基本介紹
- 中文名：劉琬璐
- 國籍：中國
- 出生地：四川省成都市
- 出生日期：1992年
- 畢業院校：加州大學洛杉磯分校
- 職業：教育科研工作者
人物經歷,主要成就,科研成就,人才培養,人物生活,人物評價,
人物經歷
劉琬墊烏巴陵璐5歲上國小，10歲上國中，16歲就參加高考。
2008年，汶川章潤少大地震給劉琬璐造成了深遠的影響，讓她選擇報考浙江大學醫學類專業。
2018年，畢業於加州大學洛杉磯分校，取得博士學位。
2018年—2019年，在加州大學洛杉磯分校從事博士後研究。
2019年3月，劉琬璐回到母校，管理自己的故洪元獨立實驗室以及招募進實驗室的幾位本科生、研究生，成為浙江大學最年輕的PI（獨立研究員）。
曾兩度獲得Philip J. Whitcome Fellowship支持。
主要成就
科研成就
- 科研綜述
劉琬璐的研究成套估拳疊果有深度解析非編碼RNA的轉錄共剪下對DNA甲基化建立的表觀遺傳學新機制；首次建立和最佳化植物肯己連中的DNA甲基化基因編輯技術；闡明TFAP2C在人胚胎幹細胞以及人原始生殖細胞發育過程中的作用及其機制。未來研究方向是細胞命運決定過程中的表觀遺傳學調控機制；逆轉座子的表觀遺傳學沉默機制；表觀基因組學算法開發旬妹。
- 論文發表
2013年—2019年，劉琬璐在Science（《科學》）、Cell（《細胞》）、Nature Cell Biology（《自然細胞生物學》）、Cell Stem Cell（《細胞&幹細胞》）、PNAS（《美國料煉遙國家科學院院刊》）等高水平期刊發表論文共20餘篇，論文被引用量多達500餘次。
An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure. Gell, Joanna J; Liu, Wanlu; Sosa, Enrique; Chialastri, Alex; Hancock, Grace; Tao, Yu; Wamaitha, Sissy E; Bower, Grace; Dey, Siddharth S; Clark, Amander T #. STEM CELL REPORTS. Year: 2020 Volume: 14 Page: 1-14 Doi: 10.1016/j.stemcr.2020.01.009
Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Chen, Di*; Sun, Na*; Hou, Lei*; Kim, Rachel; Faith, Jared; Aslanyan, Marianna ; Tao, Yu; Zheng, Yi ;Fu, Jianping; Liu, Wanlu; Kellis, Manolis#; Clark, Amander#. CELL REPORTS. Year: 2019 Volume: 29 Issue: 13 Page: 4568-4582 Doi: 10.1016/j.celrep.2019.11.083.
Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Lin, Feng*; Meng, Xiaoyu*; Guo, Yixin; Cao, Wenqiang; Liu, Wanlu; Xia, Qiming; Hui, Zhaoyuan; Chen, Jian; Hong, Shenghui; Zhang, Xuliang; Wu, Chuan; Wang, Di; Wang, Jianli; Lu, Linrong; Qian, Wenbin; Wei, Lai; Wang, Lie#. SCIENCE ADVANCES. Year: 2019 Volume: 5 Doi: 10.1126/sciadv.aax1608
CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Wongpalee, Somsakul Pop*; Liu, Shiheng*; Gallego-Bartolome, Javier*; Leitner, Alexander; Aebersold, Ruedi; Liu, Wanlu; Yen, Linda; Nohales, Maria A.; Kuo, Peggy Hsuanyu; Vashisht, Ajay A.; Wohlschlegel, James A.; Feng, Suhua; Kay, Steve A.; Zhou, Z. Hong#; Jacobsen, Steven E.#. NATURE COMMUNICATIONS. Year: 2019 Volume: 10 Doi:10.1038/s41467-019-11759-9
Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition. Potok, Magdalena E.*; Wang, Yafei*; Xu, Linhao; Zhong, Zhenhui; Liu, Wanlu; Feng, Suhua; Naranbaatar, Bilguudei; Rayatpisheh, Shima; Wang, Zonghua; Wohlschlegel, James A.; Ausin, Israel#; Jacobsen, Steven E.#. NATURE COMMUNICATIONS. Year: 2019 Volume: 10 Doi: 10.1038/s41467-019-11291-w
Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian Clock. Nohales, Maria A.; Liu, Wanlu; Duffy, Tomas; Nozue, Kazunari; Sawa, Mariko; Pruneda-Paz, Jose L.; Maloof, Julin N.; Jacobsen, Steven E.#; Kay, Steve A. #. DEVELOPMENTAL CELL. Year: 2019 Volume: 49 Issue: 6 Page: 840-+Doi:10.1016/j.devcel.2019.04.030
