Wu JG, Zhang ZL, Liu ZS (2011). Hypoxia induces genomic DNA demethylation through the activation of HIF-1a and transcriptional up-regulation of MAT2A in hepatoma cells. Mol Cancer Ther 10(6):1113-1123. (IF:5.225)

21.Liu MY, Liu WY, Luo J, Liu YL, Zhu Y, Berman H, Wu JG (2011). Characterization of an outbreak of hand, foot, and mouth disease in Nanchang, China in 2010. PLoS One 6(9): e25287. (IF:4.411)

22.Qu J, Yang ZH, Zhang Q, Liu WY, Li YX, Ding Q, Liu F, Liu YL, Pan ZS, He B, Zhu Y, Wu JG (2011). Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by direct targeting HCV 5’-untranslated region. FEBS Lett 585(24):4002-4009. (IF:3.601)

23.Luo M, Qu X, Pan R, Zhu D, Zhang Y, Wu JG, Pan ZS (2011). The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine 29(14):2561-2567. (IF:3.572)

24.Xu P, Li Z, Sun DY, Lin Y, Wu JG, Rota P, He B (2011). Rescue of wild-type mumps virus from a strain associated with recent outbreaks helps to define the role of the SH ORF in the pathogenesis of mumps virus. Virology 417(1):126-136. (IF:3.305)

25.Li W, Sun W, Liu L, Yang F, Li Y, Chen Y, Fang J, Zhang W, Wu JG, Zhu Y (2010). IL-32: A host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. J Immunol 185(9):5056-5065. (IF:5.745)

26.Li W, Yang F, Liu Y, Gong R, Liu L, Feng Y, Hu P, Sun W, Hao Q, Kang L, Wu JG, Zhu Y (2009). Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur J Immunol 39(4):1019-1024. (IF:4.942)

27.Mukhtar MM, Li SF, Li W, Wan T, Mu YX, Wei W, Kang L, Rasool ST, Xiao YB, Zhu Y, Wu JG (2009). Single-chain intracellular antibodies inhibit influenza virus replication by disrupting interaction of proteins involved in viral replication and transcription. Int J Biochem Cell Biol 41(3):554-560. (IF:4.956)

28.Zhu CL, Zhang R, Liu L, Rasool ST, Mu YX, Sun W, Hao Q, Liu F, Zhu Y, Wu JG (2009). Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Clin Immunol 131(1):92-97. (IF:3.932)

29.Xia LM, Huang WJ, Wu JG, Yang YB, Zjang Q, Zhou ZZ, Zhu HF, Lei P, Shen GX, Tian GA (2009). HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB. Virology 385(2):335-342. (IF:3.305)

30.Peng GQ, Yan Y, Zhu CL, Wang SQ, Yan XH, Lu LL, Li W, Hu J, Wei W, Mu YX, Chen YN, Feng Y, Gong R, Wu KL, Zhang FM, Zhang XL, Zhu Y, Wu JG (2008). Borna disease virus P protein affects neural transmission through interacting with gamma-aminobutyric acid receptor-associated protein. J Virol 82 (24):12487-12497. (IF:5.189)

31.Wang K, Zhang Y, Li X, Chen L, Wang H, Wu JG, Zheng J, Wu D (2008). Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 283(34):23371-23375. (IF:5.328)

32.Lu LL, Wei L, Peng GQ, Mu YX, Wu KL, Kang L, Yan XH, Zhu Y, Wu JG (2008). NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. Virology 371:61-70. (IF:3.305)

33.Feng Y, Wang SQ, Luo FL, Ruan Y, Kang L, Xiang XH, Peng GQ, Zhu CL, Mu YX, Zhang XL, Wu JG (2008). A novel recombinant bacterial vaccine strain expressing dual viral antigens induces multiple immune responses to the gag and gp120 proteins of HIV-1 in immunized mice. Antivir Res 80:272-279. (IF:4.439)

34.Li W, Liu Y, Mukhtar MM, Gong R, Pan Y, Rasool ST, Gao Y, Kang L, Hao Q, Peng GQ, Chen YN, Chen X, Wu JG, Zhu Y (2008). Activation of interleukin-32 proinflammatory pathway in response to influenza A virus infection. PLoS One 3(4):e1985. (IF:4.411)

35.Liu M, Yang YB, Gu CF, Yue YP, Wu KK, Wu JG, Zhu Y (2007). Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways. FASEB J 21(7):1586-1596. (IF:6.515)

36.Peng GQ, Zhang FM, Zhang Q, Wu KL, Zhu F, Wu JG (2007). Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes. Virology 366:446-452. (IF:3.305)

37.Zhang X, Wu KL, Wang D, Yue X, Song DG, Zhu Y, Wu JG (2007). Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB. Virology 365(2):324-335. (IF:3.305)

38.Li PF, Wan Q, Feng Y, Liu M, Wu JG, Chen XW, Zhang XL (2007). Engineering of N-glycosylation of hepatitis C virus envelope protein E2 enhances T cell responses for DNA immunization. Vaccine 25:1544-1551. (IF:3.572)

39.Wu KL, Mu YX, Hu J, Lu L, Zhang X, Yang YB, Li Y, Liu F, Song DG, Zhu Y, Wu JG (2007). Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system. Antivir Res 74:142-149. (IF:4.439)

40.Mukhtar MM, Rasool ST, Song D, Zhu CL, Hao Q, Zhu Y, Wu JG (2007). Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. J Gen Virol 88:3094-3099. (IF:3.568)

41.Yan XH, Hao Q, Mu YX, Timani KT, Ye LB, Zhu Y, Wu JG (2006). Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein. Int J Biochem Cell Biol 38(8):1417-1428. (IF:4.956)

