閔軍霞

簡介

浙江大學醫學院閔軍霞教授團隊發現，心臟細胞“鐵死亡”是心臟疾病的關鍵致病機制，並基於分子調控機制提出了多種預防心臟損傷的有效途徑。這一發現為心肌病及心肌梗死等致死性拳勸請心臟疾病的防治提供了新策略，相關論文於2019年1月29日發表於《美國科學院院報》。

“心肌細胞作為一種終末分化細胞，它的死亡將導致數量的減少，從而引起心臟結構和功能上的缺陷，加劇心力衰竭。”王福俤介紹說，細胞死亡方式主要分為探定堡經典的壞死和凋亡兩種，近年來隨著對細胞死亡機制的深入研究，鐵死亡等多種新的細胞死亡方式被相繼發現。

為了深入研究心台協棗髒疾病中細胞死亡的作用，研究團隊採用了多種細胞死亡類型抑制劑處理小鼠，發現抑制細胞鐵死亡能夠明顯改善心肌損傷，通過抑制劑來阻斷細胞鐵死亡還能夠明顯減輕由心肌缺血再灌注導致的急慢性心臟損傷。

“必需微量元素鐵與心臟疾病的關係廣泛而緊密。我們發現，攝入膳食鐵過多，特別是血紅素鐵，會顯著增加心血管疾病風險，而鐵死亡抑制劑、鐵螯合劑、線粒體抗氧化劑、低鐵膳食等是預防心臟損傷的有效途

“關於鐵死亡的研究還主要集中於體外細胞水平，本研究為我們深入了解鐵死亡在心臟損傷中的作用，探索利用鐵死亡抑制劑治療心臟損傷提供了大量的證據。”哈爾濱工業大學生命科學中心研究員高明輝評價說。

該研究提示鐵死亡可能參與臨床上心肌梗死等多種心臟疾病的發病，下一步應促進這一成果套用於臨床，為心臟病防治做出更多貢獻。

主要研究方向

1. CAR-T的全程最佳化研究；2. 腫瘤的轉化醫學研究。3.人類衰老與長壽的轉化醫學研究;

運用醫學及生命科學前沿技術以中國高發腫瘤患者多組學大數據結合功能篩選為出發點，探索適用於中國消化道惡性腫瘤霉求定霸基因型的有效新型靶向治療、免疫治療及克服靶向耐藥的綜合治療策略；基於中國長壽人群佇列系統性研究長壽的遺傳學、代謝及免疫特徵，為人類衰老及相關慢性疾病防治提供了新思路。

主持及參加項目

1. 國家自然科學基金面上項目，RNA解旋酶DDX17與p53抑癌基因突變的協同作用及分子機制研究，槳遙辣紋項目批准號：31570791，2016/01-2019/12，84萬元，主持。

2. 國家自然科學基金重大項目（應對老齡社會的基礎科學問題研究課題二）“健康老齡化--老年人口健康影響因素及有效干預的基礎科學問題研究”項目批准號: 71490732, 2015年1月-2019年12月; 425萬；課題組副組長。

3. 國家自然科學基金重大研究計畫，肝臟樹突狀細胞在移植肝區域免疫中的作用及研究機制，項目批准號：91542205，2016/01-2020/12，280萬元，課題骨幹。

4. 浙江省自然科學基金重點項目，項目批准號：Z15H160009，胃癌中靶向ERBB3 抑癌效應及分子機制研究，2015/01-2018/12，30萬元，主持

5. 浙江大學橫向課題，人類衰老與長壽的轉化醫學研究，艱斷107萬，項目負責人盼燥蒸。

成果及獎項

諾華優秀課題負責人獎（2012、2013），諾華科技創新獎（2012），諾華腫瘤藥物研發最佳業績獎（2011）。在國際著名雜誌包括Nature Medicine、Cancer Cell, Blood、Hepatology、PNAS等發表系列原創性論文；獲得發明專利2項；多次應邀在國內外學術大會進行主旨報告。承擔國家自然科學基金重大研究計畫（1項）、面上項目（2項）、科技部國家重點研發計畫“蛋白質機器與生命過程調控”重點專項（骨幹）、科技部國家重點研發計畫“中國健康長壽大人群多佇列的系統研究”（項目負責人）、浙江大學與史丹福大學的國際頂尖大學合作項目（項目負責人）。

代表性論著

通訊作者論文

1. Yang L#, Wang H#, Yang X#, Wu Q, An P, Jin X, Liu W, Huang X, Li Y, Yan S, Shen S, Liang T*, Min J*, Wang F*. Auranofin mitigates systemic iron overload and induces Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms. Signal Transduction and Targeted Therapy. (Accepted 2020 June 19)

2. Yang X#, Wang H#, Xie E, Tang B, Mu Q, Song Z, Chen J, Wang F, Min J*. Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation. Protein&Cell. (Accepted 2020 June 15)

3. Yu Y#, Jiang L#, Wang H, Shen Z, Cheng Q, Zhang P, Wang J, Wu Q, Fang X, Duan L, Wang S, Wang K, An P, Shao T, Chung RT, Zheng S, Min J*, Wang F*. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020 May 6

4. Fang X#, Cai Z, Wang H, Han D, Cheng Q, Zhang P, Gao F, Yu Y, Song Z, Wu Q, An P, Huang S, Pan J, Chen HZ, Chen J, Linkermann A, Min J*, Wang F*. Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circulation Research. 2020 Apr 30.