A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase. Stoddard, Caitlin I.; Feng, Suhua; Campbell, Melody G.; Liu, Wanlu; Wang, Haifeng; Zhong, Xuehua; Bernatavichute, Yana; Cheng, Yifan; Jacobsen, Steven E.#; Narlikar, Geeta J.#. MOLECULAR CELL. Year: 2019 Volume: 73 Issue: 1 Page: 73-+Doi: 10.1016/j.molcel.2018.10.006
Co-targeting RNA polymerases IV and V promotes efficient de novo DNA methylation in Arabidopsis. Gallego-Bartolome, Javier*; Liu, Wanlu*; Kuo, Peggy Hsuanyu; Feng, Suhua; Ghoshal, Basudev; Gardiner, Jason; Zhao, Jenny Miao-Chi; Park, Soo Young; Chory, Joanne; Jacobsen, Steven E.#. CELL. Year: 2019 Volume: 176 Issue: 5 Page: 1068-+Doi: 10.1016/j.cell.2019.01.029
Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems. Papikian, Ashot; Liu, Wanlu; Gallego-Bartolome, Javier; Jacobsen, Steven E.#. NATURE COMMUNICATIONS. Year:2019 Volume:10 Doi:10.1038/s41467-019-08736-7
The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Chen, Di*; Liu, Wanlu*; Zimmerman, Jill; Pastor, William A.; Kim, Rachel; Hosohama, Linzi; Ho, Jamie; Aslanyan, Marianna; Gell, Joanna J.; Jacobsen, Steven E.; Clark, Amander T#. CELL REPORTS. Year:2018 Volume:25 Isuue: 13 Page: 3591-+ Doi:10.1016/j.celrep.2018.12.011
A DNA methylation reader complex that enhances gene transcription. Harris, C. Jake*; Scheibe, Marion*; Wongpalee, Somsakul Pop; Liu, Wanlu; Cornett, Evan M.; Vaughan, Robert M.; Li, Xueqin; Chen, Wei; Xue, Yan; Zhong, Zhenhui; Yen, Linda; Barshop, William D.; Rayatpisheh, Shima; Gallego-Bartolome, Javier; Groth, Martin; Wang, Zonghua; Wohlschlegel, James A.; Du, Jiamu; Rothbart, Scott B.; Butter, Falk#; Jacobsen, Steven E.#. SCIENCE. Year: 2018 Volume: 362 Issue: 6419 Page: 1182-+Doi: 10.1126/science.aar7854
TFAP2C regulates transcription in human naive pluripotency by opening enhancers. Pastor, William A.; Liu, Wanlu; Chen, Di; Ho, Jamie; Kim, Rachel; Hunt, Timothy J.; Lukianchikov, Anastasia; Liu, Xiaodong; Polo, Jose M.; Jacobsen, Steven E.#; Clark, Amander T.#. NATURE CELL BIOLOGY. Year: 2018 Volume: 20 Issue: 5 Page: 553-+Doi: 10.1038/s41556-018-0089-0
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. Liu, Wanlu*; Duttke, Sascha H.*; Hetzel, Jonathan; Groth, Martin; Feng, Suhua; Gallego-Bartolome, Javier; Zhong, Zhenhui; Kuo, Hsuan Yu; Wang, Zonghua; Zhai, Jixian; Chory, Joanne; Jacobsen, Steven E.#. NATURE PLANTS. Year: 2018 Volume: 4 Issue: 3 Page: 181-188 Doi: 10.1038/s41477-017-0100-y
Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain. Gallego-Bartolome, Javier*; Gardiner, Jason*; Liu, Wanlu*; Papikian, Ashot*; Ghoshal, Basudev; Kuo, Hsuan Yu; Zhao, Jenny Miao-Chi; Segal, David J.; Jacobsen, Steven E.#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2018 Volume: 115 Issue: 9 Page: E2125-E2134 Doi: 10.1073/pnas.1716945115
Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis. Zhang, Yu*; Harris, C. Jake*; Liu, Qikun*; Liu, Wanlu; Ausin, Israel; Long, Yanping; Xiao, Lidan; Feng, Li; Chen, Xu; Xie, Yubin; Chen, Xinyuan; Zhan, Lingyu; Feng, Suhua; Li, Jingyi Jessica; Wang, Haifeng#; Zhai, Jixian#; Jacobsen, Steven E.#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2018 Volume: 115 Issue: 5 Page: E1069-E1074 Doi: 10.1073/pnas.1716300115
Germline competency of human embryonic stem cells depends on eomesodermin. Chen, Di; Liu, Wanlu; Lukianchikov, Anastasia; Hancock, Grace V.; Zimmerman, Jill; Lowe, Matthew G.; Kim, Rachel; Galic, Zoran; Irie, Naoko; Surani, M. Azim; Jacobsen, Steven E.; Clark, Amander T#. BIOLOGY OF REPRODUCTION. Year: 2017 Volume: 97 Issue: 6 Page: 850-861 Doi: 10.1093/biolre/iox138
Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. Clark, Amander T.#; Gkountela, Sofia; Chen, Di; Liu, Wanlu; Sosa, Enrique; Sukhwani, Meena; Hennebold, Jon D.; Orwig, Kyle E. STEM CELL REPORTS. Year: 2017 Volume: 9 Issue: 1 Page: 329-341 Doi: 10.1016/j.stemcr.2017.05.002
Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. Li, Sisi; Yen, Linda; Pastor, William A.; Johnston, Jonathan B.; Du, Jiamu; Shew, Colin J.; Liu, Wanlu; Ho, Jamie; Stender, Bryan; Clark, Amander T.; Burlingame, Alma L.; Daxinger, Lucia#; Patel, Dinshaw J.#; Jacobsen, Steven E.#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2016 Volume: 113 Issue: 35 Page: E5108-E5116 Doi: 10.1073/pnas.1609709113
DNA methylome of the 20-gigabase Norway spruce genome. Ausin, Israel; Feng, Suhua; Yu, Chaowei; Liu, Wanlu; Kuo, Hsuan Yu; Jacobsen, Elise L.; Zhai, Jixian; Gallego-Bartolome, Javier; Wang, Lin; Egertsdotter, Ulrika; Street, Nathaniel R.; Jacobsen, Steven E.#; Wang, Haifeng#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2016 Volume: 113 Issue: 50 Page: E8106-E8113 Doi: 10.1073/pnas.1618019113
Arabidopsis AtMORC4 and AtMORC7 Form Nuclear Bodies and Repress a Large Number of Protein-Coding Genes. Harris, C. Jake*; Husmann, Dylan*; Liu, Wanlu; El Kasmi, Farid; Wang, Haifeng; Papikian, Ashot; Pastor, William A.; Moissiard, Guillaume; Vashisht, Ajay A.; Dangl, Jeffery L.; Wohlschlegel, James A.; Jacobsen, Steven E.#. PLOS GENETICS. Year: 2016 Volume: 12 Issue: 5 Doi: 10.1371/journal.pgen.1005998
Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory. Pastor, William A.*; Chen, Di*; Liu, Wanlu*; Kim, Rachel; Sahakyan, Anna; Lukianchikov, Anastasia; Plath, Kathrin; Jacobsen, Steven E.#; Clark, Amander T.#. CELL STEM CELL. Year: 2016 Volume: 18 Issue: 3 Page: 323-329 Doi: 10.1016/j.stem.2016.01.019
