基本介紹
- 中文名：韓彥弢
- 學位/學歷：博士
- 職業：教師
- 專業方向：生物醫藥的開發與藥理作用研究
- 任職院校：青島大學基礎醫學院
研究方向,學術成果,
研究方向
生物醫藥的開發與藥理作用研究，對天然活性藥物的分子靶向作用機理有深入研究
學術成果
主持和參與國家自然科學基金3項，完成科技部863重大項目子課題及科技部支撐計畫各1項，山東省自然科學基金、山東省、青島市科技攻關項目各1項，承擔青島市重大創新項目1項。研究成果《ROS-MAPK、死亡受體、NF-κB、NO-HSP通路對紫外線誘導皮膚細胞凋亡的調控》，獲山東省自然科學二等獎（2011年，首位）。參與產學研開發項目--海生素腸溶膠囊的研發，已獲臨床製劑批號，研究成果《蚶類提取物腸溶膠囊及其製造方法》獲得國家發明專利。參與研製海婦潔膜，自牡蠣中製備溶菌酶，完成其藥學、藥理學、毒理學及臨床研究，以其為主要原料製備海婦潔膜，已獲臨床製劑批號。近年來共發表SCI收錄論文30餘篇。
主持或參加科研項目：
1.國家自然科學基金面上項目，81473384、鈍擬蟹守螺提取物卡尼汀群經內質網和線粒體途徑抗老年痴呆的保護作用研究、2015/01-2018/12、75萬元、在研、主持。
2．國家高技術研究發展計畫(863計畫)子課題，2007AA091602、海貝素膠囊的研製及抗腫瘤作用的基礎研究、2007/12 -2010/12、35萬元、已結題、參加。
3.山東省科技攻關項目，2009GG10002070、保肝藥—甘薯滴丸的研製、2009/01 -2012/12、16萬元、已結題、主持。
獲得獎項：
ROS-MAPK、死亡受體、NF-κB、NO-HSP通路對紫外線誘導皮膚細胞凋亡的調控。韓彥弢，王春波，李丙華。山東省自然科學二等獎，證書編號：ZR2010-2-7。
發明專利
(2S,3S,4R,9E)-2-[(2′R)-2′-羥基-二十九碳醯胺]-十八碳-1,3,4-三醇及其製備方法和套用。韓彥弢;王春波;朱莉;陳雪紅。ZL201610322020X
近年來發表的論文：
1. Zhou Y, Chen X#, Li X,Han Y*, Wang Y, Yao R, Li S. Purification and Characterization of A New Cold-Adapted and Thermo-Tolerant Chitosanase from Marine Bacterium Pseudoalteromonas sp. SY39. Molecules. 2019 Jan 6;24(1).(SCI收錄)
2. Li S, Wang L, Chen X, Sun M,Han Y*. Design and Synthesis of a Chitodisaccharide-Based Affinity Resin for Chitosanases Purification. Mar Drugs. 2019 Jan 21;17(1). (SCI收錄)
3. Li SY, Wang ZP, Wang LN, Peng JX, Wang YN,Han YT*,Zhao SF. Combined enzymatic hydrolysis and selective fermentation for green production of alginate oligosaccharides from Laminaria japonica. Bioresour Technol. 2019 Feb 12;281:84-89.
4. Li S, Wang L, Chen X, Zhao W, Sun M, Han Y. Cloning, Expression, and Biochemical Characterization of Two New Oligoalginate Lyases with Synergistic Degradation Capability. Mar Biotechnol (NY). 2018 Feb;20(1):75-86.
5. Han M, Gao H, Xie J, Yuan YP, Yuan Q, Gao MQ, Liu KL, Chen XH,Han YT,Han ZW. Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway.Acta Pharmacol Sin. 2018 Sep 14. doi: 10.1038/s41401-018-0159-7.
6. Han M, Gao H, Ju P, Gao MQ, Yuan YP, Chen XH, Liu KL,Han YT,Han ZW. Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ. Biomed Pharmacother. 2018 Jul;103:272-283.