42.Huang WJ, Liu ZC, Wei W, Wang GH, Wu JG, Zhu F (2006). Human endogenous retroviral pol RNA and protein detected and identified in the blood of individuals with schizophrenia. Schizophr Res 83(2-3):193-199. (IF:4.374)

43.Wei W, Huang WJ, Pan Y, Zhu F, Wu JG (2006). Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein Ras. Cancer Lett 244(1):119-128. (IF:4.864)

44.Ecker DJ, Sampath R, Blyn LB, Eshoo MW, Ivy C, Ecker JA, Libby B, Samant V, Sannes-Lowery KA, Melton RE, Russell K, Freed N, Barrozo C, Wu JG, et al. (2005). Rapid identification and strain typing of respiratory pathogens for epidemic surveillance. Proc Natl Acad Sci USA 102(22):8012-8017. (IF:9.771)

45.Crum NF, Russell KL, Kaplan EL, Wallace MR, Wu JG, Ashtari P, Morris DJ, Hale BR (2005). Pneumonia outbreak associated with group a Streptococcus species at a military training facility. Clin Infect Dis 40(4):511-518. (IF:8.161)

46.Pan Q, Zhang XL, Wu HY, He PW, Wang F, Zhang MS, Hu JM, Xia B, Wu JG (2005). Aptamers that preferentially bind type IVB pili and inhibit human monocytic-cell invasion by Salmonella enterica serovar typhi. Antimicrob Agents Ch 49(10):4052-4060. (IF:4.672)

47.Metzgar D, Osuna M, Yingst S, Rakha M, Earhart K, Elyan D, Esmat H, Saad MD, Kajon A, Wu JG, Gray GC, Ryan MA, Russell KL (2005). PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections. J Clin Microbiol 43(11):5743-5752. (IF:4.220)

48.Sun G, Guo M, Shen A, Mei F, Peng X, Gong R, Guo DY, Wu JG, Tien P, Xiao GF (2005). Bovine PrPC directly interacts with alphaB-crystalline. FEBS Lett 579:5419-5424. (IF:3.601)

49.Wang F, Zhang XL, Zhou Y, Ye LB, Qi ZT, Wu JG (2005). Type IVB piliated Salmonella typhi enhance IL-6 and NF-kappaB production in human monocytic THP-1 cells through activation of protein kinase C. Immunobiology 210:283-293. (IF:4.114)

50.Blasiole D, Metzgar D, Daum L, Ryan M, Wu JG, Wills C, Le C, Freed NE, Hansen C, Gray G, Russell KL (2004). Molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults. J Clin Microbiol 42 (4):1686-1693. (IF:4.220)

51.Wu JG, Ohta N, Zhao J, Newton A (1999). A novel bacterial tyrosine kinase essential for cell division and differentiation. Proc Natl Acad Sci USA 96:13068-13073. (IF:9.771)

52.Wu JG, Ohta N, Newton A (1998). An essential, multi-component signal transduction pathway required for cell cycle regulation in Caulobacter. Proc Natl Acad Sci USA 95:1443-1448. (IF:9.771)

53.Wu JG, Miller BL (1997). Aspergillus asexual reproduction and sexual reproduction are differentially affected by transcriptional and translational mechanisms regulating stunted gene expression. Mol Cell Biol 17:6191-6201. (IF:6.188)

54.Wu JG, Ohta N, Benson AK, Ninfa A, Newton A (1997). Purification, characterization, and reconstitution of DNA-dependent RNA polymerases from Caulobacter crescentus. J Biol Chem 272:21558-21564. (IF:5.328)

55.Wu JG, Newton A (1997). Regulation of the Caulobacter flagellar gene hierarchy; not just for motility. Mol Microbiol 24:33-239. (IF:4.819)

56.Wu JG, Newton A (1997). The Caulobacter heat shock sigma factor gene rpoH is positively autoregulated from a sigma32-dependent promoter. J Bacteriol 179:514-521. (IF:3.726)

57.Wu JG, Newton A (1996). Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol 178:2094-2101. (IF:3.726)

58.Wu JG, Benson AK, Newton A (1995). Global regulation of a sigma54-dependent flagellar gene family in Caulobacter crescentus by the transcription activator FlbD. J Bacteriol 177:3241-3250. (IF:3.726)

59.Miller KY, Wu JG, Miller BL (1992). StuA is required for cell pattern formation in Aspergillus. Gene Dev 6:1770-1782. (IF:12.889)

60.Wu JG, Miller LK (1989). Sequence, transcription, and translation of a late gene of the Autographa californica nuclear polyhedrosis virus encoding a 34.8K polypeptide. J Gen Virol 70:2449-2459. (IF:3.368)

61.Tomalski MD, Wu JG, Miller LK (1988). The location, sequence, transcription, and translation of a baculovirus DNA polymerase gene. Virology 167:591-600. (IF:3.305)

62.Wu JG, Lu WJ, Tien P (1986). Multiplication of Velvet tobacco mottle virus in Nocotiana clevelandii protoplasts is resistant to alpha-Amanitin. J Gen Virol 67:2757-2762. (IF:3.368)

獲獎記錄

2011年：吳建國。藥明康德生命化學研究二等獎。
2011年：吳建國。中國僑聯特聘專家。
2011年：吳建國。湖北省創新創業人才。
2010年：吳建國，葉林柏，朱應，劉映樂，鄔開朗。湖北省自然科學獎一等獎。
2010年：吳建國。湖北省十大有突出貢獻中青年專家。
2010年：吳建國。湖北省人民政府編鐘獎。
2010年：吳建國。武漢東湖高新區3551人才。
2009年：吳建國。湖北省新僑創業先進個人。
1999年：吳建國。教育部長江學者特聘教授。