A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis. Zhai, Jixian*; Bischof, Sylvain*; Wang, Haifeng; Feng, Suhua; Lee, Tzuu-fen; Teng, Chong; Chen, Xinyuan; Park, Soo Young; Liu, Linshan; Gallego-Bartolome, Javier; Liu, Wanlu; Henderson, Ian R.; Meyers, Blake C.; Ausin, Israel#; Jacobsen, Steven E.#. CELL. Year: 2015 Volume: 163 Issue: 2 Page: 445-455 Doi: 10.1016/j.cell.2015.09.032
MORC1 represses transposable elements in the mouse male germline. Pastor, William A.*; Stroud, Hume*; Nee, Kevin; Liu, Wanlu; Pezic, Dubravka; Manakov, Sergei; Lee, Serena A.; Moissiard, Guillaume; Zamudio, Natasha; Bourc'his, Deborah; Aravin, Alexei A.; Clark, Amander T.#; Jacobsen, Steven E.#. NATURE COMMUNICATIONS. Year: 2014 Volume: 5 Doi: 10.1038/ncomms6795
Incorporation of bioactive polyvinylpyrrolidone-iodine within bilayered collagen scaffolds enhances the differentiation and subchondral osteogenesis of mesenchymal stem cells. Jiang, Yangzi; Chen, Longkun; Zhang, Shufang; Tong, Tong; Zhang, Wei; Liu, Wanlu; Xu, Guowei; Tuan, Rocky S.; Heng, Boon Chin; Crawford, Ross; Xiao, Yin; Ouyang, Hong Wei#. ACTA BIOMATERIALIA. Year: 2013 Volume: 9 Issue: 9 Page: 8089-8098 Doi: 10.1016/j.actbio.2013.05.014
Neonatal Desensitization Supports Long-Term Survival and Functional Integration of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression. Zhang, Shufang; Jiang, Yang Zi; Zhang, Wei; Chen, Longkun; Tong, Tong; Liu, Wanlu; Mu, Qin; Liu, Hua; Ji, Junfeng; Ouyang, Hong Wei; Zou, Xiaohui#. STEM CELLS AND DEVELOPMENT. Year: 2012 Volume: 22 Issue: 1 Page: 90-101 Doi: 10.1089/scd.2012.0116
人才培養
- 學生培養
2019年8月，劉琬璐開始正式培養自己的博士生。
- 教授課程
據2020年11月浙江大學官網顯示，劉琬璐承擔以下浙大—愛丁堡聯合學院（海寧國際校區）全英文本科生課程：
2019年春夏學期：MBE3 - Molecular Biology and Epigenetics 3
2019年秋冬學期：ADS2 - Applied Data Science 2 (Course Deputy Organizer)
2019年秋冬學期：ABMS2 - Applied Biomedical Sciences 2
2019年秋冬學期：Infection 3
2019年秋冬學期：DST2 - Database and Software Technology 2 (Course Deputy Organizer, 資料庫部分主講人)
2019年秋冬學期：PoN3 - Principles of Neuroscience 3
2020春夏學期：MBE3 - Molecular Biology and Epigenetics 3 (Course Deputy Organizer)
2020春夏學期：GP2 - Genomics and Proteomics 2
2020春夏學期：ADS2 - Applied Data Science 2 (Course Deputy Organizer)
承擔以下浙江大學本科生課程：
2019年冬學期：生科院病理分子生物學 Molecular Pathology （全英文教學）
人物生活
- 母親患病
高三時，劉琬璐的母親患上了一種罕見病，花了一年的時間才確診，卻一直沒有很好的治療方法，只能保守治療。因此劉琬璐選擇做研究，希望通過基礎研究去改善這一情況。
- 業餘愛好
除了工作的業餘時間，劉琬璐是一個羽毛球健將和攝影愛好者。
- 卡通形象
談到為什麼會進入科研領域，劉琬璐說道“因為我是個愛冒險的人，而且最大願望是能睡到自然醒”，因此同學們給她封了“卡比獸”的卡通形象。
人物評價
“27歲的劉琬璐老師應該是目前浙大最年輕的PI獨立研究員，醫學出身的她這么年輕就是博導，這在全國都非常稀少。入職後，她很快進入導師角色，很有‘教授范’。劉琬璐是國內非常緊缺的交叉型科研人才，學術成果非常豐富。”（浙江大學愛丁堡大學聯合學院院長歐陽宏偉評）