7. Chen XH,Han YT,Ye JL, Chang ZS, Wang CB, Chen SG. Tegillarca granosa extract Haishengsu inhibits tumor activity via a mitochondrial‑mediated apoptotic pathway. Mol Med Rep. 2018 May;17(5):6828-6834.
8. Gao H, Gao MQ, Peng JJ, Han M, Liu KL,Han YT.Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation. Acta Pharmacol Sin. 2017 Dec;38(12):1618-1631.
9. Zhao W, Feng H, Guo S, Han Y, Chen X. Danshenol A inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells. Sci Rep. 2017 Oct 11;7(1):12953
10.Han Y, Jiang Q, Wang Y, Li W, Geng M, Han Z, Chen X. The anti-proliferative effects of oleanolic acid on A7r5 cells-Role of UCP2 and downstream FGF-2/p53/TSP-1. Cell Biol Int. 2017 Dec;41(12):1296-1306.
11. Zhao M, Jiang Q, Wang W, Geng M, Wang M,Han Y,Wang C The Roles of Reactive Oxygen Species and Nitric Oxide in Perfluorooctanoic Acid-Induced Developmental Cardiotoxicity and l-Carnitine Mediated Protection. Int J Mol Sci. 2017 Jun 8;18(6).
12.Han Y, Zhao Q, Zhou J, Shi R. miR-429 mediates tumor growth and metastasis in colorectal cancer. Am J Cancer Res. 2017 Feb 1;7(2):218-233. eCollection 2017.
13.Han Y, Yang X, Zhao N, Peng J, Gao H, Qiu X. Alpinumisoflavone induces apoptosis in esophageal squamous cell carcinoma by modulating miR-370/PIM1 signaling. Am J Cancer Res. 2016 Dec 1;6(12):2755-2771. E Collection 2016.
14. Zhang D,Han Y*, Xu L. Upregulation of miR-124 by physcion 8-O-β-glucopyranoside inhibits proliferation and invasion of malignant melanoma cells via repressing RLIP76. Biomed Pharmacother. 2016 Dec;84:166-176.
15. Jiang Q,Han Y, Gao H, Tian R, Li P, Wang C. Ursolic acid induced anti-proliferation effects in rat primary vascular smooth muscle cells is associated with inhibition of microRNA-21 and subsequent PTEN/PI3K. Eur J Pharmacol. 2016 Jun 15;781:69-75.
16. Li J, Zhang Y, Luan H, Chen X,Han Y, Wang C. l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway. Can J Physiol Pharmacol. 2016 May;94(5):517-25.
17. Kong D,Han Y, Wang C, Chen X, Jiang Q, Wang Q, Han Z. Cytoprotective Effects of Oleanolic Acid in Human Umbilical Vascular Endothelial Cells is Mediated Via UCP2/ROS/Cytochrome C/AIF Pathway. J Cardiovasc Pharmacol. 2016 Apr;67(4):344-50.
18.Han YT,Chen XH, Gao H, Ye JL, Wang CB. Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2. Acta Pharmacol Sin. 2016 Feb;37(2):264-75.（ESI高被引）
19.Han Y,Zhao H, Jiang Q, Gao H, Wang C.Chemopreventive mechanism of polypeptides from Chlamy Farreri (PCF) against UVB-induced malignant transformation of HaCaT cells. Mutagenesis. 2015 Mar;30(2):287-96. doi: 10.1093/mutage/geu071. Epub 2014 Nov 12.
20.Han Y,Xie J, Gao H, Xia Y, Chen X, Wang C. Hepatoprotective effect of collagen peptides from cod skin against liver oxidative damage in vitro and in vivo. Cell Biochem Biophys. 2015 Mar;71(2):1089-95. doi: 10.1007/s12013-014-0313-x.
21.Han Y, Jiang Q, Gao H, Fan J, Wang Z, Zhong F, Zheng Y, Gong Z, Wang C. The anti-apoptotic effect of polypeptide from Chlamys farreri (PCF) in UVB-exposed HaCaT cells involves inhibition of iNOS and TGF-β1. Cell Biochem Biophys. 2015 Mar;71(2):1105-15.
