韓大力，男，漢族，1987年1月生，在中科院遺傳所獲生物信息學博士學位，赴美國芝加哥大學從事博士後研究，中國科學院北京基因組研究所（國家生物信息中心） 研究員。
基本介紹
人物經歷,研究方向,主要成就,所獲榮譽,
人物經歷
學習經歷
2003年9月- 2007年7月 中國科學技術大學生命科學院 生物技術學士
2007年9月- 2012年7月 中國科學院遺傳與發育生物學研究所 生物信息學 博士
工作經歷
2017年- 中國科學院北京基因組研究所 研究員 博士生導師
2012年12月-2017年 芝加哥大學 博士後學者
研究方向
生物信息學、RNA修飾調控機制和干預治療
主要成就
2017回國入職中科院北京基因組研究所任研究員並組建獨立研究團隊，入選國家百千萬人才工程。聚焦新型RNA修飾的表觀調控機制，結合多學科前沿交叉，開發疾病治療診斷新策略；合作完成新冠病毒靶標蛋白的系統性藥物虛擬篩選，並建立“神農項目”可視化網站共享研究成果和技術方案。
發表論文
[1] Xiao-Yang Jin, Zu-Rui Huang, Li-Jun Xie, Li Liu, Da-Li Han, Liang Cheng. Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA. Angewandte Chemie International Edition[J]. 2022, 61: e202210652-, [2] Dong, Lihui, Chen, Chuanyuan, Zhang, Yawei, Guo, Peijin, Wang, Zhenghang, Li, Jian, Liu, Yi, Liu, Jun, Chang, Renbao, Li, Yilin, Liang, Guanghao, Lai, Weiyi, Sun, Mengxue, Dougherty, Urszula, Bissonnette, Marc B, Wang, Hailin, Shen, Lin, Xu, Meng Michelle, Han, Dali. The loss of RNA N-6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8(+) T cell dysfunction and tumor growth. CANCER CELL[J]. 2021, 39(7): 945-+, http://dx.doi.org/10.1016/j.ccell.2021.04.016.
[3] Liu, Yi, Liang, Guanghao, Xu, Hongjiao, Dong, Wenxin, Dong, Ze, Qiu, Zhiwei, Zhang, Zihao, Li, Fangle, Huang, Yue, Li, Yilin, Wu, Jun, Yin, Shenyi, Zhang, Yawei, Guo, Peijin, Liu, Jun, Xi, Jianzhong Jeff, Jiang, Peng, Han, Dali, Yang, CaiGuang, Xu, Meng Michelle. Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. CELL METABOLISM[J]. 2021, 33(6): 1221-+, http://dx.doi.org/10.1016/j.cmet.2021.04.001.
[4] Jun Liu, Xiaoyang Dou, Chuanyuan Chen, Chuan Chen, Chang Liu, Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao, Dali Han, Chuan He. N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. SCIENCE (NEW YORK, N.Y.). 2020, 367(6477): 580-586, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213019/.
[5] Han, Dali, Liu, Jun, Chen, Chuanyuan, Dong, Lihui, Liu, Yi, Chang, Renbao, Huang, Xiaona, Liu, Yuanyuan, Wang, Jianying, Dougherty, Urszula, Bissonnette, Marc B, Shen, Bin, Weichselbaum, Ralph R, Xu, Meng Michelle, He, Chuan. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells (vol 566, pg 270, 2019). NATUREnull. 2019, 568(7751): E3-E3, [6] Gu, Tongnian, Zhao, Siqi, Pi, Yishuang, Chen, Weizhong, Chen, Chuanyuan, Liu, Qian, Li, Min, Han, Dali, Ji, Quanjiang. Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase. CHEMICAL SCIENCE[J]. 2018, 9(12): 3248-3253, https://www.webofscience.com/wos/woscc/full-record/WOS:000428987200020.
[7] Tian, Xin, Sun, Baofa, Chen, Chuanyuan, Gao, Chunchun, Zhang, Ji, Lu, Xingyu, Wang, Linchen, Li, Xiangnan, Xing, Yurong, Liu, Ruijuan, Han, Xiao, Qi, Zheng, Zhang, Xiaojian, He, Chuan, Han, Dali, Yang, YunGui, Kan, Quancheng. Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer. CELL RESEARCHnull. 2018, 28(5): 597-600, http://lib.cqvip.com/Qikan/Article/Detail?id=675657276.
[8] Qing Dai, Sharon MoshitchMoshkovitz, Dali Han, Nitzan Kol, Ninette Amariglio, Gideon Rechavi, Dan Dominissini, Chuan He. Nm-seq maps 2′- O- methylation sites in human mRNA with base precision. NATURE METHODS. 2017, 14(7): 695-698, [9] Han, Dali, Lu, Xingyu, Shih, Alan H, Nie, Ji, You, Qiancheng, Xu, Meng Michelle, Melnick, Ari M, Levine, Ross L, He, Chuan. A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations. MOLECULAR CELL[J]. 2016, 63(4): 711-719, http://dx.doi.org/10.1016/j.molcel.2016.06.028.
[10] Lu, Xingyu, Han, Dali, Zhao, Boxuan Simen, Song, ChunXiao, Zhang, LiSheng, Dore, Louis C, He, Chuan. Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics. CELL RESEARCH[J]. 2015, 25(3): 386-389, https://www.webofscience.com/wos/woscc/full-record/WOS:000350568800012.
[11] Bo Xia, Dali Han, Xingyu Lu, Zhaozhu Sun, Ankun Zhou, Qiangzong Yin, Hu Zeng, Menghao Liu, Xiang Jiang, Wei Xie, Chuan He, Chengqi Yi. Bisulfite-free and Base-resolution Analysis of 5-formylcytosine at Whole-genome Scale. NATURE METHODS. 2015, 12(11): 1047-1050, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626315/.
[12] Su, Ming, Han, Dali, BoydKirkup, Jerome, Yu, Xiaoming, Han, JingDong J. Evolution of Alu Elements toward Enhancers. CELL REPORTS[J]. 2014, 7(2): 376-385, http://dx.doi.org/10.1016/j.celrep.2014.03.011.
[13] Yixing HanDali HanZheng YanJerome D Boydx2010KirkupChristopher D GreenPhilipp KhaitovichJingx2010Dong J Han. Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain. AGING CELL[J]. 2012, 11(6): http://gooa.las.ac.cn/external/index?type=-1&pid=1076521.
[14] Liu, Yi, Han, Dali, Han, Yixing, Yan, Zheng, Xie, Bin, Li, Jing, Qiao, Nan, Hu, Haiyang, Khaitovich, Philipp, Gao, Yuan, Han, JingDong J. Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(4): 1408-1418, http://dx.doi.org/10.1093/nar/gkq956.
所獲榮譽
2020 國家自然科學基金優秀青年科學基金項目資助
2020 入選國家百千萬人才工程，並授予“有突出貢獻中青年專家”榮譽稱號
2022年01月06日，獲得鐘南山青年科技創新獎。