二十七歲女博導，醫學科研劉琬璐。生於成都普通家，聰明好學肯鑽研。加倍努力有收穫，學校“學霸”任連年。汶川地震震心靈，眾多生命太震撼。立志學醫救人民，考入浙大搞醫研。畢業之後到美國，碩博五年成績顯。發表論文二十篇，“學術超女”不一般。美國醫界想挖走，條件美金五十萬。琬璐微笑做拒絕，回國工作是心愿。中華兒女好楷模，報效祖國心相連。（國家發展和改革委員會離退休幹部局93歲離休幹部劉偉如評）
Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Lin, Feng*; Meng, Xiaoyu*; Guo, Yixin; Cao, Wenqiang; Liu, Wanlu; Xia, Qiming; Hui, Zhaoyuan; Chen, Jian; Hong, Shenghui; Zhang, Xuliang; Wu, Chuan; Wang, Di; Wang, Jianli; Lu, Linrong; Qian, Wenbin; Wei, Lai; Wang, Lie#. SCIENCE ADVANCES. Year: 2019 Volume: 5 Doi: 10.1126/sciadv.aax1608
CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Wongpalee, Somsakul Pop*; Liu, Shiheng*; Gallego-Bartolome, Javier*; Leitner, Alexander; Aebersold, Ruedi; Liu, Wanlu; Yen, Linda; Nohales, Maria A.; Kuo, Peggy Hsuanyu; Vashisht, Ajay A.; Wohlschlegel, James A.; Feng, Suhua; Kay, Steve A.; Zhou, Z. Hong#; Jacobsen, Steven E.#. NATURE COMMUNICATIONS. Year: 2019 Volume: 10 Doi:10.1038/s41467-019-11759-9
Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition. Potok, Magdalena E.*; Wang, Yafei*; Xu, Linhao; Zhong, Zhenhui; Liu, Wanlu; Feng, Suhua; Naranbaatar, Bilguudei; Rayatpisheh, Shima; Wang, Zonghua; Wohlschlegel, James A.; Ausin, Israel#; Jacobsen, Steven E.#. NATURE COMMUNICATIONS. Year: 2019 Volume: 10 Doi: 10.1038/s41467-019-11291-w
Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian Clock. Nohales, Maria A.; Liu, Wanlu; Duffy, Tomas; Nozue, Kazunari; Sawa, Mariko; Pruneda-Paz, Jose L.; Maloof, Julin N.; Jacobsen, Steven E.#; Kay, Steve A. #. DEVELOPMENTAL CELL. Year: 2019 Volume: 49 Issue: 6 Page: 840-+Doi:10.1016/j.devcel.2019.04.030
A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase. Stoddard, Caitlin I.; Feng, Suhua; Campbell, Melody G.; Liu, Wanlu; Wang, Haifeng; Zhong, Xuehua; Bernatavichute, Yana; Cheng, Yifan; Jacobsen, Steven E.#; Narlikar, Geeta J.#. MOLECULAR CELL. Year: 2019 Volume: 73 Issue: 1 Page: 73-+Doi: 10.1016/j.molcel.2018.10.006
Co-targeting RNA polymerases IV and V promotes efficient de novo DNA methylation in Arabidopsis. Gallego-Bartolome, Javier*; Liu, Wanlu*; Kuo, Peggy Hsuanyu; Feng, Suhua; Ghoshal, Basudev; Gardiner, Jason; Zhao, Jenny Miao-Chi; Park, Soo Young; Chory, Joanne; Jacobsen, Steven E.#. CELL. Year: 2019 Volume: 176 Issue: 5 Page: 1068-+Doi: 10.1016/j.cell.2019.01.029
Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems. Papikian, Ashot; Liu, Wanlu; Gallego-Bartolome, Javier; Jacobsen, Steven E.#. NATURE COMMUNICATIONS. Year:2019 Volume:10 Doi:10.1038/s41467-019-08736-7