22.Han YT,Chen XH, Xie J, Zhan SM, Wang CB, Wang LX. Purple sweet potato pigments scavenge ROS, reduce p53 and modulate Bcl-2/Bax to inhibit irradiation-induced apoptosis in murine thymocytes. Cell Physiol Biochem. 2011;28(5):865-72. doi: 10.1159/000335801. Epub 2011 Dec
23. Gao H, Xie J, Peng J,Han Y, Jiang Q, Han M, Wang C. Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1α.Exp Cell Res. 2015 Mar 15;332(2):236-46. （通訊作者）
24. Chen XH, Miao YX, Wang XJ, Yu Z, Geng MY,Han YT,Wang LX. Effects of Ginkgo biloba extract EGb761 on human colon adenocarcinoma cells. Cell Physiol Biochem. 2011;27(3-4):227-32. doi: 10.1159/000327948. Epub 2011 Apr 1. （通訊作者）
25. Wang W, Li J, Wang Z, Gao H, Su L, Xie J, Chen X, Liang H, Wang C,Han Y. Oral hepatoprotective ability evaluation of purple sweet potato anthocyanins on acute and chronic chemical liver injuries. Cell Biochem Biophys. 2014 Jul;69(3):539-48. doi: 10.1007/s12013-014-9829-3. （通訊作者）
26. Yu J, Ye J, Liu X,Han Y,Wang C. Protective effect of L-carnitine against H(2)O(2)-induced neurotoxicity in neuroblastoma (SH-SY5Y) cells. Neurol Res. 2011 Sep;33(7):708-16. doi: 10.1179/1743132810Y.0000000028.（通訊作者）
27. Bian J, Zhang L,Han Y,Wang C, Zhang L. Histone Deacetylase Inhibitors: Potent Anti-leukemic Agents. Curr Med Chem. 2015 Apr 15. [Epub ahead of print]
28. Gao H, Jiang Q,Han Y,Peng J, Wang C. shRNA-mediated EMMPRIN silencing inhibits human leukemic monocyte lymphoma U937 cell proliferation and increases chemosensitivity to adriamycin. Cell Biochem Biophys. 2015 Mar;71(2):827-35. doi: 10.1007/s12013-014-0270-4.
29. Gao H, Jiang Q,Han Y, Peng J, Wang C. Hispidulin potentiates the antitumor effect of sunitinib against human renal cell carcinoma in laboratory models. Cell Biochem Biophys. 2015 Mar;71(2):757-64. doi: 10.1007/s12013-014-0260-6.
30. Chen X,Han Y,Zhan S, Wang C, Chen S. Tegillarca granosa extract Haishengsu induces apoptosis in human hepatocellular carcinoma cell line BEL-7402 via Fas-signaling pathways. Cell Biochem Biophys. 2015 Mar;71(2):837-44. doi: 10.1007/s12013-014-0271-3.
31. Ye J,Han Y,Chen X, Xie J, Liu X, Qiao S, Wang C. L-carnitine attenuates H2O2-induced neuron apoptosis via inhibition of endoplasmic reticulum stress. Neurochem Int. 2014 Dec;78:86-95. doi: 10.1016/j.neuint.2014.08.009. Epub 2014 Sep 9.
32. Zhang L,Han Y,Jiang Q, Wang C, Chen X, Li X, Xu F, Jiang Y, Wang Q, Xu W. Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. Med Res Rev. 2015 Jan;35(1):63-84. doi: 10.1002/med.21320. Epub 2014 Apr 29.
33. Wang X, Jiang Q, Wang W, Su L,Han Y, Wang C. Molecular mechanism of polypeptides from Chlamys farreri (PCF)'s anti-apoptotic effect in UVA-exposed HaCaT cells involves HSF1/HSP70, JNK, XO, iNOS and NO/ROS. J Photochem Photobiol B. 2014 Jan 5;130:47-56.
