研究方向
2、流感病毒誘導急性肺損傷的致病機制研究
學術成果
科研項目
1.上海市科委(18DZ2293800):上海市野生動物源疫病監控專業技術服務平台能力提升專項,2018-2021,主持
2.上海市野生動植物保護管理站合作項目:上海野生鳥類禽流感病毒監控,2018-2019,主持
3. 上海市野生動植物保護管理站合作項目:野鳥攜帶禽流感病毒的高通量測序技術方法探索與實踐,2016-2017,主持。
4. 上海市野生動植物保護管理站合作項目:上海野生鳥類禽流感病毒監控,2016-2017,子項目負責任人。
5. 國家自然科學基金(青年項目):MIF在H9N2禽流感病毒誘導急性肺損傷中的作用及機制研究(31402163),2015-2017,主持。
市疾病預防控制中心合作項目:
禽流感病毒溯源調查(48105990),2014-2015,主持。
7.中國科學院分子病毒與免疫重點實驗室開放課題:SOCS3 對H9N2 禽流感病毒誘發急性肺損傷的影響(KLMVI-OP-2014002),2014-2015,主持。
8. 中國醫學科學院合作項目:蝙蝠病毒譜分析,2013-2015,主持。
9.中央高校基本科研業務費專項資金(青年項目):溶菌酶基因在蝙蝠中的基因複製及適應性進化研究(78210159),2011-2012,主持。
10.上海市城市化生態過程和生態恢復重點實驗室開放課題基金:城市化過程中新發傳染病防禦問題(SHUES2011B02),2011-2012,主持。
11.長江學者與創新團隊計畫:中國華東地區野生動物攜帶重要流行病的研究與監測(IRT0826),2009-2011,參加。
主要論文
Tang W, Li X, Hu C, Zhu C, Li A, Wu D, Wang T, He G*. Isolation of H8N4 avian influenza virus from wild birds in Shanghai, China, Acta virological 2019, 63: 121-125
Zhu C,Hu C,Gui B, Chen Q, Zhang S,He G*.Genetic characteristics of H9N2 avian influenza viruses isolated from free-range poultry in Eastern China, in 2014–2015,Poultry Science 2018,97:3793-3800
He G, Zhou L, Zhu C, Shi H, Li X, Wu D, Liu J, Lv J, Hu C, Li Z, Wang Z, Wang T.Identification of Two Novel Avian Influenza A (H5N6) Viruses in Wild Birds, Shanghai, in 2016, Veterinary Microbiology 2017, 28: 53-57
Gui B, Chen Q, Hu C, Zhu C, He G*, Effects ofcalcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in mice,Virology Journal 2017, 14:10
Wu Z#, Yang L#, Ren X#,He G#(共同第一作者), Zhang J, Yang J, Qian Z, Dong J, Sun L, Zhu Y,Du J, Yang F,Zhang S, Jin Q. Deciphering the bat virome catalog to better understand theecological diversity of bat viruses and the bat origin of emerging infectiousdiseases, The ISME Journal. 2016,10:609-620
Liu Y, He G (共同第一作者), Xu H, Han X, Jones G, Rossiter SJ*, Zhang S* , Adaptive Functional Diversification of Lysozyme in Insectivorous Bats, Mol Biol Evol 2014,31 (11):2829-2835 DOI:10.1093/molbev/msu240
Chen Q, Zhu G, Wang R, Zhang J, He G*. Adjuvant effect of CD40 on H5N1 DNA vaccine in mice, Archives of Virology 2014,159: 1359-1364
Zhu G, Wang R, Xuan F, Dazark P, Anthony S, Zhang S, Zhang L,He G*.Characterization of recombinant H9N2 influenza viruses isolated from wild ducks in China, Veterinary Microbiology 2013, 166: 327-336
He G, Dong C, Luan Z, McAllan BM‚ Xu T, Zhao L, Qiao J*. Oxygen free radical involvement in acute lung injury induced by H5N1 virus in mice, Influenza and Other Respiratory Viruses 2013,6:945-953
Wang Y, Zou G, Xia A, Wang X,Cai J, Gao Q, Yuan S, He G, Zhang S, Zeng M*, Altmeryer R*. Enterovirus71 infection in children with hand, foot, and mouth disease in Shanghai, China:Epidemiology, clinical feature and diagnosis Positive-strand RNA viruses,Virology Journal. 2015, 12:83
Yang L, Wu Z, Ren X, Yang F, Zhang J, He G, Dong J, Sun L, Zhu Y, Zhang S, Jin Q*. MERS-related betacoronavirus in Vespertilio superans bats, China. Emerg Infect Dis. 2014 Jul;20(7):1260-2
Yang L, Wu Z, Ren X, Yang F, He G, Zhang J, Dong J, Sun L, Zhu Y, Du J, Zhang S, Jin Q* . Novel SARS-like Betacoronaviruses in Bats, China, 2011,Emerging Infectious Diseases 2013, 19:989-991
Wang L, Yin Q, He G, Rossiter SJ, Holmes EC, Cui J. Ancient invasion of an extinct gammaretrovirus in cetaceans, Virology 2013, 441:66-69
Wu Z, Ren X, Yang L, Hu Y, Yang J, He G, Zhang J, Dong J, Sun L, Du J, Liu L, Xue Y, Wang J, Yang F, Zhang S*, Jin Q*. Virome Analysis for Identification of Novel Mammalian Viruses in Bat Species from Chinese Provinces, Journal of Virology 2012, 86 (20) : 10999-11012;