青年化學家，南京工業大學先進化學製造研究院教授，主要研究方向化學藥物研究導向的天然產物全合成及相關化學生物學研究。
基本介紹
2016年至今，南京工業大學教授
2014.08-2016， 美國Scripps 研究所（The Scripps Research Institute），天然產物，化學，研究助理（博士後）
2012.05-2014.07，德國漢諾瓦大學，天然產物化學“洪堡學者”（博士後）
2010.01-2012.04，蘇州美諾醫藥科技有限公司，助理主任
2010.10-2011.12，蘇州美諾醫藥科技有限公司，組長
2010.07-2010.09，凱萊英生命科學技術(天津)有限公司 高級有機合成研究員，
2005.09-2010.06，華中師範大學 有機化學 理學博士
1999.09-2003.06，華中農業大學，套用化學，理學學士
主要研究方向
化學藥物研究導向的天然產物全合成及相關化學生物學研究
主要學術成績
主要從事藥用天然產物全合成及相關化學生物學方面的研究工作。先後完成了paleo-soraphens(抗菌)、(-)-jiadifenolide（促神經生長）、(+)-diisocyanoadociane(抗痢疾)等具有重要生理活性及藥物開發前景的複雜非天然及天然產物的不對稱全合成；部分成果以第一作者先後發表在國際權威期刊Angewandte Chemie International Edition, Nature Chemistry和Journal of American Chemical Society。迄今為止，共發表SCI論文15篇（單篇最高他引149次），得到了權威學術媒體和期刊chemistry world, Synfacts 等的高度評價。曾獲得德國洪堡獎學金（2012年）。
代表性著作
1. H.-H. Lu, S. Pronin, Y. Antonova-Koch, S. Meister, E.A. Winzeler,R. A. Shenvi, "Synthesis of (+)-7,20-Diisocyanoadociane and its Liver Stage Antiplas-modial Activity of the ICT Class", J. Am. Chem. Soc. 2016, 138, DOI: 10.1021/jacs.6b03899.
2. H.-H. Lu, M. Martinez, R. A. Shenvi, An Eight-step, Gram-scale Synthesis of (–)-Jiadifenolide, Nat. Chem. 2015, 7, 604-607.
3. H.-H. Lu, B. Hinkelmann, T. Tautz, J. Li, R. Franke, F. Sasse, M. Kalesse, Paleo-Soraphens: Chemical Total Syntheses and Biological Studies, Org. Biomol. Chem. 2015, 13, 8029-8036.
4. M. Kalesse, M. Cordes, G. Symkenberg, H.-H. Lu, The Vinylogous Mukaiyama Aldol Reaction (VMAR) in Natural Product Synthesis, Nat. Prod. Rep. 2014, 31, 563-594.
5. H.-H. Lu, A. Raja, R. Franke, D. Landsberg, F. Sasse, M. Kalesse, Syntheses and Biological Evaluation of Paleo-Soraphens, Angew. Chem. Int. Ed. 2013, 52, 13549-13552.
6. S.-W. Duan, H.-H. Lu, F.-G. Zhang, J. Xuan, J.-R. Chen, W.-J. Xiao, Organocatalytic Conjugate Additions of Acetylacetone to 3-Ylideneoxindoles: A Direct Access to Highly Enantioenriched Oxindole Derivatives, Synthesis 2011, 1847-1852.
7. H.-H. Lu, F. Tan, W.-J. Xiao, Enantioselective Organocatalytic Friedel-Crafts Alkylations, Curr. Org. Chem. 2011, 15, 4022-4045.
8. F.-G. Zhang, Q.-Q. Yang, J. Xuan, H.-H. Lu, S.-W. Duan, J.-R. Chen, W.-J. Xiao, Enantioselective Conjugate Addition of Oximes to Trisubstituted β-Nitroacrylates: An Organocatalytic Approach to β2,2-Amino Acid Derivatives, Org. Lett. 2010, 12, 5636–5639.
9. H.-H. Lu, H. Liu, W. Wu, X.-F. Wang, L.-Q. Lu, W.-J. Xiao, Catalytic Asymmetric Intramolecular Hydroarylations of ω-Aryloxy- and Arylamino Tethered α,β-Unsaturated Aldehydes, Chem. Eur. J. 2009, 15, 2742-2746.
10. H.-H. Lu, X.-G. Meng, F.-G. Zhang, S.-W. Duan, W.-J. Xiao, Enantioselective Michael Reactions of β,β-Disubstituted Nitroalkenes: A New Approach to β2,2-Amino Acids with Hetero-Quaternary Stereocenters, Org. Lett. 2009, 11, 3946-3949
11. H.-H. Lu, X.-F. Wang, C.-J. Yao, J.-M. Zhang, H. Wu, W.-J. Xiao, Highly Enantioselective Organocatalytic Michael Addition of Nitroalkanes to 4-oxo-Enoates, Chem. Commun. 2009,4251-4253.
12. J.-R. Chen, Y.-Y. Lai, H.-H. Lu, X.-F. Wang, W.-J. Xiao, Highly Enantioselective Desymmetrization of meso- and Prochiral Cyclic Ketones via Organocatalytic Michael Reaction, Tetrahedron 2009, 65,9238-9243.
13. H.-M. Dong, H.-H. Lu, L.-Q. Lu, C.-B. Chen, W.-J. Xiao, Asymmetric Friedel-Crafts Alkylations of Indoles with Ethyl Glyoxylate Catalyzed by (S)-BINOL-Ti (IV) Complex: Direct Access to Enantiomerically Enriched 3-Indolyl-hydroxyacetates, Adv. Synth. Catal. 2007, 349, 1597-1603.
