齊紅藝：博士、特聘教授、碩士研究生導師
基本介紹
- 中文名：齊紅藝
- 國籍：中國
- 民族：漢族
- 職業：博士
人物履歷,學術兼職,研究領域,研究課題,學術論文,
人物履歷
2011.10- 西南大學藥學院&中醫藥學院任職；
2007-2011: 博士 香港大學李嘉誠醫學院；
2004-2007: 碩士 成都中醫藥大學藥學院；
2000-2004: 學士 成都中醫藥大學藥學院；
學術兼職
目前為中藥全球化聯盟（CGCM）重慶地區協調人（Ordinator），中華中醫藥學會會員，中國藥理學會會員與重慶市中醫藥學會科研產業化專委會委員。擔任國家自然科學基金委等項目評審專家以及多種國內與國際學術期刊審稿人。
研究領域
：中藥分子藥理學與中藥化學
（1）中樞神經系統疾病防治的中藥活性成分與分子機理研究；
在不斷面對各種內在與外在的不利因素時，細胞進化形成了細胞應激回響（Cellular Stress Response）機制，維持生命功能穩態（Homeostasis）。中樞神經系統尤其進化出高度特異化的細胞應激信號通路，如：Nrf2通路，熱休克蛋白回響（Heat Shock Response）、未摺疊蛋白回響（Unfolded Protein Response）、DNA損傷回響（DNA Damage Response）等。源於植物次生代謝產物的中藥活性成分在調控細胞應激回響方面具有進化和生態學的獨特優勢。因此，本方向將運用中藥化學、細胞生物學、分子生物學及分子藥理學等手段，解析中藥或複方對細胞應激回響的調控與在防治中樞神經系統疾病時的潛在作用，以闡明傳統功效的關鍵分子機制。
（2）天然產物活性成分的表型篩選（Phenotypic Screening）與分子靶標解析（Target Deconvolution）；
包括中藥在內的天然產物往往具有多成分-多靶標作用的特點。與單一的靶標篩選（Target Screening）相比，表型篩選（Phenotypic Screening）以特定疾病相關的表型為指標，篩選出的是能影響所有相關生物信號通路而改變最終表型的活性成分（群），因此更適合天然產物活性成分的研究。此方向我們將在本實驗室已建立的適合高通量篩選的提取物庫基礎上，構建中樞神經系統疾病相關的表型篩選模型，篩選並分離出活性成分（群）。同時運用靶標解析（Target Deconvolution）技術（如：差異蛋白質組學、化學蛋白質組學等），鑑定出相關多重分子靶標，系統闡明相應整合作用機制。
（3）中藥活性成分的化學生態學與生態藥理學研究；
中藥活性成分絕大多數源於植物次生代謝產物（Secondary Metabolites）。植物遭受生物與非生物脅迫，特別是植食性昆蟲取食時，將合成釋放次生代謝產物，構成化學防禦（Chemical Defense）機制，進而對抗嚴重的、甚至毀滅性的傷害，此過程即植物次生代謝產物的化學興奮效應（Hormesis）。而植食性昆蟲也會針對性地進化形成解毒機制與應激回響。由於共同的祖先、進化保守性與趨同性，植物、昆蟲及人類存在很多生物相似性。當中藥活性成分（次生代謝產物）為人類所服用，亦可能經相似受體或酶等激活適應性細胞應激回響，構築人體防禦機制，從而抵抗疾病的危害，此過程即中藥的外源性化學興奮效應（Xenohormesis）。這種從進化與生態角度探討中藥生物效應的研究對理解其作用機理與本質十分重要。本研究方向主要運用中藥化學、分析化學、化學生態學、生物化學、分子生物學等為手段，從在自然生態的植物-植物、植物-昆蟲/動物相互作用中扮演的功能之角度，揭示中藥活性成分的生物合成和作用機理或發現新的重要活性化合物，供進一步新藥研究。
研究課題
主持縱向研究課題8項與橫向開發課題1項，主要包括：
國家自然科學基金面上項目（項目編號：81373903；2014.1-2017.12）；
國家自然科學基金青年項目（項目編號：81202946；2013.1-2015.12）；
重慶市科技人才培養(創新青年科技人才培養)項目（項目編號：cstc2013kjrc-qnrc10002；2013.9-2016.9）；
重慶市自然科學基金項目（項目編號:cstc2012jjA10142；2012.9-2015.9）；
重慶市研究生教育教學改革研究重點項目（項目編號：yjg122018，2013.1-2015.12）；
重慶市衛生局中醫藥科研專項（項目編號：2012-2-87；2012.7-2014.7）；
學術論文
(1)Yang Liu, Qiang Xue, Qing Tang, Min Hou ,Hongyi Qi, Gang Chen, Weihai Chen, Jifen Zhang, Yi Chen, Xiaoyu Xu. A simple method for isolating and culturing the rat brain microvascular endothelial cells. Microvasc Res. 2013, 90:199-205.
(2) 齊紅藝,李莉,余潔. Xenohormesis: 從進化與生態角度理解中藥的生物效應. 中國中藥雜誌. 2013, 38（19）：3388-3394.
(3) Xue Qiang, Liu Yang, Qi Hongyi, Ma Qiang, Xu Ling, Chen Weihai, Chen Gang, Xu Xiaoyu. A novel brain neurovascular unit model with neurons, astrocytes and microvascular endothelial cells of rat. Int J Biol Sci. 2013, 9(2):174-89.