5. Li J#, Pan X#, Pan G, Song Z, He Y, Zhang S, Ye X, Yang X, Xie E, Wang X, Mai X, Yin X, Tang B, Shu X, Chen P, Dai X, Tian Y, Yao L, Han M, Xu G, Zhang H, Sun J, Chen H, Wang F*, Min J* and Xie L*. Transferrin receptor 1 regulates thermogenic capacity and cell fate in brown/beige adipocytes. Advanced Science. 2020 Mar 4.

6. An P #, Wang J#, Wang H, Jiang L, Wang J, Min J*, Wang F*. Gnpat does not play an essential role in systemic iron homeostasis in murine model. Journal of Cellular and Molecular Medicine. 2020 Feb 28.

7. Wang S#, He X#, Wu Q, Jiang L, Chen L, Yu Y, Zhang P, Huang X, Wang J, Ju Z, Min J *, Fudi Wang*. Transferrin Receptor 1-Mediated Iron Uptake Plays An Essential Role In Hematopoiesis. Haematologica. 2019 Oct 10.

8. Jiang L#, Wang K#, Lo K#, Zhong Y, Yang A, Fang X, Akezhuoli H, Song Z, Chen L, An P, Xu M*, Min J*, Wang F*. Sex-specific association of circulating ferritin level and risk of type 2 diabetes: A dose-response meta-analysis of prospective studies. The Journal of Clinical Endocrinology & Metabolism. 2019 Oct 1.

9. Wang X#, Wu W#, Zheng W, Fang X, Chen L, Rink L, Min J*, Wang F*. Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition. 2019 Jul 1.

10. Zhang P#, He J, Wang F, Gong J, Wang L, Wu Q, Li W, Liu H, Wang J, Zhang K, Li M, Huang X, Pu C, Li Y, Jiang F, Wang F *, Min J *, Chen X*. Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age‐related muscle wasting. Journal of Cachexia, Sarcopenia and Muscle. 2019 Mar 18.

11. Li G #, Zhang Y#, Xie E, Yang X, Wang H, Wang X, Li W, Song Z, Mu Q, Zhan W, Wu Q, Huang J, Chen Y, Zhang Y, Wang F, Min J*. Functional characterization of a potent anti-tumor polysaccharide in a mouse model of gastric cancer. Life Sciences. 2019 Feb 15.

12. Fang X#, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A*, Gu W*, Min J*, Wang F*. Ferroptosis as a target for protection against cardiomyopathy. Proceedings of the National Academy of Sciences. 2019 Feb 12.

13. Gao H#, Dai W, Zhao L*, Min J*, Wang F*. The Role of Zinc and Zinc Homeostasis in Macrophage Function. Journal of Immunology Research. 2018 Dec 6.

14. Wang X#, Gao H#, Wu W, Xie E, Yu Y, He X, Li J, Zheng W, Wang X, Cao X, Meng Z, Chen L*, Min J*, Wang F*. The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2. Protein & Cell.2018 Oct 15.

15. Zeng Y*, Nie C, Min J*, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie E, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL, Yang H, Vaupel J. Sex differences in genetic associations with longevity. JAMA Network Open. 2018 Aug 24.

16. Zhao X#, Liu X#, Zhang A#, Chen H#, Huo Q, Li W, Ye R, Chen Z, Liang L, Liu QA, Shen J, Jin X, Li W, Nygaard M, Liu X, Hou Y, Ni T, Bolund L, Gottschalk W, Tao W, Gu J, Tian XL, Yang H, Wang J, Xu X, Lutz MW, Min J*, Zeng Y*, Nie C*. The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging (Albany NY). 2018 Jun 5.

17. Yin X#, Wu Q#, Monga J, Xie E, Wang H, Wang S, Zhang H, Wang ZY, Zhou T, Shi Y, Rogers J, Lin H, Min J*, Wang F*. HDAC1 governs iron homeostasis independent of histone deacetylation in iron-overload murine models. Antioxidants & Redox Signaling. 2018 May 1.

18. Fang X#, Wei J#, He X#, Lian J#, Han D, An P, Zhou T, Liu S, Wang F*, Min J*. Quantitative association between body mass index and the risk of cancer: A global Meta-analysis of prospective cohort studies. International Journal of Cancer. 2018 Apr 26.

19. An P#, Wang H#, Wu Q, Wang J, Xia Z, He X, Wang X, Chen Y, Min J*, Wang F*. Smad7 deficiency decreases iron and haemoglobin through hepcidin up-regulation by multilayer compensatory mechanisms. Journal of Cellular and Molecular Medicine, 2018 Mar 30.

20. Zhang Y#, Wang X#, Wu Q, Wang H, Zhao L, Wang X, Mu M, Xie E, He X, Shao D, Shang Y, Lai Y, Ginzburg Y, Min J* and Wang F*. Adenine alleviates iron overload by cAMP/PKA mediated hepatic hepcidin in mice. Journal of Cellular Physiology, 2018 Mar 30.