14. Y.-J. Cao, H.-H. Lu, Y.-Y. Lai, L.-Q. Lu, W.-J. Xiao, An Effective Bifunctional Thiourea Catalyst for Highly Enantio- and Diastereoselective Michael Addition of Cyclohexanone to Nitroolefins, Synthesis 2006, 3795-3800.
15. J.-R. Chen, H.-H. Lu, X.-Y. Li, L. Cheng, J. Wan, W.-J. Xiao, Readily Tunable and Bifunctional L-Prolinamide Derivatives: Design and Application in the Direct Enantioselective Aldol Reactions, Org. Lett. 2005, 7, 4543-4545.
1. H.-H. Lu, S. Pronin, Y. Antonova-Koch, S. Meister, E.A. Winzeler,R. A. Shenvi, "Synthesis of (+)-7,20-Diisocyanoadociane and its Liver Stage Antiplas-modial Activity of the ICT Class", J. Am. Chem. Soc. 2016, 138, DOI: 10.1021/jacs.6b03899.
2. H.-H. Lu, M. Martinez, R. A. Shenvi, An Eight-step, Gram-scale Synthesis of (–)-Jiadifenolide, Nat. Chem. 2015, 7, 604-607.
3. H.-H. Lu, B. Hinkelmann, T. Tautz, J. Li, R. Franke, F. Sasse, M. Kalesse, Paleo-Soraphens: Chemical Total Syntheses and Biological Studies, Org. Biomol. Chem. 2015, 13, 8029-8036.
4. M. Kalesse, M. Cordes, G. Symkenberg, H.-H. Lu, The Vinylogous Mukaiyama Aldol Reaction (VMAR) in Natural Product Synthesis, Nat. Prod. Rep. 2014, 31, 563-594.
5. H.-H. Lu, A. Raja, R. Franke, D. Landsberg, F. Sasse, M. Kalesse, Syntheses and Biological Evaluation of Paleo-Soraphens, Angew. Chem. Int. Ed. 2013, 52, 13549-13552.
6. S.-W. Duan, H.-H. Lu, F.-G. Zhang, J. Xuan, J.-R. Chen, W.-J. Xiao, Organocatalytic Conjugate Additions of Acetylacetone to 3-Ylideneoxindoles: A Direct Access to Highly Enantioenriched Oxindole Derivatives, Synthesis 2011, 1847-1852.
7. H.-H. Lu, F. Tan, W.-J. Xiao, Enantioselective Organocatalytic Friedel-Crafts Alkylations, Curr. Org. Chem. 2011, 15, 4022-4045.
8. F.-G. Zhang, Q.-Q. Yang, J. Xuan, H.-H. Lu, S.-W. Duan, J.-R. Chen, W.-J. Xiao, Enantioselective Conjugate Addition of Oximes to Trisubstituted β-Nitroacrylates: An Organocatalytic Approach to β2,2-Amino Acid Derivatives, Org. Lett. 2010, 12, 5636–5639.
9. H.-H. Lu, H. Liu, W. Wu, X.-F. Wang, L.-Q. Lu, W.-J. Xiao, Catalytic Asymmetric Intramolecular Hydroarylations of ω-Aryloxy- and Arylamino Tethered α,β-Unsaturated Aldehydes, Chem. Eur. J. 2009, 15, 2742-2746.
10. H.-H. Lu, X.-G. Meng, F.-G. Zhang, S.-W. Duan, W.-J. Xiao, Enantioselective Michael Reactions of β,β-Disubstituted Nitroalkenes: A New Approach to β2,2-Amino Acids with Hetero-Quaternary Stereocenters, Org. Lett. 2009, 11, 3946-3949
11. H.-H. Lu, X.-F. Wang, C.-J. Yao, J.-M. Zhang, H. Wu, W.-J. Xiao, Highly Enantioselective Organocatalytic Michael Addition of Nitroalkanes to 4-oxo-Enoates, Chem. Commun. 2009,4251-4253.
12. J.-R. Chen, Y.-Y. Lai, H.-H. Lu, X.-F. Wang, W.-J. Xiao, Highly Enantioselective Desymmetrization of meso- and Prochiral Cyclic Ketones via Organocatalytic Michael Reaction, Tetrahedron 2009, 65,9238-9243.
13. H.-M. Dong, H.-H. Lu, L.-Q. Lu, C.-B. Chen, W.-J. Xiao, Asymmetric Friedel-Crafts Alkylations of Indoles with Ethyl Glyoxylate Catalyzed by (S)-BINOL-Ti (IV) Complex: Direct Access to Enantiomerically Enriched 3-Indolyl-hydroxyacetates, Adv. Synth. Catal. 2007, 349, 1597-1603.
14. Y.-J. Cao, H.-H. Lu, Y.-Y. Lai, L.-Q. Lu, W.-J. Xiao, An Effective Bifunctional Thiourea Catalyst for Highly Enantio- and Diastereoselective Michael Addition of Cyclohexanone to Nitroolefins, Synthesis 2006, 3795-3800.
15. J.-R. Chen, H.-H. Lu, X.-Y. Li, L. Cheng, J. Wan, W.-J. Xiao, Readily Tunable and Bifunctional L-Prolinamide Derivatives: Design and Application in the Direct Enantioselective Aldol Reactions, Org. Lett. 2005, 7, 4543-4545.
