黃利華，畢業於湖南師範大學，博士，鄭州大學化學學院教授，博士生導師。
基本介紹
- 中文名：黃利華
- 畢業院校：鄭州大學、湖南師範大學
- 學位/學歷：博士
- 職業：教師
- 任職院校：鄭州大學
- 職稱：教授
個人簡介,學習經歷,工作經歷,研究方向,主持項目,代表論文,
個人簡介
黃利華，教授 ，博士生導師。
學習經歷
2007.09-2011.03鄭州大學藥學院攻讀藥物化學博士學位；
2002.09-2005.06 鄭州大學化學學院攻讀有機化學碩士學位;
1991.09-1995.06 湖南師範大學化學系攻讀化學教育學士學位。
工作經歷
2022.03 - 鄭州大學化學學院有機化學教研室任教授；
2011.04 - 2022.02 鄭州大學化學學院有機化學教研室任副教授；
2002.04- 2011.03 鄭州大學無機化學教研室任講師；
1995.07- 2002.03 河南醫科大學(現鄭州大學醫學院)無機化學教研室任助教。
研究方向
靶向蛋白小分子抑制劑的設計、合成以及生物活性評價。
主持項目
1. SQS處方抗癌有效成分研究，橫向課題，在研，主持；
2. 有機螢光發光材料及其柔性器件研究與開發，橫向課題，已結題，主持；
3. 新型前列腺癌靶向抑制劑的設計、合成及抗腫瘤活性評價，河南省科技廳，182102310121，已結題，主持；
4. 表觀遺傳抗腫瘤靶向藥物的研究與開發，橫向課題，已結題，主持；
5. 甾體核苷類似物的設計、合成與抗癌活性研究，橫向課題，已結題，主持。
6. 4-氮雜甾體氮苷類似物的設計、合成及抗癌活性研究，河南省科技廳，142102310309，已結題，主持；
7. 鹼基為6-哌嗪衍生物取代的嘌呤甾體氮苷類似物的合成及抗癌活性研究，鄭州市科技局，121PPTGG507，已結題，主持。
代表論文
1. Wenjuan Zhu, Hui Xi, Wenyang Jiao, Lihua Huang*, Lianjie Wang,* and Junliang Wu*, Difunctionalization of gem-Difluoroalkenes via Photoredox Catalysis: Synthesis of Diverse α,α-Difluoromethyl-β-alkoxysulfones. Organic Letter, 2022, 24(2), 720-72.
2. Yazhen You , Yundong Fu, Mingjie Huang, Dandan Shen, Bing Zhao, Hongmin Liu*, Yichao Zheng*, Lihua Huang*, Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases. International journal of Molecular Sciences, 2022, 23, 5815.
3. Ming-jie Huang, Jia-Wen Guo , Yun-Dong Fu, Ya-Zhen You, Wen-Yu Xu, Ting-Yu Song, Ran Li, Zi-Tong Chen, Li-Hua Huang*, Hong-Min Liu*, Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors . Bioorganic and Medicinal Chemistry Letters, 2021, 41, 127993.
4. Yun-Dong Fu, Ming-Jie Huang, Jia-Wen Guo, Ya-Zhen You, Hong-Min Liu, Li-Hua Huang*, Bin Yu**, Targeting histone demethylase KDM5B for cancer treatment. European Journal of Medicinal Chemistry, 2020, 208, 112760.
5. Jian-Wei Zhao,Zeng-Hui Wu, Jia-Wen Guo, Ming-Jie Huang, Ya-Zhen You, Hong-Min Liu*, Li-Hua Huang*,Synthesis and anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties. European Journal of Medicinal Chemistry, 2019, 181, 111520.
6. Jian-Wei Zhao, Jia-Wen Guo, Ming-Jie Huang, Ya-Zhen You, Zeng-Hui Wu, Hong-Min Liu*, Li-Hua Huang*,Design, synthesis and biological evaluation of new steroidal β-triazoly enones as potent antiproliferative agents. Steroids, 2019, 150, 108431-108437.
7. Li-Hua Huang, Hong-De Xu, Zhuo-Ya Yang, Yong-Fei Zheng, Hong-Min Liu*, Synthesis and anticancer activity of novel C6-piperazine substituted purine steroid–nucleosides analogues. Steroids, 2014, 82, 1-6.
8. Li-Hua Huang, Yang Li, Hong-De Xu, Yong-Fei Zheng, Hong-Min Liu*, Synthesis and biological evaluation of novel C6-cyclo secondary amine substituted purine steroid-nucleosides analogues. Steroids, 2014, 85, 13-17.
9. Li-Hua Huang, Yong-Fei Zheng, Chuan-Jun Song, Yan-Guang Wang, Zhi-Yu Xie, Yao-Wen Lai, Yong-Zheng Lu, Hong-Min Liu*, Synthesis and biological evaluation of novel steroidal[17,16-d][1,2,4]triazolo [1,5-a]pyrimidines. Steroids, 2012, 77, 710-715.
10. Li-Hua Huang, Yong-Fei Zheng, Yong-Zheng Lu, Chuan-Jun Song, Yan-Guang Wang, Bin Yu, Hong-Min Liu*, Synthesis of novel D-ring fused 7’-aryl-androstano[17,16-d][1,2,4] triazolo[1,5-a]pyrimidines. Steroids, 2012, 77, 367-374.
11. Li-Hua Huang, Yan-Guang Wang, Gong Xu, Xiang-Hua Zhang, Yong-Fei Zheng, Hui-Li He, Wen-Zheng Fu, Hong-Min Liu*, Novel 4-azasteroidal N-glycoside analogues bearing sugar-like D-ring: Synthesis and anticancer activities. Bioorganic and Medicinal Chemistry Letters, 2011, 21, 6203-6205.
12. Li-Hua Huang, Juan Li, Gong Xu, Xiang-Hua Zhang, Yang-Guang Wang, Ye-Lin Yin, Hong-Min Liu*, Biotransformation of dehydroepiandrosterone (DHEA) with Penicillium griseopurpureum Smith and Penicillium glabrum (Wehmer) Westling. Bioorganic and Medicinal Chemistry Letters, 2010, 75, 1039-1046.