21. Gao H, Zhao L, Wang H, Xie E, Wang X, Wu Q, Yu Y, He X, Ji H, Rink L, Min J, Wang F. Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. Proceedings of the National Academy of Sciences. 2017 Dec 5;114(49):12940-12945. Epub 2017 Nov 2

22. Wang H, An P, Xie E, Wu Q, Fang X, Gao H, Zhang Z, Li Y, Wang X, Zhang J, Li G, Yang L, Liu W, Min J*, Wang F*. Characterization of Ferroptosis in Murine Models of Hemochromatosis. Hepatology. 2017 Aug;66(2):449-465. Epub 2017 May 162017.

23. Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, Zhang H, Wang ZY, Zhou T, Shi Y, Rogers J, Lin H, Min J*, Wang F*. HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-overload Murine Models. Antioxidants & Redox Signaling. 2017 Nov 7.

24. Wu Q, Shen Y, Tao Y, Wei J, Wang H, An P, Zhang Z, Gao H, Zhou T, Wang F*, Min J*. Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice. Cell Discovery. 2017 Aug 15; 3:17028. doi: 10.1038/celldisc.2017.28.

25. Xia Z, Wei J, Li Y, Wang J, Li W, Wang K, Hong X, Zhao L, Chen C, Min J*, Wang F*. Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis. PLOS Genetics. 2017 Jul 10;13(7): e1006892.doi: 10.1371/journal.pgen.1006892.

26. Wang X#, An P#, Zeng J, Liu X, Wang B, Fang X, Wang F*, Ren G*, Min J*. Serum ferritin in combination with prostate-specific antigen improves predictive accuracy for prostate cancer. Oncotarget 2017. doi:10.18632/oncotarget.14977

27. Fang X, Wei J, He X, An P, Wang H, Jiang L, Shao D, Liang H, Li Y, Wang F*, Min J*. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. European Journal of Cancer. 2015; 51:2820–2832.

28. An P, Wang H, Wu Q, Guo X, Wu A, Zhang Z, Zhang D, Xu X, Mao Q, Shen X, Zhang L, Xiong Z, He L, Liu Y, Min J*, Zhou D*, Wang F*. Elevated serum transaminase activities were associated with increased serum levels of iron regulatory hormone hepcidin and hyperferritinemia risk. Scientific Reports. 2015; 5:13106.

29. Wu Q, Wang H, An P, Tao Y, Deng J, Zhang Z, Shen Y, Min J*, Wang F*. HJV and HFE Play Distinct Roles in Regulating Hepcidin. Antioxidants & Redox Signaling. 2015;22(15):1325-36.

第一作者論文

1.Min J, Fedele G, Zaslavsky A, Reczek E, Guney I, Strochlic D, Bronson RT, Hahn WC, Ryeom S, Loda M and Cichowski K. (2010) An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and NF-kB. Nature Medicine, Mar;16(3):286-94 (Article)

2.Min J, Mesika A, Sivaguru M, Van Veldhoven PP, Alexander H, Anthony H. Futerman AH and Alexander S. (2007) LASS1 dihydroceramide synthase induced sensitivity to cisplatin is mediated through the activation of p38 MAP kinase and is abrogated by sphingosine kinase 1. Molecular Cancer Research. 5(8):801-12 (Cover article)

3.Min J., Sridetive P., Hanigan MH., Alexander H. (2006) Sensitive cell viability assay for use in drug screens and for studying the mechanism of action of drugs in Dictyosteliumdiscoideum. Biotechniques, 41(5):591-5. (Featured article)

4.Min J., Van Veldhoven PP, Zhang L, Hanigan MH, Alexander H, Alexander S. (2005) Sphingosine-1-Phosphate Lyase Regulates Sensitivity of Human Cells to Select Chemotherapy Drugs in a p38-Dependent Manner. Molecular Cancer Research,3:287-296.

5.Min J., Traynor D., Stegner A.L, Zhang L., Hanigan M.H., Alexander H., and Alexander S. (2005) Sphingosine kinase regulates the sensitivity of Dictyostelium Discoideum cells to the anticancer drug cisplatin. Eukaryotic Cell, 4:178-189

6.Min J, Stegner A.L, Alexander H. and Alexander S. (2004) Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum based chemotherapy drugs. Eukaryotic Cell, 3:795-805

7.Jaeger S#, Min J#, Nigsch F, Camargo M, Hutz J, Cornett A, Cleaver S, Buckler A, Jenkins J. L. Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer. Journal of Biomolecular Screening. 2014;19(5):791-802.

8.Zeng Y#, Nie C#, Min J#, Liu X#, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW. Novel loci and pathways significantly associated with longevity. Scientific Reports 2016; 6:21243.

閔軍霞

基本介紹

簡介

主要研究方向

主持及參加項目

成果及獎項

代表性論著

通訊作者論文

第一作者論文

成果及獎項

代表性論著

通訊作者論文

第一作者論文

相關詞條

熱門詞條