The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Chen, Di*; Liu, Wanlu*; Zimmerman, Jill; Pastor, William A.; Kim, Rachel; Hosohama, Linzi; Ho, Jamie; Aslanyan, Marianna; Gell, Joanna J.; Jacobsen, Steven E.; Clark, Amander T#. CELL REPORTS. Year:2018 Volume:25 Isuue: 13 Page: 3591-+ Doi:10.1016/j.celrep.2018.12.011
A DNA methylation reader complex that enhances gene transcription. Harris, C. Jake*; Scheibe, Marion*; Wongpalee, Somsakul Pop; Liu, Wanlu; Cornett, Evan M.; Vaughan, Robert M.; Li, Xueqin; Chen, Wei; Xue, Yan; Zhong, Zhenhui; Yen, Linda; Barshop, William D.; Rayatpisheh, Shima; Gallego-Bartolome, Javier; Groth, Martin; Wang, Zonghua; Wohlschlegel, James A.; Du, Jiamu; Rothbart, Scott B.; Butter, Falk#; Jacobsen, Steven E.#. SCIENCE. Year: 2018 Volume: 362 Issue: 6419 Page: 1182-+Doi: 10.1126/science.aar7854
TFAP2C regulates transcription in human naive pluripotency by opening enhancers. Pastor, William A.; Liu, Wanlu; Chen, Di; Ho, Jamie; Kim, Rachel; Hunt, Timothy J.; Lukianchikov, Anastasia; Liu, Xiaodong; Polo, Jose M.; Jacobsen, Steven E.#; Clark, Amander T.#. NATURE CELL BIOLOGY. Year: 2018 Volume: 20 Issue: 5 Page: 553-+Doi: 10.1038/s41556-018-0089-0
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. Liu, Wanlu*; Duttke, Sascha H.*; Hetzel, Jonathan; Groth, Martin; Feng, Suhua; Gallego-Bartolome, Javier; Zhong, Zhenhui; Kuo, Hsuan Yu; Wang, Zonghua; Zhai, Jixian; Chory, Joanne; Jacobsen, Steven E.#. NATURE PLANTS. Year: 2018 Volume: 4 Issue: 3 Page: 181-188 Doi: 10.1038/s41477-017-0100-y
Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain. Gallego-Bartolome, Javier*; Gardiner, Jason*; Liu, Wanlu*; Papikian, Ashot*; Ghoshal, Basudev; Kuo, Hsuan Yu; Zhao, Jenny Miao-Chi; Segal, David J.; Jacobsen, Steven E.#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2018 Volume: 115 Issue: 9 Page: E2125-E2134 Doi: 10.1073/pnas.1716945115
Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis. Zhang, Yu*; Harris, C. Jake*; Liu, Qikun*; Liu, Wanlu; Ausin, Israel; Long, Yanping; Xiao, Lidan; Feng, Li; Chen, Xu; Xie, Yubin; Chen, Xinyuan; Zhan, Lingyu; Feng, Suhua; Li, Jingyi Jessica; Wang, Haifeng#; Zhai, Jixian#; Jacobsen, Steven E.#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2018 Volume: 115 Issue: 5 Page: E1069-E1074 Doi: 10.1073/pnas.1716300115
Germline competency of human embryonic stem cells depends on eomesodermin. Chen, Di; Liu, Wanlu; Lukianchikov, Anastasia; Hancock, Grace V.; Zimmerman, Jill; Lowe, Matthew G.; Kim, Rachel; Galic, Zoran; Irie, Naoko; Surani, M. Azim; Jacobsen, Steven E.; Clark, Amander T#. BIOLOGY OF REPRODUCTION. Year: 2017 Volume: 97 Issue: 6 Page: 850-861 Doi: 10.1093/biolre/iox138
Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. Clark, Amander T.#; Gkountela, Sofia; Chen, Di; Liu, Wanlu; Sosa, Enrique; Sukhwani, Meena; Hennebold, Jon D.; Orwig, Kyle E. STEM CELL REPORTS. Year: 2017 Volume: 9 Issue: 1 Page: 329-341 Doi: 10.1016/j.stemcr.2017.05.002
Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. Li, Sisi; Yen, Linda; Pastor, William A.; Johnston, Jonathan B.; Du, Jiamu; Shew, Colin J.; Liu, Wanlu; Ho, Jamie; Stender, Bryan; Clark, Amander T.; Burlingame, Alma L.; Daxinger, Lucia#; Patel, Dinshaw J.#; Jacobsen, Steven E.#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2016 Volume: 113 Issue: 35 Page: E5108-E5116 Doi: 10.1073/pnas.1609709113
DNA methylome of the 20-gigabase Norway spruce genome. Ausin, Israel; Feng, Suhua; Yu, Chaowei; Liu, Wanlu; Kuo, Hsuan Yu; Jacobsen, Elise L.; Zhai, Jixian; Gallego-Bartolome, Javier; Wang, Lin; Egertsdotter, Ulrika; Street, Nathaniel R.; Jacobsen, Steven E.#; Wang, Haifeng#. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Year: 2016 Volume: 113 Issue: 50 Page: E8106-E8113 Doi: 10.1073/pnas.1618019113
Arabidopsis AtMORC4 and AtMORC7 Form Nuclear Bodies and Repress a Large Number of Protein-Coding Genes. Harris, C. Jake*; Husmann, Dylan*; Liu, Wanlu; El Kasmi, Farid; Wang, Haifeng; Papikian, Ashot; Pastor, William A.; Moissiard, Guillaume; Vashisht, Ajay A.; Dangl, Jeffery L.; Wohlschlegel, James A.; Jacobsen, Steven E.#. PLOS GENETICS. Year: 2016 Volume: 12 Issue: 5 Doi: 10.1371/journal.pgen.1005998
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人才培養
- 學生培養
2019年8月，劉琬璐開始正式培養自己的博士生。
- 教授課程
據2020年11月浙江大學官網顯示，劉琬璐承擔以下浙大—愛丁堡聯合學院（海寧國際校區）全英文本科生課程：
2019年春夏學期：MBE3 - Molecular Biology and Epigenetics 3
2019年秋冬學期：ADS2 - Applied Data Science 2 (Course Deputy Organizer)
2019年秋冬學期：ABMS2 - Applied Biomedical Sciences 2
2019年秋冬學期：Infection 3
2019年秋冬學期：DST2 - Database and Software Technology 2 (Course Deputy Organizer, 資料庫部分主講人)
2019年秋冬學期：PoN3 - Principles of Neuroscience 3
2020春夏學期：MBE3 - Molecular Biology and Epigenetics 3 (Course Deputy Organizer)
2020春夏學期：GP2 - Genomics and Proteomics 2
2020春夏學期：ADS2 - Applied Data Science 2 (Course Deputy Organizer)
承擔以下浙江大學本科生課程：
2019年冬學期：生科院病理分子生物學 Molecular Pathology （全英文教學）
人物生活
- 母親患病
高三時，劉琬璐的母親患上了一種罕見病，花了一年的時間才確診，卻一直沒有很好的治療方法，只能保守治療。因此劉琬璐選擇做研究，希望通過基礎研究去改善這一情況。
- 業餘愛好
除了工作的業餘時間，劉琬璐是一個羽毛球健將和攝影愛好者。
- 卡通形象
談到為什麼會進入科研領域，劉琬璐說道“因為我是個愛冒險的人，而且最大願望是能睡到自然醒”，因此同學們給她封了“卡比獸”的卡通形象。
人物評價
“27歲的劉琬璐老師應該是目前浙大最年輕的PI獨立研究員，醫學出身的她這么年輕就是博導，這在全國都非常稀少。入職後，她很快進入導師角色，很有‘教授范’。劉琬璐是國內非常緊缺的交叉型科研人才，學術成果非常豐富。”（浙江大學愛丁堡大學聯合學院院長歐陽宏偉評）
二十七歲女博導，醫學科研劉琬璐。生於成都普通家，聰明好學肯鑽研。加倍努力有收穫，學校“學霸”任連年。汶川地震震心靈，眾多生命太震撼。立志學醫救人民，考入浙大搞醫研。畢業之後到美國，碩博五年成績顯。發表論文二十篇，“學術超女”不一般。美國醫界想挖走，條件美金五十萬。琬璐微笑做拒絕，回國工作是心愿。中華兒女好楷模，報效祖國心相連。（國家發展和改革委員會離退休幹部局93歲離休幹部劉偉如評）