(4)Qin Wang, Mao Xing, Weihai Chen, Jifen Zhang, Hongyi Qi, Xiaoyu Xu. HPLC-APCI-MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: Application to an in vivo pharmacokinetic study. J Pharm Biomed Anal. 2012, 70:337-43.
(5)Hongyi Qi, Yifan Han, Jianhui Rong. Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation.Neuropharmacology.2012, 62(4): 1659-1670.
(6)Hongyi Qi, Jia Zhao, Yifan Han, Allan Sik Yin Lau, Jianhui Rong. Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells. Neurotoxicity Research. 2012,DOI:10.1007/s12640-012-9319-6.
(7) Hongyi Qi, Baowei Chen, X. Chris Le, Jianhui Rong. Concomitant induction of heme oxygenase-1 attenuates the cytotoxicity of arsenic species from Lumbricus extract in human liver HepG2 cells. Chemistry&Biodiversity. 2012, 9(4):739-754.
(8)Hongyi Qi, Shiu On Siu, Yan Chen, Yifan Han, Ivan K. Chu, Yao Tong, Allan S.Y. Lau, Jianhui Rong. Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1.Chemico-Biological Interactions. 2010, 183 (3) 380-389.
(9)Hongyi Qi, Lai Wei, Yifan Han, Qinlin Zhang, Allan S.Y. Lau, Jianhui Rong. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2.International Journal of Oncology. 2010, 36(3):725-735.
(10)Hongyi Qi, Wenwen Chen, Chunyan Huang, Li Li, Chuming Chen, Wenmin Li, Chunjie Wu. Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin.International Journal of Pharmaceutics. 2007, 337(1-2):178-187.
(11)Hongyi Qi, Li Li, Chunyan Huang, Wenmin Li, Chunjie Wu. Optimization and Physicochemical Characterization of Thermosensitive Poloxamer Gel Containing Puerarin for Ophthalmic Use.Chemical & Pharmaceutical Bulletin. 2006, 54(11):1500-1507.
(12) Chunjie Wu,Hongyi Qi, Wenwen Chen, Chunyan Huang, Cheng Su, Wenmin Li, Shixiang Hou. Preparation and Evaluation of a Carbopol®/HPMC-based In Situ Gelling Ophthalmic System for Puerarin.YAKUGAKU ZASSHI-journal of the pharmaceutical society of japan. 2007, 127(1):183-191.
(13) Chunjie Wu, Qinwan Huang,Hongyi Qi, Ping Guo, Shixiang Hou. Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro.Pharmazie. 2006, 61(9):783-788.
(2) 齊紅藝,李莉,余潔. Xenohormesis: 從進化與生態角度理解中藥的生物效應. 中國中藥雜誌. 2013, 38（19）：3388-3394.
(3) Xue Qiang, Liu Yang, Qi Hongyi, Ma Qiang, Xu Ling, Chen Weihai, Chen Gang, Xu Xiaoyu. A novel brain neurovascular unit model with neurons, astrocytes and microvascular endothelial cells of rat. Int J Biol Sci. 2013, 9(2):174-89.
(4)Qin Wang, Mao Xing, Weihai Chen, Jifen Zhang, Hongyi Qi, Xiaoyu Xu. HPLC-APCI-MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: Application to an in vivo pharmacokinetic study. J Pharm Biomed Anal. 2012, 70:337-43.
(5)Hongyi Qi, Yifan Han, Jianhui Rong. Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation.Neuropharmacology.2012, 62(4): 1659-1670.
(6)Hongyi Qi, Jia Zhao, Yifan Han, Allan Sik Yin Lau, Jianhui Rong. Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells. Neurotoxicity Research. 2012,DOI:10.1007/s12640-012-9319-6.
(7) Hongyi Qi, Baowei Chen, X. Chris Le, Jianhui Rong. Concomitant induction of heme oxygenase-1 attenuates the cytotoxicity of arsenic species from Lumbricus extract in human liver HepG2 cells. Chemistry&Biodiversity. 2012, 9(4):739-754.
(8)Hongyi Qi, Shiu On Siu, Yan Chen, Yifan Han, Ivan K. Chu, Yao Tong, Allan S.Y. Lau, Jianhui Rong. Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1.Chemico-Biological Interactions. 2010, 183 (3) 380-389.
(9)Hongyi Qi, Lai Wei, Yifan Han, Qinlin Zhang, Allan S.Y. Lau, Jianhui Rong. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2.International Journal of Oncology. 2010, 36(3):725-735.
(10)Hongyi Qi, Wenwen Chen, Chunyan Huang, Li Li, Chuming Chen, Wenmin Li, Chunjie Wu. Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin.International Journal of Pharmaceutics. 2007, 337(1-2):178-187.
(11)Hongyi Qi, Li Li, Chunyan Huang, Wenmin Li, Chunjie Wu. Optimization and Physicochemical Characterization of Thermosensitive Poloxamer Gel Containing Puerarin for Ophthalmic Use.Chemical & Pharmaceutical Bulletin. 2006, 54(11):1500-1507.
(12) Chunjie Wu,Hongyi Qi, Wenwen Chen, Chunyan Huang, Cheng Su, Wenmin Li, Shixiang Hou. Preparation and Evaluation of a Carbopol®/HPMC-based In Situ Gelling Ophthalmic System for Puerarin.YAKUGAKU ZASSHI-journal of the pharmaceutical society of japan. 2007, 127(1):183-191.
(13) Chunjie Wu, Qinwan Huang,Hongyi Qi, Ping Guo, Shixiang Hou. Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro.Pharmazie. 2006, 61(9):783-788.
